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Ride the wind,cleave the waves,and set sail to cross the sea——A newfound journal,a new platform,and a new hope

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Translational Neuroscience and Clinics 2015年第1期1卷 1-2页

作者： Huancong Zuo Akira Teramoto Yuqi Zhang tatsuya kondo Tsinghua University Yuquan Hospital Nippon Medical School Pharmaceuticals and Medical Devices Agency(PMDA)

Taking the first step is as good as being half *** congratulations and wishes for the success of this newly founded *** thanks to Ihe Chinese and international editorial board,reviewers,editorial staff,friends of the ... 详细信息

关键词： Ride the wind,cleave the waves,and set sail to cross the sea A newfound journal,a new platform,and a new hope

《文学杂志》、《文艺月报》与左联活动探赜——以北方左联克服“关门主义”的过程为中心

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东岳论丛 2011年第3期32卷 12-29页

作者：近藤龙哉吉田薰日本女子大学文学部

1933年间,北平相继出现了两种大型文学杂志《文学杂志》和《文艺月报》。体裁与内容相似的这两种公开杂志之间有何关系?关于《文学杂志》,据当时左联负责人员陆万美的证言,它被当做了北方左联的机关刊物。但朱正以王志之在其《鲁迅印象... 详细信息

1933年间,北平相继出现了两种大型文学杂志《文学杂志》和《文艺月报》。体裁与内容相似的这两种公开杂志之间有何关系?关于《文学杂志》,据当时左联负责人员陆万美的证言,它被当做了北方左联的机关刊物。但朱正以王志之在其《鲁迅印象记》里所描写的该杂志发刊筹备的情况为证据,主张它不是左联机关刊物。我再三慎重斟酌两种杂志的内容以及两位论者的主张,最后得出了如下结论:与朱正的主张相反,我认为《文学杂志》的产生是北方左联在纠正"关门主义"的过程中所做的实践之一。但这个富有重要意义的尝试也被文总(即指导左联的上级机关)视为"右倾化"的产物而拒绝了。负责开展左联活动的潘漠华、陆万美等人受到批判,左联又改变了方向。《文艺月报》是在文总的指导下以北平社联的负责人员为中心创办的刊物,它是在推动北方左联全体走上"左倾"路线起了很大作用的一种杂志。

关键词：文学杂志文艺月报北方(北平)左联 “右倾化”

Xyloglucan for Generating Tensile Stress to Bend Tree Stem

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Molecular Plant 2009年第5期2卷 893-903页

作者： Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji kondo Ziv Shani Oded Shoseyov tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi Kyoto University RISH Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural-Sciences Nagoya University Nagoya 464-8601 Japan Forest Tree Breeding Center Hitachi Ibaraki 319-1301 Japan CBD Technologies Rehovot 76100 Israel Division of Forest and Biomaterials Science Kyoto University Kyoto 606-8502 Japan Graduate School of Frontier Biosciences Osaka University Suita Osaka 565-0871 Japan Institute of Sustainability Science Kyoto University Gokasho Uji Kyoto 611-0011 Japan

In response to environmental variation, angiosperm trees bend their stems by forming tension wood, which consists of a cellulose-rich G （gelatinous）-Iayer in the walls of fiber cells and generates abnormal tensile stress in the secondary xylem. We produced transgenic poplar plants overexpressing several endoglycanases to reduce each specific polysaccharide in the cell wall, as the secondary xylem consists of primary and secondary wall layers. When placed horizontally, the basal regions of stems of transgenic poplars overexpressing xyloglucanase alone could not bend upward due to low strain in the tension side of the xylem. In the wild-type plants, xyloglucan was found in the inner surface of G-layers during multiple layering. In situ xyloglucan endotransglucosylase （XET） activity showed that the incorporation of whole xyloglucan, potentially for wall tightening, began at the inner surface layers S1 and S2 and was retained throughout G-layer development, while the incorporation of xyloglucan heptasaccharide （XXXG） for wall loosening occurred in the primary wall of the expanding zone. We propose that the xyloglucan network is reinforced by XET to form a further connection between wall-bound and secreted xyloglucans in order to withstand the tensile stress created within the cellulose G-layer micro fibrils.

关键词： G-layer tensile stress xyloglucan xyloglucan endotransglucosylase

Influence of Kupffer cells and platelets on ischemia-reperfusion injury in mild steatotic liver

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World Journal of Gastroenterology 2013年第9期19卷 1396-1404页

作者： Koichi Ogawa Tadashi kondo Takafumi Tamura Hideki Matsumura Kiyoshi Fukunaga tatsuya Oda Nobuhiro Ohkohchi Department of Surgery Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba 305-8575 Japan

AIM: To investigate the effect of mild steatotic liver on ischemia-reperfusion injury by focusing on Kupffer cells (KCs) and platelets. METHODS: Wistar rats were divided into a normal liver group (N group) and a mild steatotic liver group (S group) induced by feeding a choline-deficient diet for 2 wk. Both groups were subjected to 20 min of warm ischemia followed by 120 min of reperfusion. The number of labeled KCs and platelets in sinusoids and the blood perfusion in sinusoids were observed by intravital microscopy (IVM), which was performed at 30, 60 and 120 min after reperfusion. To evaluate serum alanine aminotransferase as a marker of liver deterioration, blood samples were taken at the same time as ***: In the S group, the number of platelets adhering to KCs decreased significantly compared with the N group (120 after reperfusion; 2.9±1.1 cells/acinus vs 4.8±1.2 cells/acinus, P<0.01). The number of KCs in sinusoids was significantly less in the S group than in the N group throughout the observation periods (before ischemia, 19.6±3.3 cells/acinus vs 28.2±4.1 cells/acinus, P<0.01 and 120 min after reperfusion, 29.0±4.3 cells/acinus vs 40.2±3.3 cells/acinus, P<0.01). The blood perfusion of sinusoids 120 min after reperfusion was maintained in the S group more than in the N group. Furthermore, elevation of serum alanine aminotransferase was lower in the S group than in the N group 120 min after reperfusion (99.7±19.8 IU/L vs 166.3±61.1 IU/L, P=0.041), and histological impairment of hepatocyte structure was prevented in the S group. CONCLUSION: Ischemia-reperfusion injury in mild steatotic liver was attenuated compared with normal liver due to the decreased number of KCs and the reduction of the KC-platelet interaction.

关键词： Steatotic liver Mild steatotic liver Kupffer cell Platelet Ischemia-reperfusion Intravital microscopy

Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy

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World Journal of Gastroenterology 2017年第11期23卷 2060-2067页

作者： Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki kondo Shiei Yoshida tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of Medicine Department of Pharmacy Kobe University Hospital

AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical *** The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were *** The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms.

关键词： Gastroesophageal reflux disease CYP2C19 FSSG Residual symptoms Proton pump inhibitor

Glioblastoma-initiating cells transformed from oligodendrocyte precursor cells are sensitive for the combination of Cox2 inhibitor and EGFR inhibitor

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Glioblastoma-initiating cells transformed from oligodendrocy...

Growth processes and crystallographic properties of nanographenes synthesized employing in-liquid plasma

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Takuichiro Hide tatsuya Takezaki Hideo Nakamura Keishi Makino Jun-ichi Kuratsu Toru kondo Laboratory for Cell Lineage Modulation Center for Developmental BiologyRIKENKobeJapan Department of Neurosurgery Kumamoto University Graduate School of Medical ScienceKumamotoJapan. Department of Neurosurgery Kumamoto University Graduate School of Medical ScienceKumamotoJapan

＜正＞Purpose:Malignant tumors,including glioblastoma multiforme（GBM）,contain cancer stem cells（CSCs）,which self-renew indefinitely and are *** identify new therapeutic targets of GBM,we tried to establish glioma ...

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Growth processes and crystallographic properties of nanograp...

Electrical Stimulation in Addition to Passive Exercise Has a Small Effect on Spasticity and Range of Motion in Bedridden Elderly Patients: A Pilot Randomized Crossover Study

第三届微电子及等离子体技术国际会议

作者： Hiroki kondo tatsuya Hagino Kenji Ishikawa Keigo Takeda Hiroyuki Kano Makoto Sekine Masaru Hori Department of electrical engineering and computer science graduate school of engineeringNagoya University Plasma nanotechnology research center graduate school of engineeringNagoya University

Nanographene materials have attracted much attention as their unique structures,interesting properties,and promising device ***,we established a high-speed synthesis technique of nanographene employing alcohols and in-liquid plasma,and confirm high crystallinity of synthesized *** this study,growth processes and mechanisms of nanographenes are *** this method,one Ni electrode was immersed into an ethanol,and the other was fixed above the ethanol level at gaseous Ar *** a 9 kV and 60 Hz ac-power to these electrodes,the in-liquid plasma was *** the plasma discharge for 20 minutes,it was found that black-colored nanographenes with a size of microns were dispersed in the *** black substances and yellow-colored extraction liquid were separated by *** sharp G-band peaks at 1581 cm-1 in Raman spectra and the interlayer spacing（3.33 A） between graphite basal planes observed in the transmission electron microscopy（TEM） images revealed the high-crystallinity of synthesized *** the crystallographic properties were not significantly changed owing to the kinds of alcohols and electrode *** the other hand,according to the liquid chromatography analysis,various types of aromatic hydrocarbons were generated in the *** results indicate that the in-liquid plasma discharge induce the dissolution of alcoholic molecules and generation of aromatic hydrocarbons as elementary steps of nanographene ***,the polymerization of the aromatic hydrocarbons results in the nanographene *** results will open the way to further development of high-speed synthesis and precise control of crystallographic properties.

关键词： Nanographene In-liquid plasma transmission electron microscopy Raman spectroscopy liquid chromatography

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Health 2019年第8期11卷 1072-1086页

作者： Hideki Kataoka Shunpei Nakashima Hideki Aoki Kyo Goto Junichiro Yamashita Yuichiro Honda Yasutaka kondo tatsuya Hirase Junya Sakamoto Minoru Okita Department of Rehabilitation Nagasaki Memorial Hospital Nagasaki Japan Department of Physical Therapy Science Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan Department of Rehabilitation Nagasaki University Hospital Nagasaki Japan Department of Rehabilitation Nagasaki Genbaku Hospital Nagasaki Japan Institute of Biomedical Sciences Nagasaki University Nagasaki Japan

Purpose: Belt electrode skeletal muscle electrical stimulation (B-SES) can stimulate large portions of muscles including deep sites without localisation of the stimulation area. The purpose of this study is to investigate both immediate treatment effects of B-SES and long-term treatment effects of B-SES with passive exercise on range of motion (ROM) and muscle tone of lower extremities in bedridden elderly patients. Methods: Outcome measures before and after B-SES treatment alone (4 Hz, 20 min, both lower extremities) were examined for the immediate effect. Outcome measures were: ROM and Modified Ashworth scale (MAS) of hip flexion and adduction;knee flexion and extension;and knee joint distance at position of flexion abduction in hip (distance of knee). A randomized crossover trial was conducted to examine the long-term effect of adding B-SES to passive exercise on ROM and MAS. Results and Discussion: The immediate effect study had 18 patients. ROM and MAS of 4 joint angles in 2 joints and distance of knee significantly improved after B-SES treatment. The long-term effect study had 11 patients. Friedman test revealed ROM and MAS of 4 joint angles in 2 joints and distance of knee significantly improved during B-SES intervention but not control intervention. B-SES in addition to passive stretch has a more statistically significant effect on contracture and spasticity in large portions of the lower extremities of bedridden elderly patients than passive stretching alone. Conclusions: We consider B-SES a useful tool to improve the ROM in lower extremities of bedridden patients.

关键词： Bedridden Patients Belt Electrode Skeletal Muscle Electrical Stimulation Lower Extremity Muscle Tone Restriction of Range of Joint Motion

Impact of looping on premalignant polyp detection during colonoscopy

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 694-703页

作者： Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida tatsuya Matsuno Toru Arano Ryo kondo Kazunori Kinoshita Yuki Yasumi Yosuke Tsuji Mitsuhiro Fujishiro Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalNarita 286-8520Japan Department of Obstetrics and Gynecology Seijo Kinoshita HospitalTokyo 157-0066Japan Department of Internal Medicine Yasumi HospitalMorioka 028-4125Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

BACKGROUND The presence of premalignant polyps on colonoscopy is an indicator of metachronous colorectal *** during colonoscopy is associated with old age,female sex,and colonoscopy insertion ***,the clinical significance of looping is not fully *** aimed to clarify the effect of looping on colorectal premalignant polyp *** To assess the effects of looping on premalignant polyp detection using logistic regression *** We retrospectively investigated patients who underwent colonoscopy at Toyoshima Endoscopy Clinic between May,2017 and October,*** the clinic’s endoscopy database,we extracted data on patient age,sex,endoscopist-assessed looping,colonoscopy duration,endoscopist experience,detection rate,and number of premalignant *** We assessed 12259 patients(mean age,53.6 years;men,50.7%).Looping occurred in 54.3%of the *** and severe looping were noted in 4399 and 2253 patients,*** detection rates of adenomas,advanced adenomas,high-risk adenomas,clinically significant serrated polyps(CSSPs),and sessile serrated lesions(SSLs)were 44.7%,2.0%,9.9%,8.9%and 3.5%,*** mean numbers of adenomas and SSLs were 0.82 and 0.04,*** detection rates of adenomas,high-risk adenomas,and CSSPs increased with looping severity(all P<0.001).The number of adenomas increased with looping severity(P<0.001).Multivariate analyses found that detection of adenomas,high-risk adenomas,and CSSPs was associated with severe looping(P<0.001,P<0.001,and P=0.007,respectively)regardless of age,sex,time required for colonoscope insertion and withdrawal,and endoscopist *** Looping severity was independently associated with high detection rates of premalignant ***,looping may predict the risk of metachronous colorectal *** should carefully examine the colorectum of patients with looping.

关键词： Looping Colorectal polyp Colonoscopy Adenoma Serrated polyp Colorectal neoplasm