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Pancreatic cancer secondary to intraductal papillary mucinous neoplasm with collision between gastric cancer and B-cell lymphoma: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2400-2408页

作者： Yu-Hong ma tatsuya Yamaguchi Tomoki Yasumura Toru Kuno Shoji Kobayashi Takashi Yoshida Takeshi Ishida Yasuaki Ishida Shinya Takaoka Jiang-Lin Fan Nobuyuki Enomoto Department of Gastroenterology Ningxia Hui Autonomous Region People’s HospitalYinchuan 750021Ningxia Hui Autonomous RegionChina Department of the First Internal Medicine Faculty of MedicineUniversity of YamanashiChuo 409-3898YamanashiJapan Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashiChuo 409-3898YamanashiJapan

BACKGROUND Patients with intraductal papillary mucinous neoplasm(IPMN)have an increased risk of pancreatic and extrapancreatic *** are rare extrapancreatic malignancies,and in situ collisions of early gastric cancer and diffuse large B-cell lymphoma(DLBCL)are even ***,we report the first case of pancreatic cancer comorbid with in situ collision of extrapancreatic malignancies(early gastric cancer and DLBCL)in a follow-up IPMN ***,we have made innovations in the treatment of such *** SUMmaRY An 81-year-old Japanese female diagnosed with IPMN developed elevated carbohydrate antigen(CA)19-9 levels during *** her CA19-9 levels continued to rise,endoscopic ultrasound(EUS)was performed and revealed a suspicious lesion at the pancreatic ***,lesions in the pancreas were not found by computed tomography,magnetic resonance imaging,or endoscopic retrograde *** make an exact pathological diagnosis,EUS-guided fine needle aspiration was *** our supprise,early gastric cancer was found in preoperative *** gastric cancer was completely resected through endoscopic submucosal dissection before postoperative pathology identified early adenocarcinoma collided with *** EUS-guided fine needle aspiration provided pathological support forthe pancreatic cancer diagnosis, and then laparoscopic distal pancreatectomy andsplenectomy were performed. CA19-9 levels returned to normal *** Endoscopic submucosal dissection is appropriate for submucosal lymphomas inpatients intoleratant of chemotherapy. EUS can detect small IPMN-relatedpancreatic tumors.

关键词： Stomach neoplasms Pancreatic intraductal neoplasms Pancreatic neoplasms B-cell lymphoma Treatment Case report

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Carbon-Ion Beams Efficiently Induce Cell Killing in X-Ray Resistant Human Squamous Tongue Cancer Cells

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第3期3卷 133-142页

作者： Akihisa Takahashi Hongyu ma Akiko Nakagawa Yukari Yoshida Tatsuaki Kanai tatsuya Ohno Yoshikazu Kuwahara manabu Fukumoto Takashi Nakano Advanced Scientific Research Leaders Development Unit Gunma University Gunma Japan Department of Pathology IDAC Tohoku University Sendai Japan Department of Radiation Oncology Gunma University Graduate School of Medicine Gunma Japan Gunma University Heavy Ion Medical Center Gunma Japan

In order to see whether carbon ion (C-ion) beams have a biological advantage over X-rays, studies were designed to examine the effects of C-ion beams on radiosensitivity in X-ray resistant cells. Clinically relevant X-ray resistant SAS-R cells derived from human tongue cancer SAS cells were used. The cells were exposed to X-rays or Spread-Out Bragg peak (SOBP) beam C-ions. Cell survival was measured using a modified high-density survival assay. Cell survival signaling and cell death signaling were analyzed using flow cytometry. The cells were labeled with putative cancer stem cell markers such as CD44 and CD326. SAS-R cells were 1.6 times more radioresistant than SAS cells after exposure to X-rays. Cell survival was similar in each cell line after exposure to C-ion beams. SAS-R cells displayed enhanced cell survival signaling when compared to SAS cells under normal conditions. On the other hand, the phosphorylation of AKT-related proteins decreased and polycaspase activities were enhanced when cells were irradiated with C-ion beams in both cell lines. More CD44 and CD326 positive cells were seen in SAS-R cells than in SAS cells. Moreover, the marker positive cell numbers significantly decreased after exposure to C-ion beams when compared to X-rays at iso-survival doses in SAS-R cells. C-ion beams efficiently induced cell killing in X-ray resistant cells which displayed activated cell survival signaling and contained more numerous cancer stem-like cells.

关键词： Carbon-Ion Beams X-Ray Resistant Cells Cell Survival and Death Signaling Cancer Stem-Like Cells

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Significance of functional hepatic resection rate calculated using 3D CT/^(99m)Tc-galactosyl human serum albumin singlephoton emission computed tomography fusion imaging

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World Journal of Gastroenterology 2016年第17期22卷 4373-4379页

作者： Yosuke Tsuruga Toshiya Kamiyama Hirofumi Kamachi Shingo Shimada Kenji Wakayama tatsuya Orimo Tatsuhiko Kakisaka Hideki Yokoo Akinobu Taketomi Department of Gastroenterological Surgery I Hokkaido University Graduate School of Medicine

AIM: To evaluate the usefulness of the functional hepatic resection rate (FHRR) calculated using 3D computed tomography (CT)/99mTc-galactosyl-human serum albumin (GSA) single-photon emission computed tomography (SPECT) fusion imaging for surgical decision ***: We enrolled 57 patients who underwent bi- or trisectionectomy at our institution between October 2013 and march 2015. Of these, 26 patients presented with hepatocellular carcinoma, 12 with hilar cholangiocarcinoma, six with intrahepatic cholangiocarcinoma, four with liver metastasis, and nine with other diseases. All patients preoperatively underwent three-phase dynamic multidetector CT and 99mTc-GSA scintigraphy. We compared the parenchymal hepatic resection rate (PHRR) with the FHRR, which was defined as the resection volume counts per total liver volume counts on 3D CT/99mTc-GSA SPECT fusion ***: In total, 50 patients underwent bisectionectomy and seven underwent trisectionectomy. Biliary reconstruction was performed in 15 patients, including hepatopancreatoduodenectomy in two. FHRR and PHRR were 38.6 ± 19.9 and 44.5 ± 16.0, respectively; FHRR was strongly correlated with PHRR. The regression coefficient for FHRR on PHRR was 1.16 (P 1000 mL, and/or macroscopic vascular invasion was significantly smaller than that for patients without these factors (0.73 ± 0.19 vs 0.82 ± 0.18, P major morbidities (Clavien-Dindo grade ≥ 3) occurred in 17 patients (29.8%). There was no case of surgery-related ***: Our results suggest that FHRR is an important deciding factor for major hepatectomy, because FHRR and PHRR may be discrepa

关键词： 99mTc-galactosyl human serum albumin Single-photon emission computed tomography Hepatectomy Functional hepatic resection rate Parenchymal hepatic resection rate

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Cardiorespiratory and muscular fitness associations with older adolescent cognitive control

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Journal of Sport and Health Science 2021年第1期10卷 82-90,I0001页

作者： tatsuya T.Shigeta Angus A.Leahy Jordan J.Smith Narelle Eather David R.Lubans Charles H.Hillman Department of Psychology Northeastern UniversityBostonMA 02115USA Priority Research Centre for Physical Activity and Nutrition School of EducationUniversity of NewcastleCallaghanNSW 2308Australia Department of Physical Therapy Movement&Rehabilitation SciencesNortheastern UniversityBostonMA 02131USA

Background:Participation in physical activity supports greater cardiorespiratory fitness(CRF),a correlate of cognitive ***,the relationship between muscular fitness(MF)and cognitive control is less *** present study investigated the differential relationship of CRF and MF with cognitive control in older ***:This cross-sectional study involved students(1517 years old,n=541,43%female)from 20 secondary schools who completed tests of inhibition(modified flanker task),working memory(n-back task),CRF(Progressive Aerobic Cardiovascular Endurance Run),and MF(standing long jump and push-up test).Multilevel analyses tested the association between CRF or MF and cognitive outcomes while accounting for the influence of the other fitness variable and relevant demographic ***:CRF predicted response accuracy during incongruent flanker trials,the condition requiring greater *** the working memory task,CRF predicted greater target accuracy and greater d’scores on the 1-back task,requiring lesser amounts of working *** the 2-back task,which requires greater amounts of working memory,CRF also predicted greater target and non-target accuracy and d’***,MF did not predict any cognitive outcomes after adjustment for ***:CRF was selectively related to better performance during task conditions that require greater amounts of inhibition and working *** finding suggests that CRF,but not MF,may benefit cognitive control in older *** selective influence of CRF on older adolescents’cognition highlights the value of aerobic physical activity.

关键词： Adolescence Cognition Physical activity Physical fitness

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Antagonism effect of residual S triggers the dual-path mechanism for water oxidation

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Journal of Energy Chemistry 2024年第6期93卷 568-579,I0014页

作者： Li Liu Jinming Cao Siqi Hu Tinghui Liu Can Xu Wensheng Fu Xinguo ma Xiaohui Yang Chongqing Key Laboratory of Green Catalytic materials and Technology College of ChemistryChongqing Normal UniversityChongqing 401331China School of Science Hubei University of TechnologyWuhan 430068HubeiChina Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China

Transition metal chalcogenides(TMCs)are recognized as pre-catalysts,and their(oxy)hydroxides derived from electrochemical reconstruction are the active species in the water ***,understanding the role of the residual chalcogen in the reconstructed layer is lacking in detail,and the corresponding catalytic mechanism remains ***,taking Cu_(1-x)Co_(x)S as a platform,we explore the regulating effect and existence form of the residual S doped into the reconstructive layer for oxygen evolution reaction(OER),where a dual-path OER mechanism is ***-principles calculations and operando~(18)O isotopic labeling experiments jointly reveal that the residual S in the reconstructive layer of Cu_(1-x)Co_(x)S can wisely balance the adsorbate evolution mechanism(AEM)and lattice oxygen oxidation mechanism(LOM)by activating lattice oxygen and optimizing the adsorption/desorption behaviors at metal active sites,rather than change the reaction mechanism from AEM to *** such a dual-path OER mechanism,Cu_(0.4)Co_(0.6)S-derived Cu_(0.4)Co_(0.6)osh not only overcomes the restriction of linear scaling relationship in AEM,but also avoids the structural collapse caused by lattice oxygen migration in LOM,so as to greatly reduce the OER potential and improved stability.

关键词： Electrochemical reconstruction Adsorbate evolution mechanism Lattice oxygen oxidation mechanism Oxygen evolution reaction Residual sulfur

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Approaches for High-Efficiency III-V/Si Tandem Solar Cells

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Energy and Power Engineering 2021年第12期13卷 413-427页

作者： masafumi Yamaguchi Kan-Hua Lee Patrick Schygulla Frank Dimroth tatsuya Takamoto Ryo Ozaki Kyotaro Nakamura Nobuaki Kojima Yoshio Ohshita Toyota Technological Institute Nagoya Japan Fraunhofer Institute for Solar Energy System Freiburg Germany Sharp Corporation Nara Japan

The Si tandem solar cells are very attractive for realizing high efficiency and low cost. This paper overviews current status of III-V/Si tandem solar cells including our results. The analytical results for efficiency potential of Si tandem solar cells and loss analysis of Si bottom cells as well as bandgap energy optimization of sub-cells are presented. The 2-junction and 3-junction Si tandem solar cells have potential efficiencies of 36% and 42%, respectively. ERE (external radiative efficiency) analysis for Si solar cells is analyzed in order to clarify properties of Si bottom solar cells. Properties of single-crystalline Si heterojunction solar cell fabricated in this study were analyzed. The current status of efficiencies of our Si bottom cell, upper III-V 2-junction solar cell and III-V/Si 3-junction tandem solar cell was shown to be 5.2% and 28.6% and 33.8%. Achievement of Jsc of 12 mA/cm2 for Si bottom cell is necessary to realize high-efficiency 3-junction Si tandem solar cells with an efficiency of more than 37%. In addition, this paper presents ERE analysis of III-V 2-junction upper solar cells for improving III-V/Si 3-junction tandem solar cells. Several ways to improve efficiency of III-V/Si 3-junction tandem solar cells by reducing non-radiative recombination, optical and resistance losses are shown.

关键词： High-Efficiency Solar Cells Si Tandem Multi-Junction Efficiency Analysis

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基于中吉乌铁路线路走向方案的客货运量预测探析

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铁道运输与经济 2020年第12期42卷 24-31页

作者：马海超中铁第一勘察设计院集团有限公司陕西省铁道及地下交通工程重点实验室陕西西安710043

中吉乌铁路作为“一带一路”倡议陆路国际通道的重要组成部分,同时与规划的吉尔吉斯斯坦的南北铁路衔接,重新构筑吉尔吉斯斯坦的国家铁路网骨架。在工程可行的线路备选方案基础上,分析中吉乌铁路走向方案及影响区概况,运用四阶段法对不... 详细信息

中吉乌铁路作为“一带一路”倡议陆路国际通道的重要组成部分,同时与规划的吉尔吉斯斯坦的南北铁路衔接,重新构筑吉尔吉斯斯坦的国家铁路网骨架。在工程可行的线路备选方案基础上,分析中吉乌铁路走向方案及影响区概况,运用四阶段法对不同方案下通道客、货运量进行预测,从客货运量的角度对中吉乌铁路阿尔帕方案、杜斯托克方案和奥什方案3个线路走向方案进行评价。结果表明,阿尔帕方案在运量吸引上表现最佳,杜斯托克方案次之,奥什方案较差。基于运量预测角度对中吉乌铁路线路走向方案提供决策,对其他国际通道走向方案研究具有一定的借鉴意义。

关键词：中吉乌铁路规划方案四阶段法客运量预测货运量预测

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一种基于低温多晶硅TFT技术的柔性8位异步微处理器

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现代显示 2006年第4期 30-34页

作者： Nobuo Karaki Takashi Nanmoto Hiroaki Ebihara Satoshi Inoue tatsuya Shimoda 代永平精工爱普生公司技术平台中心南开大学

介绍基于低温多晶硅TFT技术和采用激光退火表面刻蚀技术的柔性8位异步微处理器,并且给出了异步电路描述语言Verilog+。32,000个晶体管的微处理器在500kHz,5V的条件下消耗电流180ma,功耗是同步微处理器的30%。

关键词：低温多晶硅激光退火表面刻蚀异步微处理器

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振动刺激诱发前庭诱发电位检测系统的初步研究

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中华耳科学杂志 2022年第1期20卷 111-115页

作者：高滢张青鸭頭辉山岨達也岩崎真一张滟马伟军陈耔辰张玉忠许珉任晓勇西安交通大学第二附属医院耳鼻咽喉头颈外科日本东京大学耳鼻咽喉头颈外科上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室日本名古屋市立大学耳鼻咽喉头颈外科

目的探索振动刺激诱发前庭诱发电位(VsEP Vestibular Evoked Potential)检测系统的构建及电位记录方法。旨在建立一套操作简便,无创伤,可长期反复操作,结果稳定的前庭诱发电位检测系统。方法选取健康小鼠6只,随机分为健康对照组(3只)和... 详细信息

目的探索振动刺激诱发前庭诱发电位(VsEP Vestibular Evoked Potential)检测系统的构建及电位记录方法。旨在建立一套操作简便,无创伤,可长期反复操作,结果稳定的前庭诱发电位检测系统。方法选取健康小鼠6只,随机分为健康对照组(3只)和庆大霉素造模组(3只)。使用振动刺激诱发记录前庭诱发电位(Vestibular evoked potential,VsEP),并与声刺激诱发的听性脑干反应(ABR)进行比较。结果6只小鼠均能引出稳定的VsEP波。庆大霉素造模组在SPLR波形振动刺激下比较健康对照组阈值升高(P<0.01),N1-P1振幅降低(P<0.05)。ABR阈值无明显差异。结论振动刺激诱发的前庭诱发电位检测系统是一种操作简便、无创伤、波形稳定的动物前庭功能检测系统,可用于小鼠前庭功能电生理状态的客观评价研究。

关键词：前庭诱发电位耳石器小鼠

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实现安全环保无隐患管理的基本原则

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油气田环境保护 2005年第1期15卷 10-11,58-59页

作者：马廷雷辽河石油勘探局质量安全环保部环保科

为了贯彻环境保护基本国策及落实安全第一的生产方针,各企业应该推行ISO14001/osh/HSE体系管理制度,保障生产设施性能符合HSE管理体系的要求,弘扬企业文化,建设学习型组织,完善事故应急救援预案,推进战略决策型基层组织建设。真正做到... 详细信息

为了贯彻环境保护基本国策及落实安全第一的生产方针,各企业应该推行ISO14001/osh/HSE体系管理制度,保障生产设施性能符合HSE管理体系的要求,弘扬企业文化,建设学习型组织,完善事故应急救援预案,推进战略决策型基层组织建设。真正做到“关爱生命、关注环境、关心公众”,实现安全环保无隐患管理。

关键词：环境保护 ISO14001/osh/HSE体系管理制度企业文化学习型组织事故应急救援预案环境管理中国

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