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Optimizing air quality and health Co-benefits of mitigation technologies in China: An integrated assessment

Environmental Science and Ecotechnology 2024年第6期22卷 206-214页

作者： Mengdan Zhao Yang Xie Meng Xu Zhixiong Weng tatsuya hanaoka Yuqiang Zhang Dan Tong School of Economics and Management Beihang UniversityBeijing100191China School of Management Wuhan Institute of TechnologyWuhan430205China Institute of Circular Economy Beijing University of TechnologyBeijing100124China Center for Social and Environmental Systems Research National Institute for Environmental StudiesTsukuba3058506Japan Environment Research Institute Shandong UniversityQingdaoShandong266237China Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China

Carbon mitigation technologies lead to air quality improvement and health co-benefits,while the practical effects of the technologies are dependent on the energy composition,technological advancements,and economic *** China,mitigation technologies such as end-of-pipe treatment,renewable energy adoption,carbon capture and storage(CCS),and sector electrification demonstrate significant promise in meeting carbon reduction ***,the optimization of these technologies for maximum co-benefits remains ***,we employ an integrated assessment model(AIM/enduse,CAM-chem,IMED|HEL)to analyze air quality shifts and their corresponding health and economic impacts at the provincial level in China within the two-degree *** findings reveal that a combination of end-of-pipe technology,renewable energy utilization,and electrification yields the most promising results in air quality improvement,with a reduction of fine particulate matter(PM2.5)by−34.6μg m^(−3) and ozone by−18.3 ppb in 2050 compared to the reference *** contrast,CCS technology demonstrates comparatively modest improvements in air quality(−9.4μg m^(−3) for PM2.5 and−2.4 ppb for ozone)and cumulative premature deaths reduction(−3.4 million from 2010 to 2050)compared to the end-of-pipe ***,densely populated regions such as Henan,Hebei,Shandong,and Sichuan experience the most health and economic *** study aims to project effective future mitigation technologies and climate policies on air quality improvement and carbon ***,it seeks to delineate detailed provincial-level air pollution control strategies,offering valuable guidance for policymakers and stakeholders in pursuing sustainable and health-conscious environmental management.

关键词： Air pollution Mitigation technology2-Degree target Health co-benefits Economic impacts

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Can we go beyond INDCs： Analysis of a future mitigation possibility in China, Japan, EU and the U.S.

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Advances in Climate Change Research 2017年第2期8卷 117-122页

作者： JIANG Ke-Jun Kentaro TAMURA tatsuya hanaoka Energy Research Institute (ERI) Beijing 100038 China Institute for Global Environmental Strategies (IGES) Hayama 240-0115 Japan National Institute for Environmental Studies (NIES) Tsukuba 305-8506 Japan

The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could not match with the emission pathway for the global to keep a global temperature rise this century well below 2 ℃ and to drive efforts to limit the temperature increase even further to 1.5 ℃ above pre- industrial levels. It is important for countries to do more than their commitment in INDCs, especially in near term. This paper looks at the near term trend for possibilities for further emission reduction compared with INDCs, and found there do have the possibility. It concludes there is space for the four countries/regions to do more than their INDCs submitted to UNFCCC, and see the light towards to a global 2 ℃ target.

关键词： Climate change Mitigation INDC NDC COP21

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A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients

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World Journal of Gastroenterology 2009年第22期15卷 2782-2786页

作者： Shuichi Sato tatsuya Miyake Hiroshi Tobita Naoki Oshima Junichi Ishine Takuya hanaoka Yuji Amano Yoshikazu Kinoshita Department of Gastroenterology and Hepatology Shimane UniversitySchool of Medicine Division of Gastrointestinal Endoscopy Shimane University Hospital

AIM:To examine whether a dose-up to 900 mg of ursodeoxycholic acid(UDCA) decreases transaminases in hepatitis C ***:From January to December 2007,patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus(HCV)(43-80 years old) showing positive serum HCV-RNA who had already taken 600 mg/d of UDCA were recruited into this *** parameters were examined at 4,8 and 24 wk after increasing the dose of oral UDCA from 600 to 900 mg/***:Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transpeptidase(GGT) levels were signifi cantly decreased following the administration of 900 mg/d as compared to 600 mg/*** decrease in ALT from immediately before the dose-up of UDCA to 8 wk after the dose-up was 14.3 IU/L,while that for AST was 10.5 IU/L and for GGT was 9.8 IU/*** count tended to increase after the dose-up of UDCA,although it did not show a statistically signifi cant level(P=0.05).Minor adverse events were observed in 3 cases,although no drop-outs from the study ***:Oral administration of 900 mg/d of UDCA was more effective than 600 mg/d for reducing ALT,AST,and GGT levels in patients with HCV-related chronic liver disease.

关键词： Chronic hepatitis Hepatitis C virus Liver fibrosis Transaminase Ursodeoxycholic acid

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Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors

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World Journal of Clinical Oncology 2022年第11期13卷 880-895页

作者： Winn Aung Atsushi B Tsuji Kenjiro hanaoka tatsuya Higashi Department of Molecular Imaging and Theranostics Institute for Quantum Medical ScienceNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Keio UniversityTokyo 105-8512Japan

BACKGROUND Photodynamic therapy(PDT)is a minimally invasive form of cancer therapy,and the development of a novel photosensitizer(PS)with optimal properties is important for enhancing PDT *** receptor(FR)membrane protein is frequently overexpressed in 40%of human cancer and a good candidate for tumor-specific *** active targeting of PS to FR can be achieved by conjugation with the folate moiety.A folate-linked,near-infrared(NIR)-sensitive probe,folate-Si-rhodamine-1(FolateSiR-1),was previously developed and is expected to be applicable to *** To investigate the therapeutic efficacy of NIR-PDT induced by FolateSiR-1,a FRtargeted PS,in preclinical cancer *** FolateSiR-1 was developed by conjugating a folate moiety to the Si-rhodamine derivative through a negatively charged tripeptide *** expression in the designated cell lines was examined by western blotting(WB).The selective binding of FolateSiR-1 to FR was confirmed in FR overexpressing KB cells(FR+)and tumors by fluorescence microscopy and in vivo fluorescence *** FR expressing OVCAR-3 and A4 cell lines were used as negative controls(FR-).The NIR light(635±3 nm)-induced phototoxic effect of FolateSiR-1 was evaluated by cell viability imaging *** time-dependent distribution of FolateSiR-1 and its specific accumulation in KB tumors was determined using in vivo longitudinal fluorescence *** PDT effect of FolateSiR-1 was evaluated in KB tumor bearing mice divided into four experimental groups:(1)FolateSiR-1(100μmol/L)alone;(2)FolateSiR-1(100μmol/L)followed by NIR irradiation(50 J/cm2);(3)NIR irradiation(50 J/cm2)alone;and(4)no *** volume measurement and immunohistochemical(IHC)and histological examinations of the tumors were performed to analyze the effect of *** High FR expression was observed in the KB cells by WB,but not in the OVCAR-3 and A4 *** FR-specific binding of FolateSiR-1 was observed by in vitro an

关键词： Photodynamic therapy Near-infrared Photosensitizer Folate receptor Fluorescence Cancer

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