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Berberine for prevention of dementia associated with diabetes and its comorbidities:A systematic review

Journal of Integrative Medicine 2020年第2期18卷 125-151页

作者： Noriko Shinjyo James Parkinson Jimmy Bell tatsuro katsuno Annie Bligh Department of Infection and Host Defense Graduate School of MedicineChiba UniversityChuo-kuChiba 260-8670Japan Department of Life Sciences Faculty of Science and Technology at the University of WestminsterLondon W1W 6UWUnited Kingdom Kashiwanoha Clinic of East Asian Medicine Chiba University HospitalKashiwaChiba 277-0882Japan School of Health Sciences Caritas Institute of Higher EducationTseung Kwan ONT 999077Hong KongChina

Background: A growing number of epidemiological studies indicate that metabolic syndrome(MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia. Produced by several different medicinal plants, berberine is a bioactive alkaloid with a wide range of pharmacological effects, including antidiabetic ***, it is not clear whether berberine could prevent the development of dementia in association with ***: To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with *** strategy: Database searches A and B were conducted using Pub Med and Science Direct. In search A,studies on berberine’s antidementia activities were identified using “berberine” and “dementia” as search terms. In search B, recent studies on berberine’s effects on diabetes were surveyed using “berberine” and“diabetes” as search *** criteria: Clinical and preclinical studies that investigated berberine’s effects associated with Met S and cognitive dysfunction were *** extraction and analysis: Data from studies were extracted by one author, and checked by a second;quality assessments were performed independently by two ***: In search A, 61 articles were identified, and 22 original research articles were selected. In search B, 458 articles were identified, of which 101 were deemed relevant and selected. Three duplicates were removed, and a total of 120 articles were reviewed for this study. The results demonstrate that berberine exerts beneficial effects directly in the brain: enhancing cholinergic neurotransmission, improving cerebral blood flow, protecting neurons from inflammation, limiting hyperphosphorylation of tau and facilitating b-amyloid peptide clearance. In addition, evidence is growing that berberine is effective against diabetes and associated disorders, such as atherosclerosis

关键词： Berberine Diabetes Dementia Alzheimer’s disease Vascular dementia

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Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

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World Journal of Gastroenterology 2014年第43期20卷 16318-16322页

作者： Makoto Arai Tomoaki Matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa tatsuro katsuno Osamu Yokosuka Department of Gastroenterology and Nephrology (K1) Graduate School of MedicineChiba UniversityChiba 260-8670Japan

AIM: To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers.

关键词： Proton pump inhibitor Endoscopic submucosal dissection Esomeprazole Rebamipide Randomized control trial

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Efficacy of computed image modification of capsule endoscopy in patients with obscure gastrointestinal bleeding

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 421-428页

作者： Tomoaki Matsumura Makoto Arai Toru Sato Tomoo Nakagawa Daisuke Maruoka Masaru Tsuboi Sachio Hata Eiji Arai tatsuro katsuno Fumio Imazeki Osamu Yokosuka Department of Medicine and Clinical Oncology Graduate School of MedicineChiba UniversityChiba 2608670Japan

AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 *** FICE,there were three different sets with different *** randomly selected sets of FICE,images of CE were evaluated again by two individuals who were not shown the conventional CE reports and *** difference between FICE and conventional imaging was ***:The overall diagnostic yields in FICE sets 1,2,3 and conventional imaging(48.1%) were 51.9%,40.7%,51.9% and 48.1%,respectively,which showed no statistical difference compared to conventional *** total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7,respectively,which showed a significant difference(P = 0.01).CONCLUSION:The diagnostic yield for OGIB is not improved by ***,FICE can detect significantly more small bowel lesions compared to conventional imaging.

关键词： Computed virtual chromoendoscopy Flexible spectral color enhancement Capsule endoscopy Obscure gastro-intestinal bleeding Diagnostic yield

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