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Feasibility of a Direct-Conversion Method from Magnetic Susceptibility to Relative Electron Density for Radiation Therapy Treatment Planning

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第3期6卷 252-265页

作者： Kengo Ito Noriyuki Kadoya Yujiro Nakajima Masahide Saito Kiyokazu Sato tatsuo nagasaka Kazuomi Yamanaka Suguru Dobashi Ken Takeda Haruo Matsushita Keiichi Jingu Department of Radiation Oncology Tohoku University Graduate School of Medicine Sendai Japan Department of Radiology Tokyo Metropolitan Komagome Hospital Tokyo Japan Department of Radiology University of Yamanashi Chuo-shi Japan Department of Radiology Tohoku University Hospital Sendai Japan Department of Therapeutic Radiology Tohoku University School of Medicine Sendai Japan

Recently, several institutions have been developing magnetic resonance imaging (MRI)-guided radiotherapy treatment systems. In this study, we examine whether it is possible to perform radiation therapy planning (RTP) using a magnetic susceptibility map obtained using MRI. The head of a healthy volunteer was scanned using dual-energy computed tomography (CT) and MRI. A T2-star-weighted 3D gradient echo-based sequence (GRE) with images taken at four different echo times was acquired using the MRI scanner. The CT images were converted to relative electron density (rED) using a predefined ΔCT-rED conversion table. ΔCT was derived using the energy-subtraction method. The rED map was obtained from a single-linear relationship with the ΔCT-rED conversion table, whereas the magnetic susceptibility map was obtained from quantitative susceptibility mapping (QSM) via MRI. Subsequently, to obtain the relationship between the magnetic susceptibility and the rED, the rED map was rigidly aligned to the susceptibility map and resampled at the susceptibility map’s resolution. Finally, the magnetic susceptibility rED conversion table was obtained via voxel-by-voxel mapping between the two maps. No strong relationship between magnetic susceptibility and rED was obtained in the healthy volunteer’s head or in this study. The coefficient correlation between these parameters was 0.0145. Magnetic susceptibility values may be not able to convert to rED using our proposed method in healthy volunteer’s head. In contrast to the magnetic-susceptibility values obtained from the QSM algorithm, which were strongly affected by calcification and iron content, the rED or CT number was not considerably affected by such materials.

关键词： Magnetic Susceptibility Quantitative Susceptibility Mapping MRI-Based Radiation Therapy Planning

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PRESS FORMABILITY OF YAG LASER WELDED TRIP STEEL SHEETS

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 21-25页

作者： A. nagasaka Dept. of Mech. Eng. Nagano Natl. Coll. of Technol. Nagano 381-8550 Tokuma 716 Japan

The effects of YAG laser welding conditions on mechanical properties andpress formability (bendability, stretch-formability and deep drawability) of high-strengthtransformation-induced plasticity-aided dual-phase (TDP) steel were investigated. Tensile tests andpress forming tests have been conducted for laser butt welded joints between two pieces of the samesteel. The tensile property and press formability were affected by the welding speed of 100 to1100mm/min and the energy of 6 to 9J/pulse. Excellent press formability was obtained with the energyof 6J/pulse and the welding speed of 300mm/min. It was concluded that the excellent weldability ofthe TDP steel can be ascribed to the weld joint formation.

关键词： YAG laser welding retained austenite transformation-induced plasticity

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Activity coefficients of NiO and CoO in CaO–Al_2O_3–SiO_2 slag and their application to the recycling of Ni–Co–Fe-based end-of-life superalloys via remelting

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International Journal of Minerals,Metallurgy and Materials 2017年第1期24卷 25-36页

作者： Xin Lu Takahiro Miki Tetsuya nagasaka Graduate School of Engineering Tohoku University

To design optimal pyrometallurgical processes for nickel and cobalt recycling, and more particularly for the end-of-life process of Ni-Co-Fe-based end-of-life（EoL） superalloys, knowledge of their activity coefficients in slags is essential. In this study, the activity coefficients of NiO and CoO in CaO-Al_2O_3-SiO_2 slag, a candidate slag used for the EoL superalloy remelting process, were measured using gas/slag/metal equilibrium experiments. These activity coefficients were then used to consider the recycling efficiency of nickel and cobalt by remelting EoL superalloys using CaO-Al_2O_3-SiO_2 slag. The activity coefficients of NiO and CoO in CaO-Al_2O_3-SiO_2 slag both show a positive deviation from Raoult＇s law, with values that vary from 1 to 5 depending on the change in basicity. The activity coefficients of NiO and CoO peak in the slag with a composition near B =（%CaO）/（%SiO_2） = 1, where B is the basicity. We observed that controlling the slag composition at approximately B = 1 effectively reduces the cobalt and nickel oxidation losses and promotes the oxidation removal of iron during the remelting process of EoL superalloys.

关键词： recycling nickel cobalt end-of-life superalloys activity coefficients remelting slag

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Up-grading of natural ilmenite ore by combining oxidation and acid leaching

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 729-736页

作者： Takehito Hiraki Yuichi Maruyama Yuta Suzuki Satoshi Iloh Tetsuya nagasaka Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan Toho Titanium Co. Ltd.Kanagawa 253-8510Japan Fanuc Co. Ltd.Oshino-muraYamanashi 401-0511Japan Before retirement:Graduate School of Environmental Studies Tohoku UniversitySendai 980-8579Japan

Rutile （TiO2） is heavily used in pigments mid colormlts, mid the most abundmlt source of rutile is ilmeinte. Upon oxidation of ilmeinte, mtile cml be formed wiffl modest energy consumption; furfflermore, after leaching, only a few byproducts are formed. Unfortunate- ly, one drawback is file necessarily long oxidative process of typically used mefflods. In fflis study, we show fflat a fluidized bed reactor cml be used to oxidize ilmeinte ore to rapidly form ruffle mid pseudobrookite （Fe2TiOs） phases. Ilmeinte was oxidized wiffl 5vo1% 02 in Ar at temperatures of 1173 K or 1223 K mid subsequently leached using a diluted H2SO4 solution to dissolve file pseudobrookite phase. The effects of acid concentration, temperature, mid cooling rate after oxidation were investigated. We show fflat file ilmeinte was rapidly oxidized to form rutile mid pseudobrookite phases at 1173 mid 1223 K in a 5vo1% O2/95vo1% Ar environment wifflin 40 min. The fmal maximum mtile yield was 84.2mo1% after leaching in （1 ＋ 1） H2SO4 solution at 393 K for 12 h.

关键词： ilmenite oxidation fluidized bed reactor acid leaching rutile pseudobrookite

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New pyrometallurgical process of EAF dust treatment with CaO addition

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 788-797页

作者： Romchat Chairaksa-Fujimoto Yosuke Inoue Naoyoshi Umeda Satoshi Itoh Tetsuya nagasaka Department of Metallurgy Graduate School of Engineering Tohoku University Toho Titanium Co. Ltd. Honda Motor Co. Ltd.

The non-carbothermic zinc pyrometallurgical processing of electric arc furnace(EAF) dust was investigated on a laboratory scale. The main objective of this process was to convert highly stable zinc ferrite(Zn Fe2O4), which accounts for more than half of total zinc in the EAF dust, into Zn O and Ca2Fe2O5 by Ca O addition. The EAF dust was mixed with Ca O powder in various ratios, pressed into pellets, and heated in a muffle furnace in air at temperatures ranging from 700 to 1100°C for a predetermined holding time. All Zn Fe2O4 was transformed into Zn O and Ca2Fe2O5 at a minimum temperature of 900°C within 1 h when sufficient Ca O to achieve a Ca/Fe molar ratio of 1.1 was added. However, at higher temperatures, excess Ca O beyond the stoichiometric ratio was required because it was consumed by reactions leading to the formation of compounds other than Zn Fe2O4. The evaporation of halides and heavy metals in the EAF dust was also studied. These components could be preferentially volatilized into the gas phase at 1100°C when Ca O was added.

关键词： electric arc furnace dust pyrometallurgy zinc oxid

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Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization

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Signal Transduction and Targeted Therapy 2023年第3期8卷 905-907页

作者： Shao-bin Wang Yosuke nagasaka Dionne Argyle Ayami nagasaka Praveen Yerramothu Bradley DGelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye underlies many forms of aberrant ocular angiogenesis and resultant vision loss,including in neovascular age-related macular degeneration(nvAMD),proliferative diabetic retinopathy(PDR).

关键词： degeneration ocular release

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An Emergent Framework of Disaster Risk Governance towards Innovating Coping Capability for Reducing Disaster Risks in Local Communities

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International Journal of Disaster Risk Science 2011年第2期2卷 1-9页

作者： Saburo Ikeda Toshinari nagasaka Professor Emeritus University of TsukubaTsukuba 305-8577Japan National Institute for Earth Science and Disaster Prevention Tsukuba 305-0006Japan

An emergent framework of disaster risk governance is presented as an implementation strategy for integrated risk management that incorporates innovative local coping capabilities that reduce disaster vulnerability. This framework calls for enhancement of self-support and mutualassistance through strengthening informal or social networking efforts in local communities, rather than depending on formal or institutional governmental-assistance. The framework is supported by a societal platform of disaster risk information, called DRIP, which the NIED(National Research Institute for Earth Science and Disaster Prevention, Japan) has developed since 2006 as a tool that promotes improved disaster risk governance. With the help of DRIP, residents, communities, and other stakeholders, linked horizontally or vertically with social networks, can(1) improve their awareness of disaster risks and management issues by sharing risk information as scientific expertise, experiential knowledge, and local/folk wisdom;(2) customize risk communication through analytic deliberation of risk information by employing risk-scenarios developed by residents themselves;(3) develo p collaborative activities for informed decision-making that can fully utilize local resources to reorganize coping capability against disaster risks;and(4) disseminate the generated risk scenarios with action plans to other residents who have not participated in the risk communication process.

关键词： disaster utilize mutual

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Effect of Thermal Drilling Condition on Burring in Ultrahigh Strengh TRIP Sheet Steels

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Journal of Iron and Steel Research International 2011年第S1期18卷 442-446页

作者： Akihiko nagasaka Takuya Matsushima Shun Hasebe Koh-ichi Sugimoto Toshio Murakami Nagano National College of Technology 716 TokumaNaganoNagano 381-8550Japan Shinshu University 4-17-1 WakasatoNaganoNagano 380-8553Japan Material Design Research Section Material Research LaboratoryKobe SteelLtd.1-5-5 TakatsukadaiNishi-kuKobeHyogo 651-2271Japan

Effect of thermal drilling condition on burring of 0.2C-(1.0-2.5)Si-(1.0-2.0)Mn (mass%) ultrahigh strength TRIP-aided sheet steels with polygonal ferrite matrix (TDP steels) was investigated for automotive *** combined rotational and downward force of the thermal drilling tool bit created friction *** height of the bushing was roughly 3 to 4 times the initial sheet *** bushings are ideal for thread applications,as the strength of threads was significantly *** found that the burring and tapping contributed to the improvement of the tensile strength of 980 MPa class TRIP steel.

关键词： TRIP sheet steel burring tapping thermal drilling

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Furanocembranoid from the Okinawan soft coral Sinularia sp.

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Natural Products and Bioprospecting 2022年第1期12卷 71-77页

作者： Misaki nagasaka Kazuki Tani Keisuke Nishikawa Riri Kinjo Takahiro Ishii Department of Biosciences and Biotechnology Faculty of AgricultureUniversity of the RyukyusSenbaru 1NishiharaOkinawa 903-0213Japan Department of Chemistry Graduate School of ScienceOsaka City UniversityOsaka 558-8585Japan

One new furanocembranoid diterpene,11-hydroxy-Δ^(12(13))-pukalide(1),along with six known secondary metabolites,11-acetoxy-Δ^(12(13))-pukalide(2),13α-acetoxypukalide(3),pukalide(4),3α-methoxyfuranocembranoid(5),Δ9(15)-africanene(6),and methyl(5′E)-5-(2′,6′-dimethylocta-5′,7′-dienyl)furan-3-carboxylate(7)were isolated from the Okinawan soft coral Sinularia *** chemical structures were elucidated based on spectroscopic analysis(FTIR,NMR,and HRESIMS),and the relative stereochemistry of 1 was determined by NOESY experiments and acetylation,which yielded derivative *** addition,compounds 1 and 7 exhibited toxicity in the brine shrimp lethality test.

关键词： Soft coral Sinularia sp. Furanocembranoid Diterpene

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Intussusception due to rectal adenocarcinoma in a young adult:A case report

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World Journal of Gastroenterology 2014年第35期20卷 12678-12681页

作者： Ryo Inada Takeshi nagasaka Toshiaki Toshima Yoshiko Mori Yoshitaka Kondo Hiroyuki Kishimoto Toshiyoshi Fujiwara Department of Gastroenterological Surgery Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences

An intussusception due to colonic adenocarcinoma has sometimes been reported. However, to the best of our knowledge, reports of intussusception due to rectal adenocarcinoma are extremely rare. In this report, the case of a young man with rectal adenocarcinoma causing intussusception is described. A 24-year-old man visited a hospital complaining of abdominal pain, and an upper rectal cancer was diagnosed by colonoscopy. Computed tomography showed intussusception caused by a large tumor in the pelvis and absence of distant metastases. Locally advanced rectal cancer causing intussusception was diagnosed, and a low anterior resection was performed. Intraoperatively, repair of the invagination could not be accomplished easily; therefore, the repair was abandoned. Instead, the tumor was removed en bloc to avoid dissemination of the cancer. Histopathologically, the tumor was diagnosed as a poorly differentiated adenocarcinoma, pStage IIA. The patient has no evidence of recurrence at 10 mo after the operation.

关键词： Adult intussusception En bloc resection Low anterior resection Rectal adenocarcinoma Young cancer

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