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凋亡的成骨细胞中核仁素与核仁组织区相关蛋白的分裂

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凋亡的成骨细胞中核仁素与核仁组织区相关蛋白的分裂

中华口腔医学会第七届全国口腔病理学术会议

作者： tatsuji haneji Kaya Yoshida Hirohiko Okamura Lihong Qiu Department of Histology and Oral Histology Institute of Health Biosciences The University of Tokushima Graduate SchoolKuramotoTokushima 770-8504Japan Department of Histology and Oral Histology Institute of Health Biosciences The University of Tokushima Graduate SchoolKuramotoTokushima 770-8504Japan Department of Histology and Oral Histology Institute of Health Biosciences The University of Tokushima Graduate SchoolKuramotoTokushima 770-8504Japan Department of Histology and Oral Histology Institute of Health Biosciences The University of Tokushima Graduate SchoolKuramotoTokushima 770-8504Japan

＜正＞在各种组织包括骨组织在内,蛋白的磷酸化与去磷酸化被认为是调节细胞代谢和功能的重要机制。蛋白的去磷酸化与蛋白质的磷酸化相协同,参与调节许多细胞的功能。核仁素是一种表达丰富的磷蛋白质,主要位于核仁的纤维状成分中,与新生...

＜正＞在各种组织包括骨组织在内,蛋白的磷酸化与去磷酸化被认为是调节细胞代谢和功能的重要机制。蛋白的去磷酸化与蛋白质的磷酸化相协同,参与调节许多细胞的功能。核仁素是一种表达丰富的磷蛋白质,主要位于核仁的纤维状成分中,与新生的前核糖体RNA相关。核仁素参与调节核糖体发生、细胞增殖及生长、胚胎发生、胞质分裂及核起源。冈田酸是

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双链RNA依赖蛋白激酶在MC3T3-E1细胞钙化中的作用

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双链RNA依赖蛋白激酶在MC3T3-E1细胞钙化中的作用

中华口腔医学会第七届全国口腔病理学术会议

作者： Kaya Yoshida Lihong Qiu Bruna Rabelo Amorim Hirohiko Okamura tatsuji haneji University of Tokushima Graduate School Kuramoto Tokushima 770-8504Japan University of Tokushima Graduate School Kuramoto Tokushima 770-8504Japan University of Tokushima Graduate School Kuramoto Tokushima 770-8504Japan University of Tokushima Graduate School Kuramoto Tokushima 770-8504Japan University of Tokushima Graduate School Kuramoto Tokushima 770-8504Japan

＜正＞目的:双链RNA依赖蛋白激酶（PKR）在哺乳动物细胞中存在serine／threonine两种蛋白激酶,PKR具有广泛的生物学作用,参与细胞因子的形成,细胞分化,肿瘤发生和凋亡发生。可是,PKR在骨形成中作用的报道还很少。本研究检测PKR是否参与...

＜正＞目的:双链RNA依赖蛋白激酶（PKR）在哺乳动物细胞中存在serine／threonine两种蛋白激酶,PKR具有广泛的生物学作用,参与细胞因子的形成,细胞分化,肿瘤发生和凋亡发生。可是,PKR在骨形成中作用的报道还很少。本研究检测PKR是否参与影响成骨细胞的钙化,探讨PKR在骨形成中的分子机制。

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Bleomycin诱导凋亡细胞histone H1.2从核向线粒体的转移

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Bleomycin诱导凋亡细胞histone H1.2从核向线粒体的转移

中华口腔医学会第七届全国口腔病理学术会议

作者： Hirohiko Okamura Kaya Yoshida Lihong Qiu Bruna Rabelo Amorim tatsuji haneji University of Tokushima Graduate School Kuramoto Tokushima 770-8504 Japan

Bleomycin是一种水溶性抗生素,被用来治疗癌症利淋巴瘤。该抗生素能与细胞表面受体结合,形成吞饮小泡而被移入细胞中,我们的实验已经证明bleomycin and peplomycin,能诱导SCCTF细胞DNA单双链碎片的形成,线粒体膜破坏,从而导致细胞凋亡...

Bleomycin是一种水溶性抗生素,被用来治疗癌症利淋巴瘤。该抗生素能与细胞表面受体结合,形成吞饮小泡而被移入细胞中,我们的实验已经证明bleomycin and peplomycin,能诱导SCCTF细胞DNA单双链碎片的形成,线粒体膜破坏,从而导致细胞凋亡。可是,该凋亡发生的信号传导途径还不很清楚,本研究检测bleomycin处理的鳞癌细胞中细胞色素C

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The transcriptional factor Osterix directly interacts with RNA helicase A

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中国口腔颌面外科杂志 2008年第B5期6卷 71-71页

作者： Bruna R. Amorim Hirohiko Okamura Kaya Yoshida Wang Jie Li Hong Qiu tatsuji haneji Department of Histology and Oral Histology Institute of Health Biosciences The University of Tokushima Graduate School Kuramoto Tokushima 770-8504 Japan Department of Fundantental Oral Health Science School of Oral Health and Wealfare The University of Tokushima Kuramoto Tokushima 770-8504 Japan Department of Endodontics School of Stomatology China Medical University Shenyang 11002 China

Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2005年第2期11卷 255-259页

作者： Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito First Department of Internal Medicine Faculty of MedicineSchool of MedicineUniversity of the RyukyusOkinawaJapan

AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease. However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type VI collagen 7S domain and hyaluronic acid. METHODS: One hundred and twelve patients with histologically proven NAFLD were studied. RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type VI collagen 75 domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type VI collagen 7S domain, 86% and hyaluronic acid, 92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type VI collagen 7S domain (≥5.0 ng/mL), 84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis. CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis.

关键词： Liver fibrosis Nonalcoholic fatty liver disease Collagen type IV Hyaluronic acid

Real impact of tumor marker AFP and PIVKA-II in detecting very small hepatocellular carcinoma(≤2 cm,Barcelona stage 0)-assessment with large number of cases

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World Journal of Hepatology 2020年第11期12卷 1046-1054页

作者： Kazuo Tarao Akito Nozaki Hirokazu Komatsu tatsuji Komatsu Masataka Taguri Katsuaki Tanaka Makoto Chuma Kazushi Numata Shin Maeda Department of Gastroenterology Tarao’s Gastroenterological ClinicYokohama 241-0821Japan Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Gastroenterology Yokohama Municipal Citizen’s HospitalYokohama 221-0855Japan Department of Clinical Research National Hospital Organization Yokohama Medical CenterYokohama 245-8575Japan Department of Data Science Yokohama City University School of Data ScienceYokohama 236-0004Japan Department of Gastroenterology Hadano Red Cross HospitalKanagawa 221-0045Japan Department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND In hepatocellular carcinoma(HCC),detection and treatment prior to growth beyond 2 cm are relevant as a larger tumor size is more frequently associated with microvascular invasion and/or *** To examine the impact of the tumor marker alpha-fetoprotein(AFP)or PIVKA-II in detecting very small HCC nodules(≤2 cm in maximum diameter,Barcelona stage 0)in the large number of very small *** difference in the behavior of these tumor markers in HCC development was also *** A total of 933 patients with single-nodule HCC were *** were subdivided into 394 patients with HCC nodules≤2 cm in maximum diameter and 539 patients whose nodules were>2 *** rates of patients whose AFP and PIVKA-II showed normal values were *** The positive ratio of the marker PIVKA-II was significantly different(P2 cm,but there was no significant difference in AFP(P=0.4254).In the patients whose tumor was≤2 cm,50.5%showed normal levels in AFP and 68.8%showed normal levels in *** 36.4%of those patients,both AFP and PIVKA-II showed normal *** PIVKA-II-positive ratio was markedly increased with an increase in the tumor *** contrast,the positivity in AFP was increased gradually and *** In the surveillance of very small HCC nodules(≤2 cm in diameter,Barcelona clinical stage 0)the tumor markers AFP and PIVKA-II are not so useful.

关键词： Hepatocellular carcinoma AFP PIVKA-II Barcelona clinical stage Tumor markers

Different natural courses of chronic hepatitis B with genotypes B and C after the fourth decade of life

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World Journal of Gastroenterology 2007年第34期13卷 4560-4565页

作者： tatsuji Maeshiro Shingo Arakaki Takako Watanabe Hajime Aoyama Joji Shiroma Tsuyoshi Yamashiro Tetsuo Hirata Akira Hokama Fukunori Kinjo Tomofumi Nakayoshi Tomokuni Nakayoshi Masashi Mizokami Jiro Fujita Hiroshi Sakugawa Control and Prevention of Infectious Disease (First Department of Internal Medicine) Department of Medicine and Therapeutics Faculty of Medicine University of the Ryukyus Okinawa Japan Department of Blood transfusion medicine Ryukyu University Hospital Okinawa Japan Department of Endoscopy Ryukyu University Hospital Okinawa Japan Department of Internal Medicine Tomishiro Central Hospital Okinawa Japan Department of Internal Medicine Heart Life Hospital Okinawa Japan Clinical Molecular Informative Medicine Nagoya City University Graduate School of Medical Science Nagoya Japan

MIM： To investigate the different impact of genotypes E and C on the development of liver cirrhosis （LC） among different age groups of patients with chronic hepatitis （CH-B）.METHODS： We examined the outcome of 121 patients with CH-B, divided by age and genotype. Univariate analyses were used to compare different groups. The Cox proportional hazard model was employed to evaluate factors affecting the development of LC.RESULTS： In patients 〈 30 years old, there were no significant predictors for development of LC. However, in patients ≥ 30 years old, genotype C was the only significant predictor. In the genotype C group, 8 of 12 patients who progressed to LC were 30-49 years old at initial diagnosis of chronic hepatitis （7 patients were positive for HBeAg）. In the genotype B group, 4 of 8 patients who developed LC were ≥50 years old at initial diagnosis and were HBeAg-negative.CONCLUSION： The rate of development of LC was comparable in patients infected with genotypes B and C when CH-B occurred at 〈 30 years old. However, CH-B patients infected with genotype C showed poor prognosis if they were 30-49 years old and were positive for HBeAg. Age-specific natural course of CH-B should be considered when patients with CH-B are treated with antiviral drugs.

关键词： Hepatitis B, chronic Hepatitis B virus Hepatitis B e antigen Genotypes Molecular epidemiology

Erratum for factors associated with visceral fat accumulation in the general population in Okinawa,Japan(World J Gastrointest Pharmacol Ther 2016;7:261-267)

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2018年第1期9卷 14-15页

作者： Shingo Arakaki tatsuji Maeshiro Akira Hokama Jiro Fujita Department of Infectious Respiratoryand Digestive MedicineGraduate School of MedicineUniversity of the RyukyusNishiharaOkinawa 903-0215Japan Department of Endoscopy Graduate School of MedicineUniversity of the Ryukyus207 UeharaNishiharaOkinawa 903-0215Japan

Correction to:Arakaki S,Maeshiro T,Hokama A,Hoshino K,Maruwaka S,Higashiarakawa M,Parrott G,Hirata T,Kinjo K,Fujita *** associated with visceral fat accumulation in the general population in Okinawa,*** J Gastrointest Pharmacol Ther 2016;7(2):261-267 PMID:27158542 DOI:10.4292/wjgpt.v7.i2.261[1].Erratum 1 In the Results and Discussion,the description regarding the relationship between several parameters and VFA is *** the Results(page 263)within the right side column,after“…(P<0.05,Table 4).”,“Although statistically not significant,a univariate analysis also indicated that FPG and HbA1c were slightly higher and HDL-C was slightly lower in males with low VFA group(Table 3).”should be added.

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Efficacy and safety of dual therapy with daclatasvir and asunaprevir in elderly patients

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World Journal of Hepatology 2017年第11期9卷 544-550页

作者： Kazuo Tarao Katsuaki Tanaka Akito Nozaki Akira Sato Toshiya Ishii Hirokazu Komatsu Takaaki Ikeda tatsuji Komatsu Shozo Matsushima Kenji Oshige Tarao’s Gastroenterological Clinic Gastroenterological Center Medical Center Yokohama City University Division of Gastroenterology Department of Internal Medicine St. Marianna University Yokohama City Seibu Hospital Department of Gastroenterology Yokohama Municipal Citizen’s Hospital Department of Gastroenterology Yokosuka General Hospital Uwamachi Department of Clinical Research National Hospital Organization Yokohama Medical Center Yokohama National University Center for Health Service Sciences

To survey the efficacy and safety of dual therapy with daclatasvir and asunaprevir in the elderly hepatitis C virus (HCV) patients multicentricity. METHODSInterferon-ineligible/intolerant patients and non-responders to previous pegylated-interferon/ribavirin therapy with chronic HCV genotype 1b infection were enrolled. Child B, C cirrhotic patients were excluded. Patients received oral direct acting antiviral treatment consisting of 60 mg daclatasvir once daily plus 200 mg asunaprevir twice daily for 24 wk. We divided the patients into two groups of 56 elderly patients (≥ 75 years-old) and 141 non-elderly patients (24). In the former, 1.8% experienced viral breakthrough, as compared with 3.5% in the latter (not significant). Adverse events occurred in 55.4% of the former and 56.0% of the latter. In the former, 7 cases (12.5%) were discontinued due to adverse events, and in the latter 9 cases were discontinued (6.4%, not significant). CONCLUSIONDual therapy with daclatasvir and asunaprevir achieved the same high rates of SVR24 in HCV elderly patients without more adverse events than in the non-elderly patients.

关键词： Asunaprevir Chronic hepatitis Daclatasvir Dual oral therapy Elderly patients Hepatitis C virus infection Hepatitis C virus Liver cirrhosis