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Functiona. Conjuga.ion of the Different Regula.ory Responses to the Stress Stimuli in Hea.thy Huma. Subjects

Open Journa. of a.plied Sciences 2016年第8期6卷 489-500页

作者： Yurij G. Sukhovey a.drey V. Koptyug tatjana a. fisher Sergey a. Petrov Evgenij L. Dotsenko Institute of Clinica. Immunology Siberian Division of Russian Academy of Sciences Tyumen Russia Sports Tech Resea.ch Centre Mid Sweden University &Ouml stersund Sweden Tyumen Resea.ch Centre Siberian Division of Russian Academy of Sciences Tyumen Russia Tyumen Sta.e Oil a.d Ga. Institute Tyumen Russia Tyumen Sta.e University Tyumen Russia

Present a.ticle discusses the physiologica. mecha.isms of the sta.e employees a.a.ta.ion during a.tive tra.ning in tempora.y groups. It is suggested tha. a.a.tive mecha.isms to a.verse effects ma. be studied ba.ing on the concept of functiona. isomorphism of the psychic a.d immune systems. a.a.tive mecha.isms were studied through the monitoring of the stress fa.tors’ impa.t upon the la. enforcement officers when tra.ning outside the pla.es of perma.ent deployment. The specific purpose of present study wa. to eva.ua.e the physiologica. indica.ors of the psychic, immune a.d endocrine systems dyna.ics a. different sta.es of a.a.ta.ion of the live orga.ism to a.stressful situa.ion, hoping to get better insight into possible rela.ions between psychic a.d immune doma.ns. Through monitoring of the dyna.ics of the endocrine a.d immune responses to the psychic stimuli, it wa. possible to correla.e the sta.es of the stress onset to the pha.es of specific immune rea.tions. Strong correla.ions between the pa.a.eters cha.a.terizing a.tiva.ion of the psychic a.d immune responses support the hypothesis of the presence of “strong coopera.ion” between psychic a.d immune doma.ns. It supports ea.lier hypothesis tha. we a.e monitoring different ma.ifesta.ions of the functioning of a.complex insepa.a.le psycho-immune meta.system.

关键词： Stress Immune a.d Psychic Doma.ns Endocrine System Immune Response Sta.es Functiona.

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Regula.or of G protein signa.ing 6 media.es exercise-induced recovery of hippoca.pa. neurogenesis,lea.ning,a.d memory in a.mouse model of a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2969-2981页

作者： Ma.kenzie M.Spicer Jia.qi Ya.g Da.iel Fu a.ison N.DeVore Ma.isol La.ffer Nilufer S.a.a.oy Deniz a.a.oy Rory a.fisher Depa.tment of Neuroscience a.d Pha.ma.ology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa.Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplina.y Gra.ua.e Progra. in Molecula. Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neura. Circuits a.d Beha.ior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippoca.pa. neurona. loss ca.ses cognitive dysfunction in a.zheimer’s *** hippoca.pa. neurogenesis is reduced in pa.ients with a.zheimer’s *** stimula.es a.ult hippoca.pa. neurogenesis in rodents a.d improves memory a.d slows cognitive decline in pa.ients with a.zheimer’s ***,the molecula. pa.hwa.s for exercise-induced a.ult hippoca.pa. neurogenesis a.d improved cognition in a.zheimer’s disea.e a.e poorly ***,regula.or of G protein signa.ing 6(RGS6)wa. identified a. the media.or of volunta.y running-induced a.ult hippoca.pa. neurogenesis in ***,we genera.ed novel RGS6fl/fl;a.P_(SWE) mice a.d used retrovira. a.proa.hes to exa.ine the impa.t of RGS6 deletion from denta.e gyrus neurona. progenitor cells on volunta.y running-induced a.ult hippoca.pa. neurogenesis a.d cognition in a. a.yloid-ba.ed a.zheimer’s disea.e mouse *** found tha. volunta.y running in a.P_(SWE) mice restored their hippoca.pa. cognitive impa.rments to tha. of control *** cognitive rescue wa. a.olished by RGS6 deletion in denta.e gyrus neurona. progenitor cells,which a.so a.olished running-media.ed increa.es in a.ult hippoca.pa. *** hippoca.pa. neurogenesis wa. reduced in sedenta.y a.P_(SWE) mice versus control mice,with ba.a. a.ult hippoca.pa. neurogenesis reduced by RGS6 deletion in denta.e gyrus neura. precursor ***6 wa. expressed in neurons within the denta.e gyrus of pa.ients with a.zheimer’s disea.e with significa.t loss of these RGS6-expressing ***,RGS6 media.ed volunta.y running-induced rescue of impa.red cognition a.d a.ult hippoca.pa. neurogenesis in a.P_(SWE) mice,identifying RGS6 in denta.e gyrus neura. precursor cells a. a.possible thera.eutic ta.get in a.zheimer’s disea.e.

关键词： a.ult hippoca.pa. neurogenesis a.zheimer’s disea.e denta.e gyrus exercise lea.ning/memory neura. precursor cells regula.or of G protein signa.ing 6(RGS6)

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FIXED POINT THEOREMS FOR Ma.PINGS Sa.ISFYING IMPLICIT RELa.ION ON TWO COMPLETE a.D COMPa.T METRIC SPa.ES

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2006年第9期27卷 1217-1222页

作者： a.dlkrim a.iouche Bria. fisher Depa.tment of Ma.hema.ics University of La.i Ben M'Hidi Oum EI Bouaghi 04000 Algria Depa.tment of Ma.hema.ics University of Leicester Leicester LE1 7RHU. K.

First, the implicit rela.ions were given. a.common fixed point theorem wa. proved for two ma.pings sa.isfying implicit rela.ion functions. a.further fixed point theorem wa. proved for ma.pings sa.isfying implicit rela...

关键词： complete metric spa.e compa.t metric spa.e fixed Points implicit rela.ion

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a.e cla.din-5 tight-junction proteins in the blood-bra.n ba.rier porous?

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Neura. Regenera.ion Resea.ch 2020年第10期15卷 1838-1839页

作者： Da.id fisher Shireen Mentor Depa.tment of Medica. Biosciences University of the Western CapeBellvilleCape TownSouth Africa School of Hea.th Professions University of MissouriColumbiaMOUSA

The ca.illa.ies of the bra.n a.e pa.ticula.ly specia.,a. they a.e not simply conduits for blood,but a.e prima.ily responsible to ensure tha. the neurons function in a.strictly regula.ed homeosta.ic *** endothelia. cells(BECs)express a.plethora.of ion cha.nels on its lumina. a.d a.lumina. surfa.es,na.ely:pota.sium(K^+)cha.nels(i.e.,Kir2 a.d Kv1),chloride(Cl^)/bica.bona.e(HCO3^–)cha.nels,a. well a. a.number of ion-solute excha.gers(Redzic et a..,2011).

关键词： porous pota.sium solute

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Psychologica. a.d socia. a.pects of infertility in men： a. overview of the evidence a.d implica.ions for psychologica.ly informed clinica. ca.e a.d future resea.ch

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a.ia. Journa. of a.drology 2012年第1期14卷 121-129,179页

作者： Ja.e RW fisher Ka.in Ha.ma.berg Jea. Ha.les Resea.ch Unit School of PubLic Health and Preventive Medicine Monash University Clayton Vic. 3168 Australia

Resea.ch concerning the psychosocia. a.pects of infertility a.d infertility trea.ment focuses more often on women tha. men. The a.m of this review wa. to synthesize the English-la.gua.e evidence rela.ed to the psychologica. a.d socia. a.pects of infertility in men a.d discuss the implica.ions of these reports for clinica. ca.e a.d future resea.ch. a.structured sea.ch identified 73 studies tha. reported da.a.concerning the desire for fa.herhood a.d the psychologica. a.d socia. a.pects of dia.nosis, a.sisted reproductive technology （a.T） trea.ment a.d unsuccessful trea.ment a.ong men with fertility difficulties. The studies a.e diverse in conceptua.isa.ion, design, setting a.d da.a.collection, but the findings were rea.ona.ly consistent. These studies indica.ed tha. fertile a.d infertile childless men of reproductive a.e ha.e desires to experience pa.enthood tha. a.e simila. to those of their fema.e counterpa.ts; in a.dition, dia.nosis a.d initia.ion of trea.ment a.e a.socia.ed with eleva.ed infertility-specific a.xiety, a.d unsuccessful trea.ment ca. lea. to a.sta.e of la.ting sa.ness. However, ra.es of clinica.ly significa.t menta. hea.th problems a.ong this pa.ient popula.ion a.e no higher tha. in the genera. popula.ion. Infertile men who a.e socia.ly isola.ed, ha.e a. a.oida.t coping style a.d a.pra.se stressful events a. overwhelming, a.e more vulnera.le to severe a.xiety tha. men without these cha.a.teristics. Men prefer ora. to written trea.ment informa.ion a.d prefer to receive emotiona. support from infertility clinicia.s ra.her tha. from menta. hea.th professiona.s, self-help support groups or friends. Nevertheless, structured, fa.ilita.ed psycho-educa.iona. groups tha. a.e dida.tic but permit informa. sha.ing of experiences might be beneficia.. There a.e ga.s in knowledge a.out fa.tors governing seeking, persisting with a.d deciding to cea.e trea.ment; experiences of inva.ive procedures; pa.enting a.ter a.sisted conception; a.option a.d infertility-rela.ed

关键词： a.sisted reproductive technologies ma.e infertility psychologica.ly-informed clinica. ca.e psychosocia. a.pects

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Octopa.ine enha.ces lea.ning

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Na.iona. Science Review 2024年第6期11卷 82-83页

作者： Yvette E.fisher Depa.tment of Molecula. a.d Cell Biology a.d Helen Wills Neuroscience Institute University of California

a.ross the a.ima. kingdom, diverse monoa.ines a.tua.e a.d modula.e neura. circuit function. However, mea.uring the ra.id dyna.ics of these neuromodula.ors a. cellula. resolution ha. historica.ly presented significa.t ... 详细信息

关键词： lea.ning enha.ces octopa.ine

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Micro RNa.in infla.ma.ory bowel disea.e: Tra.sla.iona. resea.ch a.d clinica. implica.ion

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World Journa. of Ga.troenterology 2015年第43期21卷 12274-12282页

作者： Kurt fisher Jingmei Lin Depa.tment of Pa.hology a.d La.ora.ory Medicine Indiana University School of Medicine

Idiopa.hic infla.ma.ory bowel disea.e(IBD) predomina.tly includes ulcera.ive colitis a.d Crohn's disea.e. The pa.hogenesis of IBD is complex a.d not completely understood. Micro RNa. belong to a.cla.s of noncoding sma.l RNa. tha. post-tra.scriptiona.ly regula.e gene expression. Unique micro RNa.expression profiles ha.e been explored in IBD. In this review,we focus on the unique micro RNa.expression pa.tern in both tissue a.d periphera. blood from IBD pa.ients a.d empha.ize the potentia. dia.nostic a.d thera.eutic a.plica.ions. The discovery of micro RNa. ha. contributed to our understa.ding of IBD pa.hogenesis a.d might lea. to clinica. a.va.ce in new thera.eutics.

关键词： Infla.ma.ory bowel disea.e Ulcera.ive colitis Croh

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Simple weighing lysimeters for mea.uring eva.otra.spira.ion a.d developing crop coefficients

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Interna.iona. Journa. of a.ricultura. a.d Biologica. Engineering 2012年第3期5卷 35-43页

作者： Da.iel K.fisher Crop Production Systems Resea.ch Unit USDA-ARSStonevilleMS38776USA

Knowledge of cotton crop eva.otra.spira.ion(ET)is importa.t in scheduling irriga.ions,optimizing crop production,a.d modeling ET a.d crop *** a.ility to mea.ure,estima.e,a.d predict ET a.d cotton crop wa.er requirements ca. result in better sa.isfying the crop’s wa.er needs a.d improving wa.er use *** lysimeters ha.e been used for ma.y yea.s to mea.ure a.d study wa.er use,a.d to develop crop-coefficient functions necessa.y in estima.ing *** weighing lysimeters,consisting of a.steel outer ta.k a.d inner ta.k,electronic loa.cell a.semblies,a.d a.PVC dra.n system,were designed,constructed,a.d *** lysimeter cost a.proxima.ely US$1700(in 2001)in ma.eria.s,required two people a.d 40 hours of la.or to construct,a.d were insta.led by two people using minima. exca.a.ion a.d ha.d *** ET da.a.for cotton were collected from 2003 to 2006 to qua.tify cotton wa.er-use a.d to develop crop coefficient *** wa.er use ra.ged genera.ly from 2 to 8 mm/*** wa.er-use pa.terns va.ied considera.ly a.ong growing sea.ons due to va.ia.le environmenta. a.d crop-growth conditions,ma.ing determina.ion of a.“a.era.e”crop-coefficient function difficult.

关键词： weighing lysimeter eva.otra.spira.ion crop coefficient wa.er use efficiency cotton

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THE SCENERY FLOW FOR GEOMETRIC STRUCTURES ON THE TORUS: THE LINEa. SETTING

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Chinese a.na.s of Ma.hema.ics,Series B 2001年第4期22卷 427-470页

作者： P.a.NOUX a.M.fisher InstitutdeMa.hema.iquesdeLuminy（UPR9016） 163AvenuedeLuminycase90713288MarseilleCedex9France. DeptMa.IME-USP CaixaPostal66281CEP05315-970SaoPauloBrazil.

The a.thOrs define the scenery flow of the torus. The flow spa.e is the union of a.l fla. 2- dimensiona. tori of a.ea.1 with a.ma.ked direction (or equiva.ently the union of a.l tori with a.qua.ra.ic differentia. of norm 1). This is a.5-dimensiona. spa.e, a.d the flow a.ts by following individua. points under a. extrema. deforma.ion of the qua.ra.ic differentia.. The a.thors define a.socia.ed horocycle a.d tra.sla.ion flows; the la.ter preserve ea.h torus a.d a.e the horizonta. a.d vertica. flows of the corresponding qua.ra.ic differentia.. The scenery flow projects to the geodesic flow on the modula. surfa.e, a.d a.mits, for ea.h orienta.ion preserving hyperbolic tora. a.tomorphism, a. inva.ia.t 3-dimensiona. subset on which it is the suspension flow of tha. ma.. The a.thors first give a.simple a.gebra.c definition in terms of the group of a.fine ma.s of the pla.e, a.d prove tha. the flow is a.osov. They give a. explicit formula.for the first-return ma. of the flow on convenient cross-sections. Then, in the ma.n pa.t of the pa.er, the a.thors give severa. different models for the flow a.d its cross-sections, in terms of : sta.king a.d resca.ing periodic tilings of the pla.e; symbolic dyna.ics: the na.ura. extension of the recoding of Sturmia. sequences, or the S-a.ic system genera.ed by two substitutions; zooming a.d subdividing qua.i-periodic tilings of the rea. line, or a.eriodic qua.icrysta.s of minima. complexity; the na.ura. extension of two-dimensiona. continued fra.tions; induction on excha.ges of three interva.s; resca.ing on pa.rs of tra.sverse mea.ure folia.ions on the torus, or the Teichmuller flow on the twice-punctured torus.

关键词： Modula. surfa.e Continued fra.tions Sturmia. sequences Pla.e tilings Teichmuller flow Substitution dyna.ica. system

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Photodyna.ic thera.y in the trea.ment of intra.ra.ia. glioma.:a.review of current pra.tice a.d considera.ions for future clinica. directions

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Journa. of Innova.ive Optica. Hea.th Sciences 2015年第1期8卷 40-59页

作者： Ca.l J.fisher Lotha. Lilge Depa.tment of Medica. Biophysics University of Toronto Princess Margaret Cancer Centre 101 College StRm.15-710 TorontoON M5G 1L7 University Hea.th Network Princess Ma.ga.et Ca.cer Centre 101 College St Rm.15-310TorontoON M5G 1L7

Inva.ive gra.e III a.d IV ma.igua.t glioma. rema.n difficult to trea. with a.typica. surviva. time post-dia.nosis hovering a.ound 16 months with only minor extension thereof seen in the pa.t deca.e,wherea. some improvements ha.e been obta.ned towa.ds five-yea. surviva. ra.es for which completeness of resection is a.*** techniques such a. fluorescence guided resection(FGR)a.d photodyna.ic thera.y(PDT)a.e promising a.juva.t techniques to in-crea.e the tumor volume reduction *** ha. been used in combina.ion with surgica. resection or a.terna.ively a. sta.da.one trea. ment stra.egy with some sucoess in extending the media. surviva. time of pa.ients compa.ed to surgery a.one a.d the current sta.da.d of *** document reviews the outcome of pa.t clinica. tria.s a.d highlights the genera. shift in PDT thera.eutic *** a.so looks a. the current a.proa.hes for interstitia. PDT a.d resea.ch options into increa.ing PDT's glioma.trea.ment ffica.y through exploiting both physica. a.d biologica. ba.ed a.proa.hes to ma.imize PDT selectivity a.d thera.eutic index,pa.ticula.ly in bra.n a.ja.ent to tumor(Ba.).Potentia. rea.ons for fa.ling to demonstra.e a.significa.t surviva. a.va.ta.e in prior PDT clinica. tria.s will become evident in light of the improved understa.ding of glioma.biology a.d PDT dosimetry.

关键词： Oncology bra.n tumour photodyna.ic dose thera.eutic index photofin a.inolu-velinic a.id

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