检索结果-南通市图书馆

Diagnosis of West Nile virus infections:Evaluation of different laboratory methods

World Journal of Virology 2024年第4期13卷 51-61页

作者： tatjana vilibic-cavlek Maja Bogdanic Vladimir Savic Zeljka Hruskar Ljubo Barbic Vladimir Stevanovic Ljiljana Antolasic Ljiljana Milasincic Dario Sabadi Gorana Miletic Ivona Coric Anna Mrzljak Eddy Listes Giovanni Savini Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Poultry Center Croatian Veterinary InstituteZagreb 10000Croatia Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Department of Infectious Diseases Clinical Hospital Center OsijekOsijek 31000Croatia Medical Faculty Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia Croatian Veterinary Institute Veterinary Institute SplitSplit 21000Croatia OIE Reference Center for West Nile Disease Istituto Zooprofilattico SperimentaleG.CaporaleTeramo 64100Italy

BACKGROUND The diagnosis of West Nile virus(WNV)is challenging due to short-term and low-level viremia,flavivirus cross-reactivity,and long immunoglobulin M(IgM)*** To evaluate different methods for WNV detection[reverse transcription-polymerase chain reaction(RT-PCR),IgM/IgG antibodies,IgG avidity]in serum,cerebrospinal fluid(CSF),and urine samples of patients with confirmed WNV *** The study included patients with confirmed WNV neuroinvasive infection(n=62),asymptomatic WNV seropositive individuals(n=22),and individuals with false-positive WNV IgM antibodies(n=30).WNV RNA was detected using RT-PCR.A commercial ELISA was used to detect WNV IgM/IgG antibodies with confirmation of cross-reactive samples using a virus neutralization test(VNT).IgG-positive samples were tested for IgG *** The WNV-RNA detection rates were significantly higher in the urine(54.5%)/serum(46.4%)than in CSF(32.2%).According to the sampling time,the WNV-RNA detection rates in urine collected within 7 days/8-14/≥15 days were 29.4/66.6/62.5%(P=0.042).However,these differences were not observed in the *** median RT-PCR cycle threshold values were significantly lower in urine(32.5,IQR=28-34)than in CSF(34.5,IQR=33-36).The frequency of positive WNV IgM and IgG significantly differed according to the sampling time in serum but not in *** IgM/IgG antibodies were detected in 84.3/9.3%of serum samples collected within 7 days,100/71.1%of samples collected 8-14,and 100%samples collected after≥15 *** WNV infection was confirmed by low/borderline avidity index(AI)in 13.6%of asymptomatic individuals.A correlation between ELISA and AI was strong negative for IgM and strong positive for *** significant correlation between ELISA IgG and VNT was *** The frequency of WNV RNA and antibody detection depends on the sampling time and type of clinical *** avidity could differentiate recent WNV infections from long-persisting IgM antibo

关键词： West Nile virus Reverse transcription-polymerase chain reaction Serology IgG avidity Cross-reactivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatotropic viruses:Is Roma population at risk?

引用

World Journal of Gastroenterology 2021年第2期27卷 143-151页

作者： Anna Mrzljak Lucija Bajkovec tatjana vilibic-cavlek Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Medicine County Hospital CakovecCakovec 40000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia

Roma people make up a significant ethnic minority in many European countries,with the vast majority living in Central and Eastern *** are a vulnerable population group in social,economic,and political *** migrations,life in segregated communities,substandard housing,poverty,and limited access to quality health care,including low immunization coverage,affect their health status and predispose them to various diseases,including viral *** A,B,and E are highly prevalent among Roma and mainly associated with low socioeconomic *** contrast,hepatitis C does not seem to be more frequent in the Roma *** efforts should be directed towards the implementation of screening programs,preventive measures,and treatment of viral hepatitis in Roma communities throughout Europe.

关键词： Roma population Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis E virus Europe

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Torque teno virus in liver diseases and after liver transplantation

引用

World Journal of Transplantation 2020年第11期10卷 291-296页

作者： Anna Mrzljak tatjana vilibic-cavlek Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

Torque teno virus(TTV)has been proposed as a surrogate biomarker for immune monitoring in different patient ***,TTV has been associated with different liver diseases such as post-transfusion hepatitis,hepatitis B,and hepatitis C,but the virus's pathogenicity is *** is a ubiquitous DNA virus,highly prevalent and mostly indolent in the general ***,TTV viral load is more relevant than prevalence to understand TTV *** the context of liver transplantation,TTV viral load is modulated by the immune,viral,and inflammatory *** liver transplantation,the TTV viral load positively correlates with the intensity of immunosuppression(IS),and low TTV viral burden is a predictor of acute rejection episodes,making it an attractive marker for the efficacy of ***,the TTV role as a single or a panel biomarker needs to be evaluated in further independent prospective trails.

关键词： Torque teno virus Solid-organ transplantation Biomarker Liver disease Liver transplant Immune system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lymphocytic choriomeningitis virus:An under-recognized congenital teratogen

引用

World Journal of Clinical Cases 2022年第25期10卷 8922-8931页

作者： Thomas Ferenc Mateja Vujica Anna Mrzljak tatjana vilibic-cavlek Department of Radiology Merkur University HospitalZagreb 10000Croatia Department of Emergency Medicine Institute of Emergency Medicine of Krapina-Zagorje CountyKrapina 49000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Virology Croatian National Institute of Public HealthZagreb 10000Croatia

BACKGROUND Lymphocytic choriomeningitis virus(LCMV)is a neglected rodent-borne arenavirus associated with transplacental transmission and fetal *** To summarize the epidemiological,clinical,and diagnostic features of reported patients with congenital LCMV *** A literature search was conducted in PubMed,Medline,Google Scholar,and *** keywords used were‘congenital lymphocytic choriomeningitis virus,’and 48 studies were *** addition,we conducted a relevant search by Reference Citation Analysis(RCA)(https://*** ***).RESULTS The results have shown 27 reports of congenital LCMV infection in 86 patients,with 52.73%of them being *** presented with chorioretinitis(83.53%),hydrocephalus(54.12%),and psychomotor retardation or developmental delay(54.12%).Computed tomography and/or magnetic resonance imaging most often demonstrated ventriculomegaly(74.07%),periventricular calcifications(66.67%),and microcephaly(40%).Most mothers of congenitally infected infants were exposed to rodents during pregnancy,predominantly mice,with flu-like symptoms mainly occurring during the first two trimesters of *** in congenitally infected children was 16.47%.The diagnosis of congenital LCMV infection was confirmed serologically in most patients(86.67%).CONCLUSION LCMV is still an insufficiently recognized fetal teratogen that often leads to long-term neurologic *** need to be familiar with LCMV and its potential teratogenic effect and as well as to effectively differentiate LCMV from other TORCH(T:Toxoplasma gondii,O:Other pathogens,R:Rubella virus,C:Cytomegalovirus,H:Herpes simplex virus)pathogens.

关键词： Lymphocytic choriomeningitis virus Congenital infection Epidemiology Pregnancy TORCH

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis E virus in professionally exposed: A reason for concern?

引用

World Journal of Hepatology 2021年第7期13卷 723-730页

作者： Anna Mrzljak Ivan Balen Ljubo Barbic Maja Ilic tatjana vilibic-cavlek Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Gastroenterology and Endocrinology General Hospital“Dr.Josip Bencevic”Slavonski Brod 35000Croatia Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Department of Epidemiology Croatian Institute of Public HealthSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

The zoonotic risk of hepatitis E virus(HEV)is well *** HEV seroprevalence rates vary according to geographical region,assays used,and study *** infection is still underdiagnosed,implying the need to evaluate the disease's burden in the general population and specific risk groups,such as professionally *** contact with various animal reservoirs such as pigs,rabbits,sheep,dogs,wild boars,and deer has been associated with higher anti-HEV seroprevalence as a part of occupational *** exact transmission routes remain to be determined,some general preventive measures such as proper hand hygiene,the usage of personal protective equipment,and the thermal processing of food before consumption should be followed.A“One-Health”multisectoral approach should be implemented to achieve optimal health and well-being outcomes,recognizing the interconnections between humans,animals,plants,and their shared environment,in which a vaccine against the zoonotic genotypes 3 and 4 and swine vaccination should be considered as a possible public health *** opinion review comprehensively addresses the HEV burden of professional exposure for butchers,slaughterhouse workers,veterinarians,farmers,hunters,and forestry workers delineates the current limits of protective work measures,and tackles future directions.

关键词： Hepatitis E virus Zoonotic infection Occupational disease Veterinarians Farmers Butchers Slaughterhouse workers Forestry workers Hunters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human pegivirus infection after transplant:Is there an impact?

引用

World Journal of Transplantation 2022年第1期12卷 1-7页

作者： Anna Mrzljak Bojana Simunov Ivan Balen Zeljka Jurekovic tatjana vilibic-cavlek Department of Gastroenterology and Hepatology University Hospital Center ZagrebSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Gastroenterology and Endocrinology General Hospital“Dr.Josip Bencevic”Slavonski Brod 35000Croatia Department of Virology Croatian Institute of Public HealthSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

The microbiome's role in transplantation has received growing interest,but the role of virome remains *** are single-stranded positivesense RNA viruses,historically associated with liver disease,but their pathogenicity is *** the transplantation setting,pegivirus infection does not seem to have a negative impact on the outcomes of solid-organ and hematopoietic stem cell transplant ***,the role of pegiviruses as proxies in immunosuppression monitoring brings novelty to the field of virome research in immunocompromised *** possible immunomodulatory effect of pegivirus infections remains to be elucidated in further trials.

关键词： Virome Human pegivirus Epidemiology Solid-organ transplant Hematopoietic stem cell transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

引用

World Journal of Gastroenterology 2019年第25期25卷 3168-3182页

作者： Anna Mrzljak Petra Dinjar-Kujundzic Lorena Jemersic Jelena Prpic Ljubo Barbic Vladimir Savic Vladimir Stevanovic tatjana vilibic-cavlek Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Grad ZagrebCroatia Department of Medicine Merkur University HospitalZagreb 10000Grad ZagrebCroatia Croatian Veterinary Institute Zagreb 10000Grad ZagrebCroatia Faculty of Veterinary Medicine University of ZagrebZagreb 10000Grad ZagrebCroatia Department of Virology Croatian Institute of Public HealthSchool of MedicineUniversity of ZagrebZagreb 10000Grad ZagrebCroatia

The significance of hepatitis E virus(HEV)as an important public health problem is *** a decade ago,cases of HEV infection in Eur-ope were mainly confined to returning travelers,but nowadays,hepatitis E represents an emerging zoonotic infection in many European *** aim of this manuscript is to perform a systematic review of the published literature on hepatitis E distribution in humans,animals and environmental samples("One Health"concept)in the South-Eastern European *** of the available data showed that the anti-HEV seroprevalence in the South-Eastern Europe varies greatly,depending on the population studied,geographical area and methods *** IgG seroprevalence rates in different population groups were found to be 1.1%-24.5%in Croatia,up to 20.9%in Bulgaria,5.9-%17.1%in Romania,15%in Serbia,up to 9.7%in Greece and 2%-9.7%in *** possible risk factors,older age was the most significant predictor for HEV seropositivity in most *** seroprevalence rates were found in *** IgG antibodies in domestic pigs were detected in 20%-54.5%,29.2%-50%,38.94%-50%and 31.1%-91.7%in Serbia,Bulgaria,Romania and Croatia,*** wild boars seroprevalence rates were up to 10.3%,30.3%and 31.1%in Romania,Slovenia and Croatia,respectively.A high HEV RNA prevalence in wild boars in some countries(Croatia and Romania)indicated that wild boars may have a key role in the HEV *** are very few data on HEV prevalence in environmental *** RNA was detected in 3.3%and 16.7%surface waters in Slovenia and Serbia,*** is no evidence of HEV RNA in sewage systems in this *** available data on genetic characterization show that human,animal and environmental HEV strains mainly belong to the genotype 3.

关键词： Hepatitis E virus "One-Health" Humans Animals Environment South-East Europe

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Field evaluation of COVID-19 rapid antigen test:Are rapid antigen tests less reliable among the elderly?

引用

World Journal of Clinical Cases 2022年第19期10卷 6456-6463页

作者： Irena Tabain Djivo Cucevic Nikola Skreb Anna Mrzljak Ivana Ferencak Zeljka Hruskar Anita Misic Josipa Kuzle Ana Marija Skoda Hrvojka Jankovic tatjana vilibic-cavlek Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Emergency Medicine Institute of Emergency Medicine of the City of ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Gastroenterology and Hepatology University Clinical Hospital ZagrebZagreb 10000Croatia

BACKGROUND The global outbreak of coronavirus disease 2019(COVID-19)leads to the development of accessible and cost-effective rapid antigen-detection tests(RATs),as quick and accurate diagnosis is crucial to curb the *** To evaluate the Humasis COVID-19 Ag Test(Humasis Co.,Ltd.,Gyeonggi-do,Republic of Korea)in the diagnosis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).METHODS This retrospective study was carried out at the Croatian Institute of Public Health and included patients with clinical symptoms of COVID-19 lasting no longer than 5 d prior to testing,whose nasopharyngeal swabs were primarily tested with *** RAT samples underwent confirmatory real-time reverse transcription-polymerase chain reaction(RT-PCR).Diagnostic efficacy was determined compared to *** patients were divided into three age groups(65 years).Statistical analysis was performed with the significance level set at P<*** total,2490 symptomatic patients were tested;953 samples were positive on RAT,and 1537 *** negative RAT samples were subjected to RT-PCR;266 samples were positive andmarked as false-negative results on *** calculated negative predictive value as a measure ofRAT efficacy was 82.69%.The χ^(2) test and Kruskal-Wallis test showed a significant difference in theproportion of false negatives(P<0.001)and RT-PCR cycle(Ct)values for false-negative RATs(P=0.012)among the age *** young age group was significantly less likely to be falsenegative,whereas the false negatives from the elderly group experienced significantly lower Ctvalues than the other two age *** RAT demonstrated satisfactory performance with more reliable results in *** COVID-19 Ag RAT is potentially a valuable tool in areas where access tomolecular methods is limited;however,RT-PCR remains a gold standard for SARS-CoV-2detection.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus-2 Rapid antigen test Real-time reverse transcription-polymerase chain reaction Croatia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insights into hepatitis E virus epidemiology in Croatia

引用

World Journal of Gastroenterology 2022年第37期28卷 5494-5505页

作者： Pavle Jelicic Thomas Ferenc Anna Mrzljak Lorena Jemersic Natasa Janev-Holcer Milan Milosevic Maja Bogdanic Ljubo Barbic Branko Kolaric Vladimir Stevanovic Mateja Vujica Zeljka Jurekovic Jadranka Pavicic Saric Maja vilibic tatjana vilibic-cavlek Department of Environmental Health Croatian Institute of Public HealthZagreb 10000Croatia Department of Radiology Merkur University HospitalZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Virology Croatian Veterinary InstituteZagreb 10000Croatia Department of Social Medicine and Epidemiology Faculty of Medicine University of RijekaRijeka 51000Croatia Department of Occupational and Environmental Health Andrija Stampar School of Public HealthZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Department of Gerontology and Social Medicine Andrija Stampar Teaching Institute of Public HealthZagreb 10000Croatia Institute of Emergency Medicine of Krapina-Zagorje County Krapina 49000Croatia Department of Nephrology Merkur University HospitalZagreb 10000Croatia Department of Anesthesiology University Hospital MerkurZagreb 10000Croatia Department for Social Psychiatry Psychotherapy and PsychodiagnosticsUniversity Clinical Hospital Center“Sestre Milosrdnice”Zagreb 10000Croatia

BACKGROUND Hepatitis E virus(HEV)is an emerging virus of global health *** seroprevalence rates differ greatly according to geographic region and population *** To analyze the seroprevalence of HEV in exposed(animal-related professions)and nonexposed populations,as well as solid organ and hematopoietic stem cell transplant *** Forestry workers(n=93),hunters(n=74),and veterinarians(n=151)represented the exposed *** general population(n=126)and pregnant women(n=118)constituted the control *** patients included liver transplant recipients(LTRs)(n=83),kidney transplant recipients(KTRs)(n=43),and hematopoietic stem cell transplant recipients(HSCRs)(n=39).HEV immunoglobulin G antibodies were detected using the enzyme-linked immunosorbent assay and confirmed by the immunoblot *** The HEV seroprevalence significantly differed between groups:Veterinarians 15.2%,hunters 14.9%,forestry workers 6.5%,general population 7.1%,and pregnant women 1.7%.In transplant patients,the seropositivity was highest in LTRs(19.3%),while in KTRs and HSCRs,the seroprevalence was similar to the general population(6.9%and 5.1%,respectively).A significant increase in seropositivity with age was observed from 2.9%in individuals less than 30 years to 23.5%in those older than 60 *** characteristics(sex,educational level,area of residence,and number of household members),eating habits(game meat,offal,and pork products consumption),and environmental and housing conditions(drinking water supply,type of water drainage/sewer,waste disposal,domestic animals)were not associated with HEV ***,individuals who reported a pet ownership were more often seropositive compared to those who did not have pet animals(12.5%vs 7.0%).CONCLUSION The results of this study showed that individuals in professional contact with animals and LTRs are at higher risk for HEV *** addition,age is a significant risk factor for HEV

关键词： Hepatitis E virus Seroprevalence Veterinarians Hunters Forestry workers Transplant patients Croatia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cauda equina arachnoiditis–a rare manifestation of West Nile virus neuroinvasive disease:A case report

引用

World Journal of Clinical Cases 2020年第17期8卷 3797-3803页

作者： Marija Santini Ivana Zupetic Klaudija Viskovic Juraj Krznaric Marko Kutlesa Vladimir Krajinovic Vlatka Lovrakovic Polak Vladimir Savic Irena Tabain Ljubo Barbic Maja Bogdanic Vladimir Stevanovic Anna Mrzljak tatjana vilibic-cavlek Department for Intensive Care Medicine and Neuroinfectology University Hospital for Infectious Diseases“Dr Fran Mihaljevic”Zagreb 10000Croatia Department of Radiology University Clinical Hospital CenterClinic for TraumatologyZagreb 10000Croatia Department of Radiology and Ultrasound University Hospital for Infectious Diseases“Dr Fran Mihaljevic”Zagreb 10000Croatia Department of Infectious Diseases General County Hospital KarlovacKarlovac 47000Croatia Department of Poultry Center Laboratory for Virology and SerologyCroatian Veterinary InstituteZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary MedicineUniversity of ZagrebZagreb 10000Croatia Department of Medicine University Hospital MerkurZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

BACKGROUND Data regarding the neuroradiology features of the West Nile virus neuroinvasive disease(WNV NID)is rather *** contribute to the knowledge of the WNV NID,we present a patient with a combination of encephalitis and acute flaccid paresis,with cauda equina arachnoiditis as the main magnetic resonance(MR)*** SUMMARY A 72-year-old female patient was admitted due to fever,headache and gait *** the first several days she developed somnolence,aphasia,urinary incontinence,constipation,and asymmetric lower extremities *** fluid analysis indicated *** brain computed tomography and MR were unremarkable,while spinal MR demonstrated cauda equina enhancement without cord *** testing revealed WNV IgM and IgG antibodies in serum and cerebrospinal fluid,which confirmed acute WNV *** treatment was *** two months only a slight improvement was noticed but cognitive impairment,loss of sphincter control and asymmetric inferior extremities weakness *** patient died after a month on chronic *** Cauda equina arachnoiditis is a rare,but possible neuroradiological feature in acute flaccid paresis form of WNV NID.

关键词： West Nile virus Central nervous system infection Cauda equina Magnetic resonance Neuroinvasive disease Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：