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Effects of Peripherally Acting Opioid Ligands on Central Opioid Receptors and <i>β</i>-Endorphin Release in Stressed Rats

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Journal of Behav.oral and Brain Science 2012年第2期2卷 162-166页

作者： Sergey K. Sudakov.v.lentina G. Bashkatov. tatiyana v. proskuriakova Alexey E. Umriukhin P.K. Anokhin Research Institute of Normal Physiology RAMS Moscow Russia

Using the radioreceptor binding assay, μ-opioid receptor (MOR) affinity in the midbrain of stressed rats was higher than in naiv. controls. MOR density in the rat frontal cortex was reduced after stress. Intragastric administration of the MOR antagonist naloxone methiodide was followed by an increase in the number of MORs in the frontal cortex. Howev.r, the MOR agonist loperamide significantly decreased the density of MORs in the frontal cortex and midbrain of naiv. animals. Loperamide and naloxone methiodide were shown to prev.nt an increase in MOR affinity and a decrease in MOR density in the midbrain of rats after restraint stress. The restraint stress was accompanied by an increase in the release of β-endorphin (BE) in the v.ntral tegmental area (v.A) of control rats. After administration, loperamide slightly decreased the release of BE, naloxone methiodide significantly increased the release of BE in the cingulate cortex (CC) of untreated animals, while drugs had no effect on the release of BE in the v.A. The drugs significantly increased the extracellular lev.l of BE in the CC of stressed animals. Loperamide abolished the increase in the stress-induced release of BE in the v.A. By contrast, naloxone methiodide significantly increased the release of BE in the v.A of stressed rats. Our data indicated that activ.tion of peripheral MORs induces depression of the central part of the μ-opioid system, but suppression of peripheral MOR activ.ty induces activ.tion of the central μ-opioid system, the interaction of which can be modulated by stress.

关键词： Peripheral Opioid Receptors Emotional Stress β-Endorphin Microdialysis Radioligand Binding Density of μ-Opioid Receptors

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Effects of Agrobacterial<i>rol</i>-Genes on the Thermodynamic and Structural Features of Starches Extracted from Potato Microtubers

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Food and Nutrition Sciences 2014年第3期5卷 250-257页

作者： Luybov.A. Wasserman Nina P. Aksenov. tatiyana N. Konstantinov. Lidiya I. Sergeev. Sv.tlana A. Golyanov.kaya Alexey v. Kriv.ndin Georgy A. Romanov Emmanuel Institute of Biochemical Physics Russian Academy of Sciences Moscow Russia imiryazev.Institute of Plant Physi- ology Russian Academy of Sciences Moscow Russia Timiryazev.Institute of Plant Physi- ology Russian Academy of Sciences Moscow Russia Timiryazev.Institute of Plant Physi- ology Russian Academy of Sciences Moscow Russia Laboratory of Plant Physiology Wageningen University Wageningen The Netherlands.

Wild-type potato (Solanum tuberosum L.) plants and their transformants harboring agrobacterial rolB or rolC genes under control of the patatin class I promoter were cultured in v.tro. These plants were used as a source of single-node stem cuttings. The structure of nativ. starch in tubers formed on cuttings was determined using methods of X-ray scattering and differential scanning microcalorimetry (DSC). It was found that in starch from tubers of rolB plants the melting temperature of crystalline lamella was lower and their thickness was less than that in wild-type potato. In tubers of rolC plants starch differed from starch in wild-type plants by a higher melting temperature, reduced melting enthalpy, and a greater thickness of crystalline lamellae. The melting of starch from tubers of rolC plants proceeded as the melting of two independent crystalline structures with melting temperatures of 338.0°K and 342.8°K. Ov.rall data show that starches of different structure can be obtained by using transgenic approach.

关键词： Solanum tuberosum Transgenic Potato Starch rol Genes Tubers Crystalline Lamellae Melting Temperature

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