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Relationship between mitochondrial respiratory dysfunction of blood mononuclear cells and heart failure severity

Journal of Geriatric Cardiology 2024年第1期21卷 130-134页

作者： Viacheslav A.Korepanov Tariel A.Atabekov tatiana yu.rebrova Roman E.Batalov Sergey A.Afanasiev Cardiology Research Institute Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

Chronic heart failure(CHF)is a clinical syndrome manifested by reduced pumping ability of the heart,increased pressure in heart chambers in both physical activity and at *** symptoms of this syndrome are dyspnea,undue fatigability,peripheral edema,which follow structural and functional changes of the myocardium.[1]The growing incidence of CHF,especially among elderly people,is an urgent problem for medicine in the vast majority of industrialized *** instance,in Russian Federation,CHF is diagnosed in about 7%of cardiovascular *** the same time,this indicator varies from 0.3%in young people(20-29 years old)to 70%in the older age group.[2,3].

关键词： severity instance pumping

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Potential role of peripheral blood mononuclear cell' s mitochondrial respiratory dysfunction in heart failure severity prediction in patients with cardioverter-defibrillator implantation indications

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Journal of Geriatric Cardiology 2024年第10期21卷 981-991页

作者： Tariel A Atabekov Sergey N Krivolapov Mikhail S Khlynin Viacheslav A Korepanov tatiana yu rebrova Elvira F Muslimova Sergey A Afanasiev Roman E Batalov Sergey V Popov Cardiology Research Institute Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

Background It has been reported that the mitochondrial respiratory dysfunction (MRD) is important mechanisms affecting the heart failure (HF) *** sought to evaluate the potential role of MRD of peripheral blood mononuclear cells (PBMC) in HF severity prediction in patients with cardioverter-defibrillator implantation *** In this single-center study patients with HF of New York Heart Association (NYHA) Ⅰ-Ⅲ functional class (FC) and cardioverter-defibrillator implantation indications underwent transthoracic echocardiography (TTE) and MRD assessment using *** respiration rate (MRR) indicators (pyruvate+malate+adenosine diphosphate;succinate+adenosine diphosphate;pyruvate+malate–adenosine diphosphate[V4.1];succinate–adenosine diphosphate) were *** between HF NYHA FC,TTE and MRR indicators were *** on our data,we developed a risk model regarding HF *** Of 53 (100.0%) HF patients,33 (62.3%) had mild exercise intolerance (1stgroup) and 20 (37.7%) had moderate-to-severe exercise intolerance (2ndgroup).Patients with mild exercise intolerance were likely to have a higher V4.1(P<0.001) values.V4.1was independently associated with moderate-to-severe exercise intolerance in univariate and multivariate logistic regression (OR=0.932,95%CI:0.891–0.975,P<0.001).Conclusions The severity of HF is associated with PBMC mitochondrial respiratory dysfunction in patients with cardioverter-defibrillator implantation *** HF severity risk model including V4.1parameters is able to distinguish patients with mild and moderate-to-severe exercise *** investigations of their predictive significance are warranted.

关键词： severity patients indications

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Effects of europium concentration on luminescent and scintillation performance of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3)(0≤x≤0.08)crystals

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Journal of Rare Earths 2022年第1期40卷 29-33页

作者： N.V.rebrova A.yu.Grippa I.A.Boiaryntseva P.Berastegui T.E.Gorbacheva yu.N.Datsko A.L.Rebrov C.Dujardin R.Calà L.Martinazzoli E.Auffray V.V.Kononets Institute for Scintillation Materials National Academy of Sciences of UkraineNauky Avenue 6061072KharkovUkraine Department of Chemistry Angstrom LaboratoryInorganic ChemistryUppsala University.PO.Box 583.75121.UppsalaSweden Claude Bernard Lyon 1 University CNRSInstitute of Light and MatterUMR 5306F-69100 VilleurbanneFrance The University of Milano-Bicocca Piazza dell'Ateneo Nuovo1-20126Milano.Italy CERN EP DepartmentP.0.Box 1211Geneva 23Switzerland

A series of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3)(0≤x≤0.08)crystals doped with different concentrations of Eu^(2+)were grown using the Bridgman-Stockbarger *** work describes the influence of Eu^(2+)concentration on the luminescent and kinetic properties of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3) crystals,as well as on their scintillation *** maximum in the radioluminescence spectra of these crystals shifts from 439 to446 nm with increasing europium *** scintillation decay times of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3) lengthen with the Eu^(2+)*** best light output of 33600photons/MeV is obtained for Cs_(0.2)Rb_(0.8)Ca_(0.93)Eu_(0.07)Br_(3),and the best energy resolution of 6.9%is found for Cs_(0.2)Rb_(0.8)Ca_(0.94)Eu_(0.06)Br_(3).

关键词： Inorganic material Crystal growth Luminescence Rare-earth doped scintillator X-ray and gamma-ray spectroscopies

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