检索结果-南通市图书馆

Design, Synthesis, and Evaluation of Fungicidal Activity of Novel Pyrazole-Containing Strobilurin Derivatives

Chinese Journal of Chemistry 2021年第6期39卷 1531-1537页

作者： Zesheng Hao Weibo Wang Bin Yu Xin Qi You Lv Xiaoyu Liu Haoyin Chen tatiana A.Kalinina tatiana v.glukhareva Zhijin Fan State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNonkoi UniversityTianjin 300071China The Ural Federal University Named after the First President of Russia B.N.Yeltsin Yeltsin UrFU 620002EkaterinburgRussia

In searching for novel fungicidal leads,a series of pyrazole-containing strobilurins were rationally designed,synthesized and *** indicated that compound 1-7 displayed excellent fungicidal activity against a broad spectrum of plant pathogens such as Gibberella zeae,Rhizoctonia cereolis,Sclerotinia sclerotiorum,Phytophthora infestans,Physolosporo piricola and Pellicularia sosakii with EC_(50) of 0.16,0.02,0.72,0.07,0.77 and 0.65μg/mL,respectively,which were 3-10 times more potent than the positive control azoxystrobin against the corresponding ***,like azoxystrobin and kresoxim methyl,1-7,displayed excellent protec-tive activity against *** docking validated that 1-7 and azoxystrobin would share a similar binding mode with cytochrome bc_(1) *** study demonstrates that 1-7 is a promising fungicidal candidate for further development.

关键词： Drug design Strobilurins Biological activity Structure-activity relationships Cytochrome bc_(1)complex

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis, Crystal Structure and Fungicidal Activity of 3-Chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2H-chromen-2-ones

引用

Chinese Journal of Structural Chemistry 2021年第8期40卷 1068-1074,971页

作者： Lv You LI Kun HAO Ze-Sheng KALININA tatiana A. glukhareva tatiana v. FAN Zhi-Jin State Key Laboratory of Elemento-organic Chemistry College of ChemistryNankai UniversityTianjin 300071China The Ural Federal University Named after the First President of Russia B.N.Yeltsin Yeltsin UrFU 620002Ekaterinburg.Russia

3-Chloro-4-(3,4-dichloroisothiazol-5-yl)-5-hydroxy-7-methyl-2 H-chromen-2-ones,a kind of coumarin derivatives,were synthesized byβ-ketoester formation and *** compound 5 e was crystallized from methanol for structural identification as monoclinic crystal system,space group C2/c with a=16.2700(6),b=7.1801(5),c=23.4861(10)A,v=2742.6(2)A^(3),Z=8,Dc=1.756 g/cm^(3),F(000)=1456 andμ=0.827 mm-1.8308 Reflections were collected(6.01≤2θ≤50.05°),of which 2428 were unique(Rint=0.0432)and used in all *** final R=0.0408(I>2σ(I))and w R=0.1056(reflections).In vitro bioassay indicated that compounds 5 d&5 e possessed good activity against Botrytis cinerea,Physalospora piricola,Rhizoctonia solani,and Sclerotinia sclerotiorum with lower EC50 values falling between 0.50 and 4.85μg/m L than that of positive control osthole with its EC50 values between 7.38 and 74.59μg/*** vivo screening showed that 5 e exhibited 98%and 95%efficacy against Pseudoperonospora cubensis(Berk.&Curt.)*** 100 and 50μg/mL,*** studies discovered that the combination of bioactive substructures of isothiazole with coumarin was an effective way to novel fungicide development.

关键词： coumarin synthesis crystal structure fungicidal activity

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis,Crystal Structure and Fungicidal Activity of 3,4-Dichloro-5-(6-chloro-9-(4-fluorobenzyl)-9H-purin-8-yl)isothiazole

引用

Chinese Journal of Structural Chemistry 2022年第2期41卷 91-97,I0010页

作者： WANG Wei-Bo LIU Xiao-Yu LI Zhi-Xinyi GAO Wei Lv You LI Kun glukhareva tatiana v. TANG Liang-Fu FAN Zhi-Jin State Key Laboratory of Elemento-organic Chemistry College of ChemistryNankai UniversityTianjin 300071China Frontiers Science Center for New Organic Matter College of ChemistryNankai UniversityTianjin 300071China School of Medicine Nankai UniversityTianjin 300071China Ural Federal University Named after the First President of Russia B.N.Yeltsin Yeltsin UrFU 620002EkaterinburgRussia

3,4-Dichloro-5-(6-chloro-9-(4-fluorobenzyl)-9H-purin-8-yl)isothiazole,a novel purine derivative,was synthesized by the cyclization of pyrimidine *** structure was characterized by ^(1)H NMR,^(13)C NMR,^(19)FNMR,H RMS and single-crystal X-ray *** compound 3 is crystallized from a mixed solvent of dichloromethane and n-hexane (1:2,v/v) for structural identification as monoclinic crystal system,space group P2_(1)/n with a=11.66250(10),b=8.21300(10),c=17.77920(10)?,v=1676.34(3)?^(3),Z=4,D_(c)=1.643 g/cm^(3),F(000)=832.0 andμ=6.301 mm^(-1).22315 reflections were measured (8.43≤2θ≤158.10°),of which 3532 were unique (R_(int)=0.0311) and used in all *** final R=0.0334 (I>2σ(I)) and w R=0.0842 (reflections).The title compound showed over 50%of growth inhibition against Botrytis cinereal,Cercospora arachidicola,Gibberella zeae,Rhizoctonia solani and Sclerotinia sclerotiorum at 50 mg/L,and its EC_(50) value against *** was 60.44μmol/L,which was active at the same level as that of positive control diflumetorim with its EC_(50) value of 60.29μmol/L and less active than YZK-C22 with its EC_(50) value of 12.32μmol/L,*** studies discovered that the combination of bioactive substructures of isothiazole with purine could be an effective way to novel fungicide development.

关键词： purine synthesis crystal structure fungicidal activity

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis, Crystal Structure and Biological Activity of N-(tert-butyl)-N'-(2-(4-chlorophenyl)acetyl)-5-methyl-1,2,3-thiadiazole-4-carbohydrazide

引用

Chinese Journal of Structural Chemistry 2013年第5期32卷 673-678页

作者：王盾毛武涛范志金李娟娟黄云宋海斌范谦 tatiana A. Kalinina glukhareva tatiana Morzherin Yury Yur'evich Belskaya N. Pavlovna Bakulev v. Alekseevich Department of Plant Pathology Sichuan Agricultural University State Key Laboratory of Elemento-organic Chemistry Nankai University Sichuan Functional Heterocyclic Compounds Engineering Technology Research Center Lier Chemicals Co.Ltd. The Ural Federal University Named after the First President of Russia B. N. Yeltsin

The title compound N-（tert-butyl）-N＇-（2-（4-chlorophenyl）acetyl）-5-methyl-1,2,3-thiadiazole-4-carbohydrazide （C16H19ClN4NaO2S, Mr = 366.86） has been synthesized, and its structure was characterized by IR, 1H NMR, H RMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to triclinic, space group Pī with a = 8.464（2）, b = 10.192（2）, c = 11.757（2）, α = 68.48（3）, β = 76.31（3）, γ = 80.86（3）°, Z = 2, v = 2024.6（10） 3, Dc = 1.333 g/cm3, μ = 0.339 mm-1, F（000） = 384, R = 0.0450 and wR （Ⅰ 〉 2σ（Ⅰ）） = 0.1234. X-ray analysis indicates one N-H…N intermolecular hydrogen bond and no π-π stacking interactions are observed in this crystal structure. The preliminary biological test shows that the title compound has fungicidal activity and antivirus activities against tobacco mosaic virus.

关键词： X-ray diffraction crystal structure synthesis 1,2,3-thiadiazole biological activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：