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H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression

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World Journal of Gastroenterology 2008年第6期14卷 884-891页

作者： Valeska Portela lima Marcos Antonio Pereira de lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst departament of Pathology and Forensic Federal University of Ceará State Brazil Saint House of Mercy in Fortaleza Brazil

AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

关键词： Gastric carcinoma Helicobacter pylori Epstein-Barr virus, p53, Bax, Bcl-2, c-Myc

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Apparent soil electrical conductivity in the delineation of management zones for cocoa cultivation

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Information Processing in Agriculture 2022年第3期9卷 443-455页

作者： Samuel de Assis Silva Railton Oliveira dos Santos Daniel Marcal de Queiroz Juliao Soares de Souza lima Levi Fraga Pajehua Caique Carvalho Medauar Center for Agricultural Sciences and Engineering Federal University of Espirito SantoAlegre CampusEspirito Santo 29500-000Brazil department of Agricultural Sciences Santa Cruz State UniversityIlheusBahia 45662-900Brazil department of Agricultural Engineering Federal University of Vic¸osaVic¸osaMinas Gerais 36570-900Brazil

Apparent electrical conductivity is an important parameter for describing the spatial vari-ability of physical and chemical attributes of the soil and for the delineation of manage-ment *** objective of this work is to outline management zones for the cocoa cultivation based on the spatial variability of the productivity and the apparent electrical conductivity(ECa)of the *** collection was performed in a regular sample grid con-taining 120 points in an area cultivated with cocoa trees,located in the municipality of Ilhe´us,state of Bahia,*** each sampling point(cocoa tree),soil samples were col-lected to determine chemical *** was measured for one year,counting,monthly,the number of fruits,which were classified into off-season cocoa,harvest and annual *** of the apparent electrical conductivity of the soil were performed at different times of the year using a portable conductivity *** data were analyzed using classical statistics and *** management zones were delin-eated using the fuzzy k-means *** ideal number of class was defined using the fuzziness performance index(FPI)and the entropy of the modified partition(MPE)*** Kappa coefficient was used to validate the management zones,assessing their agreement with the chemical attributes of the *** ECa of the soil values pre-sented moderate temporal variation,with maximum amplitude of 19.37 mS m1 and min-imum of 0.82 mS m1 between measurement periods;higher averages of the ECa coincided with the highest levels of water in the *** measurements of the ECa of the soil carried out in April and October showed greater correlation with the chemical attributes of the soil,with significant values for 11 and 8 of the 17 attributes evaluated,*** man-agement zones from the ECa measured in April showed:a)reduced number of classes;b)spatial continuity between classes,and;c)agreement from reasonable(kappa between

关键词： Theobroma cacao Precision agriculture Spatial variability Fuzzy k-means

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Multielement determination in orange juice by ICP-MS associated with data mining for the classification of organic samples

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Information Processing in Agriculture 2017年第3期4卷 199-205页

作者： Christian Turra Marcio Dias de lima Elisabete A.de Nadai Fernandes Marcio Arruda Bacchi Fernando Barbosa Jr. Rommel Barbosa Centro de Energia Nuclear na Agricultura Universidade de Sao PauloPiracicabaBrazil USP-Ribeirao Preto Brazil Instituto de Informatica Universidade Federal de GoiasGoianiaGOBrazil Instituto Federal de Educacao Ciencia e Tecnologia de Goias GoianiaGOBrazil

The aim of this study was to discriminate organic from conventional orange juice based on chemical elements and data mining applications.A comprehensive sampling of organic and conventional oranges was carried out in Borborema,state of Sao Paulo,*** fruits of the variety Valencia(Citrus sinensis(L.)Osbeck)budded on Rangpur lime(Citrus limonia Osbeck)were *** chemical elements were determined in 57 orange samples grown in organic and conventional *** order to classify these samples,data mining techniques(Support Vector Machine(SVM)and Multilayer Perceptron(MLP))were combined with feature selection(F-score and chi-squared).SVM with chi-squared had a better performance compared with the other techniques because it reached 93.00% accuracy using only seven chemical components(Cu,Cs,Zn,Al,Mn,Rb and Sr),and correctly classified 96.73% of the samples grown in an organic system.

关键词： Data mining Support vector machines Multilayer perceptron Orange juice Trace elements Inductively coupled plasma mass spectrometry(ICP-MS)

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Silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model

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Biomedical and Environmental Sciences 2020年第9期33卷 690-700页

作者： Miranda Laise Mara Oliveira Agostini Livia da Cunha lima Wanderson Geraldo de Camini Fernanda Caetano Costa Daniela Caldeira Programa de Pos-graduagao em Saude e Nutricao Escola de NutricaoUniversidade Federal de Ouro PretoOuro PretoMinas Gerais 35400-000Brazil Escola de Farmacia Universidade Federal de Ouro Preto.Ouro PretoMinas Gerais 35400-000Brazil Laboratorio de Morfopatologia Departamento de Ciencias BioldgicasUniversidade Federal de Ouro PretoOuro Preto 35400-000Brazil Programa de Pos-graduaqao em Ciencias Bioldgicas Nucleo de Pesquisas em Ciencias BiologicasUniversidade Federal de Ouro Preto.Ouro Preto 35400-000Brazil Laboratorio de Bioquimica Metabolica Departamento de Ciencias BiologicasUniversidade Federal de Ouro PretoOuro Preto 35400-000Brazil

Objective To evaluate the efficiency of silymarin(SMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus(T1 DM).Methods Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with SMN at doses of 50 and 100 mg/kg body weight/d for 30 consecutive days. The rats were divided into the following four groups: vehicle control, diabetic(alloxan-treated), DS50(alloxan +50 mg/kg body weight/d of SMN), and DS100(alloxan + 100 mg/kg body weight/d of SMN) groups. The bodyweight and food and water intake were evaluated. After 30 d, the animals were euthanized and the blood was collected for measuring the serum levels of glucose, triacylglycerol(TAG), urea, and creatinine. The liver and pancreas were collected for measuring the activities of superoxide dismutase(SOD) and catalase(CAT), and the levels of carbonylated protein(PC). The pancreas sample was also used for histological *** SMN reduced hepatic(P decreasing food(P decrease blood glucose levels in diabetic *** SMN improved polyphagia and polydipsia, renal function, and protected the liver and pancreas against protein damage without affecting hyperglycemia in diabetic animals.

关键词： Silymarin Silybum marianum Type 1 diabetes Oxidative stress

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Isotopic and geochemical constraints for a Paleoproterozoic accretionary orogen in the Borborema Province,NE Brazil:Implications for reconstructing Nuna/Columbia

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Geoscience Frontiers 2022年第5期13卷 267-285页

作者： Lauro Cézar M.de Lira Santos Geysson A.Lages Fabrício A.Caxito Elton L.Dantas Peter A.Cawood Haroldo M.lima Felipe Jda Cruz lima departamento de Geologia Universidade Federal de PernambucoAv.da ArquiteturaCidade UniversitáriaRecifePEBrazil Serviço Geológico do Brasil-CPRM Av.SulAfogadosRecifePEBrazil CPMTC Instituto de GeociênciasUniversidade Federal de Minas GeraisAv.Pres.Antônio CarlosPampulhaBelo HorizonteMGBrazil Instituto de Geociências Universidade de BrasíliaCampus Universitário Darcy RibeiroAsa NorteBrasíliaDFBrazil School of Earth Atmosphere and EnvironmentMonash UniversityWellington RdClaytonVIC 3800Australia departamento de Geologia Universidade Federal do CearáCampus do PiciParquelândiaFortalezaCEBrazil

The Alto MoxotóTerrane of the Borborema Province presents a wide exposure of Paleoproterozoic crust,but unlike other continental blocks of South America,its orogenic history is strongly obliterated by late Neoproterozoic *** isotopic and geochemical studies were conducted in mafic-ultramafic(Fazenda Carmo Suite)and granitic-gneissic rocks(Riacho do Navio Suite)within the *** former present zircon U-Pb crystallization ages at ca.2.13 Ga,whereas Sm-Nd data suggests a juvenile origin via melting of early Paleoproterozoic to Archean peridotitic *** data for these rocks are compatible with tholeiitic magmas with some degree of crustal contamination and trace element distribution points to a continental-arc related setting interpreted as remnants of the early stages of *** contrast,the Riacho do Navio Suite was emplaced at ca.2.08 Ga and has highly negativeεNd(t)values indicating crustal *** suite displays calc-alkali to alkali-calcic and ferroan geochemical signatures compatible with Cordilleran *** addition,trace-element distribution as well as discriminant diagrams suggest that the precursor magmas were generated during the later stages of a continental arc or in a syn-collisional *** on our results,we suggest that the studied units might represent missing pieces of a Paleoproterozoic accretionary orogen that formed the crustal framework of the Alto MoxotóTerrane,and that this represents a block associated with assembly of the Nuna/Columbia supercontinent,which is now largely hidden within the Neoproterozoic orogenic belts of West Gondwana.

关键词： Paleoproterozoic accretionary-collisional event Early orogenic and syn-collisional magmatism Paleoproterozoic inlier within West Gondwana Nuna/Columbia Supercontinent

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Existence and Multiplicity Results for a Class of Nonlinear Schrödinger Equations with Magnetic Potential Involving Sign-Changing Nonlinearity

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Analysis in Theory and Applications 2022年第2期38卷 148-177页

作者： Francisco Odair de Paiva Sandra Machado de Souza lima Olimpio Hiroshi Miyagaki departamento de Matematica UFSCarSao CarlosSP13560-970 Brazil departamento de Ciencias Exatas Biologicas e da TerraINFES-UFFSanto Antonio de Padua-RJ28470-000Brazil

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈H_(A)^(1)(R^(N)),(P)with 2 详细信息

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈H_(A)^(1)(R^(N)),(P)with 2

关键词： Magnetic potential sign-changing weight functions Nehari manifold Fibering map

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Past,present and future of preserving and restoring function in the visual system:removing galectin-3 as a promising treatment

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Neural Regeneration Research 2017年第1期12卷 58-59页

作者： Silmara de lima Henrique Rocha Mendonca Camila Oliveira Goulart Ana M.Blanco Martinez Laboratories for Neuroscience Research in Neurosurgery and F.M.Kirby Neurobiology Center Children's Hospital BostonDepartmentsof Surgery and Ophthalmology and Program in NeuroscienceHarvard Medical SchoolBostonMAUSA Laboratorio de Neurodegeneracao e Reparo-departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Polo Universitairio Macae UFRJMacaeRJBrazil

Great advances in retinal ganglion cells survival（RGCs）,optic nerve preservation and regeneration have been made in the past ***,we know that RGCs are capable of regenerating the full length of the optic nerve,cross... 详细信息

关键词： RGCs preserving regeneration preservation galectin removing optic capable ganglion microglia

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Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

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World Journal of Gastroenterology 2020年第43期26卷 6795-6809页

作者： Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira lima Leonia Maria Batista department of Pharmaceutical Sciences IPeFarMFederal University of ParaibaJoao Pessoa 58051-970ParaibaBrazil Health Sciences Center Federal University of ParaibaJoaoPessoa 58051-970ParaibaBrazil Postgraduate Program in Natural and Synthetic Bioactive Products Universidade Federal da ParaibaJoão Pessoa 58051-900Brazil

BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal *** studies report its anti-inflammatory,antioxidant,and antinociceptive *** To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial *** A castor oil-induced diarrhea model was used to evaluate antidiarrheal *** transit and gastric emptying protocols were used to assess a possible antimotility *** receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory *** antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal ***(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation *** activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or *** the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/***,when it was associated with amphotericin B,no synergism was *** The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity.

关键词： (-)-Fenchone Monoterpenes Diarrhea Motility Antifungal

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3D Printing in Fiber-device Technology

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Advanced Fiber Materials 2021年第2期3卷 1-17页

作者： Louis van der Elst Camila Faccini de lima Meve Gokce Kurtoglu Veda Narayana Koraganji Mengxin Zheng Alexander Gumennik department of Intelligent Systems Engineering Luddy School of InformaticsComputing and EngineeringIndiana University Bloomington700 North Woodlawn AvenueBloomingtonIN 47408USA Fibers and Additive Manufacturing Enabled Systems Laboratory 2425 North Milo B Sampson LaneBloomingtonIN 47408USA

Recent advances in additive manufacturing enable redesigning material morphology on nano-,micro-,and meso-scale,for achieving an enhanced functionality on the *** non-planar and flexible electronic circuits,through biomechanically realistic surgical models,to shoe soles individualized for the user comfort,multiple scientific and technological areas undergo material-property redesign and enhancement enabled by 3D ***-device technology is currently entering such a *** this paper,we review the recent advances in adopting 3D printing for direct digital manufacturing of fiber preforms with complex cross-sectional architectures designed for the desired thermally drawn fiber-device ***,taking a recursive manufacturing approach,such fibers can serve as a raw material for 3D printing,resulting in macroscopic objects with enhanced functionalities,from optoelectronic to bio-functional,imparted by the fiber-devices properties.

关键词： Recursive manufacturing 3D printing Fibers Optical fibers Pervasive sensing

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Post-mortem Microstructural Study of Aluminous Refractory Brick Used in Channels of Blast Furnaces

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China's Refractories 2023年第1期32卷 40-43页

作者： Ana Valéria de Sousa COSTA Belmira Benedita de lima-KUHN Antonio Renato BIGANSOLLI department of Chemical Engineering Technology InstituteFederal Rural University of Rio de JaneiroSeropédica 23851-970Brazil

Aluminous refractory materials with high alumina contents are widely used in the steel industry,and the higher the alumina content,the higher the working *** such as high refractoriness and thermal shock resistance lead these refractory materials to be used as channel linings of blast furnaces,where they are exposed to the attack by slag,molten steel,working cycles and sudden temperature changes between 25℃(room temperature)and 1520℃(the temperature of molten pig iron).In this work,microstructural changes in post-mortem aluminous refractory bricks were investigated by apparent porosity,X-ray diffraction analysis(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy,and X-ray dispersion energy spectrometry(SEM/EDS).The results showed an increase in the apparent porosity and the bulk density and the presence of the phases mullite,sillimanite,alumina,and quartz in the post-mortem *** and magnesium were not detected in the microstructure of the post-mortem brick,indicating that slags did not corrode these refractory ***,the microstructural changes that occurred in the post-mortem bricks must be due to thermal *** the X-ray diffraction(XRD)test,mullite,sillimanite,quartz,andα-alumina phases were *** results indicate that the aluminous refractory was obtained from *** infrared spectroscopy(FTIR)it was possible to identify the vibration bands referring to the Si-O and Al-O *** increase in the porosity is a result of cracks caused by work cycles at high temperatures and the temperature gradient to which the refractory was subjected during *** the micrograph it was possible to identify the presence of acicular *** absence of magnesium and calcium in the microanalysis results by energy dispersed X-ray spectrometry(EDS)indicates that there was no infiltration by slag or liquid *** results indicate that the microstructural changes that occurred in t

关键词： aluminous refractories steel industry microstructural blast furnace

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