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Oxidative stress and labile plasmatic iron in anemic patients following blood therapy

World Journal of Experimental Medicine 2014年第3期4卷 38-45页

作者： Marília Sabo Fernandes tatiana tamborena rissi Luisa Zuravski Juliana Mezzomo Carmen Regla Vargas Vanderlei Folmer Félix Alexandre Antunes Soares Vanusa Manfredini Mushtaq Ahmed Robson Luiz Puntel Universidade Federal do Pampa Campus Uruguaiana Uruguaiana RS 97500-970 Brazil Servi?o de Genética Médica Laboratório de Análise de MetabólitosHospital de Clínicas de Porto Alegre Porto Alegre RS CEP 90035-003 Brazil Departamento de Química Centro de Ciências Naturais e Exatas Universidade Federal de Santa Maria Santa Maria RS CEP 97105-900 Brazil Department of Biotechnology University of Science and Technology Bannu 28100Pakistan

AIM: To determine the plasmatic iron content and evaluate the oxidative stress(OS) markers in subjects receiving blood ***: Thirty-nine individuals with unspecified anemia receiving blood transfusions and 15 healthy subjects were included in the study. Anemic subjects were divided into three subgrou P:(1) those that received up to five blood transfusions(n = 14);(2) those that received from five to ten transfusions(n = 11); and(3) those that received more than ten transfusions(n = 14). Blood samples were collected by venous arm puncture and stored in tubes containing heparin. The plasma and cells were separated by centrifugation and subsequently used for analyses. Statistical analyses were performed using Kruskal-Wallis analysis of variance followed by Dunn's multiple comparison tests when ***: The eletrophoretic hemoglobin profiles of the subjects included in this study indicated that no patients presented with hemoglobinopathy. Labile plasmatic iron, ferritin, protein carbonyl, thiobarbituric acidreactive substances(TBARS) and dichlorofluorescein diacetate oxidation were significantly higher(P < 0.05), whereas total thiol levels were significantly lower(P < 0.05) in transfused subjects compared to controls. Additionally, the activity of catalase, superoxide dismutase and glutathione peroxidase were significantly lower in the transfused subjects(P < 0.05). Antioxidant enzyme activities and total thiol levels were positively correlated(P < 0.05), and negatively correlated with the levels of protein carbonyl and TBARS(P < 0.05). In contrast, protein carbonyl and TBARS were positively correlated(P < 0.05). Altogether, these data confirm the involvement of OS in patients following therapy with repeated blood ***: Our data reveal that changes in OS markers are correlated with levels of labile plasmatic iron and ferritin and the number of transfusions.

关键词： Antioxidant enzymes Labile iron content Oxidative stress Polytransfused subjects

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