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香港脑损伤患者的出院后服务(英文)

中国康复医学杂志 2011年第12期26卷 1098-1103页

作者： Helena MK Tam tatia mc lee Laboratory of Neuropsychology The University of Hong Kong

目的:建立针对脑损伤患者及其看护者的可负担、易获取的出院后电话跟进服务,并为发展区域内有成本效益的连续监护体制提供实证基础。方法:本研究从香港大学玛丽医院脑外科招募35名成年脑损伤患者和26名看护者。参与者在出院后第4周和第1... 详细信息

目的:建立针对脑损伤患者及其看护者的可负担、易获取的出院后电话跟进服务,并为发展区域内有成本效益的连续监护体制提供实证基础。方法:本研究从香港大学玛丽医院脑外科招募35名成年脑损伤患者和26名看护者。参与者在出院后第4周和第12周各接受一次结构化的电话访谈。有调整能力不足风险的患者与看护者将被送交进一步的医疗咨询或心理干预。患者的生理和认知功能,以及患者与看护者的情感功能、知觉到的社会支持和对当前所提供的服务的满意程度都被列入调查。结果:大部分患者报告他们的生理状况有明显改善。相当多的患者在出院后经历过认知困难并报告所接受到的社会心理支持不足。大多数看护者报告在看护期间健康、情感功能和社会生活受损。患者与看护者都对服务表示满意,看护者的满意程度更高。结论:脑损伤患者及其看护者都受益于出院后电话跟进服务。两者都同意该项服务有助于识别有调整能力不足风险的个体,并提供及时的建议和情感支持。看护工作会明显损害看护者的生理、情感功能和社会生活,提示需要为他们提供关于看护技巧、生活调整和压力管理的意见与建议。

关键词：脑损伤认知功能出院后跟进服务看护者压力

Gender Role,But Not Sex,Shapes Humans’Susceptibility to Emotion

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Neuroscience Bulletin 2021年第2期37卷 201-216页

作者： Jiajin Yuan Hong Li Quanshan Long Jiemin Yang tatia M.C.lee Dandan Zhang The Laboratory for Affect Cognition and Regulation Institute of Brain and Psychological SciencesSichuan Normal UniversityChengdu 610068China College of Psychology Shenzhen UniversityShenzhen 518060China Faculty of Psychology Southwest UniversityChongqing 400715China Department of Psychology The University of Hong KongHong Kong 999077China Shenzhen-Hong Kong Institute of Brain Science Shenzhen 518060China Shenzhen Institute of Neuroscience Shenzhen 518060China

It is unknown whether the famous sex-related difference in emotion processing is accounted for by biological sex,gender role,or their *** clarify the issue,in Study 1 we recorded event-related potentials in response to negative and positive images of diverse intensities when 47 masculine(26 males)and 47 feminine(22 males)subjects performed a non-emotional *** occipital P1 and N1 amplitudes were larger in women than in men,while feminine subjects showed larger N1 amplitudes than masculine subjects,regardless of ***,feminine subjects showed enhanced frontocentral N2(210–270 ms)amplitudes for highly and mildly negative than for neutral stimuli,while masculine subjects showed an emotion effect only for highly negative *** feminine-specific effect for mildly negative stimuli was positively correlated to the feminine score,and this correlation was located to the anterior cingulate and the superior and medial frontal ***,feminine but not masculine subjects showed enhanced parietal P3(330–560 ms)amplitudes for highly and mildly positive than for neutral stimuli,an effect positively related to the feminine score and localized to the precuneus,posterior cingulate,and superior temporal *** learning analyses verified that single-trial N2 and P3 amplitudes of feminine subjects reliably discriminated the intensity of negative and positive stimuli,*** ecological considerations,in Study 2 we used an observational approach(n=300)and confirmed that feminine gender role,rather than biological sex,predicted individual differences in daily experience of emotion-related psychopathological *** findings provide solid evidence for the critical impact of gender role rather than sex on emotional susceptibility.

关键词： Sex difference Gender role Emotional susceptibility Event-related potential Machine learning

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前额叶损伤患者的风险决策认知障碍

中华医学杂志 2006年第45期86卷 3169-3172页

作者：席春华傅先明汪凯牛朝诗 lee tatia mc 孟玉朱春燕杜静安徽医科大学第一附属医院神经内科神经心理学实验室230022 安徽省立医院神经外科香港大学神经心理学实验室安徽医科大学第一附属医院神经内科神经心理学实验室230022

目的探讨前额叶眶部(OBF)和背外侧(DLF)损伤对风险决策认知加工的影响,验证OBF参与风险决策认知加工过程的假说。方法OBF损伤患者21例,DLF损伤患者19例以及健康对照组(HC)40名,采用风险决策任务,比较各组执行风险决策的能力。结果组内... 详细信息

目的探讨前额叶眶部(OBF)和背外侧(DLF)损伤对风险决策认知加工的影响,验证OBF参与风险决策认知加工过程的假说。方法OBF损伤患者21例,DLF损伤患者19例以及健康对照组(HC)40名,采用风险决策任务,比较各组执行风险决策的能力。结果组内与奖赏后相比,惩罚后HC组的风险选择频率显著下降(分别为0.68±0.16和0.54±0.23,P0.05)。与HC组比较,OBF损伤组患者在奖赏后和惩罚后的风险选择频率均显著升高(奖赏后分别为0.68±0.16和0.79±0.19,惩罚后分别为0.54±0.23和0.82±0.18;P0.05)。结论OBF和DLF在人类的风险决策认知加工过程存在分离。OBF损伤后的患者追求高奖赏,惩罚后风险选择的抑制效应消失,而DLF损伤组患者的风险决策能力正常。OBF可能参与了奖赏/惩罚认知加工过程,是风险决策认知加工和处理的重要脑区。

关键词：额叶前皮质认知风险决策

Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition

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Neural Regeneration Research 2011年第34期6卷 2645-2655页

作者： Suk-Yu Yau Jada Chia-Di lee Benson Wui-Man Lau tatia M.C. lee Yick-Pang Ching Siu-Wa Tang Kwok-Fai So Department of Anatomy LKS Faculty of Medicine the University of Hong Kong State Key Laboratory of Brain and Cognitive Science LKS Faculty of Medicine the University of Hong Kong Research Centre of Heart Brain Hormone and Health Aging LKS Faculty of Medicine the University of Hong Kong Laboratory of Neuropsychology the University of Hong Kong Laboratory of Cognitive Affective Neuroscience the University of Hong Kong Joint Laboratory for Brain Function and Health (BFAH) Jinan University and the University of Hong Kong

Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone （CORT） suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2＇-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling.

关键词： hippocampal cell proliferation physical exercise spatial learning stress structural plasticity neural plasticity

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应激对风险和社会决策的影响

心理科学进展 2016年第6期24卷 974-984页

作者：杨群李煜孙得琳 tatia M.C.lee 杭州师范大学教育学院心理学系杭州311121 香港大学神经心理学实验室美国Duke-UNC脑成像分析中心香港大学认知情感神经科学实验室香港大学脑与认知科学国家重点实验室

应激是有机体在受到真实或者潜在的威胁刺激时所表现出来的全身性非特异性反应,伴随着紧张和焦虑的心理体验,交感神经系统的兴奋,糖皮质激素分泌的增多以及脑干-边缘系统-前额叶神经环路的改变。应激对个体在风险决策行为中的风险寻求... 详细信息

应激是有机体在受到真实或者潜在的威胁刺激时所表现出来的全身性非特异性反应,伴随着紧张和焦虑的心理体验,交感神经系统的兴奋,糖皮质激素分泌的增多以及脑干-边缘系统-前额叶神经环路的改变。应激对个体在风险决策行为中的风险寻求和风险回避倾向,社会决策行为中的利己和利他倾向都会产生重要影响。策略使用异常、习惯化和自动化反应增强、反馈学习过程以及奖惩敏感性的改变是应激影响决策行为的认知基础;应激激素的分泌,及杏仁核、前额叶等在决策过程发挥重要作用的脑区活动的改变则为应激作用于决策行为的神经基础。未来研究应重点关注:应激的个体差异与应激对决策影响效应多样性的关系;综合多种指标对应激进行测量;考察应激的时序效应;揭示个体的最佳应激水平;加强对慢性应激影响决策以及应激对决策影响效应可逆性的研究;揭示应激影响决策的神经机制。

关键词：应激特里尔社会应激测试风险决策社会决策

Roles of paroxetine and corticosterone on adult mammalian ciliary body cell proliferation

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Chinese Medical Journal 2010年第10期123卷 1305-1310页

作者： WANG Hua LAU Benson WM YAU Suk-yu LI Suk-yee LEUNG Nelson WANG Ning-li TANG Siu-wa lee tatia mc SO Kwok-fai Department of Anatomy Li Ka Shing Faculty of Medicine the University of Hong Kong Hong Kong Special Administrative Region China the State Key Laboratory of Brain and Cognitive Sciences the University of Hong Kong Hong Kong Special Administrative Region China Neuropsychology Laboratory the University of Hong Kong Hong Kong Special Administrative Region China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China Joint Laboratory for Brain Function and Health (BFAH) Jinan University and the University of Hong Kong

Background The neurogenesis in retina of adult mammals is generally abolished, and this renders the retina lack of regenerative capacity. Despite this, there is a small population of nestin-positive cells in the ciliary epithelium which retains neurogenic potential. The present study aimed at investigating the effect of two drugs, corticosterone and paroxetine, on the cell proliferation of the ciliary body. Methods Adult Sprague-Dawley rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine treatment for 14 days. Cell proliferation in the ciliary body was quantified using 5-bromo-2-deoxyuridine （BrdU） immunohistochemistry. Co-labelling of BrdU and stem cell marker was used to phenotype the BrdU immunoreactive cells. Results Corticosterone treatment suppressed while paroxetine treatment increased the cell proliferation of the ciliary body. Co-labelling with cell markers revealed that the BrdU positive cells also showed nestin expression but not glial fJbrillary acidic protein （GFAP）. Conclusions The results illustrate that proliferation of retinal progenitor cells situated in ciliary body are subjected to regulation by selective serotonin reuptake Jnhibitors （SSRI） and corticosteroJd, which is similar to our previous findings in neurogenic regions in central nervous system （CNS）. Paroxetine treatment could reverse the suppressive effect of corticosterone on ciliary body cell proliferation. This provides information for future investigation of retinal stem cell biology and potential treatment of retinal degenerative diseases.

关键词： paroxetine 5-bromo-2-deoxyuridine corticosterone ciliary body cell proliferation neurogenesis

Functional dynamic of ruminative neural network in patients with major depressive disorder

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Functional dynamic of ruminative neural network in patients ...

The inter-relationships of the neural basis of rumination and inhibitory control:neuroimaging-based meta-analyses

第二十一届全国心理学学术会议

作者： Ruibin ZHANG Kangguang LIN tatia lee Department of Psychology The Southern Medical University Department of Psychology The University of Hong Kong Department of Affective Disorder Guangzhou Brain Hospital

Background Rumination refers a persistent, passive focus on negative self-relevant information, is implicated in the development, maintenance and prolong of depressive symptoms. A better knowledge understanding neural correlates of depressive ruminative would pave the way to understand the pathology mechanism of major depressive disorder(MDD). In this study, we aimed to anatomize ruminative neural network organizational profile in healthy state and the specific pattern under depressive state indicated by major depressive disorder. Methods & Results In study 1, we defined the ruminative neural network by laboratory rumination induction task in 28 healthy adults in MRI scanner. We collected bold-fMRI data using EPI sequence. Firstly, we found that rumination had been successfully induced indicated by higher self-focus compared with concrete distraction condition. Furthermore, by using general linear model analysis, we found brain regions in posterior part of default mode network, visual mental imagery and emotional processing are largely engaged, which was defined as ruminative neural network. In Study 2, we acquired the resting state fMRI data from 53 patients with MDD and 47 age-, gender-matched healthy controls in 3 T Philip scanner. With standard data preprocessing including, by constructing the ruminative functional connectome in 53 MDD and 47 healthy controls, we found that compared with HC, the functional segregation and integration in MDD were disrupted severely as indicated by a decreased cluster coefficient(Cp, p = 0.037, Cohen d = 0.36), local efficiency(Eloc, p = 0.029, Cohen d = 0.40), global efficiency(Eglob, p = 0.013, Cohen d = 0.47), and increased characteristic shortest path length(Lp, p = 0.006, Cohen d = 0.52). Further spotting on the regional metrics showed decreases in MDD were located mainly at the bilateral amygdala, the right precuneus, the middle occipital gyrus, the left inferior parietal lobule, and the right superior parietal lobule. The o

关键词： Depression graph theory rumination functional connectivity

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Psychoradiology 2022年第1期2卷 11-22页

作者： Xiaoqi Song Jixin Long Chanyu Wang Ruibin Zhang tatia M.C.lee Cognitive control and Brain Healthy Laboratory Department of PsychologySchool of Public healthSouthern Medical UniversityGuangzhou510515China Department of Psychiatry Zhujiang HospitalSouthern Medical UniversityGuangzhou510285China State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong999077SAR China Laboratory of Neuropsychology and Human Neuroscience The University of Hong KongHong Kong999077SAR China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area510799

Rumination,as a clinical manifestation and pathogenic factor of depression,has long been the focus of psycho-logical research regarding its causes and ameliorating *** studies have shown that rumina-tion is related to inhibitory control deficits,which provides ideas for reducing ***,the neural relationship between them has not been clearly *** this study,we first used multi-level kernel density analysis to conduct two meta-analyses of published functional magnetic resonance imaging studies:one was rumination comprising 17 studies with 180 foci,and the other was inhibitory control comprising 205 studies with 3791 *** analysis was then performed to explore the common brain regions and further decode them through Neurosynth to confirm the cognitive *** showed that rumination was mainly related to the default mode network(DMN),while inhibitory control was associated with the frontoparietal network(FPN).In addition,the common activation areas were mainly concentrated in the bilateral precuneus,right supe-rior frontal gyrus,bilateral median cingulate,paracingulate gyri,and the left triangular part of inferior frontal gyrus(IFG).Decoding results also revealed they were involved in inhibition,memory retrieval,and self-related *** findings support that rumination is associated with inhibitory control and can be explained neu-rologically by an antagonistic relationship between the DMN and *** sum,inhibitory control may be related to rumination via inhibiting task-unrelated attention and controlling self-related *** research will help us understand and predict rumination from the perspective of inhibitory control and reduce rumination through behavioral training of inhibitory control or the application of neuromodulation techniques to common activation regions.

关键词： Rumination Inhibitory control Meta-analysis fMRI

Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis

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World Journal of Gastroenterology 2016年第16期22卷 4160-4167页

作者： Mohamad Mokadem Lama Noureddine Thomas Howard lee mc Henry Stuart Sherman Evan L Fogel James L Watkins Glen A Lehman Division of Gastroenterology and Hepatology Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Division of Nephrology and Hypertension Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Community Health Network Indianapolis IN 46219 United States Division of Gastroenterology and Hepatology Indiana University Medical Center Indianapolis IN 46202 United States

AIM: To evaluate pain control in chronic pancreatitis patients who underwent total pancreatectomy with islet cell transplantation or intrathecal narcotic pump ***: We recognized 13 patients who underwent intrathecal narcotic pump(ITNP) infusion and 57 patients who underwent total pancreatectomy with autologous islet cell transplantation(TP + ICT) for chronic pancreatitis(CP) pain control between 1998 and 2008 at Indiana University Hospital. All patients had already failed multiple other modalities for pain control and the decision to proceed with either intervention was made at the discretion of the patients and their treating physicians. All patients were evaluated retrospectively using a questionnaire inquiring about their pain control(using a 0-10 pain scale), daily narcotic dose usage, and hospital admission days for pain control before each intervention and during their last follow-up. RESULTS: All 13 ITNP patients and 30 available TP + ICT patients were evaluated. The mean age was approximately 40 years in both groups. The median duration of pain before intervention was 6 years and 7 years in the ITNP and TP + ICT groups, respectively. The median pain score dropped from 8 to 2.5(on a scale of 0-10) in both groups on their last follow up. The median daily dose of narcotics also decreased from 393 mg equivalent of morphine sulfate to 8 mg in the ITNP group and from 300 mg to 40 mg in the TP + ICT group. No patient had diabetes mellitus(DM) before either procedure whereas 85% of those who underwent pancreatectomy were insulin dependent on their last evaluation despite ICT. CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients with CP however with high incidence of DM among those who underwent TP + ICT. Prospective comparative studies and longer follow up are needed to better define treatment outcomes.

关键词： Chronic pancreatitis Intractable pain Total pancreatectomy Islet cell transplantation Intrathecal narcotic pump infusion