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Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice

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World Journal of Gastroenterology 2017年第13期23卷 2294-2307页

作者： Takuhito Sezaki Yuki hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi Department of Gastroenterology Research Center for Hepatitis and ImmunologyResearch InstituteNational Center for Global Health and Medicine Research Center for Hepatitis and Immunology Research InstituteNational Center for Global Health and Medicine 2~(nd)Department of Internal Medicine Osaka Medical College Section of Animal Models Department of Infectious DiseasesResearch InstituteNational Center for Global Health and Medicine Communal Laboratory Research InstituteNational Center for Global Health and Medicine Biogen

AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced *** Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also ***5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects.

关键词： Cancer chemotherapy Interleukin-13 Interleukin-33 Interleukin-13 receptor α2

A Study of Thermal Response and Flow Field Coupling Simulation around Hayabusa Capsule Loaded with Light-Weight Ablator

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Open Journal of Fluid Dynamics 2013年第2期3卷 100-107页

作者： Hisashi Kihara Naoya hirata Ken-ichi Abe Department of Aeronautics and Astronautics Kyushu University Fukuoka Japan

The numerical simulation of flow field around Hayabusa capsule loaded with light-weight ablator thermal response coupled with pyrolysis gas flow inside the ablator was carried out. In addition, the radiation from high temperature gas around the capsule was coupled with flow field. Hayabusa capsule reentered the atmosphere about 12 km/sec in velocity and Mach number about 30. During such an atmospheric entry, space vehicle is exposed to very savior aerodynamic heating due to convection and radiation. In this study, Hayabusa capsule was treated as a typical model of the atmospheric entry spacecraft. The light-weight ablator had porous structure, and permeability was an important parameter to analyze flow inside ablator. In this study, permeability was a variable parameter dependent on density of ablator. It is found that the effect of permeability of light-weight ablator was important with this analysis.

关键词： Light-Weight Ablator Coupling Calculation Pyrolysis Gas Flow Hayabusa Capsule

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柴达木北缘超高压变质带中的岛弧火山岩

地质学报 2004年第1期78卷 52-64页

作者：史仁灯杨经绥吴才来 Tsuyoshi IIZUKA Takafumi hirata 中国地质科学院地质研究所大陆动力学实验室北京100037 东京工业大学地球与行星科学系

青藏高原北部柴北缘发育一套与超高压变质带并行的早古生代岛弧火山岩带,岛弧火山岩以玄武岩类为主,包括一些中酸性岩类,岩石以普遍遭受绿片岩相蚀变为特征,区别于该地区普遍遭受角闪岩相区域变质的元古代的基性火山岩。该早古生代的岛... 详细信息

青藏高原北部柴北缘发育一套与超高压变质带并行的早古生代岛弧火山岩带,岛弧火山岩以玄武岩类为主,包括一些中酸性岩类,岩石以普遍遭受绿片岩相蚀变为特征,区别于该地区普遍遭受角闪岩相区域变质的元古代的基性火山岩。该早古生代的岛孤火山岩显示三组地球化学特征:①VTG-Ⅰ,岛弧拉斑玄武岩(IAT);②VTG-Ⅱ,高Al次钙碱性-碱性过渡型玄武岩;③VTG-Ⅲ,较N-MORB更亏损的拉斑玄武岩(异常MORB)。研究认为前两组火山岩是成熟岛弧两个发育阶段的特征性产物:洋壳俯冲到陆壳的初用,由俯冲洋壳和地幔楔的部分熔融形成岛弧拉斑玄武岩(IAT),随着俯冲板块的速度加快和岛弧周围地壳的加厚,则形成钙碱性玄武岩(CA)、高Al玄武岩。第三组火山岩形成于弧间盆地,由亏损的地幔楔高度部分熔融形成比N-MORB亏损的的火山岩(异常MORB)。岛弧火山岩的锆石LA-ICP-MS法U-Pb年龄为514.2±8.5 Ma,说明柴北缘在早古生代发生过洋壳向陆壳的俯冲作用。鉴于该地区代表陆-陆俯冲作用的柴北缘超高压变质岩石也是形成于早古生代(494Ma),认为陆-陆俯冲作用发生在洋-陆俯冲作用之后,二者时间和空间相伴随。

关键词：岛弧火山岩玄武岩中酸性岩基性火山岩地球化学

Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report

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World Journal of Gastroenterology 2016年第44期22卷 9865-9870页

作者： Naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta Department of Transplant Surgery Jichi Medical University Department of Surgery Jichi Medical University

This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors.

关键词： Congenital hepatic fibrosis Von Meyenburg complex Living donor liver transplantation Pediatric liver transplantation

Effect of homogenization process on the hardness of Zn-Al-Cu alloys

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International Journal of Minerals,Metallurgy and Materials 2015年第10期22卷 1076-1081页

作者： Jose D.Villegas-Cardenas Maribel L.Saucedo-Munoz Victor M.Lopez-hirata Antonio De Ita-De la Torre Erika O.Avila-Davila Jorge Luis Gonzalez-Velazquez Department of Metallurgy and Materials Instituto Politecnico Nacional(IPN-ESIQIE)Mexico City 07300Mexico Department of Industrial Engineering Universidad Politecnica del Valle de MexicoMexico CityMexico Department of Materials Universidad Autonoma Metropolitana(UAM)Unidad AzcapotzalcoMexico

The effect of a homogenizing treatment on the hardness of as-cast Zn–Al–Cu alloys was investigated. Eight alloy compositions were prepared and homogenized at 350 °C for 180 h, and their Rockwell 'B' hardness was subsequently measured. All the specimens were analyzed by X-ray diffraction and metallographically prepared for observation by optical microscopy and scanning electron microscopy. The results of the present work indicated that the hardness of both alloys(as-cast and homogenized) increased with increasing Al and Cu contents; this increased hardness is likely related to the presence of the θ and τ′ phases. A regression equation was obtained to determine the hardness of the homogenized alloys as a function of their chemical composition and processing parameters, such as homogenization time and temperature, used in their preparation.

关键词： zinc–aluminum–copper alloys casting hardness homogenization phases microstructure

Control Device on Construction of Battery B,No.6 Coke Oven at WestJapan Works（Kurashiki）

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Control Device on Construction of Battery B,No.6 Coke Oven a...

MaI-Uniformity of Two-Phase Flow Distribution in Merged Pipe Distributor under Different Outlet Channel Length

Asia Steel International Conference 2012(Asia Steel 2012)

作者： SHOICHI hirata KENICHIRO Tadokoro JFE Steel Corporation

＜正＞The battery named 6B of No.6 coke oven was newly constructed at West Japan Works（Kurashiki）,JFE *** constitutes 43 chambers and its production capacity is about 440 thousand ton per *** construction was started in September *** came into operation on December 15,2010,and it is in frill production *** most modern control technologies are adopted into this newly constructed coke oven *** control system constitutes a process computer,DCS（Distributed Control System） for instrumentation control and PLC（Program Logic controller） for electric *** process computer and DCS system controls the combustion of the coke oven automatically by using the thermometry results of each combustion chamber,and determines the distillation condition from the transition in the temperature of gas generated from the *** PLC system was introduced to carry out the factory automation control of the Pushing machine,the Charging car,the coke Guide car and the Quenching Electric Locomotive,which are equipped to the coke *** system achieves an efficient operation which brings about the result that only one operator on the Pushing machine can operate the other *** coke oven incidental facilities and CDQ（Coke Dry Quenching） are also controlled automatically according to the operating condition of these *** this report,the details of these controls are described.

关键词： Construction of Battery B control technologies Distributed Control System Program Logic controller

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Journal of Mechanics Engineering and Automation 2013年第2期3卷 107-120页

作者： Muh. Anis Mustaghfirin Akio Miyara hirata Yuki Department of Mechanical Engineering Saga University Saga-shi 840-8502 Japan Department of Marine Engineering Ship Building State Polytechnic of Surabaya Surabaya 60111 Indonesia

Two-phase flow distributions in the merged pipe distributor have still remained mal-uniformity problem and the causes have not clearly discovered yet. Therefore, the enhancement study is needed, absolutely. The experimental was carried out upon the distributor constructed by acrylics resembling merged triple pipe, 8 mm in diameter of inlet channel and two set 5 mm in diameter of each outlet channel, set horizontally sideways. Three flow patterns were fed, i.e., bubble, slug and stratified flow, observed via high speed video camera. The pressure distribution was measured by series of U-tube water gauge manometer. The flow patterns, phase distribution and pressure drop were analyzed by CFD software, validated by experimental data and compared by existing correlation, analytically. The experiment is extended by modeling, in order to vary three inclinations of distributor： horizontally, 45° and vertically up-ward as well as to vary three outlet channel lengths with length ratio lc/dc： 3.2, 10 and 70. It was revealed that the two-phase flow distribution tends to be mal-uniform and to transform to different flow pattern in outlet channels. These are promoted by different： outlet channel length, feeding two-phase flow pattern in inlet distributor and inclination angle. The changing of flow pattern is driven by fluctuating velocity in both upper and lower outlet channel.

关键词： Mal-uniformity two-phase flow pressure drop distributor flow pattern.

Association between Dopamine Transporter Gene (<i>DAT1</i>) Polymorphisms and Eating Disorders with Binge Eating Behavior

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Open Journal of Psychiatry 2017年第4期7卷 329-343页

作者： Takashi hirata Takuji Uemura Manabu Shinohara Masami Hirano Department of Neuropsychiatry and Clinical Ethics Interdisciplinary Graduate School of Medicine University of Yamanashi Yamanashi Japan Health Care Center University of Yamanashi Yamanashi Japan Kyosai Hospital Yamanashi Japan

Objectives: Dyshomeostasis of the dopaminergic system is implicated in the pathophysiology of eating disorders (EDs). We have previously reported an association between 3'-UTR VNTR (three prime untranslated region variable number of tandem repeat) of the Dopamine Transporter 1 (DAT1) gene and ED with binge eating behavior (EDBEB). Here we investigated whether variants in the coding region of the DAT1 gene also associate with EDBEB. Methods: The coding region and exon-intron junctions of the DAT1 gene were screened by direct sequencing using genomic DNA from EDBEB patients (n = 90) and healthy subjects (n = 114) on whom 3'-UTR VNTR variants had been previously determined. Results: rs2270912 and rs28363130, two of five known polymorphisms found by this screen, were significantly associated with EDBEB patients by genotype (p = 0.003, p = 0.011, respectively) and allele (p = 0.003, p = 0.012, respectively) frequency compared with healthy subjects. Interestingly, these polymorphisms associate with the risk 3'-UTR VNTR variant of EDBEB. Conclusion: Although our sample size was small, we show here that rs2270912 and rs28363130 associates with EDBEB and might act with 3'-UTR VNTR as a haplotype. These findings support the notion that the DAT1 gene plays a key role in the dopaminergic system of EDBEB.

关键词： Eating Disorder Binge Eating Behavior DAT1 Association Study Polymorphism

Effects of Cold Atmospheric Pressure Plasma on Accelerating Acute Wound Healing: A Comparative Study among 4 Different Treatment Groups

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Modern Plastic Surgery 2019年第1期9卷 18-31页

作者： Akio Nishijima Takahiro Fujimoto Takamichi hirata Junko Nishijima Department of Medical Engineering Faculty of Engineering Tokyo City University Tokyo Japan Department of Plastic and Reconstructive Surgery University of Tsukuba Ibaraki Japan Clinic F Tokyo Japan

Cold atmospheric pressure plasma (CAP) has been expected to be effective for wound healing among plasma medicines and has been attracting attention. The aim of this retrospective clinical study was to evaluate and compare the effects of CAP on acute wounds created by a fractional CO2 (FXCO2) laser on four treatment groups. Methods: This study was conducted between September 2017 and November 2018. Radiated surface wounds were created using a FXCO2 laser on four identically-sized regions on the medial side of the left forearm of 12 healthy volunteer subjects, for a total of 48 treatment regions. Each region was then randomly assigned to one of four groups: 1) no treatment (control group), 2) irradiated CAP for 60 seconds (plasma group), 3) topical application of ointment containing betamethasone valerate (steroid group), or 4) two to three sprays of basic fibroblast growth factor (bFGF group). The primary outcome of the skin was the change in absolute values of lightness index (L*), redness index (a*I) of L*a*b color space, arithmetical mean roughness (Ra), and mean melanin concentration. The secondary outcome was the clinical condition of the wounds, including inflammation, crust formation, and hyper/hypo-pigmentation on the recovering skin surface relative to the surrounding intact skin. Each item was evaluated at post-treatment 0, 1, 3, 7, 14, 28 days and 1 year. Results: Although no significant difference was observed among all groups, the CAP group exhibited more rapid recovery regarding a*I and Ra. No side-effects were observed in the CAP group. Conclusion: CAP is considered to accelerate healing of irradiated wounds via anti-inflammatory activity. Our study confirmed the effectiveness and safety of CAP which is devoid of side-effects of conventional therapies, and may aid in future development of medical plasma therapies.

关键词： Cold Atmospheric Pressure Plasma Plasma Medicine New Energy Device Wound Healing Skin Activation