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The neglect of nonnative orthopterans as potential invaders:A call for awareness

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Insect Science 2024年第4期31卷 994-1000页

作者： Anna K.Kulessa Paride Balzani Ismael Soto Antonín Kouba David Renault Ali Serhan tarkan Phillip J.Haubrock Ruhr University Bochum Faculty of Biology and BiotechnologyBochumGermany Faculty of Biology University of Duisburg-EssenUniversitätsstraße 5EssenGermany Faculty of Fisheries and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic University of Rennes CNRSECOBIO(EcosystèmesBiodiversitéEvolution)UMRRennesFrance Faculty of Fisheries Department of Basic SciencesMu˘gla SıtkıKoçman UniversityMu˘glaTurkey Department of Life and Environmental Sciences Bournemouth UniversityPooleDorsetUK Faculty of Biology and Environmental Protection Department of Ecology and Vertebrate ZoologyUniversity ofŁodzŁodzPoland Department of River Ecology and Conservation Senckenberg Research Institute and Natural History Museum FrankfurtGelnhausenGermany Center for Applied Mathematics and Bioinformatics Gulf University for Science and TechnologyMubarak Al-AbdullahKuwait

Despite the potential ecological and economic impacts of invasive species,there is a dearth of data on the presence,impacts,and management implications of potentially invasive Orthoptera *** lack of research and inconsistent data,including risk screenings and impact assessments,is especially evident in ***,assessing the status,distribution,and potential threats of nonnative Orthoptera in Europe remains challenging,impeding the development of effective management *** address this gap,we call for increased efforts to collect and curate data on non-native and possibly invasive Orthoptera in *** efforts will improve our understanding of this order’s invasion dynamics,facilitate the identification of priority areas for conservation,and support the development of effective management policies and preventive measures.

关键词： costs cricket damages grasshopper impact research

Current endoscopic approach to indeterminate biliary strictures

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World Journal of Gastroenterology 2012年第43期18卷 6197-6205页

作者： David W Victor Stuart Sherman tarkan Karakan Mouen A Khashab Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 United States Department of Medicine Indiana University School of Medicine Indianapolis IN 46202 United States Department of Medicine Gazi University 06710 Ankara Turkey

Biliary strictures are considered indeterminate when basic work-up, including transabdominal imaging and endoscopic retrograde cholangiopancreatography with routine cytologic brushing, are non-diagnostic. Indeterminate biliary strictures can easily be mischaracterized which may dramatically affect patient's outcome. Early and accurate diagnosis of malignancy impacts not only a patient's candidacy for surgery, but also potential timely targeted chemotherapies. A significant portion of patients with indeterminate biliary strictures have benign disease and accurate diagnosis is, thus, paramount to avoid unnecessary surgery. Current sampling strategies have suboptimal accuracy for the diagnosis of malignancy. Emerging data on other diagnostic modalities, such as ancillary cytology techniques, single operator cholangioscopy, and endoscopic ultrasonography-guided fine needle aspiration, revealed promising results with much improved sensitivity.

关键词： Indeterminate stricture Bile duct Single operator cholangioscope Cholangioscopy Endoscopic ultrasound Endoscopic retrograde cholangiopancrea-tography Bile duct stricture Indeterminate biliary stricture Confocal microscopy Transpapillary biopsy Cholangiocarcinoma Primary sclerosing cholangitis Spyglass

Analysis of risk factors associated with complications of colonic stenting for malignant obstruction

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World Journal of Gastroenterology 2014年第27期20卷 9215-9216页

作者： Gokhan Dindar Yucel Ustundag tarkan Karakan Department of Gastroenterology Bulent Ecevit University School of Medicine Department of Gastroenterology Gazi University School of Medicine

Self expanding metalic stent(SEMS) application can cause serious problems up to one third of the patients and some studies reported negative effect of SEMSs on survival in patients with malignancy. The SEMS type especially the rigid one like Wall-stent rather than more flexible type Ultraflex was also reported to have bad impact on the risk of perforation we believe that stent based management protocol for patients with non-perforating left sided obstructing colorectal cancer is a complex method that needs qualified medical and technical team.

关键词： Self expanding metalic stent Colon tumor Colonic obstruction Complications Perforation

Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution:A prospective randomized double-blind study

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World Journal of Gastroenterology 2007年第19期13卷 2733-2737页

作者： tarkan Karakan Meltem Ergun Ibrahim Dogan Mehmet Cindoruk Selahattin Unal Gazi University Faculty of Medicine Department of Gastroenterology Ankara Turkey

AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study ***: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy.

关键词： Severe acute pancreatitis Prebiotics Enteral nutrition Treatment

Epigenetics and pancreatic cancer:Pathophysiology and novel treatment aspects

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World Journal of Gastroenterology 2014年第24期20卷 7830-7848页

作者： Daniel Neureiter tarkan Jger Matthias Ocker Tobias Kiesslich Institute of Pathology Paracelsus Medical University/Salzburger Landeskliniken (SALK)5020 SalzburgAustria Department of Surgery Paracelsus Medical University/Salzburger Landeskliniken (SALK)5020 SalzburgAustria Experimental Medicine Oncology Bayer Pharma AG13342 BerlinGermany Department of Internal Medicine I Paracelsus Medical University/Salzburger Landeskliniken (SALK)5020 SalzburgAustria Institute of Physiology and Pathophysiology Paracelsus Medical University5020 SalzburgAustria

An improvement in pancreatic cancer treatment represents an urgent medical goal. Late diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal overall prognosis that has remained unchanged during the past decades. Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterations, such as mutations of K-ras, and especially epigenetic dysregulation of tumor-associated genes, such as silencing of the tumor suppressor p16ink4a, are hallmarks of pancreatic cancer. Here, we describe genes that are commonly affected by epigenetic dysregulation in pancreatic cancer via DNA methylation, histone acetylation or miRNA (microRNA) expression, and review the implications on pancreatic cancer biology such as epithelial-mesenchymal transition, morphological pattern formation, or cancer stem cell regulation during carcinogenesis from PanIN (pancreatic intraepithelial lesions) to invasive cancer and resistance development. Epigenetic drugs, such as DNA methyltransferases or histone deactylase inhibitors, have shown promising preclinical results in pancreatic cancer and are currently in early phases of clinical development. Combinations of epigenetic drugs with established cytotoxic drugs or targeted therapies are promising approaches to improve the poor response and survival rate of pancreatic cancer patients.

关键词： Pancreatic cancer Epigenetics DNA methylation Histone modification microRNA Targeted therapy Epithelial-mesenchymal transition

Influence of H pylori on plasma ghrelin in patients without atrophic gastritis

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World Journal of Gastroenterology 2007年第10期13卷 1595-1598页

作者： Mehmet Cindoruk Ilhan Yetkin Serpil Muge Deger tarkan Karakan Erdal Kan Selahattin Unal Gazi University Faculty of Medicine Department of GastroenterologyAnkaraTurkey Gazi University Faculty of Medicine Department of Endocrinology and MetabolismAnkaraTurkey Gazi University Faculty of Medicine Department of Internal MedicineAnkaraTurkey

AIM:To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic ***:Fifty consecutive patients(24 males and 26 females)with either H pylori-positive gastritis(n = 34)or H pylori-negative gastritis(n = 16)with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this ***-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid,1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d,followed by an additional 4 wk of 30 mg lansoprazol treatment.H pylori infection was eradicated in 23 of 34(67.6%)patients.H pylori-positive patients were given eradication *** acidity was determined via intragastric pH *** ghrelin was measured by radioimmunoassay(RIA).RESULTS:There was no signifficant difference in plasma ghrelin levels between H pylori-positive and H pylori-negative groups(81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L).In addition,there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication ***:H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis.

关键词： H pylori Ghrelin Gastric acidity Gtrophic gastritis

Comparison of Milan and UCSF criteria for liver transplantation to treat hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第37期17卷 4206-4212页

作者： tarkan Unek Sedat Karademir Naciye Cigdem Arslan Tufan Egeli Gulsen Atasoy Ozgul Sagol Funda Obuz Ibrahim Astarcioglu Department of General Surgery Dokuz Eylul UniversitySchool of Medicine Department of Pathology Dokuz Eylul UniversitySchool of MedicineIzmir 35340Turkey Department of Radiology Dokuz Eylul UniversitySchool of MedicineIzmir 35340Turkey Mesut Akarsu Department of Gastroenterology Dokuz Eylul UniversitySchool of MedicineIzmir 35340Turkey

AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center ***:This study is a retrospective review of prospectively collected *** 1998 and 2009,56 of 356 OLTs were performed in patients with *** on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) *** 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of *** cases of OLT involving living donors,the UCSF criteria may be applied.

关键词： Hepatobiliary radiology Hepatobiliary surgery Hepatobiliary pathology Hepatocellular carcinoma Liver malignancy Liver transplantation Living donor liver transplantation Living related liver transplantation Oncologic surgery Survival Transplant

Coexistence of Mirizzi syndrome with adenomyomatosis in the gallbladder:report of a case

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 438-441页

作者： Abdulkadir Bedirli Mustafa Kerem Hasan Bostanci tarkan Karakan T. Tolga Sahin Nalan Akyurek Author Affiliations:Department of General Surgery Department of Gastroenterology Department of Pathology Gazi University Medical FacultyAnkaraTurkey

BACKGROUND: Mirizzi syndrome is a rare complication of cholelithiasis. Adenomyomatosis is a common tumor-like lesion of the gallbladder. METHODS: A 52-year-old man was admitted to our hospital complaining of right hypochondriac pain and jaundice. Ultrasonography and computed tomography revealed stones in the gallbladder and dilation of the intrahepatic bile ducts. Magnetic resonance cholangiopancreatography revealed narrowing of the common bile duct caused by compression of the gallbladder. Laparotomy revealed type II Mirizzi syndrome. RESULTS: Partial cholecystectomy with a Roux-en-Y hepaticojejunostomy reconstruction was performed. Histologically, Rokitansky-Aschoff sinus proliferation, hypertrophy of smooth muscles, and fibrosis were seen in the gallbladder. A segmental type of adenomyornatosis of the gallbladder was diagnosed. CONCLUSIONS: The pathogenic link between the two peculiar entities is unclear. A possible explanation is considered that the pathogenesis of Mirizzi syndrome is resulted from chronic inflammation due to adenomyomatosis.

关键词： Mirizzi syndrome adenomyomatosis gallbladder jaundice

P-Matrices for the Action of Steenrod Power Operations on Polynomial Algebra

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Journal of Mathematics and System Science 2013年第11期3卷 543-549页

作者： tarkan Oner Bekir Tanay Department of Mathematics Mugla Sitka Kocman University Mugla 48000 Turkey

In this study, particular matrices which is called P-matrices were defined for the action of the Steenrod powers on the polynomial algebra and it was shown that they can be used to calculate the action of Steenrod pow... 详细信息

关键词： Steenrod power operations Polynomial algebra matrix calculus.