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Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration

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Neural Regeneration Research 2024年第1期19卷 49-54页

作者： Ye Xiong Asim mahmood Michael Chopp Department of Neurosurgery Henry Ford HospitalDetroitMIUSA Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA

Traumatic brain injury is a serious and complex neurological condition that affects millions of people *** significant advancements in the field of medicine,effective treatments for traumatic brain injury remain ***,extracellular vesicles released from mesenchymal stem/stromal cells have emerged as a promising novel therapy for traumatic brain *** vesicles are small membrane-bound vesicles that are naturally released by cells,including those in the brain,and can be engineered to contain therapeutic cargo,such as anti-inflammatory molecules,growth factors,and *** administered intravenously,extra cellular vesicles can cross the blood-brain barrier and deliver their cargos to the site of injury,where they can be taken up by recipient cells and modulate the inflammatory response,promote neuroregeneration,and improve functional *** preclinical studies,extracellular vesicle-based therapies have shown promising results in promoting recove ry after traumatic brain injury,including reducing neuronal damage,improving cognitive function,and enhancing motor *** further research is needed to establish the safety and efficacy of extra cellular vesicle-based therapies in humans,extra cellular vesicles represent a promising novel approach for the treatment of traumatic brain *** this review,we summarize mesenchymal ste m/stromal cell-de rived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration and brainderived extracellular vesicles as potential biofluid biomarkers in small and large animal models of traumatic brain injury.

关键词： biomarkers extracellular vesicles functional outcome mesenchymal stem/stromal cells neuroinflammation neuroplasticity neuroprotection traumatic brain injury

Reductive amination of aldehydes and ketones using sodium borohydride in the presence of silica chloride under solvent-free conditions

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Chinese Chemical Letters 2010年第1期21卷 47-50页

作者： Heshmatollah Alinezhad mahmood Tajbakhsh Neda Hamidi Faculty of Chemistry Mazandaran UniversityBabolsarIran

A simple and convenient procedure for the preparation of amines from aldehydes and ketones with sodium borohydride activated by silica chloride as a catalyst under solvent-free conditions is described.A variety of aliphatic and aromatic aldehydes,ketones and amines when mixed with NaBH;/silica chloride at room temperature,afforded excellent yield of the corresponding amines.

关键词： Reductive amination Silica chloride Solvent-free conditions Sodium borohydride

Emerging potential of exosomes for treatment of traumatic brain injury

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Neural Regeneration Research 2017年第1期12卷 19-22页

Traumatic brain injury（TBI） is one of the major causes of death and disability *** effective treatment has been identified from clinical *** evidence exists that treatment with mesenchymal stem cells（MSCs） exerts a substantial therapeutic effect after experimental brain *** addition to their soluble factors,therapeutic effects of MSCs may be attributed to their generation and release of *** are endosomal origin small-membrane nano-sized vesicles generated by almost all cell *** play a pivotal role in intercellular *** delivery of MSC-derived exosomes improves functional recovery and promotes neuroplasticity in rats after *** effects of exosomes derive from the exosome content,especially micro RNAs（mi RNAs）.mi RNAs are small non-coding regulatory RNAs and play an important role in posttranscriptional regulation of *** with their parent cells,exosomes are more stable and can cross the blood-brain *** have reduced the safety risks inherent in administering viable cells such as the risk of occlusion in microvasculature or unregulated growth of transplanted *** a cell-free exosome-based therapy may open up a novel approach to enhancing multifaceted aspects of neuroplasticity and to amplifying neurological recovery,potentially for a variety of neural injuries and neurodegenerative *** review discusses the most recent knowledge of exosome therapies for TBI,their associated challenges and opportunities.

关键词： traumatic brain injury exosomes microRNAs mesenchymal stem cells treatment neuroplasticity cell therapy

Morphological Evaluation of PLA/Soybean Oil Epoxidized Acrylate Three-Dimensional Scaffold in Bone Tissue Engineering

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Journal of Renewable Materials 2022年第9期10卷 2391-2408页

作者： mahmood Hameed Majeed Nabeel Kadhem Abd Alsaheb Department of Biomedical Engineering Al Nahrain UniversityAl Jadriya BridgeBaghdad64074Iraq

Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease,injury,or congenital *** engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and *** are utilized to attach the right cells and then grow *** prototyping appears to be the most promising technology due to its high level of precision and *** tissue replacement“scaffolding”is a common theme discussed in this *** fused deposition technique was used to construct our scaffold,and a polymer called polylactic acids and soybean oil resin were used to construct our *** samples were then divided into two groups;the first group was left without immersion in the simulated body fluid and served as a control for *** second group was immersed in the simulated body *** results of the Field Emission Scanning Electron Microscope(FESEM),Energy Dispersive X-ray Spectroscopy(EDX)and X-ray diffraction(XRD)were utilized to interpret the surface attachment to ions,elements,and compounds,giving us a new perspective on scaffold *** this study,an innovative method has been used to print therapeutic scaffold that combines fused deposition three-dimensional printing with ultraviolet curing to create a high-quality biodegradable polymeric ***,the results demonstrate that adding soybean oil resin to the PLA increased ion attachment to the surface while also attracting tricalcium phosphate formation on the surface of the scaffold,which is highly promising in bone tissue *** conclusion,the soybean oil resin,which is new in the field of bone tissue engineering,shows magnificent characteristics and is a good replacement biopolymer that replaces many ceramic and polymeric materials used in this field that have poor morphological characteristics.

关键词： Bone tissue engineering polylactic acid soybean oil biodegradable polymers fused deposition modeling scaffold

Drainage Network and Lineament Analysis:An Approach for Potwar Plateau(Northern Pakistan)

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Journal of Mountain Science 2009年第1期6卷 14-24页

作者： Faisal SHAHZAD Syed Amer mahmood Richard GLOAGUEN Remote Sensing Group Institute of GeologyFreiberg University of Mining and TechnologyFreiberg09599Germany.

Drainage responds rapidly to tectonic changes and thus it is a potential parameter for teetonogeomorphological analysis. Drainage network of Potwar is a good geological record of movement, displacements, regional uplifts and erosion of the tectonic units. This study focuses on utilizing drainage network extracted from Shuttle Radar Digital Elevation Data （SRTM-DEM） in order to constrain the structure of the Potwar Plateau. SWAN syncline divides Potwar into northern Potwar deformed zone （NPDZ） and southern Potwar platform zone （SPPZ）. We extracted the drainage network from DEM and analyzed 112 streams using stream power law. Spatial distribution of concavity and steepness indices were used to prepare uplift rate map for the area. DEM was further utilized to extract lineaments to study the mutual relationship between lineaments and drainage patterns. We compared the local correlation between the extracted lineaments and drainage network of the area that gives us quantitative information and shows promising prospects. The streams in the NPDZ indicate high steepness values as compared to the streams in the SPPZ. The spatial distribution of geomorphic parameters distinctive deformation and uplift rates suggest the among eastern, central and western parts. The local correlation between drainage network and lineaments from DEM is strongly positive in the area within I km of radius.

关键词： Drainage network lineaments streamprofile analysis uplift rate local correlation

An investigation into the effects of lime on compressive and shear strength characteristics of fiber-reinforced clays

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 885-898页

作者： mahmood Reza Abdi Abbas Ghalandarzadeh Leila Shafiei Chafi Faculty of Civil Engineering K.N.Toosi University of TechnologyTehranIran School of Engineering Tehran UniversityTehranIran

To meet the ever-increasing construction demands around the world during recent years,reinforcement and stabilization methods have been widely used by geotechnical engineers to improve the performances and behavior of fine-grained *** lime stabilization increases the compressive strength of soils,it reduces the soil ductility at the same *** research shows that random fiber inclusion modifies the brittleness of *** the current research,the effects of lime and polypropylene(PP)fiber additions on such characteristics as compressive and shear strengths,failure strain,secant modulus of elasticity(E50)and shear strength parameters of mixtures were *** was treated with 1%,3% and 5% lime by dry weight of soil and reinforced with 0.1% monovalent PP fibers with the length of 6 *** were prepared at optimum conditions and cured at 35℃ for 1 d,7 d and 28 d at 90% relative humidity and subsequently subjected to uniaxial and triaxial compression tests(UCT and TCT)under cell pressures of 25 kPa,50 kPa and 100 *** showed that inclusion of random PP fibers to clay-lime mixtures increases both compressive and shear strengths as well as the *** content and curing period were found to be the most influential *** electron microscopy(SEM)analysis showed that lime addition and the formation of cementitious compounds bind soil particles and increase soil/fiber interactions at interface,leading to enhanced shear *** more ductile the stabilized and reinforced composition,the less the cracks in roads and waste landfill covers.

关键词： Kaolinite Lime Polypropylene(PP) Fiber-reinforced clay Triaxial compression test(TCT) Uniaxial compression test(UCT) Scanning electron microscopy(SEM)

Effect of substrate concentration on stability of anammox biofilm reactors

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Journal of Central South University 2010年第1期17卷 79-84页

作者：唐崇俭郑平 mahmood Q 陈建伟 Department of Environmental Engineering Zhejiang University Department of Environmental Sciences COMSATS University

Ammonium and nitrite are two substrates of anammox bacteria, but they are also inhibitors under high concentrations. The performance of two anaerobic ammonium-oxidizing (anammox) upflow biofilm (UBF) reactors was investigated. The results show that anammox UBFs become unstable under nitrogen loading rate (NLR) applied higher than 1.0 g/(L·d). The consumptions of acidity in the anammox reaction lead to the increase of pH, which is as high as 8.70-9.05. Free nitrous acid concentration is accompanied to be lower than the affinity constant of anammox bacteria, and then starvation effect appears. Moreover, free ammonia concentration increases to 57-178 mg/L, resulting in inhibitory effect on the anammox bacteria. Both negative effects contribute to the instability of the anammox bioreactors.

关键词： anammox biofilm bioreactor pH free ammonia free nitrous acid nitrogen removal

Floristic composition and management of cropland agroforest in southwestern Bangladesh

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Journal of Forestry Research 2014年第3期25卷 597-604页

作者： Md. Hasanuzzaman mahmood Hossain Mustafa Saroar Forestry and Wood Technology Discipline Khulna University Urban and Rural Planning Discipline Khulna University

Cropland agroforest is an important production system in the southwest region of Bangladesh. This study focused on the floristic composition and management of existing cropland agroforests. A total of 313 cropland agroforests were surveyed and 83%respondents practiced pure agroforestry while the remaining 17% practiced agroforestry with fisheries. A total of 18 forest trees and 2 shrubs were recorded from 11 families and 59 species of agricultural crops were from 28 families. A higher proportion （79%） of cropland agroforests were occupied small land areas （0.12-0.80 ha）. About 63% of respondents planted trees for fruit production and 47%for timber production, and 35%of respondents engaged in commercial production （35%）. Swietenia macrophylla was the most prevalent species （relative prevalence 20.83） followed by Man-gifera indica （relative prevalence 15.57） and Cocos nucifera （relative prevalence 7.08）. Shorter spacing was used for timber and fuel wood species and wider spacing for fruit trees. A wide range of rotation periods, from 5 to 25 years, was observed for both cases. The use of chemical fertilizer was highest followed by cow dung and compost in cropland agroforests. Overall management practices of cropland agroforest in southwest Bangladesh were determined by the end product and local demand.

关键词： agroforestry Bangladesh cropland fruit production timber production

Effect of Electron Irradiation on Polypropylene Films

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Plasma Science and Technology 2011年第2期13卷 194-196页

作者： Sheila SHAHIDI Jakub WIENER mahmood GHORANNEVISS Abbas ANVARI Department of Textile Chemistry Faculty of Textile Technical University of Liberec Plasma Physics Research Center Science and Research Branch Islamic Azad University Departments of Physics Sharif University of Technology

Effects of both electron beam irradiation on the properties of polypropylene （PP） films and the irradiation on the different layers of a multilayer PP film are studied. A Fourier transform infrared spectroscope was used to investigate the chemical structure of the films. The results showed that the chemical properties of the first layer were improved, that is, more functional groups responsible for dye ability and hydrophilicity of the film were produced on its surface, while noticeable improvement was not detected on the surface of other layers. This was also confirmed by testing the dye ability of the layers. However, the results obtained by atomic force microscopy showed that the electron irradiation caused some topographical changes, not only on the surface of the first layer but also on the others.

关键词： polypropylene electron beam dye ability film