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Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection

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World Journal of Pediatrics 2017年第4期13卷 346-352页

作者： Ahmed Megahed Nanees Salem Abeer Fathy tarik barakat Mona Abd El Latif Alsayed Suzy Abd El Mabood Khaled R Zalata Ahmed F Abdalla Pediatric Gastroenterology and Hepatology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Endocrinology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Hematology&Oncology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pathology Department Faculty of MedicineMansoura UniversityEgypt

Background:The impact of chronic hepatitis C (CHC) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children,especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV).In the current work,we assessed prospectively changes in BMD in children with CHC before,during,and after ***:Forty-six consecutive children with noncirrhotic genotype 4 CHC were subjected to dual-energy X-ray absorptiometry at baseline,24 weeks,48 weeks of therapy and 24 weeks after ***,bone mineral content (BMC),and Z score of lumbar spine (L2-L4) were *** pubertal stage,viral load,liver function tests,serum calcium,phosphorus,alkaline phosphatase,parathyroid hormone,and liver histopathology were assessed in all included ***:Thirty (65.2%) patients had normal BMD,10 (21.7%) were at risk for low BMD,and 6 (13.1%) had low BMD for chronological *** with low BMD were significantly older (P=0.001),with higher frequency of delayed puberty than other groups (P=0.002).Baseline densitometric parameters (BMD & BMC) were significantly positively correlated with patients' age,weight,height,body mass index and hemoglobin level;while they were insignificantly correlated with basal viral load,histopathology activity index and fibrosis *** parameters improved significantly on PEG-IFN plus RV treatment,this improvement was found to be sustainable 24 weeks after ***:Low BMD is detectable in a proportion of CHC *** therapy leads to a sustainable increase in BMD.

关键词： bone mineral density chronic hepatitis C pegylated interferon ribavirin

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Acute flaccid paralysis in a patient with sacral dimple

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World Journal of Clinical Pediatrics 2013年第3期2卷 26-30页

作者： Mohammed Mostafa Nehad Nasef tarik barakat Amany K El-Hawary Hesham Abdel-Hady Faculty of Medicine Mansoura University Children’s Hospital Department of Pediatrics Faculty of MedicineUniversity of Mansoura

Sacral dimples are the most common cutaneous anomaly detected during neonatal spinal examination. Congenital dermal sinus tract, a rare type of spinal dysraphism, occurs along the midline neuraxis from occiput down to the sacral region. It is often diagnosed in the presence of a sacral dimple together with skin signs, local infection, meningitis, abscess, or abnormal neurological examination. We report a case of acute flaccid paralysis with sensory level in a 4 mo old female infant with sacral dimple, diagnosed by magnetic resonance imaging to be a paraspinal subdural abscess. Surgical exploration revealed a congenital dermal sinus tract extending from the subdural abscess down to the sacral dimple and open to the exterior with a minute opening.

关键词： Paralysis Paraplegia Spinal dysraphism Spinal cord compression Spinal epidural abscess

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