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Extracellular Micro-RNAs in Health and Disease: Basic Science, Biogenesis and Release

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American Journal of Molecular Biology 2016年第1期6卷 1-11页

作者： Wael Nassar Mervat el-Ansary tarek Fayyad Mostafa Abdel Aziz Department of Nephrology Sahel Teaching Hospital General Organization of Teaching Hospitals and Institutes (GOTHI) Cairo Egypt Department of Nephrology Kidney Transplantation Unit October Six University Hospitals Cairo Egypt Department of Clinical Pathology Stem Cells Unit Faculty of Medicine Cairo University Cairo Egypt Department of Nephrology Faculty of Medicine Cairo University Cairo Egypt

Small non-protein coding micro-RNAs are regularly exported out of cells, both in health and disease. More than ninety percent of extracellular miRNAs are associated with lower-molecular-mass complexes bound to Argonaute 2 (Ago2), nucleophosmin-1 (NPM1) and high density lipoproteins (HDL), whereas the rest (~10%) are membrane-vesicle-encapsulated within exosomes, shedding microvesicles and apoptotic bodies. Regardless of the debate of the nature of circulating miRNA as byproducts of routine cell activities or mediators of cell-cell communication, proper understanding of the molecular behaviors of miRNA in health and disease, is expected to open a new gate for the discovery of new diagnostic tools and possibly therapeutic implementation in the near future.

关键词： Extracellular miRNAs Extracellular Vesicles (EVs) Exosomes Horizontal Gene Transfer (HGT) Microvesicles (MVs)

Investigation of androgen receptor-dependent alternative splicing has identified a unique subtype of lethal prostate cancer

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Asian Journal of Andrology 2023年第3期25卷 296-308页

作者： Sean Seltzer Paresa N Giannopoulos tarek A Bismar Mark Trifiro Miltiadis Paliouras Lady Davis Institute for Medical Research Segal Cancer Centre-Jewish General HospitalMontrealQC H3T 1E2Canada Cumming School of Medicine Department of Pathology and Laboratory MedicineUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Medicine Division of Experimental MedicineMcGill UniversityMontrealQC H4A 3J1Canada Department of Oncology McGill UniversityMontrealQC H4A 3T2Canada

A complete proteomics study characterizing active androgen receptor(AR)complexes in prostate cancer(PCa)cells identified a diversity of protein interactors with tumorigenic annotations,including known RNA splicing ***,we chose to further investigate the functional role of AR-mediated alternative RNA splicing in PCa disease *** selected two AR-interacting RNA splicing factors,Src associated in mitosis of 68 kDa(SAM68)and DEAD(Asp-Glu-Ala-Asp)box helicase 5(DDX5)to examine their associative roles in AR-dependent alternative RNA *** assess the true physiological role of AR in alternative RNA splicing,we assessed splicing profiles of LNCaP PCa cells using exon microarrays and correlated the results to PCa clinical *** a result,we were able to highlight alternative splicing events of clinical *** use of exon-mini gene cassettes illustrated hormone-dependent AR-mediated exon-inclusion splicing events with SAM68 or exon-exclusion splicing events with DDX5 *** physiological significance in PCa was investigated through the application of clinical exon array analysis,where we identified exon-gene sets that were able to delineate aggressive disease progression profiles and predict patient disease-free outcomes independently of pathological clinical *** a clinical dataset with patients categorized as prostate cancer-specific death(PCSD),these exon gene sets further identified a select group of patients with extremely poor disease-free ***,these results strongly suggest a nonclassical role of AR in mediating robust alternative RNA splicing in ***,AR-mediated alternative spicing contributes to aggressive PCa progression,where we identified a new subtype of lethal PCa defined by AR-dependent alternative splicing.

关键词： alternative RNA splicing androgen receptor exon-gene sets lethal prostate cancer subtype prostate cancer

Evaluating Biotic elicitation with Phenylalanine and/or Yeast for Rosemary (Rosmarinus officinalsL.) Sustainable Improvement under Traditional and Organic Agriculture

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Agricultural Sciences 2021年第3期12卷 273-292页

作者： tarek elsayed S. A. el Sayed S. A. Radioisotopes Department Nuclear Research Center Egyptian Atomic Energy Authority Cairo Egypt

Rosemary (Rosmrinus officinals) is one of the most important medicinal plants was cultivated for two subsequent seasons field experiment trial (March 2018, 2019) designed as factorial split-plot design with three replicates. The main factor 4 biotic elicitors: control (E1), phenylalanine (E2), yeast (E3) and (E4), E2 + F3 Whereas, the sub-main factor, four fertilizers: (F1) NPK, (F2) 1/2NPK + PGPB and humic acid + PGPB (F3), and moringa dry leaves extract. + PGPB (F4). Statistical analysis for collected data revealed significant promotion for growth traits leading to significant increment biomass yield, secondary metabolites production and quality. Total phenolics, total flavonoids and essential oil its terpenes contents in which solitary, E2, E3 acted positive significant impact while E4exhiboted significant positive impact over E1 whereas, F1-4 achieved significant increment in which, biofertilser f4 > f3 > f2 over NPK biofertilser, while paired E1-4 with F1-4 performed E4E4 exceeded E3F3 exceeded E3F2 that exceeded E1F1. Therefore, multi-repeating elicitation with E2, 3, 4 coupled with Biofertilizers F2, 4 could be considered as eco-friendly innovative reliable practical application for sustainable improvement and sustainable use that exceeded significantly over traditional agriculture NPK alone or 1/2 NPK-PGPB for R. officinals.

关键词： Rosemary Aromatic Plant Medicinal Plant elicitation Biotic elicitor

Purkait’s triangle revisited:role in sex and ancestry estimation

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Forensic Sciences Research 2022年第3期7卷 440-455页

作者： MennattAllah Hassan Attia Mohamed Hassan Attia Yasmin tarek Farghaly Bassam Ahmed el-Sayed Abulnoor Sotiris K.Manolis Ruma Purkait Douglas H.Ubelaker Forensic Medicine&Clinical Toxicology Department Faculty of MedicineAlexandria UniversityAlexandriaEgypt Institute for Intelligent Systems Research and Innovation Deakin UniversityVictoriaAustralia Biomedical Engineering Medical Research InstituteAlexandria UniversityAlexandriaEgypt Diagnostic Radiology Faculty of MedicineAlexandria UniversityAlexandriaEgypt Fixed Prosthodontics Faculty of DentistryFayoum UniversityFaiyumEgypt Animal&Human Physiology Faculty of BiologyNational&Kapodistrian University of AthensAthensGreece Department of Anthropology University of AllahabadAllahabadIndia Department of Anthropology Smithsonian InstitutionWashingtonDCUS

Identification of unknown remains recovered from marine and terrestrial locations is a significant humanitarian *** investigation proposes a simple method applicable to fragmentary femora for a more refined level of ancestry and/or sex *** that end,we re-examined Purkait’s triangle which involves three inter-landmark distances between the traction epiphyses and the articular rim of femoral head.A large sample(n=584)from geographically diverse(Egyptian,Indian and Greek)populations was ***,shape(n=3)and trigonometrically derived variables and ratios(n=9 variables)were employed to detect any geographically-clustered morphological differences between these *** forest modelling(RFM)and linear discriminant function analysis(LDA)were employed to create classification models in instances where sex was known or *** sample was apportioned into training and test sets with a ratio 70/*** classification accuracies were evaluated by means of k fold cross-validation *** sex estimation,RFM showed similar performance to ***,RFM outperformed LDA in ancestry *** estimation was satisfactory in the Indian and Egyptian samples albeit the Greek sample was *** Greek samples presented greater morphological overlap with the Indian sample due to high within-group *** samples were accurately assigned to their ancestral category when sex was ***,higher classification accuracies in the validation sample were obtained in the sex-specific model of females than in *** RFM and the linear variables,the overall accuracy reached 83%which is distributed as 95%,71%and 86%for the Egyptian,Indian and Greek females,respectively;whereas in males,the overall accuracy is 72%and is distributed as 58%,87%and 50%for the Egyptian,Indian and Greek males,*** accuracies were also calculated per group in the test data using the 12 derived *** the f

关键词： Forensic sciences forensic anthropology Purkait’s triangle fragmentary femora ancestry estimation random forest modelling international forensic investigations

A study evaluating the impact of nerve preserving surgery and adjuvant pelvic irradiation for rectal cancer on quality of life

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The Chinese-German Journal of Clinical Oncology 2010年第8期9卷 459-465页

作者： tarek Khairy Hisham el Hossieny Mohamed Abd Moiety Department of Surgery National Cancer InstituteCairo University Department of Radiation Oncology National Cancer InstituteCairo University Department of Medical Oncology National Cancer InstituteCairo University

Objective： Preservation of the pelvic autonomic nerves in order to lower bladder and sexual dysfunction after radical rectal cancer surgery ＆ to evaluate functional outcome, local recurrence. Methods： A prospective study was under- taken on Egyptian patients. Forty one patients participated in the study in the period from December 2002 till June 2004 where they underwent radical surgery but with preservation of the pelvic autonomic nerves this was followed by adjuvant pelvic radiotherapy. Results： Six months, 1-year and 2-year follow-up of urinary function was complete in 32 out of 41 （78%）, 30 out of 41 （73%） and 27 out of 41 patients （65%） respectively There was no statistically significant correlation between the extent of nerve preservation and the reported minor voiding dysfunction. None of the patients reported major incontinence. Six months, 1-year and 2-year follow-up of sexual function revealed that 22 out of 41 patients （53%） were sexually active. Three out of 41 patients （7.3%） developed local recurrence. 38 （92.7%） patients were free of local recurrence, regarding pa- tients who received adjuvant radiotherapy 3 out of the 34 （8.8%） patients developed local pelvic recurrence while 9 patients （26.5%） developed distant metastases （3 of them did not receive adjuvant chemotherapy）, while patients who received adju- vant chemotherapy, 2 out of 20 patients （10%） developed local recurrence while distant metastases developed in 6 patients （30%）. Conclusion： Preservation of the pelvic autonomic nerves minimizes bladder and sexual dysfunction especially in male patients after rectal cancer surgery.

关键词： rectal neoplasms colorectal surgery urination nerve preservation adjuvant radiotherapy

Improving patient care and accuracy of given doses in radiation therapy using in vivo dosimetry verification

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Oncology and Translational Medicine 2015年第5期1卷 212-217页

作者： Ahmed Shawky Shawata tarek el Nimr Khaled M.elshahat Radiation Oncology Center Tanta Military Hospital Department of Physics Faculty of ScienceTanta University Department of Clinical Oncology Faculty of MedicineAl Azhar University

Objective This work aims to verify and improve the dose given for cancer patients in radiation therapy by using diodes to enhance patient in vivo dosimetry on a routine basis. Some characteristics of two available semi-conductor diode dosimetry systems were evaluated. Methods The diodes had been calibrated to read the dose at Dmax below the surface. Correction factors of clinical relevance were quantified to convert the diode readings into patient dose. The diode was irradiated at various gantry angles （increments of 45~）, various Field Sizes and various Source to Surface Distances （SSDs）. Results The maximal response variation in the angular response with respect to an arbitrary angle of 0~ was 1.9%, and the minimum variation was 0.5%. The response of the diode with respect to various field siz- es showed the minimum and the maximum variations in the measured dose from the diode; the calculated doses were -1.6% （for 5 cm x 5 cm field size） and 6.6% （for 40 cm x 40 cm field size）. The diode exhibited a significant perturbation in the response, which decreased with increasing SSD. No discrepancies larger than 5% were detected between the expected dose and the measured dose. Conclusion The results indicate that the diodes exhibit excellent linearity, dose reproducibility and minimal anisotropy; that they can be used with confidence for patient dose verification. Furthermore, diodes render real time verification of the dose delivered to patients.

关键词： in vivo dosimetry diode dosimetry external beam radiation therapy uncertainty water slab phantom diode correction factors.

Harnessing deep transient testing for reservoir characterization and CO_(2) emission reduction in challenging geological settings

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Petroleum Research 2024年第3期9卷 380-392页

作者： Eghbal Motaei tarek Ganat Khairul Azhar Hamoud Al-Hadrami Petroleum Engineering Department Petronas Carigali SDN BHDP.O.Box 10500088Kuala LumpurMalaysia Petroleum and Chemical Engineering Department Sultan Qaboos UniversityMuscatP.O.Box 50 A-Khod123Oman Vestigo Petroleum Sdn Bhd Menara BinjaiJalan BinjaiJalan Ampang50450Kuala LumpurMalaysia

This paper provides a comprehensive overview of Deep Transient Testing(DTT),a cutting-edge technique for reservoir characterization that has revolutionized the oil and gas *** main aim of DTT is to characterize the reservoir with a deeper radius of *** optimization of the radius of investigation with the DTT approach is studied in *** is a commercial numerical simulation application used to simulate the DTT process and evaluate the pressure wave analysis in the porous *** main aim of the simulation is to understand the impact of the reservoir quality on the pressure response and use it to address the noise-to-pule ratio,which is a determinantal parameter in testing *** tested wells with the DTT tool show that measured well productivity can deliver the minimum commercial *** has been delivered within 2 days compared to the potential test time of 21 days which saved the 19 rig days and contributed to C02 emission reduction of(gas flaring 1340+rig emission 600)1940 Metric tons equivalent to 421 cars emission in a ***,DTT also presents certain limitations,such as the requirement for specialized equipment and expertise,as well as the potential for formation damage during *** study provides a detailed description of the DTT technique,encompassing its history,theory,and practical ***,it discusses the benefits and limitations of DTT and presents case studies to illustrate its effectiveness across various reservoir ***,this study serves as a valuable resource for reservoir engineers,geologists,and other professionals involved in the exploration and production of oil and gas.

关键词： Deep transient testing Reservoir characterization Wireline formation testers Drill stem test Radius of investigation

A novel forecasting approach to schedule aggregated electric vehicle charging

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Energy and AI 2023年第4期14卷 522-535页

作者： Nico Brinkel Lennard Visser Wilfried van Sark tarek AlSkaif Copernicus Institute of Sustainable Development Utrecht UniversityPrincetonlaan 8aUtrecht3584 CBThe Netherlands Information Technology Group(INF) Wageningen University and Research(WUR)Hollandseweg 1Wageningen6706 KNThe Netherlands

To be able to schedule the charging demand of an electric vehicle fleet using smart charging,insight is required into different charging session characteristics of the considered fleet,including the number of charging sessions,their charging demand and arrival and departure *** use of forecasting techniques can reduce the uncertainty about these charging session characteristics,but since these characteristics are interrelated,this is not ***,forecasting frameworks that cover all required characteristics to schedule the charging of an electric vehicle fleet are absent in scientific *** cover this gap,this study proposes a novel approach for forecasting the charging requirements of an electric vehicle fleet,which can be used as input to schedule their aggregated charging *** the first step of this approach,the charging session characteristics of an electric vehicle fleet are translated to three parameter values that describe a virtual ***,optimal predictor variable and hyperparameter sets are *** serve as input for the last step,in which the virtual battery parameter values are *** approach has been tested on a real-world case study of public charging stations,considering a high number of predictor variables and different forecasting models(Multivariate Linear Regression,Random Forest,Artificial Neural Network and k-Nearest Neighbors).The results show that the different virtual battery parameters can be forecasted with high accuracy,reaching R^(2) scores up to 0.98 when considering 400 charging *** addition,the results indicate that the forecasting performance of all considered models is somehow similar and that only a low number of predictor variables are required to adequately forecast aggregated electric vehicle charging characteristics.

关键词： Forecasting electric vehicle smart charging electric vehicle aggregation Virtual battery method

The Effect of Starvation on the Biochemical Composition of the Digestive Gland, the Gonads and the Adductor Muscle of the Scallop Flexopectenglaber

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Food and Nutrition Sciences 2013年第4期4卷 405-413页

作者： Khaoula Telahigue tarek Hajji Imen Rabeh M’hamed el Cafsi Research Unit of Physiology and Aquatic Environment Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia

The effects of the starvation trial on the biochemical composition and the fatty acid dynamics in the triacylglycerol fraction of the digestive gland, gonads and adductor muscle of the scallop Flexopecten glaber were assessed. Results show that three weeks of food deprivation induce depletion of carbohydrates and a significant decrease in proteins and lipids. The noteworthy patterns recorded for the various classes of lipids were the increase of the amount of phosphatidylethanolamine against a strong decline of mono-diacylglycerols, triacylglycerol and phosphatidylserine classes in gonads. These results reflect the ability of Flexopecten glaber to remodel endogenous lipid classes in order to avoid the gonads deterioration. In the starved specimens, severe declines of the n-3 polyunsaturated fatty acid group were recorded in the triacylglycerol fraction of digestive gland and adductor muscle against the increase of this group in gonads. These results confirm the role of triacylglycerol as a polyunsaturated fatty acids reservoir and pointed out to their mobilization from storage organs to the developing gonads during the food shortage trial. Examination of fatty acid data revealed that food deprivation lead Flexopecten glaber to invest in saving and accumulation of highly unsaturated fatty acids in gonads. This applies mainly to the arachidonic acid (20:4n-6) and the docosahexaenoic acid (22:6n-3).

关键词： Starvation Scallop Chemical Composition Organs Fatty Acid