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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i>Infection

Journal of Biosciences and Medicines 2015年第7期3卷 31-53页

作者： tarek el-banna Ahmed Abd el-Aziz Nageh el-Mahdy Yasmine Samy Microbiology Department Faculty of Pharmacy Tanta University Tanta Egypt Pharmacology Department Faculty of Pharmacy Tanta University Tanta Egypt Pharmaceutical Sciences Faculty of Pharmacy Tanta University Tanta Egypt

There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies have reported that some antibiotics have efficacy in clearing resistant bacterial infections. On account of that it was interesting to evaluate the efficacy of erythromycin, chloramphenicol and/or tenoxicam in curing and/or relieving wound infection of highly resistant Escherichia coli and investigate the possible mechanisms beyond their antibacterial activity. This was achieved through evaluating highly resistant E. coli strains in vitro using agar dilution and in vivo rat models of E. coli infected wound and acute inflammation by carrageenin, where possible mechanisms were evaluated through measuring immunological mediators and histopathological examination. This study revealed that in vivo, erythromycin alone or in combination with tenoxicam significantly improved the healing of infected skin wounds with E. coli irresspective of resistancy in vitro. In addition to the improvement of immunological mediators involved in inflammatory reaction, oxidative stress and in cytokines expression as response to the bacterial infection in vivo. On the other hand chloramphenicol neither alone nor in combination with tenoxicam, achieved any significant effect. Tenoxicam didn’t show antimicrobial activity alone nor in combination with tested antibiotics in vitro, but it has shown synergestic activity in combination with tested antibiotics in vivo. Thus we concluded that immunomodulatory activity of erythromycin through anti-inflammatory and antioxidant effects was the possible mechanisms by which this antibiotic had healed infection with resistant E. coli in vivo, despite its resistancy to this antibiotic in vitro.

关键词： Efficacy Antibiotics Resistant E. coli Infection

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Long-term changes in sea surface temperature(SST)within the southern Levantine Basin

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Acta Oceanologica Sinica 2021年第3期40卷 27-33页

作者： tarek M.el-Geziry Laboratory of Physical Oceanography Division of Marine EnvironmentNational Institute of Oceanography and Fisheries(NIOF)Alexandria21556Egypt

Knowledge of sea surface temperature(SST)behaviour is vital for long-term climate *** study highlights essential outcomes about the distinguishable and unsurprising warming of the SST along the southern border of the Levantine *** analysis is based on monthly SST data for the period *** southern Levantine Basin has undergone SST increase,during the last 71 *** this study,a consistent warming trend has been found for the analysed SST data series,with a rate of 0.04℃/a,i.e.,0.4℃/(10 a).From 1975 to 1991 the mean annual SST was 17.1℃,and this increased to be 19.2℃,over the period *** revealed two opposite trends of variability:a decreasing trend(−0.06℃/a)over the period 1975-1991,and an increasing trend(0.2℃/a)from 2002 to *** the period 1948-2018,positive mean annual SST anomalies had an average of 1.8℃,and negative anomalies had an average of−1.1℃.The lowest SST total increase was found from January to April,with values about 0.03℃,while the highest warming appeared from June to *** driving mechanisms behind the SST changes need to be more investigated,to understand the future trends and impacts of climate change in the Levantine Basin.

关键词： Mediterranean Sea Levantine Basin sea surface temperature anomaly trends warming

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Development and characterization of a regional lunar soil simulant for emirates lunar missions

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International Journal of Mining Science and Technology 2024年第9期34卷 1305-1315页

作者： Bo Peng Prabu Thannasi Waleed el-Sekelly tarek Abdoun Kemal Celik Division of Engineering New York University Abu DhabiAbu Dhabi PO Box 129188United Arab Emirates Structural Engineering Department Faculty of EngineeringMansoura UniversityMansoura 35516Egypt

Lunar soil simulants(LSS)have been pivotal in the success of past and current lunar *** have enhanced the design of lander and rover wheels through interaction studies on the lunar testbed under simulated environmental *** have also been used to evaluate the geotechnical,geomechanical,and dynamic characteristics of the lunar soil(LS),which is vital for future lunar *** most simulants have focused on either the chemical and mineralogical or geotechnical properties,developing a comprehensive LSS that mimics the lunar soil is of paramount importance for lander and rover soft-landing and future lunar *** article presents the significant development and characterization of the new LSS NYUAD-1,the first regional soil simulant tailored for the planned Emirates lunar *** material and geotechnical properties of NYUAD-1,including chemical composition,mineralogy,particle size,morphology,specific gravity,density,shear strength,and compressibility behaviors,were assessed through laboratory tests conducted per ASTM *** analysis with authentic lunar regolith and various regolith simulants confirms the significance and applicability of NYUAD-1 for lunar-based research,offering a promising step toward future lunar habitation.

关键词： LSS Chemical composition Mineralogy Density Shear strength Compressibility

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Smart prediction of liquefaction-induced lateral spreading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2310-2325页

作者： Muhammad Nouman Amjad Raja tarek Abdoun Waleed el-Sekelly New York University(NYU)Abu Dhabi Abu Dhabi129188United Arab Emirates University of Management and Technology Lahore54372Pakistan Department of Civil and Environmental Eng. Rensselaer Polytechnic Institute(RPI)1108th StreetJEC 4049TroyNY12180USA Department of Structural Engineering Mansoura UniversityMansoura35516Egypt

The prediction of liquefaction-induced lateral spreading/displacement(Dh)is a challenging task for civil/geotechnical *** this study,a new approach is proposed to predict Dh using gene expression programming(GEP).Based on statistical reasoning,individual models were developed for two topographies:free-face and gently sloping *** with a comparison with conventional approaches for predicting the Dh,four additional regression-based soft computing models,*** process regression(GPR),relevance vector machine(RVM),sequential minimal optimization regression(SMOR),and M5-tree,were developed and compared with the GEP *** results indicate that the GEP models predict Dh with less bias,as evidenced by the root mean square error(RMSE)and mean absolute error(MAE)for training(i.e.1.092 and 0.815;and 0.643 and 0.526)and for testing(i.e.0.89 and 0.705;and 0.773 and 0.573)in free-face and gently sloping ground topographies,*** overall performance for the free-face topology was ranked as follows:GEP>RVM>M5-tree>GPR>SMOR,with a total score of 40,32,24,15,and 10,*** the gently sloping condition,the performance was ranked as follows:GEP>RVM>GPR>M5-tree>SMOR with a total score of 40,32,21,19,and 8,***,the results of the sensitivity analysis showed that for both free-face and gently sloping ground,the liquefiable layer thickness(T_(15))was the major parameter with percentage deterioration(%D)value of 99.15 and 90.72,respectively.

关键词： Lateral spreading Intelligent modeling Gene expression programming(GEP) Closed-form solution Feature importance

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Repeated occurrence of palaeo-wildfires during deposition of the Bahariya Formation(early Cenomanian) of Egypt

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Journal of Palaeogeography 2019年第4期8卷 332-345页

作者： Haytham el Atfy tarek Anan Andre Jasper Dieter Uhl Department of Geology Faculty of ScienceMansoura UniversityMansoura 35516Egypt Programa de Pos-Graduacao em Ambiente e Desenvolvimento PPGADUniversidade do Vale do Taquari UnivatesLajeadoRio Grande do SulBrazil Senckenberg Research Institute and Natural History Museum 60325 Frankfurt am MainGermany Senckenberg Centre for Human Evolution and Palaeoenvironment Tubingen University72076 TubingenGermany

The Upper Cretaceous(early Cenomanian)Bahariya Formation of Egypt has an outstanding reputation for its wealth of vertebrate remains,including a variety of iconic dinosaurs,like the carnivorous Spinosaurus and Carcharodontosaurus,as well as the herbivorous Aegyptosaurus and *** these dinosaur fossils,the Bahariya Formation yielded also a wealth of invertebrate and plant remains,but even today many aspects concerning the continental palaeoenvironments reflected in these deposits(including the occurrence of palaeo-wildfires)have not been studied in *** far six distinct macro-charcoal bearing levels could be identified within the type section of the Bahariya Formation at Gabal el Dist profile,one of the most prolific outcrops of this formation in terms of fossil occurrence located in the north of the Bahariya Oasis,Western Desert,*** of the charcoal investigated by means of SEM originates from ferns,pointing to a considerable proportion of this plant group within the palaeo-ecosystems that experienced *** and(putative)angiosperms have less frequently been *** collected data present evidence that the landscapes at the northern shores of Gondwana repeatedly experienced palaeo-wildfires,adding extra proof to previous statements that the Late Cretaceous was a fiery world on a global scale.

关键词： Bahariya Oasis Gabal el Dist Charcoal Wildfire Dinosaurs Upper Cretaceous Early Cenomanian Egypt

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Impact Assessment and Mitigation Techniques for High Penetration Levels of Renewable Energy Sources in Distribution Networks:Voltage-control Perspective

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 450-458页

作者： Ahmed S.A.Awad Dave Turcotte tarek H.M.el-Fouly Natural Resources Canada Can-metENERGYVarennesCanadaon leave from the Electrical Power and Machines DepartmentFaculty of EngineeringAin Shams UniversityCairo 11566Egyp Natural Resources Canada CanmetENERGYVarennesCanada Advanced Power and Energy Center Khalifa UniversityAbu DhabiUnited Arab Emirates

The integration of renewable distributed generation(RDG)into distribution networks is promising and increasing ***,high penetration levels of distributed generation(DG)are often limited as they may have an adverse effect on the operation of distribution *** of the operation challenges is the interaction between DG and voltage-control equipment,e.g.,an under-load tap changer(ULTC),which is basically designed to compensate for voltage changes caused by slow load *** integration of variable DGs leads to rapid voltage fluctuations,which can negatively affect the tap operation of *** paper investigates the impact of high penetration levels of RDG on the tap operation of ULTC in distribution networks through *** mitigation techniques that can alleviate this impact are also *** these techniques,constant power-factor mode is regarded as the best trade-off between the simplicity and effectiveness of minimizing the number of tap *** are performed on a Canadian benchmark rural distribution feeder using OpenDSS software.

关键词： Renewable energy distributed generation(DG) voltage regulator load tap changer distribution network.

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Unlocking the power of blockchain in education:An overview of innovations and outcomes

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Blockchain(Research and Applications) 2023年第4期4卷 99-117页

作者： Amr el Koshiry Entesar eliwa tarek Abd el-Hafeez Mahmoud Y.Shams Department of Curricula and Teaching Methods College of EducationKing Faisal UniversityAl-Ahsa31982Saudi Arabia Faculty of Specific Education Minia UniversityMinia61519Egypt Department of Mathematics and Statistics College of ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Computer Science Faculty of ScienceMinia UniversityMinia61519Egypt Computer Science Unit Deraya UniversityMinia UniversityMinia61519Egypt Faculty of Artificial Intelligence Kafrelsheikh UniversityKafrelsheikh33516Egypt

Blockchain is a revolutionary technology that has the potential to revolutionize various industries,including finance,supply chain management,healthcare,and *** decentralized,secure,and transparent nature makes it ideal for use in industries where trust,security,and efficiency are of paramount *** integration of blockchain technology into the education system has the potential to greatly improve the efficiency,security,and credibility of the educational *** creating secure and transparent platforms for tracking and verifying students’academic achievements,blockchain technology can help to create a more accessible and trustworthy education system,making it easier for students to showcase their skills and knowledge to potential *** the potential benefits of blockchain in education are significant,there are also several challenges that must be addressed in order to fully realize the potential of this technology in the educational *** of the major challenges include adoption,technical knowledge,interoperability,regulation,cost,data privacy and security,scalability,and *** necessary equipment for the implementation of blockchain technology in education is diverse and critical to the success of this innovative *** should carefully consider this equipment when planning their implementation of blockchain technology in education to ensure the efficient and secure transfer of educational data and transactions within the blockchain *** technology has the potential to play a significant role in promoting sustainability education and advancing the sustainability goals of both individuals and *** should consider incorporating blockchain technology into their sustainability education programs,in order to enhance the transparency,verifiability,and efficiency of their sustainability-related *** the use of blockchain technology in education is still i

关键词： Blockchain Education Sustainability Internet of things Machine learning Credential verification

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An Enhanced Deep Learning Method for Skin Cancer Detection and Classification

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Computers, Materials & Continua 2022年第10期73卷 1109-1123页

作者： Mohamed W.Abo el-Soud tarek Gaber Mohamed Tahoun Abdullah Alourani Department of Computer Science and Information College of Science in ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia Faculty of Computers and Informatics Suez Canal UniversityIsmailia41522Egypt School of Science Engineeringand EnvironmentUniversity of SalfordUK

The prevalence of melanoma skin cancer has increased in recent *** greatest risk from melanoma is its ability to broadly spread throughout the body by means of lymphatic vessels and ***,the early diagnosis of melanoma is a key factor in improving the prognosis of the *** learning makes it possible to design and develop intelligent systems that can be used in detecting and classifying skin lesions from visible-light *** systems can provide early and accurate diagnoses of melanoma and other types of skin *** paper proposes a new method which can be used for both skin lesion segmentation and classification *** solution makes use of Convolutional neural networks(CNN)with the architecture two-dimensional(Conv2D)using three phases:feature extraction,classification and *** proposed method is mainly designed for skin cancer detection and *** the public dataset International Skin Imaging Collaboration(ISIC),the impact of the proposed segmentation method on the performance of the classification accuracy was *** obtained results showed that the proposed skin cancer detection and classification method had a good performance with an accuracy of 94%,sensitivity of 92%and specificity of 96%.Also comparing with the related work using the same dataset,i.e.,ISIC,showed a better performance of the proposed method.

关键词： Convolution neural networks activation function separable convolution 2D batch normalization max pooling classification

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Human recombinant soluble ACE2(hrsACE2)shows promise for treating severe COVID19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 303-304页

作者： tarek Mohamed Abd el-Aziz Ahmed Al-Sabi James D.Stockand Department of Cellular and Integrative Physiology University of Texas Health Science Center at San AntonioSan AntonioTX 78229-3900USA Zoology Department Faculty of ScienceMinia UniversityEl-Minia 61519Egypt College of Engineering and Technology American University of the Middle EastKuwaitKuwait

A recent study by Zoufaly et *** in The Lancet Respiratory Medicine describes encouraging data from the first severe COVID-19 patient successfully treated with human recombinant soluble angiotensin-converting enzyme-2(hrsACE2).1 The published data document upon treatment of an adaptive immune response,the disappearance of the virus swiftly from the serum,the nasal cavity and lungs,and a reduction of inflammatory cytokine levels that are critical for COVID-19 ***,the use of hrsACE2 did not impede the generation of neutralizing antibodies,leading to a significant clinical improvement of the treated patient.

关键词： ACE2 al cavity

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Assessing effects of deficit irrigation techniques on water productivity of tomato for subsurface drip irrigation system

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International Journal of Agricultural and Biological Engineering 2018年第4期11卷 156-167页

作者： Mahmoud S Hashem tarek Zin el-Abedin Hussein M Al-Ghobari Agricultural Engineering Department College of Food and Agriculture SciencesKing Saud UniversityRiyadh 11451Saudi Arabia Agricultural Engineering Research Institute(AEnRI) Agricultural Research CenterGizaEgypt Agricultural Engineering Department College of AgricultureAlexandria UniversityAlexandriaEgypt

Water resources are subjected to ever-increasing supply constraints due to extensive agricultural water demand for irrigated ***,water-saving irrigation strategies need to be *** present study was conducted to explore the possibilities of using regulated deficit irrigation(RDI)and partial root zone drying irrigation(PRD)methods as water-saving irrigation techniques for subsurface *** objective of this study are to assess the effects of RDI and PRD irrigation on the water productivity of vegetable crops(tomato)under SSD systems in arid climatic conditions,and to compare the responses of tomato crops to PRD,RDI,and FI under an SSD system in terms of productivity,crop quality,and the amount of water *** field experiment was conducted during the fall 2014-2015 and 2015-2016 seasons in an experimental field located on an educational farm owned by the Faculty of Food and Agriculture Sciences Department,King Saud University,Riyadh,Kingdom of Saudi *** area of 102.7 m^(2)(13 m×7.9 m)was allocated for the experiment to manage three treatments:RDI,PRD,and full irrigation(FI).The RDI and PRD treatments received 70%of the irrigation water volume of *** was replicated three *** most important results indicated that the soil water content(SWC)for the RDI and PRD treatments was lower than that of the FI *** had the highest stomatal conductance values(gs),while PRD had the lowest stomatal conductance *** photosynthetic rate(A_(n))was lower under RDI and PRD compared to ***,there was no significant change in A_(n) between treatments for most readings taken during both time periods,which means that the water saving treatments(PRD and RDI)did not affect the net photosynthesis rate,thereby enhancing irrigation water use efficiency(IWUE)under DI *** water-saving irrigation techniques decreased transpiration rate(T)compared to the FI *** values of the abscisic acid(ABA)contents were higher

关键词： full irrigation(FI) regulated deficit irrigation(RDI) partial root zone drying(PRD) irrigation water use efficiency(IWUE)

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