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Serum ferritin in neonatal cholestasis: A specific and active molecule or a non-specific bystander marker?

Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 173-180页

作者： Behairy el-Sayed Behairy Hatem abd-Alsattar Konswa Hanaa Talaat Ahmed Dina Shehata el-Azab Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterology and Nutrition National Liver Institute Menofiya University Department of Pathology National Liver Institute Menofiya University

Background: Serum ferritin(SF) and consequently hepatic iron have long been considered important in liver fibrosis progression. They have been studied in different liver diseases with no previous reports in neonatal cholestasis(NC). This study aimed to measure SF in different etiologies of NC and investigate its relation to hepatic iron and fibrosis. Methods: SF was measured in 75 infants, including 50 with NC and 25 with sepsis. SF was compared between these two groups. Biochemical parameters, hepatic iron grades, and liver fibrosis and other histopathological characteristics and correlated with SF were assessed in NC group. Finally, a comparison between intrahepatic cholestasis and obstructive etiology was performed. Results: SF was elevated in NC(1598 ± 2405 ng/mL) with no significant difference from those with sepsis( P = 0.445). NC and sepsis constituted augmenting factors leading to more elevation of SF(2589 ± 3511 ng/mL). SF was significantly correlated with hepatic iron grades( r = 0.536, P ell transformation( P = 0.009) and hepatocyte swelling( P = 0.023) than those with obstructive etiology(672 ± 566 ng/mL) and their prevalent pathological findings of ductular proliferation( P = 0.003) and bile plugs( P = 0.002). SF was unrelated to the grade of liver fibrosis( P = 0.058). Conclusions: SF is non-specifically elevated in NC, with positive correlation to hepatic iron grades. SF ≥ 803.5 ng/mL can predict higher grades( ≥ grade 3) of hepatic iron. However, an active role of increased SF and hepatic iron in disease progression remains questionable.

关键词： Biliary atresia Liver fibrosis Hepatic iron grade Intrahepatic cholestasis Iron

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Facies Analysis and Biostratigraphy of the Miocene Sequence,Cairo-Suez District,Egypt

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Journal of Earth Science 2017年第1期28卷 1-8页

作者： abdelbaset el-Sorogy mohamed abd-elmoneim Ahmed Mowafi Khaled Al-Kahtany Hisham Gahlan Department of Geology and Geophysics College of Science King Saud University Riyadh 11451 Saudi Arabia Geology Department Faculty of Science Zagazig University Zagazig 44519 Egypt

Miocene siliciclastic-carbonate deposits are widely exposed in Cairo-Suez District, Egypt. These deposits are underlain and overlain by continental sediments of Oligocene and post Miocene, respectively. Three stratigraphic sections were investigated at Gabals Geneife, Homeira and Gharra. Lithostrtigraphically, the Miocene sequence could be differentiated into two main rock units representing shallow deposits with relatively intermittent deep marine incursions. These are from base to top, Gharra Formation and Genefe Formation. Detailed macrofossils investigations led to the recognition of four macrofossil zones, namely Alectryonella plicatula-Crassostrea frondosa Range Zone, Echinolampas amplus-Scutella ammonis Range Zone, Chlamys（Macrochlamys） sardoa-Chlamys（Argopecten） submalvinae Range Zone, and Chlamys gentoni-Pecten（Oppenheimopecten） benedictus-Pecten（P.） ziziniae Assemblage Zone. Microfacies analysis and identified taxa indicated that the Miocene sequence was deposited in transgressive-regressive cycles ranged from near shore, warm shallow inner to middle shelf marine environments with storm influence during the accumulation of the oyster banks.

关键词： facies analysis biostratigraphy Miocene Cairo-Suez District Egypt.

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Effect of single subconjunctival injection of bevacizumab on primary pterygium:clinical,histopathological and immunohistochemical study

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 797-801页

作者： tarek A mohamed Wael Soliman Ahmed M.Fathalla Abeer el Refaie Department of Ophthalmology Assiut University Hospital Department of Pathology Faculty of MedicineAssiut University

AIM：To evaluate the effect（clinically,histopathologically and immunohistochemically） and safety of a single intrapterygium injection of ***：Prospective interventional study comprised 40 eyes of 40 patients with primary fleshy pterygia who attended the Outpatient Clinic of Department of Ophthalmology,Assiut University Hospitals,Egypt from May 2015 to May *** were randomly classified into 2 groups：the first group received a single intralesional injection of bevacizumab（Avastin;Genentech,San Francisco,CA,USA）;the second group comprised patients who did not receive subconjunctival *** of pterygium and conjunctival auto graft was done in both *** excised pterygium tissues were subjected to histopathological and immunohistochemical ***：The study comprised 40 eyes of 40 patients（33 men,7 women） of age range from 31-58 *** study group included 22 *** control group included 18 eyes.A decrease in the vascularity of the pterygium was noted in all injected *** mean vessel count was higher in non-injected pterygia than that in injected pterygia and the difference was statistically significant（P=0.001）.Also,the mean vessel count in both groups was significantly higher than normal conjunctive（P=0.005 and 0.001）.A statistically significant difference in vascular endothelial growth factor（VEGF） expression between injected and non-injected cases was detected in the epithelial,stromal and endothelial cells（P=0.0001,0.016,0.014）.No serious intraoperative complications occurred in both ***：The use of single intra lesional injection of Avastin in pterygium decreased vascularity and decreased VEGF expression in injected pterygium after one *** study proved the effect of single intra lesional injection of Avastin on *** studies may enable limiting the need for surgery and improve quality of life for patients with pterygia.

关键词： pterygiurn vascularity bevacizumab vessel count

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Weight Prediction Using the Hybrid Stacked-LSTM Food Selection Model

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Computer Systems Science & Engineering 2023年第7期46卷 765-781页

作者： Ahmed M.elshewey Mahmoud Y.Shams Zahraa tarek mohamed Megahed el-Sayed M.el-kenawy mohamed A.el-dosuky Faculty of Computers and Information Computer Science DepartmentSuez UniversitySuezEgypt Faculty of Artificial Intelligence Kafrelsheikh UniversityKafrelsheikh33511Egypt Faculty of Computers and Information Computer Science DepartmentMansoura University35561Egypt Faculty of Physical Education Track and Field Competitions DepartmentArish UniversityEgypt Delta Higher Institute of Engineering and Technology Mansoura35111Egypt Department of Computer Science Arab East CollegesRiyadh13544Saudi Arabia

Food choice motives(i.e.,mood,health,natural content,convenience,sensory appeal,price,familiarities,ethical concerns,and weight control)have an important role in transforming the current food system to ensure the healthiness of people and the sustainability of the *** from several domains have presented several models addressing issues influencing food choice over the ***,a multidisciplinary approach is required to better understand how various aspects interact with one another during the decision-making *** this paper,four Deep Learning(DL)models and one Machine Learning(ML)model are utilized to predict the weight in pounds based on food *** Long Short-Term Memory(LSTM)model,stacked-LSTM model,Conventional Neural Network(CNN)model,and CNN-LSTM model are the used deep learning *** the applied ML model is the K-Nearest Neighbor(KNN)*** efficiency of the proposed model was determined based on the error rate obtained from the experimental *** findings indicated that Mean Absolute Error(MAE)is 0.0087,the Mean Square Error(MSE)is 0.00011,the Median Absolute Error(MedAE)is 0.006,the Root Mean Square Error(RMSE)is 0.011,and the Mean Absolute Percentage Error(MAPE)is ***,the results demonstrated that the stacked LSTM achieved improved results compared with the LSTM,CNN,CNN-LSTM,and KNN regressor.

关键词： Weight prediction machine learning deep learning LSTM CNN KNN

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Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

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World Journal of Gastroenterology 2016年第16期22卷 4238-4249页

作者： Behairy el-Sayed Behairy Mostafa mohamed Sira Khaled Refat Zalata el-Sayed Ebrahem Salama mohamed Ahmed abd-Allah Department of Pediatric Hepatology National Liver Institute Menofiya University Department of Pathology Faculty of Medicine Mansura University

AIM: To evaluate transient elastography (TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver ***: A total of 90 children [50 with chronic hepatitis C virus (HCV), 20 with autoimmune hepatitis (AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement (LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction (FAF) using digital image analysis (morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was also performed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiver-operating characteristic curve. Cut-off values with optimal clinical performance (optimal sensitivity and specificity simultaneously) were ***: The majority of HCV group had minimal activity (80%) and no/mild fibrosis (72%). On the other hand, the majority of AIH group had mild to moderate activity (70%) and moderate to severe fibrosis (95%) and all Wilson disease group had mild to moderate activity (100%) and moderate to severe fibrosis (100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter (r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH (16.15 ± 7.23 kPa) compared to Wilson disease (8.30 ± 0.84 kPa) and HCV groups (7.43 ± 1.73 kPa). Multiple regression analysis revealed that Ishak fibrosis stage was the only ind

关键词： Autoimmune hepatitis Chronic hepatitis C Liver fibrosis Liver stiffness Morphometry Pediatrics Transient elastography Wilson disease

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Prediction of fold-of-increase in productivity index post limited entry fracturing using artificial neural network

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Petroleum Research 2022年第2期7卷 236-245页

作者： Shady Galal Ramah mohamed abdalla Othman Ahmed Z.Nouh tarek el-Kwidy Faculty of Petroleum Engineering Suez UniversityEgypt Qarun Petroleum Company Egypt Egyptian Petroleum Research Institute Egypt American University in Cairo Egypt

Unified Fracture Design(UFD)bridges the gap between practices and theory in the hydraulic fracturing *** represents a technique to design hydraulic fracturing treatment with a particular amount of *** design could provide the maximum fold-of-increase(FOI)in productivity-index(PI)after hydraulic fracturing *** UFD optimization tool is very effective,but it has assumptions like any other *** assumption of UFD optimization technique;is a single-layer *** assumption does not align with the limited entry fracturing design *** limited entry fracturing,the frictional pressure is employed to offset the stress differences between multi-layers reservoirs to attain fluid injection through these layers,intended to deliver an optimal fracture conductivity in all *** drawback of this assumption is the underestimation of the actual value of FOI in *** paper aims to recast the original unified fracture design approach to extend the optimal UFD to a multilayer reservoir to predict the FOI in PI after limited entry fracturing *** recasting tool for this problem to find the optimum solution is Artificial Neural Networks(ANN).The architected ANN model is based on actual historical data of limited entry fracturing treatments.A statistical comparison between the proposed ANN model and classical UFD technique demonstrates that ANN model solution has a more reliable estimation of FOI in PI with the actual historical data.

关键词： Unified fracture design Hydraulic fracturing Limited-entry Fold of increase Artificial neural networks

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Histopathological changes in the oesophageal mucosa in Egyptian children with corrosive strictures: A single-centre vast experience

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World Journal of Gastroenterology 2019年第7期25卷 870-879页

作者： Ayman EskANDer Carolyne Ghobrial Nabil A Mohsen Bahaa Mounir Dalia abd el-Kareem Sara tarek Mortada HF el-Shabrawi Department of Paediatrics Kasr Alainy School of Medicine Cairo University Department of Pathology Kasr Alainy School of Medicine Cairo University

BACKGROUND The caustic ingestion continues to be a major problem worldwide especially in developing countries. The long-term complications include stricture and increased life time risk of oesophageal carcinoma. Patients suffered from corrosive induced oesophageal strictures have more than a 1000-fold risk of developing carcinoma of the *** To determine the possibility of oesophageal mucosal dysplasia after prolonged dilatation in post corrosive *** This observational study was conducted at the Paediatric Endoscopy Unit in Cairo University Children's Hospital. It included children of both sexes older than 2 years of age who had an established diagnosis of post-corrosive oesophageal stricture and repeated endoscopic dilatation sessions for more than 6 mo. All patients were biopsied at the stricture site after 6 mo of endoscopic dilatation. A histopathological examination of an oesophageal mucosal biopsy was performed for the detection of chronic oesophagitis, inflammatory cellular infiltration and *** The mean age of the enrolled children was 5.9 ± 2.6 years; 90% of the patients had ingested an alkaline corrosive substance(potash). The total number of endoscopic dilatation sessions were ranging from 16 to 100 with mean number of sessionswas 37.2 ± 14.9. Histopathological examination of the specimens showed that 85%of patients had evidence of chronic oesophagitis(group A) in the form of basal cell hyperplasia, hyperkeratosis and subepithelial fibrosis. Thirteen percent of the patients had evidence of reactive atypia(group B) in the form of severe neutrophilic intraepithelial inflammatory cellular infiltration, and 2 patients(2%)had mild squamous dysplasia(group C); we rebiopsied these two patients 6 mo after the initial pathological assessment, guided by chromoendoscopy by Lugol's *** The histopathology of oesophageal mucosal biopsies in post-corrosive patients demonstrates evidence of chronic oesophagitis, intraepi

关键词： Children Endoscopic dilatation Dysplasia Oesophageal strictures Postcorrosive

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Training program for caregivers to prevent pressure ulcers among elderly residents at geriatric homes

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Frontiers of Nursing 2021年第3期8卷 249-259页

作者： Donia Atef Ibrahiem Mona mohamed abd el-Maksoud Community Health Nursing Faculty of NursingHelwan UniversityCairo 11571Egypt

Objectives:Pressure ulcer(PU)is one of the most common problem among the bedridden elderly and has significantly more burden on elderly and *** study is aimed to evaluate the effects of the training program for caregivers to prevent PUs among elderly residents at geriatric ***:A quasi-experimental design was used to carry out the current study.A purposive sample comprised of all formal(39 nurses)or informal caregivers(39)and all immobilized elderly residents(35)who are found in all geriatric centers in Helwan district.A structured questionnaire was used to assess caregivers’socio-demographic characteristics,knowledge,attitude,and observational checklists for their practice for prevention of PU at pre-and posttest and during ***:After the training program,there were improvements in the level of knowledge,practice,and positive attitude of caregivers about PU prevention with a statistically significant difference between pre-,post-,and follow-up training programs(Pelderly caregivers’attitudes as well as practice for prevention could be important in reducing the burden of PU among the ***,conducting a training program for caregivers at different geriatric homes about caring skills for elders can prevent PU,and using spontaneous reposition is very effective to prevent PUs.

关键词： caregivers elderly residents geriatric homes pressure ulcers training program

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Determination of a novel ACE inhibitor in the presence of alkaline and oxidative degradation products using smart spectrophotometric and chemometric methods

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Journal of Pharmaceutical Analysis 2014年第2期4卷 132-143页

作者： Maha abdel-Monem Hegazy Maya Shaaban Eissa Osama Ibrahim abd el-Sattar mohamed mohamed abd el-Kawy Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyEgyptian Russian UniversityCairoEgypt National Organization of Drug Control and Research GizaEgypt

Simple, accurate, sensitive and validated UV spectrophotometric and chemometric methods were developed for the determination of imidapril hydrochloride （IMD） in the presence of both its alkaline （AKN） and oxidative （OXI） degradation products and in its pharmaceutical formulation. Method A is the fourth derivative spectra （D4） which allows the determination of IMD in the presence of both AKN and OXD, in pure form and in tablets by measuring the peak amplitude at 243.0 nm. Methods B, C and D, manipulating ratio spectra, were also developed. Method B is the double divisor-ratio difference spectrophotometric one （DD-RD） by computing the difference between the amplitudes of IMD ratio spectra at 232 and 256.3 nm. Method C is the double divisor-first derivative of ratio spectra method （DD-DR1） at 243.2 nm, while method D is the mean centering of ratio spectra （MCR） at 288.0 nm. Methods A, B, C and D could successfully determine IMD in a concentration range of 4.0-32.0 mg/mL. Methods E and F are principal component regression （PCR） and partial least-squares （PLS）, respectively, for the simultaneous determination of IMD in the presence of both AKN and OXI, in pure form and in its tablets. The developed methods have the advantage of simultaneous determination of the cited components without any pre-treatment. The accuracy, precision and linearity ranges of the developed methods were determined. The results obtained were statistically compared with those of a reported HPLC method, and there was no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

关键词： Double divisor-ratio difference Double divisor-ratio derivative Mean centering of ratio spectra Chemometry Imidapril hydrochloride

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Availability,sustainability and accessibility of agro crop residue production and solar radiation in Egypt for producing highly chemical products through pyrolysis processes

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Clean Energy 2023年第3期7卷 654-670页

作者： Saad A.el-Sayed mohamed A.Ismail mohamed E.Mostafa Emad H.Noseir tarek M.Khass Mechanical Power Engineering Department Faculty of EngineeringZagazig UniversityAl-SharkiaEgypt Mechanical Engineering Department College of EngineeringKing Faisal UniversityAl-AhsaSaudi Arabia Environmental Engineering Department Faculty of EngineeringZagazig UniversityAl-SharkiaEgypt

This study examines the large amount of agricultural waste produced in Egypt between 2010 and 2019 by analysing data from various departments within the Agriculture *** also provides a comprehensive database on the biomass available from agricultural waste in Egypt and its potential applications for producing power,heat and chemical *** biomass-pyrolysis systems powered by solar energy are used,research demonstrates the potential to convert agricultural waste into a variety of chemical *** approach utilizes solar energy,a clean and renewable source,and has wide-ranging industrial and power generation *** Egypt’s reliance on agriculture,the country currently utilizes little biomass for energy production and has not previously used it as a source for creating chemical products,which could potentially save on the imported oil used in these *** findings of the study are graphically presented using histograms,pie charts,*** overall production of residues reached the 30-Mt level in *** it contains the most rice-cultivated land,Dakahlia(Lower Egypt region)produces the highest percentage of the total residue(37.17%).Qena governorate(Upper Egypt region)produces 1.14 metric tons of residues,with sugarcane accounting for 20.3%of the total.

关键词： biomass agro-residue solar radiation pyrolysis chemical products sustainability

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