检索结果-南通市图书馆

Genetic and epigenetic control on clock genes in multiple sclerosis

Journal of Genetics and Genomics 2022年第1期49卷 74-76页

作者： tarek k.motawi Olfat G.Shaker Soha O.Hassanin Shaymaa G.Ibrahim Mahmoud A.Senousy Biochemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Medical Biochemistry and Molecular Biology Department Faculty of MedicineCairo UniversityCairoEgypt Biochemistry Department Faculty of PharmacyModern University for Technology and Information(MTI)CairoEgypt

The study of circadian rhythm performance is prominent in chronic diseases, such as multiple sclerosis(MS). Circadian rhythm dysregulation has been observed in several neurodegenerative disorders, including MS, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease(Videnovic et al., 2014;Hedstr om et al.,2015). In addition, subjects who work in shifts have an increased risk of developing MS(Hedstr om et al., 2015). Furthermore, impaired sleep and alertness are common symptoms of MS and neurodegenerative disorders(Videnovic et al., 2014).

关键词： Huntington impaired

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats

引用

The Journal of Biomedical Research 2019年第2期33卷 113-121页

作者： tarek k motawi Samia A Ahmed Manal A Hamed Shohda A El-Maraghy Wessam M Aziz Biochemistry Department Faculty of Pharmacy Cairo University Therapeutic Chemistry Department National Research Centre

The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin(50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen(BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide(NO), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH), total antioxidant capacity(TAC),kidney injury molecule-1(kIM-1), heat shock protein-70(HSP-70), caspase-3, transforming growth factor β1(TGFβ1), DNA degradation by the comet assay and total protein contents. Histopathologic study was also done for the kidney and the pancreas. Drastic changes in all measured parameters of the diabetic rats were observed. Treatment with melatonin and rowatinex showed amelioration to variable degrees. In conclusion, melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy followed by its combination with rowatinex.

关键词： diabetic nephropathy melatonin rowatinex histopathology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：