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Animal models in the study of Alzheimer's disease and Parkinson's disease:A historical perspective

Animal models and Experimental medicine 2022年第1期5卷 27-37页

作者： Rajashree Banerjee Arushi Rai Shreyas m.Iyer Sonia Narwal meghana tare Department of Biological Sciences Birla Institute of Technology and SciencePilaniIndia

Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases *** are proteinopathic conditions and while occasionally inherited,are largely sporadic in *** the advances in our understanding of the two have been significant,they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately *** models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological *** review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease,and highlights the shifting paradigms in studying two humanspecific conditions in non-human organisms.

关键词： Alzheimer's disease animal models neurodegeneration Parkinson's disease

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Intrahepatic flow diversion prior to segmental Yttrium-90 radioembolization for challenging tumor vasculature

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Journal of Interventional medicine 2022年第2期5卷 79-83页

作者： Lindsay B.Young marcin Kolber michael J.King mona Ranade Vivian L.Bishay Rahul S.Patel Francis S.Nowakowski Aaron m.Fischman Robert A.Lookstein Edward Kim Icahn School of medicine at mount Sinai Deparmnent of Dignostc Molecular and lterventionl RadiologyOne Gustave L.Levry Place Box 1234NY100296574New YorkUSA University of Teras Southwestem medical Center Division of Vascular and Inerentional Radiology5323 Hary Hines BhvdTx753909316DallasUSA David Geffen School of medicine at the Univerity of Calfornia-LoS Angeles Deparment of Itrentionol Radiology27235 Toumey RoadSuite 1500Califormia91355ValenciaUSA

Background: Hepatic tumors with complex vascular supply or poor relative perfusion are prone to decreased rates of objective response. This is compounded in the setting of Yttrium-90(Y90) transarterial radioembolization(tare., which is minimally embolic and flow-dependent, relying on high threshold dose for complete ***: we describe our experience with intrahepatic flow diversion(FD) prior to tare.of hepatocellular carcinoma(HCC) with challenging vascular *** and methods: Between April 2014 and January 2020, 886 cases of coinciding mAA or tare.and bland embolization or temporary occlusion were *** embolizations performed for more routine purposes were excluded. FD was performed by bland embolization or temporary occlusion of vessels supplying non-malignant parenchyma in cases where flow was not preferential to target tumor. Lesion characteristics, vascular supply, treatment approach, angiography, and adverse events(AEs) were reviewed. Radiographic response was assessed using mRECIST ***: 22 cases of FD of focal HCC were identified. Embolics included calibrated microspheres(n = 11), microcoils(n = 4), gelfoam(n = 3), temporary balloon occlusion(n = 2) and temporary deployment of a microvascular plug(n = 1). Post-treatment SPECT-CT dosimetry coverage was concordant with target lesions in all cases. mean follow-up was 16.7 months(1.4–45 mos). Tumor-specific response per m RECIST was 41% complete response, 50% objective response, and 59% disease control rate. No major adverse events or grade 3/4 hepatotoxicity were ***: Our findings suggest that FD prior to tare.is safe and potentially effective in treating HCC with complex vascular supply or poor tumor perfusion.

关键词： embolization routine balloon

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维普期刊数据库

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Diffusion of hydrogen and its isotopes in BCC-metals

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广东有色金属学报 2005年第2期15卷 232-232页

作者： Kashlev Yu.A. Sadykov N.m. Vinogradova N.A. A.A.Baikov Institute of metallurgy and materials Science Russian Academy of Sciences Moscow Russia

Quantum states and potential configurational relief of hydrogen atom in BCC-metals is considered.

关键词：金属材料金属组织氢同位素

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