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Vitamin D therapy in children with inflammatory bowel disease: A systematic review

World Journal of Clinical Pediatrics 2019年第1期8卷 1-14页

作者： tarah rigterink Laura Appleton Andrew S Day Vrije Universiteit Amsterdam Department of Paediatrics University of Otago Christchurch

BACKGROUND Vitamin D deficiency is highly prevalent in children with inflammatory bowel disease(IBD). This may contribute to an increased risk of poor bone health and may also influence the course of disease. An optimal treatment strategy of vitamin D therapy in children with IBD has not yet been *** To analyse the published intervention studies of vitamin D therapy in children with *** A systematic review was conducted of clinical studies involving children with IBD(including Crohn disease or ulcerative colitis) who had received vitamin D therapy. Studies up to March 31 st 2018 were identified through MEDLINE,PubMed, EMBASE and the Cochrane Library. Search terms included synonyms of the following terms: vitamin D, paediatric, supplementation, IBD. References of included articles based on abstract were searched for other relevant *** relevant articles were accessed and reviewed in full text. Studies fitting the set criteria were included and the remainder were *** Two hundred and seventy-seven discrete articles were identified. Following assessment of these articles included in the initial search and application of inclusion and exclusion criteria, ten published studies were included in this review. The included studies showed a heterogeneity in study design, inclusion and exclusion criteria, baseline demographics and treatment strategies. Treatment regimens differed in length, supplemented form of vitamin D and factors based upon which dosage was adjusted. Each of the reports included in this review concluded their vitamin D regimens to be safe and well-tolerated. Few of the included studies reported secondary outcomes on the efficacy of vitamin D treatment upon the clinical course of disease or markers of inflammation. Themajority of included trials were not sufficient in raising serum vitamin D levels to an adequate level(30 ng/mL) in children with IBD with vitamin D *** The included trials featured dive

关键词： Child Inflammatory bowel diseases Vitamin D Therapeutics Systemic review

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Genetics of canine behavior: A review

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World Journal of Medical Genetics 2014年第3期4卷 46-57页

作者： Amanda rigterink Indiana Veterinary Behavior Services LLCWest LafayetteIN 47906United StatesKatherine HouptCollege of Veterinary MedicineDepartment of Clinical Sciences Cornell UniversityCVM Cornell UniversityIthacaNY 14853-6401United States

The past decade has seen rapid progress in the field of canid behavioral genetics. The recent advances are summarized in this review. The identification of the genes responsible for tameness in silver foxes is the culmination of a half century of behavioral testing and,more recently, genomic investigation. There is agreement that domestic dogs evolved from wolves, but when and from which population remains *** genetic differences between wolves and dogs identified include those for neurotransmitters and *** differences in behavior are well known, but only recently have the genetics underlying these differences been investigated. The genes responsible for flank sucking in Doberman Pinschers and for several other obsessive compulsive problems in other breeds have been identified. Aggression is the least desirable canine trait, and several laboratories have detected differences in neurotransmitters and their receptors between aggressive and non-aggressive dogs. In English Cocker Spaniels, the genes linked to aggressive behavior code for dopamine, serotonin, and glutamate receptors. A dopamine transporter gene has been associated with impulsive behavior in Malinois.

关键词： Dog Wolf Fox Canine aggression Dopamine Serotonin Canid

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