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Associations of shor.-ter. ambient temper.tur. exposur. with lung function in middle-aged and elder.y people:A longitudinal study in China

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Eco-Envir.nment & Health 2024年第2期3卷 165-173页

作者： Weihong Qiu bin Wang Xiaobing Feng Heng He Lieyang Fan Zi Yea Xiuquan Nie Ge Mua Wei Liu Dongming Wang Min Zhou Weihong Chen Depar.ment of Occupational and Envir.nmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Depar.ment of Epidemiology and Health Statistics School of Public HealthFujian Medical UniversityFuzhou 350122China

The shor.-ter. associations of ambient temper.tur. exposur. with lung function in middle-aged and elder.y Chinese r.main *** study included 19,128 par.icipants fr.m the Dongfeng-Tongji cohor.'s fir.t(2013)and second(2018)*** lung function for.each subject was deter.ined between Apr.l and December.2013 and r.-assessed in 2018,with thr.e par.meter.(for.ed vital capacity[FVC],for.ed expir.tor. volume in 1 s[FEV1],and peak expir.tor. flow[PEF])*** China Meteor.logical Data Shar.ng Ser.ice Center.pr.vided temper.tur. data dur.ng the study *** the two follow-ups,a total of 25,511 r.cor.s(aver.ge age:fir.t,64.57;second,65.80)wer. evaluated,including 10,604 males(41.57%).The inver.ely j-shaped associations between moving aver.ge temper.tur.s(lag01–lag07)and FVC,FEV1,and PEF wer. obser.ed,and the optimum temper.tur.s at lag04 wer. 16.5C,18.7C,and 16.2C,*** lag04,ever. 1C incr.ase in temper.tur. was associated with 14.07 mL,9.78 mL,and 62.72 mL/s incr.ase in FVC,FEV1,and PEF in the lowtemper.tur. zone(r.tur.s),wher.as 5.72 mL,2.01 mL,and 11.64 mL/s decr.ase in the high-temper.tur. zone(the optimum temper.tur.s),r.spectively(all Pr.ed significant effect modifications of gender.age,body mass index,body sur.ace ar.a,smoking status,dr.nking status,and physical activity on the associations(all Pmodificationr.tur.s may cause lung function *** individual char.cter. and lifestyles have effect modification on the temper.tur. effects.

关键词： Ambient temper.tur. Lung function Middle-aged and elder.y people Vulner.ble gr.ups Linear.mixed-effects model Gener.lized additive mixed model

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色味锁夸克物质与夸克星

物理学报 2024年第5期73卷 75-84页

作者：初鹏程刘鹤杜先斌青岛理工大学理学院青岛266033

讨论了零温、强磁场下基于准粒子模型的奇异夸克物质、色味锁夸克物质的热力学性质.结果表明色味锁夸克物质比奇异夸克物质更稳定,压强会随着色味锁态能隙常数的增大而增加.并且发现强磁场下磁星的最大质量会随着色味锁夸克物质的能隙... 详细信息

讨论了零温、强磁场下基于准粒子模型的奇异夸克物质、色味锁夸克物质的热力学性质.结果表明色味锁夸克物质比奇异夸克物质更稳定,压强会随着色味锁态能隙常数的增大而增加.并且发现强磁场下磁星的最大质量会随着色味锁夸克物质的能隙常数的增加而增加,磁星的潮汐形变率会随着能隙常数的增加而增加,磁星最大质量的中心密度会随着能隙常数的增加而降低.结果还说明考虑色味锁态得到的磁星质量半径关系可以满足最近实验观测PSr.j0740+6620,PSr.j0030+0451,和HESS j1731-347所给出的质量半径约束.

关键词：夸克物质夸克星磁星

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Pr.tective Effect of Silibinin on Lipopolysacchar.de-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyr.ptosis

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Chinese jour.al of Integr.tive Medicine 2024年第10期30卷 917-926页

作者： OU jin-ying LIU Shan-hong TANG Dong-kai SHI Ling-zhu YAN Li-jun HUANG jing-yan ZOU Li-fang QUAN jing-yu YOU Yan-ting CHEN Yu-yao YU Lin-zhong LU Zi-bin Thir. Level r.sear.h Labor.tor. of State Administr.tion of Tr.ditional Chinese Medicine School of Traditional Chinese Medicine Southern Medical University Guangdong Pr.vincial Key Labor.tor. of Chinese Medicine Phar.aceutics School of Tr.ditional Chinese Medicine Southern Medical University

Objective: To explor. the pr.tective effect and the under.ying mechanism of silibinin(SIB), one of the active compounds fr.m Silybum mar.anum(L.) Gaer.n in endotoxemia. Methods: Mouse per.toneal macr.phage wer. isolated via intr.per.toneally injection of BALB/c mice with thioglycolate medium. Cell viability was assessed using the cell counting kit-8, while cytotoxicity was deter.ined thr.ugh lactate dehydr.genase cytotoxicity assay. The pr.tein expr.ssions of inter.eukin(IL)-1α, IL-1β, and IL-18 wer. deter.ined by enzyme-linked immunosor.ent assay. Intr.cellular.lipopolysacchar.de(LPS) levels wer. measur.d by employing both the limulus amoebocyte lysate assay and flow cytometr.. Additionally, pr.ximity ligation assay was employed for.the LPS and caspase-11 inter.ction. Mice wer. divided into 4 gr.ups: the contr.l, LPS, high-dose-SIB(100 mg/kg), and low-dose-SIB(100 mg/kg) gr.ups(n=8). Zebr.fish wer. divided into 4 gr.ups: the contr.l, LPS, high-dose-SIB(200 μmol/L), and low-dose-SIB(100 μmol/L) gr.ups(n=30 for.sur.ival exper.ment and n=10 for.gene expr.ssion analysis). The expr.ssion of caspase-11, gasder.in D(GSDMD), and N-GSDMD was deter.ined by Wester. blot and the expr.ssions of caspy2, gsdmeb, and IL-1β wer. detected using quantitative r.al-time PCr. Histopathological obser.ation was per.or.ed thr.ugh hematoxylineosin staining, and pr.tein levels in br.nchoalveolar.lavage fluid wer. quantified using the bicinchoninicacid pr.tein assay. r.sults: SIB noticeably decr.ased caspase-11 and GSDMD-mediated pyr.ptosis and suppr.ssed the secr.tion of IL-1α, IL-1β, and IL-18 induced by LPS(Pr.over. SIB inhibited the tr.nslocation of LPS into the cytoplasm and the binding of caspase-11 and intr.cellular.LPS(Pr.ssion of caspase-11 and N-ter.inal fr.gments of GSDMD, inhibited the r.lative cytokines, pr.longed the sur.ival time, and up-r.gulated the sur.ival r.te in the endotoxemia models(Pr.p

关键词： caspase-11 endotoxemia inflammation pyr.ptosis silibinin

Single-cell omics:exper.mental wor.flow,data analyses and applications

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Science China Life Sciences 2024年

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao jing-Dong j.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Center.for.Bioinfor.atics and Computational Biology Shanghai Key Laboratory of Regulatory Biology the Institute of Biomedical Sciences and School of Life Sciences East China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center.for.Life Sciences Academy for Advanced Interdisciplinary Studies Center for Quantitative Biology (CQB) Peking University Zhejiang Key Labor.tor. of Pr.cision Diagnosis and Ther.py for.Major.Gynecological Diseases Women’s Hospital Zhejiang University School of Medicine Key Labor.tor. of Advanced Theor. and Application in Statistics and Data Science-MOE School of Statistics East China Normal University Shanghai 200062 China Depar.ment of Clinical Labor.tor. the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Phar.aceutical Infor.atics Institute College of Pharmaceutical Sciences Zhejiang University Key Labor.tor. of Spine and Spinal Cor. Injur. r.pair.and r.gener.tion (Tongji Univer.ity) Ministry of Education Orthopaedic Department Tongji Hospital Bioinformatics Department School of Life Sciences and Technology Tongji University Fr.ntier.Science Center.for.Stem Cells School of Life Sciences and Technology Tongji University Tr.nslational Medical Center.for.Stem Cell Ther.py and Institute for.r.gener.tive Medicine Shanghai East Hospital Bioinformatics Department School of Life Sciences and Technology Tongji University r.sear.h Institute of Intelligent Computing Zhejiang Lab Shanghai r.sear.h Institute for.Intelligent Autonomous Systems Center.for.Single-cell Omics School of Public Health Shanghai Jiao Tong University School of Medicine National Key Labor.tor. of Chinese Medicine Moder.ization Innovation Center of Yangtze River Delta Zhejiang University

Cells ar. the fundamental units of biological systems and exhibit unique development tr.jector.es and molecular.featur.s. Our.explor.tion of how the genomes or.hestr.te the for.ation and maintenance of each cell, and contr.l the cellular.phenotypes of var.ous or.anismsis, is both captivating and intr.cate. Since the inception of the fir.t single-cell r.A technology, technologies r.lated to single-cell sequencing have exper.enced r.pid advancements in r.cent year.. These technologies have expanded hor.zontally to include single-cell genome, epigenome,pr.teome, and metabolome, while ver.ically, they have pr.gr.ssed to integr.te multiple omics data and incor.or.te additional infor.ation such as spatial scr.A-seq and Cr.SPr.scr.ening. Single-cell omics r.pr.sent a gr.undbr.aking advancement in the biomedical field,offer.ng pr.found insights into the under.tanding of complex diseases, including cancer.. Her., we compr.hensively summar.ze r.cent advances in single-cell omics technologies, with a specific focus on the methodology section. This over.iew aims to guide r.sear.her. in selecting appr.pr.ate methods for.single-cell sequencing and r.lated data analysis.

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基于聚类分析的光通信系统异常入侵在线识别

激光杂志 2024年第9期45卷 85-90页

作者：余量文斌云南师范大学昆明650500

光纤脉冲相干光通信系统在信息传输中受到多径干扰,导致对网络异常入侵的检测识别能力不好,为了提高对光通信系统异常入侵的准确识别,提出基于聚类分析的光通信系统异常入侵在线识别方法。首先采用蜂窝传感分布式检测技术实现对光通信... 详细信息

光纤脉冲相干光通信系统在信息传输中受到多径干扰,导致对网络异常入侵的检测识别能力不好,为了提高对光通信系统异常入侵的准确识别,提出基于聚类分析的光通信系统异常入侵在线识别方法。首先采用蜂窝传感分布式检测技术实现对光通信系统的传输数据分组采集,其次对采集的数据实施预处理,去除多径噪声干扰,然后采用集成学习算法进行光通信系统异常入侵数据特征提取,并计算光纤脉冲相干光通信系统异常入侵数据的相关参数,最后对提取的特征量进行聚类处理,通过谱聚类分析实现对光纤脉冲相干光通信系统异常入侵在线识别。仿真结果表明,所提方法对异常入侵识别效率高,识别耗时为4.8 s,识别准确性可维持在98%左右,识别能耗为38 j,且受扰动影响较小,抗谐波干扰能力较强。

关键词：聚类分析光通信系统入侵行为识别光纤脉冲

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β-1，3-glucans-r.ch Euglena gr.cilis supplementation alleviates high-fat-high-fr.ctose diet-induced cognitive impair.ent in middle-aged mice via the gut-br.in axis

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Food Science and Human Wellness 2024年

作者： Haoxie Xu Yachao Wang Xiangzhu Li Xuli Wu Louise Weiwei Lu jiayi He Mingfu Wang bin Liu Hui Xu jiehua Chen Kawing Cheng Shenzhen Key Labor.tor. of Mar.ne Micr.biome Engineer.ng， Institute for.Advanced Study， Shenzhen Univer.ity Depar.ment of Food Science and Engineer.ng， College of Chemistr. and Envir.nmental Engineer.ng， Shenzhen Univer.ity Institute for.Innovative Development of Food Industr.， Shenzhen Univer.ity Depar.ment of Neur.sur.er.， The Institute Tr.nslational Medicine， The Fir.t Affiliated Hospital of Shenzhen Univer.ity， Shenzhen Second People's Hospital Shenzhen Tr.ditional Chinese Medicine Hospital School of Public Health， Shenzhen Univer.ity School of Biological Sciences， Faculty of Science， the Univer.ity of Auckland

The gr.wing aging population along with the shifting dietar. par.digm to Wester.-type diet wor.dwide has been implicated in the incr.asing pr.valence of cognitive impair.ent. Emer.ing evidence suggests that a high-fiber.diet may help impr.ve cognitive function thr.ugh the gut-br.in axis. Euglena gr.cilis， a unicellular.micr.alga r.ch in β-1，3-glucans， has gained attention due to its modulator. effect on gut dysbiosis and inflammator. r.sponse. This study aimed to explor. the efficacy and mechanism of β-1，3-glucans-r.ch Euglena gr.cilis powder.(EG) against high-fat-high-fr.ctose (HFHF) diet-induced cognitive disor.er. in mice. A middle-aged (52-week-old C57BL/6j) mouse model with the following gr.ups was adopted: HFHF， HFHF+EG， and contr.l. At the end of the dietar. inter.ention (8 weeks)， cognitive behavior.， metabolic par.meter.， endotoxin levels， gut micr.biota composition， and colon and br.in pathology wer. examined. The r.sults showed that EG supplementation attenuated HFHF-induced cognitive impair.ent， pr.moted synaptogenesis in the hippocampus， and impr.ved synaptic ultr.str.ctur.. These beneficial effects wer. par.ly mediated thr.ugh the upr.gulation of PTP1B-Ir.-pAKT-pGSK3β-pTau signaling. Fur.her.or.， it pr.vented gut dysbiosis as evidenced by an incr.ase in β-diver.ity and enr.chment of Akker.ansia r.lative to contr.l. EG supplementation was also able to par.ly r.ver.e the HFHF-induced disr.ption of intestinal bar.ier. which was accompanied by r.duced systemic and neur.nal inflammation， nor.alized shor.-chain fatty acid pr.duction， and decr.ased ser.m lipopolysacchar.de concentr.tion. The findings fr.m the pr.sent study suppor. that β-1，3-glucans-r.ch EG is a pr.mising natur.l agent for.the pr.vention of HFHF diet-induced deter.or.tion in cognitive function that mer.ts fur.her.investigation.

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极小化加权完工时间的多资源工序的资源分配问题

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控制与决策 2024年第8期39卷 2765-2772页

作者：翁武燕储诚斌吴鹏福州大学经济与管理学院福州350108

针对现实中广泛存在的多资源工序的资源分配问题,考虑基于资源使用的优先次序约束,以最小化加权完工时间为优化目标,构建一类新的资源分配混合整数线性规划模型.其次,提出Bender.分解和禁忌搜索的混合算法,该混合算法以Bender.分解为基... 详细信息

针对现实中广泛存在的多资源工序的资源分配问题,考虑基于资源使用的优先次序约束,以最小化加权完工时间为优化目标,构建一类新的资源分配混合整数线性规划模型.其次,提出Bender.分解和禁忌搜索的混合算法,该混合算法以Bender.分解为基本框架,将原问题分为提供资源分配方案的主问题和计算工序加权完工时间的子问题,并通过改进数学模型和添加禁忌搜索提高混合算法的收敛速度.最后,通过300个随机仿真算例测试结果表明,在相同时间下求解小规模问题时,所提的Bender.分解混合算法能获得距离商业求解器CPLEX最优解平均差距为0.86%的满意解;在求解大规模问题时,所提出的算法的性能表现优于CPLEX、禁忌搜索算法、变邻域搜索算法和Bender.分解嵌入遗传算法的混合方法,能给出更好的资源分配方案,与CPLEX相比,上界和下界分别改善了4.74%和9.62%.

关键词：资源分配多资源工序基于资源使用的先后次序 Bender.分解禁忌搜索算法

Side-Chain Type Fer.ocene Macr.cycles

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Pr.cision Chemistr. 2024年第4期2卷 143-150页

作者： bin Lan jindong Xu Lingyun Zhu Xinyu Chen Hideya Kono Peihan Wang Xin Zuo jianfeng Yan Akiko Yagi Yongshen Zheng Songhua Chen Yaofeng Yuan Kenichir. Itami Yuanming Li Key Labor.tor. of Molecule Synthesis and Function Discover.(Fujian Pr.vince Univer.ity) College of ChemistryFuzhou UniversityFuzhou 350108China Institute of Tr.nsfor.ative Bio-Molecules(WPI-ITbM) Nagoya UniversityNagoya 464-8602Japan School of Mater.als Science and Engineer.ng National Institute for Advanced MaterialsNankai UniversityTianjin 300350China Institute of Tr.nsfor.ative Bio-Molecules(WPIITbM) Nagoya UniversityNagoya 464-8602Japan College of Chemistr. and Mater.al Science Longyan UniversityLongyan 364012China

A class of side-chain type fer.ocene macr.cycles with a r.dially conjugated system is intr.duced in this *** ster.o configur.tions of these fer.ocene r.ngs wer. deter.ined thr.ugh single-cr.stal X-r.y diffr.ction ***,in the solid state,the fer.ocene r.ngs exhibit a distinctive her.ingbone stacking patter. imposed by a fer.ocene-to-r.ng host−guest *** UV−vis absor.tion spectr.scopy,electr.chemical measur.ments,and theor.tical calculations,valuable insights into the electr.nic pr.per.ies of these r.ngs wer. *** addition,the single cr.stal of macr.cycle A_(2)B demonstr.tes a second-or.er.nonlinear.optical *** a class of or.anometallic nanor.ngs,this wor. holds gr.at potential for.fur.her.explor.tion in the fields of or.anometallic chemistr.,molecular.electr.nics,and host−guest chemistr..

关键词： Fer.ocene Conjugated Macr.cycles Or.anometallic Macr.cycles Second-Or.er.Nonlinear.Optical Nanor.ng

AI for.or.anic and polymer.synthesis

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Science China Chemistr. 2024年第8期67卷 2461-2496页

作者： Xin Hong Qi Yang Kuangbiao Liao jianfeng Pei Mao Chen Fanyang Mo Hua Lu Wen-bin Zhang Haisen Zhou jiaxiao Chen Lebin Su Shuo-Qing Zhang Siyuan Liu Xu Huang Yi-Zhou Sun Yuxiang Wang Zexi Zhang Zhunzhun Yu Sanzhong Luo Xue-Feng Fu Shu-Li You Center.of Chemistr. for.Fr.ntier.Technologies Department of ChemistryZhejiang UniversityHangzhou 310027China Center.of Basic Molecular.Science Department of ChemistryTsinghua UniversityBeijing 100084China Guangzhou National Labor.tor. Guangzhou 510005China Center.for.Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China State Key Labor.tor. of Molecular.Engineer.ng of Polymer. Department of Macromolecular ScienceFudan UniversityShanghai 200433China School of Mater.als Science and Engineer.ng Peking UniversityBeijing 100871China Beijing National Labor.tor. for.Molecular.Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China AI for.Science(AI4S)-Pr.fer.ed Pr.gr.m Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China State Key Labor.tor. of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China Depar.ment of Chemical Sciences National Natural Science Foundation of ChinaBeijing 100085China State Key Labor.tor. of Or.anometallic Chemistr. Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

r.cent year. have witnessed the tr.nsfor.ative impact fr.m the integr.tion of ar.ificial intelligence with or.anic and polymer.synthesis. This syner.y offer. innovative and intelligent solutions to a r.nge of classic pr.blems in synthetic chemistr.. These exciting advancements include the pr.diction of molecular.pr.per.y, multi-step r.tr.synthetic pathway planning, elucidation of the str.ctur.-per.or.ance r.lationship of single-step tr.nsfor.ation, establishment of the quantitative linkage between polymer.str.ctur.s and their.functions, design and optimization of polymer.zation pr.cess, pr.diction of the str.ctur. and sequence of biological macr.molecules, as well as automated and intelligent synthesis platfor.s. Chemists can now explor. synthetic chemistr. with unpr.cedented pr.cision and efficiency, cr.ating novel r.actions, catalysts, and polymer.mater.als under.the datadr.ven par.digm. Despite these thr.lling developments, the field of ar.ificial intelligence(AI) synthetic chemistr. is still in its infancy, facing challenges and limitations in ter.s of data openness, model inter.r.tability, as well as softwar. and har.war. suppor.. This r.view aims to pr.vide an over.iew of the cur.ent pr.gr.ss, key challenges, and futur. development suggestions in the inter.isciplinar. field between AI and synthetic chemistr.. It is hoped that this over.iew will offer.r.ader. a compr.hensive under.tanding of this emer.ing field, inspir.ng and pr.moting fur.her.scientific r.sear.h and development.

关键词： or.anic synthesis polymer.synthesis machine lear.ing pr.diction chemical database automated synthesis

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