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Expanding endoscopic boundaries:Endoscopic resection of large appendiceal orifice polyps with endoscopic mucosal resection and endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 386-396页

作者： Ankur P Patel Mai A Khalaf Margarita Riojas-Barrett tara keihanian Mohamed O Othman Department of Internal Medicine Baylor College of MedicineHoustonTX 77030United States Department of Tropical Medicine Tanta UniversityTanta 31527Egypt Department of Gastroenterology Baylor College of MedicineHoustonTX 77030United States

BACKGROUND Large appendiceal orifice polyps are traditionally treated ***,endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been utilized as alternative resection *** To evaluate the efficacy and safety of endoscopic resection techniques for the management of large appendiceal orifice *** This was a retrospective observational study conducted to assess the feasibility and safety of EMR and ESD for large appendiceal orifice *** project was approved by the Baylor College of Medicine Institutional Review *** who underwent endoscopic resection of appendiceal orifice polyps≥1 cm from 2015 to 2022 at a tertiary referral endoscopy center in the United States were *** main outcomes of this study included en bloc resection,R0 resection,post resection adverse events,and polyp *** A total of 19 patients were *** patients were female(53%)and Caucasian(95%).The mean age was 63.3±10.8 years,and the average body mass index was 28.8±*** mean polyp size was 25.5±14.2 mm.74%of polyps were localized to the appendix(at or inside the appendiceal orifice)and the remaining extended into the cecum.68%of polyps occupied≥50%of the appendiceal orifice *** mean procedure duration was 61.6±37.9 *** were resected via endoscopic mucosal resection,endoscopic submucosal dissection,and hybrid procedures in 5,6,and 8 patients,*** pathology was remarkable for tubular adenoma(n=10)[one with high grade dysplasia],sessile serrated adenoma(n=7),and tubulovillous adenoma(n=2)[two with high grade dysplasia].En bloc resection was achieved in 84%with an 88%R0 resection *** the large polyp sizes and challenging procedures,89%(n=17)of patients were discharged on the same day as their *** patients were admitted for post-procedure observation for conservative pain *** patients underwent repeat colonoscopy without evide

关键词： Appendiceal orifice polyps Endoscopic mucosal resection Endoscopic submucosal dissection Polyp resection Adenomatous polyps En bloc resection

Efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19:A randomized placebo-controlled trial

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Asian Journal of Urology 2024年第1期11卷 128-133页

作者： Iman Shamohammadi Seyedmohammad Kazemeyni Mohammadali Sadighi tara Hasanzadeh Alireza Dizavi Department of Urology Nemazee HospitalShiraz University of Medical ScienceShirazIran Department of Urology Shariati HospitalTehran University of Medical ScienceTehranIran

Objective: According to the high prevalence of COVID-19 and the subsequent risk of men's sexual health, we decided to investigate the efficacy of tadalafil on improvement of men with erectile dysfunction caused by ***: In this study, 70 outpatients who were recovered from COVID-19 without acute respiratory distress syndrome with negative polymerase chain reaction test and a complaint of erectile dysfunction were divided into two groups: 35 patients who received tadalafil 5 mg daily and 35 who received placebo. For each patient, basic assessment of sexual function was performed using the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Then, treatment was started from 2 months after complete recovery of COVID-19 with negative polymerase chain reaction test for 3 months. At the end of the treatments, the patients were re-evaluated for sexual function using the complete version of IIEF questionnaire. Finally, the results before and after treatment in the intervention group were compared with those of the control ***: Treatment with both tadalafil and placebo improved the patients' sexual function criteria compared to the baseline. However, this improvement was significantly higher in the intervention group with tadalafil than the control group with placebo (p<0.05).Conclusion: Daily administration of tadalafil 5 mg seems to be effective and safe for improvement of erectile dysfunction caused by COVID-19.

关键词： Tadalafil Erectile dysfunction COVID-19 Sexual function

Inferring the Effects of Protein Variants on Protein-Protein Interactions with Interpretable Transformer Representations

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Research 2024年第2期2023卷 473-489页

作者： Zhe Liu Wei Qian Wenxiang Cai Weichen Song Weidi Wang Dhruba tara Maharjan Wenhong Cheng Jue Chen Han Wang Dong Xu Guan Ning Lin Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina School of Information Science and Technology Institute of Computational BiologyNortheast Normal UniversityChangchunChina Department of Electrical Engineering and Computer Science University of MissouriColumbiaMO 65211USA Christopher S.Bond Life Sciences Center University of MissouriColumbiaMO 65211USA

Identifying pathogenetic variants and inferring their impact on protein-protein interactions sheds light on their functional consequences on *** by the availability of experimental data on the consequences of protein interaction,most existing methods focus on building models to predict changes in protein binding ***,we introduced MIPPI,an end-to-end,interpretable transformer-based deep learning model that learns features directly from sequences by leveraging the interaction data from *** was specifically trained to determine the types of variant impact(increasing,decreasing,disrupting,and no effect)on protein-protein *** demonstrate the accuracy of MIPPI and provide interpretation through the analysis of learned attention weights,which exhibit correlations with the amino acids interacting with the ***,we showed the practicality of MIPPI in prioritizing de novo mutations associated with complex neurodevelopmental disorders and the potential to determine the pathogenic and driving ***,we experimentally validated the functional impact of several variants identified in patients with such ***,MIPPI emerges as a versatile,robust,and interpretable model,capable of effectively predicting mutation impacts on protein-protein interactions and facilitating the discovery of clinically actionable variants.

关键词： consequences weights versatile

Ten misconceptions regarding decision-making in critical care

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World Journal of Critical Care Medicine 2024年第2期13卷 72-82页

作者： tara Ramaswamy Jamie L Sparling Marvin G Chang Edward A Bittner Department of Anesthesiology Perioperative and Pain MedicineStanford University School of MedicineStanfordCA 94305United States Department of Anesthesia Critical Care and Pain MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States

Diagnostic errors are prevalent in critical care practice and are associated with patient harm and costs for providers and the healthcare *** complexity,illness severity,and the urgency in initiating proper treatment all contribute to decision-making ***-related factors such as fatigue,cognitive overload,and inexperience further interfere with effective *** science has provided insight into the clinical decision-making process that can be used to reduce *** evidence-based review discusses ten common misconceptions regarding critical care *** understanding how practitioners make clinical decisions and examining how errors occur,strategies may be developed and implemented to decrease errors in Decision-making and improve patient outcomes.

关键词： Clinical reasoning Cognitive bias Critical care Debiasing strategies decision making Diagnostic reasoning Diagnostic error Heuristics Medical knowledge Patient safety

Detection of Bisphenol A (BPA) in Plastic Bottles Using Vertical Cultivation at Various Temperatures

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Journal of Environmental Protection 2024年第6期15卷 656-671页

作者： Karwan Alkaradaghi tara Ali Nadhir Al-Ansari Polla Khanaqa Jan Laue Department of Civil Environmental and Natural Resources Engineering Lulea University of Technology Lulea Sweden Kurdistan Institution for Strategic Studies and Scientific Research Sulaimaniyah Iraq

Polycarbonate plastics containing bisphenol A (BPA) used to manufacture drinking water bottles. Kurdistan region in northern Iraq is a developed area with increased pollution from plastic bottles. Trace amounts of BPA have been detected in bottled water samples. The absorption of BPA was measured with HPLC using a vertical cultivation system with Bulbs of the Allium Cepa plant planted in these plastic bottles with monitored growth. Vertical cultivation was found to have a low level of BPA in the plant cells, making it a safe cultivation method under specific climate conditions. The mean concentration of BPA in vertical cultivation is 0.19 ug/ml (3.8 ng for a 20 uL injection), and the Limit of Quantification (LOQ) is 0.63 ug/ml (12.7 ng for 20 uL injection). While Scanning Electron Microscope (SEM) shows that the concentrations are relatively low in water samples stored at room temperature compared to those exposed to direct sunlight (40°C) and water bottle samples stored at (-4°C), The correlation coefficients were found to be good (0.9992). SEM is used for plastic bottle samples stored at different temperatures. The images identify compound decay and explore the morphology of BPA in manufactured plastic materials.

关键词： Vertical Cultivation Allium Bisphenol A Plastic Bottles Scanning Electron Microscope (SEM)

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个人护理湿巾持续强劲增长

生活用纸 2024年第5期24卷 24-28页

作者： tara Olivo 不详

消费者对于既简单又高效便捷的皮肤清洁或护理方式的追求,持续推动个人护理湿巾品类保持积极的增长态势。现在,消费者几乎可以在生活中的任何方面享受到湿巾带来的便利——无论是卸妆、涂抹防晒霜,还是清洁腋下及身体的其他部位。此外,... 详细信息

消费者对于既简单又高效便捷的皮肤清洁或护理方式的追求,持续推动个人护理湿巾品类保持积极的增长态势。现在,消费者几乎可以在生活中的任何方面享受到湿巾带来的便利——无论是卸妆、涂抹防晒霜,还是清洁腋下及身体的其他部位。此外,湿巾生产商对这一市场的前景一直保持乐观态度,尤其是湿厕纸这一个人护理湿巾细分品类的增长势头更加明显。

关键词：个人护理湿巾防晒霜乐观态度护理方式增长态势皮肤清洁高效便捷

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天然材料卫生用品市场持续增长

生活用纸 2024年第1期24卷 38-41页

作者： tara Olivo 不详

各大品牌不断推出含植物成分的材料制成的婴儿纸尿裤、经期护理用品和轻度失禁用品。由于消费者对天然成分的偏好及环保意识的提高,吸收性卫生用品中使用植物纤维和生物基成分的趋势不断扩大。同时,全球反塑料立法旨在限制石油基塑料的... 详细信息

各大品牌不断推出含植物成分的材料制成的婴儿纸尿裤、经期护理用品和轻度失禁用品。由于消费者对天然成分的偏好及环保意识的提高,吸收性卫生用品中使用植物纤维和生物基成分的趋势不断扩大。同时,全球反塑料立法旨在限制石油基塑料的使用。

关键词：天然材料持续增长婴儿纸尿裤天然成分植物成分石油基环保意识生物基

卫生用品原材料供应商:为产品的可持续性发挥效力

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生活用纸 2024年第1期24卷 44-47页

作者： tara Olivo 不详

薄膜供应商:能源及成本管控,最大化实现可持续性近年来,卫生用品原材料供应商专注于可持续性和性能与成本之间的平衡。在吸收性卫生用品中增加生物基或植物基材料含量的趋势有增无减,Kudos、Dyper和Sparkle等卫生用品品牌已将业务重点... 详细信息

薄膜供应商:能源及成本管控,最大化实现可持续性近年来,卫生用品原材料供应商专注于可持续性和性能与成本之间的平衡。在吸收性卫生用品中增加生物基或植物基材料含量的趋势有增无减,Kudos、Dyper和Sparkle等卫生用品品牌已将业务重点放在降低卫生用品中石化材料成分的占比上。随着消费者越来越渴望获得更健康、更具可持续性和使用植物基材的吸收性卫生用品,原材料供应商面临的挑战是以具有成本效益的方式开发此类产品,同时保证它们的性能与传统产品一样好。

关键词：成本管控卫生用品成本效益原材料供应商材料成分可持续性植物基生物基

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湿巾帮助宠物保持洁净健康

生活用纸 2024年第2期24卷 33-35页

作者： tara Olivo 周杨(终审) 不详

宠物行业是一个庞大的产业。据美国宠物产品协会报道,2021年美国人在宠物用品上的支出为1,236亿美元,高于2020年的1,036亿美元。根据该协会2021—2022年全美宠物主人调查,美国有宠物的家庭占70%,高于2019—2020年调查的67%。实际上,14%... 详细信息

宠物行业是一个庞大的产业。据美国宠物产品协会报道,2021年美国人在宠物用品上的支出为1,236亿美元,高于2020年的1,036亿美元。根据该协会2021—2022年全美宠物主人调查,美国有宠物的家庭占70%,高于2019—2020年调查的67%。实际上,14%的受访者(宠物主人和非宠物主人)在疫情期间养了新的宠物,至少1/4的新宠物主人表示,他们是受到疫情的影响才领养了新宠物。调查还显示,消费者用在宠物身上的支出增加,35%的宠物主人表示,他们在过去12个月里在宠物(包括食品、健康相关产品和其他宠物护理用品)上的支出比前一年增加了。湿巾等非织造布产品在宠物用品中的份额正在增长。

关键词：非织造布产品宠物用品护理用品湿巾宠物主人宠物行业