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Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster

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Journal of Genetics and Genomics 2017年第10期44卷 493-501页

作者： Dwayne J.Byrne Mark J.Harmon Jeremy C.Simpson Craig Blackstone Niamh C. o'Sullivan UCD School of Biomolecular and Biomedical Science UCD Conway Institute University College Dublin Dublin 4 Ireland UCD School of Biology and Environmental Science UCD Conway Institute of Biomolecular and Biomedical Research University College Dublin Dublin 4Ireland Cell Biology Section Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD 20892 USA

The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for *** in VCP are associated with two neurodegenerative diseases,amyotrophic lateral sclerosis（ALS） and inclusion body myopathy with Paget＇s disease of the bone and frontotemporal dementia（IBMPFD）,and extensive study has revealed crucial functions of VCP within *** contrast,little is known about the functions of Npl4 or Ufd1 in *** neuronalspecific knockdown of Npl4 or Ufd1 in Drosophila melanogaster,we infer that Npl4 contributes to microtubule organization within developing motor ***,Npl4 RNAi flies present with neurodegenerative phenotypes including progressive locomotor deficits,reduced lifespan and increased accumulation of tar DNA-binding protein-43 homolog（TBPH）.knockdown,but not overexpression,of TBPH also exacerbates Npl4 RNAi-associated adult-onset neurodegenerative *** contrast,we find that neuronal knockdown of Ufd1 has little effect on neuromuscular junction（NMJ） organization,TBPH accumulation or adult *** findings suggest the differing neuronal functions of Npl4 and Ufd1 in vivo.

关键词： Proteasome TDP-43 accumulation Neurodegeneration Drosophila

Nonlinearity in Stock Exchange Markets: The Case of Bist 100 Indices

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Chinese Business Review 2021年第1期20卷 15-21页

作者： Jamilu said Babangida Department of Economics Ahmadu Bello UniversityNigeria Department of International Finance Istanbul Commerce UniversityTurkey Department of Economics Ibn Haldun UniversityTurkey

In this paper,using data for the Bist 100 index,we investigate the presence of nonlinearities by employing several nonlinearity *** Brock,Dechert,and Scheinkman(BDS)and runs tests were first applied to the series to show an initial indication of *** findings for the BDS and runs test of randomness were followed by other sets of direct nonlinearity tests developed by White(1989),Terasvirta(1993),keenan(1985),and Tsay(1986).Also,the Threshold Autoregression(tar)test is employed as a final test to confirm the existence of nonlinearity in the Turkish stock exchange *** the results of the nonlinearity test,it is concluded that the Bist 100 index is characterised by the presence of nonlinearities and *** finding is in contrast with the efficient market hypothesis(EMH)implying that the Turkish stock exchange market is inefficient.

关键词： stock market nonlinearity efficient market hypothesis Bist 100 index

Multiple floating metatarsals： a unique injury

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Chinese Journal of Traumatology 2013年第2期16卷 110-112页

作者： Vivek Trikha tarun Goyal Amit k. Agarwal Department of orthopaedics Jai Prakash Narayan Apex Trauma Centre All India Institute of Medical Sciences New Delhi 110029 India

tarsometatarsal 的伴随物脱臼和脚的 metatarsophalangeal 关节是极其稀罕的损害。在一个单身者或邻近的双光线介绍的如此的损害以前在很少情况中被描述了。我们描述如此的损害在邻近一个 polytrauma 病人的三 metatarsals。这些损害... 详细信息

tarsometatarsal 的伴随物脱臼和脚的 metatarsophalangeal 关节是极其稀罕的损害。在一个单身者或邻近的双光线介绍的如此的损害以前在很少情况中被描述了。我们描述如此的损害在邻近一个 polytrauma 病人的三 metatarsals。这些损害是可能的在对一个 polytrauma 病人的起始的评价被错过。这些病人在俯看的诊断的风险，但是错过这类损害的后果可能是相当严重的。鉴于它的唯一，这个盒子与损害的可能的机制一起被介绍，减小和后续的顺序。

关键词：受伤浮动可能机制伤害患者

梅子苦味寡肽及氨基酸之萃取、分离与鉴定(英文)

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北京林业大学学报 1999年第2期21卷 61-71页

作者：方祖达黄仁皇台湾大学园艺学研究所

先将梅子破碎、冷冻干燥后，以溶剂萃取肽，再将之浓缩，将萃取液经凝胶过滤分离肽后，以高效液相层析仪将各组分进一步分离得肽．由凝胶过滤分离出之肽，以官能品评找出具有苦味之部分，结果显示３个梅子品种在第１９～２８试管中具有... 详细信息

先将梅子破碎、冷冻干燥后，以溶剂萃取肽，再将之浓缩，将萃取液经凝胶过滤分离肽后，以高效液相层析仪将各组分进一步分离得肽．由凝胶过滤分离出之肽，以官能品评找出具有苦味之部分，结果显示３个梅子品种在第１９～２８试管中具有苦味；经以高效液相层析仪分析，结果其肽含量与苦味之强弱呈正相关．由杏仁苷阈值试验得知梅子中所含有之杏仁苷尚未达到苦味阈值之要求。

关键词：梅氨基酸寡肽苦味物质

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膨胀石墨基镍/炭复合物(英文)

新型炭材料 2011年第5期26卷 335-340页

作者： I.M.Afanasov o.I.Lebedev B.A.kolozhvary A.V.Smirnov G.Van Tendeloo Chemistry Department Moscow State University119991 MoscowRussia Laboratoire CRISMAT UMR 6508 CNRS/ENSICAEN6 bd du Maréchal Juin F-14050 CAEN Cedex 4France EMAT University of AntwerpGroenenborgerlaan 171B-2020AntwerpBelgium

Nio粒子修饰的压缩膨胀石墨(EGNio)浸以煤焦油沥青,经550℃裂解,继而800℃水蒸气活化,制得Ni/C复合物块体。应用TEM考察了复合物中含Ni纳米粒的微结构排列方式。以N2吸附测定分析了复合物的比表面积和孔隙度。以2,2,3—三甲基戊烷脱氢... 详细信息

Nio粒子修饰的压缩膨胀石墨(EGNio)浸以煤焦油沥青,经550℃裂解,继而800℃水蒸气活化,制得Ni/C复合物块体。应用TEM考察了复合物中含Ni纳米粒的微结构排列方式。以N2吸附测定分析了复合物的比表面积和孔隙度。以2,2,3—三甲基戊烷脱氢裂解模型反应评估了复合物的催化活性并与EGNio常规H2处理获得的参照物的活性做了比较。

关键词：膨胀石墨镍/炭复合物微结构催化活性

Evolution in the formation of graphene nanocapsules from coal tar pitch

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International Journal of Coal Science & Technology 2020年第4期7卷 816-824页

作者： D.M.Puente-Siller A.E.Garcia-Castillo J.A.Lopez-Corpus A.Perea-Garduno Department of Research and Development Altos Hornos de MexicoS.A.B.de C.V.Prolongacion JuarezS/NLa Loma.25770 Monclova.CoahuilaMexico

It has recently been reported that coal tar pitch(CTP)can be utilised as raw material for the production of graphene nanocapsules(GNCs)because it is formed by a great quantity of aromatic organic compounds(which promote the rearrangement of double bonds by a process of polymerisation).Due to the importance of graphene and the search for a non-expensive methodology to produce it,this work used CTP to synthesise GNCs using an in situ activation technique at low temperatures and evaluating the effect of the working temperature on the formation of such *** other words,analysing the form of the particle as the temperature rises from 600 to 900℃.As result of the experimentation,powders were obtained and analysed by the techniques of X-Ray Diffraction,Raman Spectroscopy and Microscopy,employing Field Fmission Scanning Electron Microscopy by normal mode as well as by Scanning Transmission Electron Microscopy and a High-Resolution Scanning Electron *** results show that working with temperatures between 800 and 850℃promotes the production of GNCs,considering that their size reduces as the working temperature rises.

关键词： Synthesis Nanocapsule Graphene tar Agglomeration

Lowering Gasifier tars and Particulates Using Heated Dololmite Catalyst and a Particulate Filter

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Smart Grid and Renewable Energy 2012年第1期3卷 56-61页

作者： Christopher o. Akudo Beatrice G. Terigar Chandra S. Theegala Department of Biological and Agricultural Engineering Louisiana State University Baton Rouge USA.

For this study, a fixed-bed, down-draft gasifier was designed to investigate the effect of a dolomite catalytic bedon tar removal. Pine pellets and wood chips (cypress) were used to produce syngas from the down-draft gasifier. For the gas conditioning, a combination of a heated dolomite (bed temperature at 850?C for catalytic cracking of tars) and a particulate filter (for particulate removal) was used. Investigation of temperature effects on dolomite activity between 650?C and 950 C bed temperatures, showed optimum catalytic efficiency at approximately 850?C. At the optimum conditions, gravimetric tar and particulate concentrations in syngas produced from pine pellets were 0.85 g/Nm3 (±0.16) and 4.75 g/Nm3 (±0.07), respectively before gas conditioning, and 0.09 g/Nm3 (±0.02) and 2.01 g/Nm3 (±0.13), respectively after gas conditioning. Syngas from wood chips contained 1.63 g/Nm3 (±0.45) and 3.84 g/Nm3 (±1.16) of tars and particulates, respectively before gas cleaning and 0.19 g/Nm3 (±0.02) and 2.27 g/Nm3 (±0.27) tars and particulates, respectively after gas conditioning. The combustible portion of the gas constituted carbon monoxide (12% - 14%), hydrogen (11% - 12%), and methane (~2%). These results suggest that syngas produced from gasification of pine pellets and wood chips in a down-draft biomass gasifier can be effectively cleaned using a heated catalyst bed and a particulate filter. However, the benefits of gas conditioning will be offset by the need to maintain a heated catalyst bed for tar cracking.

关键词： Gasification Dolomite tars Particulates Syngas

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淋洗层析法测定聚苯乙烯的分子量分布

吉林大学自然科学学报 1963年第3期 163-171页

作者：吴忠文沈家骢万景太高志武吉林大学1963年化学系吉林大学1963年化学系应届毕业生

1956年 *** 等提出了测定高聚物分子量分布的淋洗层析法,之后就得到了广泛的重视和应用。应用到聚苯乙烯的分级的研究工作,到目前为止,已发表了十几篇论文。在这些工作中,还没有看到为保证可靠实验结果的系统的实验条件的研究,对窄分布... 详细信息

1956年 *** 等提出了测定高聚物分子量分布的淋洗层析法,之后就得到了广泛的重视和应用。应用到聚苯乙烯的分级的研究工作,到目前为止,已发表了十几篇论文。在这些工作中,还没有看到为保证可靠实验结果的系统的实验条件的研究,对窄分布样品的分级亦做得很少。我们在前人工作基础上,作了一些条件试验,对不同分布宽度的样品进行了分级,并且讨论了数据处理的方法。

关键词：聚苯乙烯人元聚合塑料分子量分布溶剂层析法

Selecting an Appropriate Type of Basement in Regions with Complicated Permafrost Conditions(an example for north of Western Siberia)

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Selecting an Appropriate Type of Basement in Regions with Co...