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Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer:A review

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Chronic Diseases and Translational Medicine 2018年第3期4卷 156-163页

作者： meri R.Raiha Pauli A.Puolakkainen Department of Surgery Helsinki University Hospital and University of HelsinkiHelsinki 00014Finland

Gastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown to play a role in carcinogenesis. Consequently, macrophages are important in phagocytosis, antigen presenting and producing cytokines and growth factors. As a response to microenvironmental signals, they may polarize into tumor resisting M1 or tumor promoting M2 macrophages. Recently, studies have indicated that M2-type macrophage resembling tumor-associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use in clinical environment.

关键词： Gastric cancer Tumor-associated macrophages Biomarkers Prognosis Diagnosis

Influence of coating on the triamcinolone release of alginate chitosan beads for colonic drug delivery

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Natural Science 2011年第11期3卷 955-962页

作者： Nadir Veiga Vier Ruth meri Lucinda-Silva 不详

The aim of this study was to evaluate the effect of coating of alginate-chitosan (AL:CS) beads on the colonic drug delivery. The AL:CS systems containing triamcinolone (TC) were coated with the HPMCP and Eudragit? L100 by immersion and by spraying methods. The drug release profile in simulated colonic medium was determined using 5% human fecal content suspension in 0.01 N buffer solution, pH 6.8. The systems coated with HPMCP showed a lower rate of drug delivery in simulated enteric medium. The delivery profile in simulated colonic medium followed zero-order kinetic. The coated systems provided a promising drug-delivery profile for application in colonic drug delivery.

关键词： Alginate Beads Chitosan Colon-Specific Drug Delivery Triamcinolone

Evaluation of Weather Research and Forecasting Model Parameterizations under Sea-Breeze Conditions in a North Sea Coastal Environment

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Journal of Meteorological Research 2016年第6期30卷 998-1018页

作者： SALVADOR Nadir REIS Jr. Neyval Costa SANTOS Jane meri ALBUQUERQUE Taciana Toledo de Almeida LORIATO Ayres Geraldo DELBARRE Herve AUGUSTIN Patrick SOKOLOV Anton MOREIRA Davidson Martins Federal University of Espirito Santo Vitoria Espirito Santo Brazil Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil Universite Lille Nord de France Lille France Integrated Center for Manufacturing and Technology Salvador Bahia Brazil

Three atmospheric boundary layer （ABL） schemes and two land surface models that are used in the Weather Research and Forecasting （WRF） model, version 3.4.1, were evaluated with numerical simulations by using data from the north coast of France （Dunkerque）. The ABL schemes YSU （Yonsei University）, ACM2 （Asymmetric Convective Model version 2）, and MYJ （Mellor-Yamada-Janjic） were combined with two land surface models, Noah and RUC （Rapid Update Cycle）, in order to determine the performances under sea-breeze conditions. Particular attention is given in the determination of the thermal internal boundary layer （TIBL）, which is very important in air pollution scenarios. The other physics parameterizations used in the model were consistent for all simulations. The predictions of the sea-breeze dynamics output from the WRF model were compared with observations taken from sonic detection and ranging, light detection and ranging systems and a meteorological surface station to verify that the model had reasonable accuracy in predicting the behavior of local circulations. The temporal comparisons of the vertical and horizontal wind speeds and wind directions predicted by the WRF model showed that all runs detected the passage of the sea-breeze front. However, except for the combination of MYJ and Noah, all runs had a time delay compared with the frontal passage measured by the instruments. The proposed study shows that the synoptic wind attenuated the intensity and penetration of the sea breeze. This provided changes in the vertical mixing in a short period of time and on soil temperature that could not be detected by the WRF model simulations with the computational grid used. Additionally, among the tested schemes, the combination of the local- closure MYJ scheme with the land surface Noah scheme was able to produce the most accurate ABL height compared with observations, and it was also able to capture the TIBL.

关键词： sea-breeze detection WRF model parameterizations

10-YUAN CHALLENGE Surviving in Beijing on Less Than US $2 a Day

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Women of China 2011年第12期 62-63页

作者： meri E. G. JOSWlAK 周马（美国） United States

你有没有试过像别人那样生活？或者说，像上百万人那样生活？现在北京约有两千万人口。北京市统计局的数据显示，工薪阶层的月平均工资是4200元。而2011年8月新华社的报道称，北京的月平均房租是3250元。如果没人分担房租，北京人的人... 详细信息

你有没有试过像别人那样生活？或者说，像上百万人那样生活？现在北京约有两千万人口。北京市统计局的数据显示，工薪阶层的月平均工资是4200元。而2011年8月新华社的报道称，北京的月平均房租是3250元。如果没人分担房租，北京人的人均可支配收入恐怕会所剩无几。在大城市里—个人生活不仅需要预算，也需要一点创造力。《中国妇女》英文月刊的记者亲身实践了每天花10元过一周的生活。

关键词：北京工薪阶层工资生活

The Natural Remarkable Monuments Create by Geodinamical Processes （Basin Rioni, Georgia）

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Journal of Geological Resource and Engineering 2017年第1期5卷 48-52页

作者： Giorgi Dvalashvili Liana Khandolishvili Salome Tabatadze meri Gugeshashvili Exact and natural sciences faculty 1vane Javakhishvili Tbilisi State University Georgia Vakhushti Bagrationi Institute of Geography 1vane Javakhishvili Tbilisi State University Georgia

This interest, first of all, was a result of Georgia＇s unique natural conditions with its mountainous sights or the sea, diverse herbs, animals, different traditions from people living in different comers of the country, agriculture and historical-architectural monuments. By the final stage of the Soviet Union Georgia had a well-developed tourist-resort infrastructure; there were tens of particularly important resorts centers and several hundreds of tourist headquarters. Hundreds of thousands of astonished foreigners or soviet tourists used to visit country every year. They had an opportunity to enjoy pleasantness of each natural area from subtropics of the Black Sea to glaciers of the Caucasus, from Kolkheti Valley to Alazani Valley, Darially Valley to Vardzia--all the tourist routes were filled of natural sights or historical monuments. In 2015 the faculty of Natural Sciences of Ivane Javakhishvili State University conducted a research--Research and Popularization of Natural Monuments of Endogenous Origin in River Rioni Basin EN/15/2015. During research it was revealed very interesting and unique naturally remarkable places, which have a great potential of consumption allowing regions to develop tourist potential. Within frames of the project it was possible to search unique forms of relief, visit and evaluate on spot; in case of necessity include specialists for conducting further ground researches. Recommendations were made to grant status of natural monument to these forms. Meetings were held with the local population in order to notify them importance of the objects within their region and reveal new and unknown places which can be studied in the future.

关键词： Caves waterfalls canyons colunms lakes vaucluse.

Liver Xeno-Repopulation with Human Hepatocytes in Fah-/-Rag2-/- Mice after Pharmacological Immunosuppression

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Liver Xeno-Repopulation with Human Hepatocytes in Fah-/-Rag2...

Peculiarities of Radiation Effects in MgO:Mn<sup>2+</sup>Crystals

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Kirk J.Wangensteen Stephen C.Ekker meri Firpo Department of Genetics Cell Biology and Development Stem Cell Institute University of Minnesota55455MinnesotaUSA

Functional human hepatocytes xeno-engrafted in mouse liver can be used as a model system to study hepatitis virus infection and vaccine *** liver xeno-repopulation has been reported in two kinds of genetically modified mice that have both immune deficiency and liver injury-induced donor hepatocyte selection:the uPA/SCID mice and Fah Rag2Il2rg *** lack of hardy breeding and the overly elaborated technique in these two models may hinder the potential future application of these models to hepatitis virus infection and vaccination *** the transplantation protocol for liver xeno-repopulation from human hepatocytes will increase the model efficiency and *** this study,we successfully apply immunosuppressive drug treatments of anti-asialo GM1 and FK506 in FahRag2’ mice,resulting in significant liver xeno-repopulation from human hepatocytes and human fetal liver *** methodology decreases the risk of animal mortality during breeding and *** infected with hepatitis B virus(HBV) sera,FahRag2 mice with liver xeno-repopulation from human hepatocytes accumulate significant levels of HBV DNA and HBV *** new protocol for humanized liver could be applied in the study of human hepatitis virus infection in vivo,as well as the pharmacokinetics and efficacy of potential vaccines.

关键词： Fah-/-Rag2-/- mice humanized liver pharmacological immunosuppression human hepatocyte transplantation human fetal liver cells

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Journal of Modern Physics 2011年第8期2卷 841-844页

作者： meri Abramishvili Zaira Akhvlediani Makvala Galustashvili Guram Dekanozishvili Tamaz Kalabegishvili Vakhtang Kvatchadze Valery Tavkhelidze 不详

The thermally stimulated luminescence and IR absorption spectra of MgO:Mn2+ crystals irradiated in different reactors have been studied. It has been shown that dependence of TSL peaks (450 and 550 K) and optical absorption bands (3290, 3720 and 1600 cm-1) on neutron fluence correlate. The trend of these changes in the same fluence range (1014-1017 n/cm2) depends both on the initial state of the crystal and on the irradiation source, which may be explained by the “small dose effect”.

关键词： Magnesium Oxide Radiation defects Thermally Stimulated Luminescence IR spectra

Presence of disease specific autoantibodies against liver sinusoidal cells in primary biliary cirrhosis

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World Journal of Hepatology 2013年第10期5卷 568-576页

作者： Ourania Sfakianaki Maria Tzardi Argyro Voumvouraki Aikaterini Afgoustaki meri Koulentaki Elias Kouroumalis Liver Research Laboratory Medical School University of Crete Department of Pathology University Hospital of Heraklion Department of Gastroenterology University Hospital of Herak-lion

AIM: To investigate the presence of autoantibodies directed against liver sinusoidal cells in primary biliary cirrhosis(PBC).METHODS: Liver biopsies from 21 PBC patients were studied and compared with 12 liver biopsies from disease controls [3 patients with hepatitis B(HBV) virus,3 patients with hepatitis C virus(HCV), 3 patients with non-alcoholic steatohepatitis and 3 patients with acute alcoholic hepatitis(AAH)]. As healthy controls, we used tissue specimens adjacent to metastatic liver adenocarcinoma. Normal serum was taken from staff members of the unit. The determination of the cell type targetedby autoantibodies present in the patients sera was performed by indirect immunofluorescence(IIF) analysis using paraffin-embedded liver sections as a *** from homologous or heterologous PBC patients or sera from the disease control group were used as primary antibodies. The presence of autoantibodies was identified using confocal ***: In total, 18/21(85.7%) PBC patients exhibited positive staining in the sinusoidal cells, 10/21(47.6%) in lymphocytes, 8/21(38%) in cholangiocytes and 7/21(33.3%) in hepatocytes, when homologous serum and fluorescein isothiocyanate-conjugated immunoglobulin type G(IgG) secondary antibody were used. PBC sections incubated with heterologous PBC serum showed reduced staining(20% for sinusoidal cells, 20% for lymphocytes, 20% for cholangiocytes and 13.3% for hepatocytes). When IgM immunoglobulin, instead of IgG, was used as secondary antibody,positive staining was observed in 75% of lymphocytes,62.5% of cholangiocytes, 37.5% of hepatocytes and50% of the sinusoidal cells with a much stronger staining intensity. No staining was observed when either normal or PBC sera were used as a primary antibody on liver sections from the disease control group. When PBC sera were incubated with healthy control sections,weak positive staining of cholangiocytes was observed in 3/21(14.3%) PBC serum samples. Steatohepatitis serum on PBC

关键词： Primary biliary cirrhosis Autoantibodies Sinusoidal cells Cholangiocytes Liver tissue

基于国际跨组织的知识转移与知识创造研究——以中法医学公私合作为例

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基于国际跨组织的知识转移与知识创造研究——以中法医学公私合作...