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A New Model Inspired by the Pompeii Worm to Reverse Overheating in Nanosatellites

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Space(Science & Technology) 2023年第1期3卷 133-140页

作者： Ayşe meriçYazıcı Erik Persson Department of Philosophy Lund UniversityLundSweden

Nanosatellites are exposed to extreme temperatures on the spacecraft surface,which can reach up to±100℃.In this paper,we suggest a novel solution to this challenge by the use of *** imitation of the behavior of living creatures in nature is an attempt to understand and synthesize a natural object or phenomenon in an abstract or concrete *** inspiration from living things in nature can come through the materials,processes,or designs we see around us,and there is no engineering effort *** nature,the best example of temperature reversal is the Pompeii *** Pompeii worm realizes the conversion of the excess heat it is exposed to into cooling inside a multilayered *** this work,inspired by the strategy of the Pompeii worm in reversing overheating,we present a new model for the overheating problem in nanosatellites.

关键词： form heating extreme

Do multiparous women need to work or exercise extra hard to control gestational diabetes?

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Journal of Sport and Health Science 2022年第5期11卷 550-551页

作者： Niina Matikainen Seppo meri Endocrinology Abdominal CenterHelsinki University Hospital and University of HelsinkiFIN-00029 HUSHelsinkiFinland Department of Bacteriology and Immunology and Translational Immunology Research program University of HelsinkiFIN-00014HelsinkiFinland HUS Diagnostic Center HUSLABHelsinki University HospitalFIN-00029 HUSHelsinkiFinland

In the current issue of the Journal of Sport and Health Science,Wang et al.^(1)describe their prospective study,where they analyzed whether or not multiple pregnancies would influence glycemia and the glycemic response to physical exercise in gestational diabetes mellitus(GDM).2 Multiparous women are known to be at a higher risk for GDM than *** carries an increased risk for adverse perinatal outcomes,not only for the mothers but also for the newborn *** to a contemporary environment that is conducive to a sedentary lifestyle and obesity,the incidence of GDM among pregnant women is increasing.

关键词： mother diabetes

Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients

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World Journal of Gastroenterology 2010年第39期16卷 4938-4943页

作者： Ourania Sfakianaki meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos Elias Castanas Elias A Kouroumalis Liver Research Laboratory Medical SchoolUniversity of Crete Department of Gastroenterology University Hospital of Heraklion Department of Pathology University Hospital of Heraklion Department of Biochemistry Medical SchoolUniversity of Crete Department of Experimental Endocrinology Medical SchoolUniversity of Crete Liver ResearchLaboratory Medical SchoolUniversity of Crete

AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)***:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent *** were correlated with clinical data,histology,and ***:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 *** ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative *** had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative *** positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ***:The presence of ANEA and anti-gp210 identifies a subgroup of PBC pati

关键词： Primary biliary cirrhosis Antimitochondrial antibodies Antinuclear antibodies Antibodies against nuclear envelope antigens Anti-gp210 antibodies

Litter decomposition in pure and mixed Quercus and Fagus stands as influenced by arthropods in Belgrad Forest,Turkey

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Journal of Forestry Research 2020年第4期31卷 1123-1137页

作者： meric Caklr Ender Makineci Department of Soil Science and Ecology Faculty of ForestryCanklrl Karatekin University18100 CanklrlTurkey Department of Soil Science and Ecology Faculty of ForestryIstanbul University-Cerrahpasa34473 Sariyer/IstanbulTurkey

Arthropod assemblages and decomposition rates were compared in the litter of pure and mixed Quercus(Quercus petraea L.)and Fagus(Fagus orientalis L.)*** was sampled on a monthly basis for 1 year and stored in litterbags of different mesh *** experimental objective was to test the effect of mesh size on litter decomposition,decomposition rates of litter,and diversity of the invertebrate fauna between the two types of *** rates were measured by filling three fiber litterbags of different mesh sizes with pure Quercus litter(3 g)left in the pure Quercus stand,and litterbags with Fagus litter(3 g)were left in the pure Fagus *** litter samples were prepared by mixing of equal amounts of each litter in the same litterbag and leaving them in the mixed *** residual mass of litter from the pure Quercus stand was significantly lower in fine-and coarse-mesh bags than in the medium-mesh bags in pure the Fagus *** and nitrogen levels in the pure Quercus litter were significantly different among the mesh sizes at the end of the incubation *** from 27 taxa were collected from pitfall traps every *** relative numbers differed significantly between the pure and mixed-stand litter ***-dwelling Isotomidae(Collembola)and Mesostigmata(Acarina),and soil-dwelling Mesostigmata were the most numerous in the mixed *** is significant that the abundance of macroarthropods contributed to the mass loss of litter in both the medium and coarse mesh sizes in the mixed stand,but did not significantly affect the mass of litter in the pure *** the mixed stand,there was a negative correlation between litter mass loss and total number of microarthropods in all mesh ***-stand litter decomposed more slowly than pure-stand litter.

关键词： Collembola(springtails) Mesh size Pitfall trap RDA Quercus Fagus litter decay

Photoneutron dose and flux determination of a typical LINAC by MCNP simulation

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Radiation Detection Technology and Methods 2021年第4期5卷 627-632页

作者： Aydin Ghalehasadi Eren Sahiner Saleh Ashrafi Sasan Geranmayeh Hadi kasani Niyazi meriç University of Tabriz TabrizIran Institute of Nuclear Sciences Ankara University06100 Be¸sevlerAnkaraTurkey

Purpose High-energy electron linear accelerators(LINACs)have a wide use in *** photoneutron production in medical linear accelerators,when operating at energies greater than 10 MeV,is an important subject to consider in patient’s treatment *** this work,we simulate a typical LINAC to calculate photoneutron dose and flux in radiotherapy *** The latest version of MCNPX Monte Carlo code along with MCNP visual editor has been used to simulate the LINAC and its *** production has been successfully simulated by selecting appropriate physics card and *** and flux of produced photoneutrons have been calculated by using mesh tally *** Production of photoneutrons in LINAC head and its components have been successfully simulated by using MCNPX *** visual editor has been used to track the *** dose and flux have been calculated using mesh tally function,with good results of statistical *** The photoneutron production has been successfully simulated and *** proposed simulation code is able to calculate photoneutron dose and *** to photoneutron production cross sections,the appropriate parameters have been selected to reduce the run-time of simulation code.

关键词： LINAC Photoneutron Dose Flux MCNPX code

Damage Curves Derived from Hurricane Ike in the West of Galveston Bay Based on Insurance Claims and Hydrodynamic Simulations

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International Journal of Disaster Risk Science 2023年第6期14卷 932-946页

作者： Chaoran Xu Benjamin T.Nelson-Mercer Jeremy D.Bricker meri Davlasheridze Ashley D.Ross Jianjun Jia State Key Laboratory of Estuarine and Coastal Research School of Marine SciencesEast China Normal UniversityShanghai 200241China Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109USA Department of Marine and Coastal Environmental Science Texas A&M University at GalvestonGalvestonTX 77553USA Faculty of Civil Engineering and Geosciences Delft University of Technology2628 CN DelftThe Netherlands

Hurricane Ike,which struck the United States in September 2008,was the ninth most expensive hurricane in terms of *** caused nearly USD 30 billion in damage after making landfall on the Bolivar Peninsula,*** used the Delft3dFM/SWAN hydrodynamic and spectral wave model to simulate the storm surge inundation around Galveston Bay during Hurricane *** curves were established through the relationship between eight hydrodynamic parameters(water depth,flow velocity,unit discharge,flow momentum flux,significant wave height,wave energy flux,total water depth(flow depth plus wave height),and total(flow plus wave)force)simulated by the model and National Flood Insurance Program(NFIP)insurance damage *** NFIP insurance database contains a large amount of building damage data,building stories,and elevation,as well as other information from the Ike *** found that the damage curves are sensitive to the model grid resolution,building elevation,and the number of *** also found that the resulting damage functions are steeper than those developed for residential structures in many other locations.

关键词： Delft3d-FM Flood risk Hurricane Ike Residential damage ratio SWAN Weibull function

Synergistic Effect of Halloyosite Nanotube and Nanocellulose on Thermal and Mechanical Properties of Poly(Ethylmethacrylate-co-Acrylonitrile)Bionanocomposites

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Journal of Renewable Materials 2020年第3期8卷 301-317页

作者： Karima Ben Hamou Amal Kadimi Remo merijs meri Sergei Gaidukov Hamid Kaddami Mustapha Raihane Mouhamed Lahcini Fouad Erchiqui Laboratory of Organometallic and Macromolecular Chemistry-Composites Materials Faculty of Sciences and Technology of MarrakechCadi Ayyad UniversityGuélizAv.A.El KhattabiMarrakechBP 618Morocco Engineering School University of Québec in Abitibi-Témiscamingue445 Boulevard de l'UniversitéRouyn-NorandaJ9X 5E4QuébecCanada Institute of Polymer Materials Riga Technical UniversityKaļķu iela 1Centra rajonsRīgaLV-1658Latvia

This work reports a comprehensive study on poly(Ethylmethacrylateco-Acrylonitrile)Poly(EMA-AN)nanocomposites reinforced with a hybrid mixture of nanoreiforcements based on nanocrystals of cellulose(NCC)(1 or 5%wt)and halloysite nanotubes(HNTs)(1 or 5%wt).The morphology,thermal and mechanical properties of these nanocomposites were *** dispersion of the nanofillers has been shown by scanning electron microscopy.A significant increase of the rubbery modulus and glass transition temperature were obtained upon filler addition,due to the reduction of mobility of the matrix macromolecular *** the other hand,compared with the neat Poly(EMAAN),the storage modulus of the nanocomposites increased by a factor 38 when adding 5 wt%NCC and by 17 for the same concentration of *** properties of ternary nanocomposites were furthers increased resulting from a synergistic effect of these two nanofillers.

关键词： Poly(Ethylmethacrylate-co-Acrylonitrile) nanocrystals cellulose halloysite nanotubes nanocomposites hybrid mechanical properties

Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

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World Journal of Gastroenterology 2016年第41期22卷 9104-9116页

作者： Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance meri K Tulic Faculty of Medicine and Dentistry School of Medicine and Pharmacology University of Western Australia Perth WA 6009 Australia Department of Immunology Fremantle Hospital Royal Brisbane and Women’s Hospital Perth WA 6160 Australia Royal Brisbane Queensland 4006 Australia University of Nice Sophia-Antipolis EA6302 06202 Nice France Department of Gastroenterology and Nutrition l’Archet Hospital 2 06202 Nice France School of Paediatrics and Child Health University of Western Australia Subiaco WA 6008 Australia International Inflammation network (in-FLAME) of the World Universities Network University of Western Australia Subiaco WA 6008 Australia Centre for Inflammatory Bowel Diseases St John of God Subiaco Hospital Perth WA 6009 Australia Mediterranean Center for Molecular Medicine (C3M)-INSERM U1065 Team 12 06204 Nice France

AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) *** Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC "responders"(n = 12) and "non-responders"(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with *** Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy

关键词： Ulcerative colitis Innate immunity Antitumor necrosis factor therapy Toll-like receptor IRAK4 Inflammatory bowel disease

Importance of ROS1 gene fusions in non-small cell lung cancer

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Cancer Drug Resistance 2023年第2期6卷 332-344页

作者： meri Muminovic Carlos Rodrigo Carracedo Uribe Andres Alvarez-Pinzon Khine Shan Luis E.Raez Department of Hematology-Oncology Memorial Cancer Institute/Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Department of Internal Medicine Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Office of Human Research Memorial Healthcare SystemPembroke PinesFL 33028USA

Targeted therapy has become one of the standards of care for advanced lung *** than 10 genetic aberrations have been discovered that are actionable and several tyrosine kinase inhibitors(TKIs)have been approved to target each of *** several genetic aberrations that are actionable in non-small cell lung cancer(NSCLC),ROS1 translocations also known as gene fusion proteins,are found in only 1%-2%of the patient ***1 mutations can usually be detected using a combination of techniques such as immunohistochemistry(IHC),Fluorescence in-situ testing(FISH),polymerase chain reaction(PCR),and nextgeneration sequencing(NGS).However,RNA NGS and ctDNA NGS(liquid biopsies)also contribute to the *** are currently numerous FDA-approved agents for these tumors,including crizotinib and entrectinib;however,there is in-vitro sensitivity data and clinical data documenting responses to ceritinib and *** responses and survival rates with these agents are frequently among the best compared to other TKIs with genetic aberrations;however,intrinsic or extrinsic mechanisms of resistance may develop,necessitating research for alternative treatment *** combat the mechanisms of resistance,novel agents such as repotrectenib,cabozantinib,talotrectinib,and others are being *** this article,we examine the literature pertaining to patients with ROS1 tumors,including epidemiology,clinical outcomes,resistance mechanisms,and treatment options.

关键词： ROS1 targeted therapy non-small cell lung cancer