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Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 186-198页

作者： Edgar Salas Pedro Sanchez Juan Postigo Carlos A.Castaneda Miluska castillo Valeria Villegas Luis Cano Sandro Casavilca Luis A.Bernabe Carolina Belmar Maria R.Villa-Robles Raul Mantilla Henry Guerra Head&Neck Surgery Department Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Research Department Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Medicine Universidad Peruana San Juan BautistaLima 15067Peru Pathology Department Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

Aim:Upper alveolar ridge and hard palate squamous cancer is an infrequent *** evaluated factors associated with neck involvement and with ***:Head and neck squamous-cell carcinoma(SCC)patients who went to Head and Neck Department between 1997 and 2011 were screened,and 73 resected upper alveolar ridge and 5 hard palate SCC were *** with available tissue were stained with p16 ***:Median age was 64.4 years,55.1%were female,and 73.1%were in clinical stage *** dissections were performed in 24 and pathologically confirmed node metastases were found in 19(24.3%).Cervical recurrence was found in 18 patients(23.1%)and was associated with histological grade(P=0.037).Three(7.3%)of 41 lesions were positive for p16 and tended to be younger(P=0.067).Lymphovascular invasion was associated with shorter disease-free survival(DFS)(P=0.026)and overall survival(OS)(P=0.021).Larger cT(P=0.019),perineural invasion(P=0.039)and neck dissection(P=0.010)were associated with shorter *** node involvement tended to have shorter DFS(31%vs.48.7%,P=0.278)and OS(25.1%vs.48.5%,P=0.340),and neck recurrence tended to have shorter OS(9.3%vs.52.3%,P=0.064).Conclusion:Neck involvement and recurrence are frequent in this location.P16-positive cases were present in 7.3%and tended to be associated with younger age.

关键词： P16 head neck maxilla prognosis survival

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Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas

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World Journal of Gastrointestinal Surgery 2014年第7期6卷 136-141页

作者： Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone Departments of Surgery Massachusetts General HospitalBoston MA 02114 United States Department of Surgery University of ArizonaTucson AZ 85724 United States Departments of Radiology Massachusetts General Hos-pitalBoston MA 02114 United States Department of Radiology University of Napoli80138 Napoli Italy Departments of Pathology Massachusetts General HospitalBoston MA 02114 United States Departments of Gastroenterology Massachu-setts General HospitalBoston MA 02114 United States

AIM: To identify their diagnostic and prognostic clinical characteristics in a large ***: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General ***: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the *** enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions ***: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided.

关键词： Lymphoepithelial cysts Cystic lymphangio-mas Pancreas Asymptomatic cysts Benign cystic le-sions of the pancreas

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与自身免疫性甲状腺炎相关的激素敏感性脑病

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 11-12页

作者： castillo P. Woodruff B. Caselli R. B. Boeve 郭俊 Mayo Clinic 200First St SW Rochester MN 55905 United States Dr.

Background: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), often termed Hashimoto encephalopathy, is a poorly understood and often misdiagnosed entity. Objective: To characterize the clinical, laboratory, and radiologic findings in patients with SREAT to potentially improve recognition of this treatable entity. Design: Retrospective analysis of clinical features and diagnostic test data. Setting: Two affiliated tertiary care referral institutions. Patients: Twenty consecutive (6 male) patients diagnosed as having SREAT from 1995 to 2003. Main Outcome Measures: Clinical features and ancillary test findings associated with SREAT. Results: The median age at disease onset was 56 years (range, 27-84 years). The most frequent clinical features were tremor in 16 (80%), transient aphasia in 16 (80%), myoclonus in 13 (65%), gait ataxia in 13 (65%), seizures in 12 (60%), and sleep abnormalities in 11 (55%). All patients were assigned an alternative misdiagnosis at presentation, most commonly viral encephalitis (n=5), Creutzfeldt-Jakob disease (n=3), or a degenerative dementia (n=4). The most frequent laboratory abnormalities were increased liver enzyme levels in 11, increased serum sensitive thyroid-stimulating hormone levels in 11, and increased erythrocyte sedimentation rate in 5. In only 5 patients (25%) did cerebrospinal fluid abnormalities suggest an inflammatory process. Magnetic resonance imaging abnormalities believed to be related to the encephalopathy were present in 5 patients (26%). Conclusions: The clinical, laboratory, and radiologic findings associated with SREAT are more varied than previously reported. Misdiagnosis at presentation is common. This treatable syndrome should be considered even if the serum sensitive thyroid-stimulating hormone level and erythrocyte sedimentation rate are normal, the cerebrospinal fluid profile does not suggest an inflammatory process, and neuroimaging results are normal. Until the pathophysiolo

关键词：自身免疫性甲状腺炎激素敏感性脑病克罗伊茨费尔特-雅各布病实验室检查异常甲状腺激素水平红细胞沉降率病理生理学机制影像学检查

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Electroencephalographic Abnormalities in Patients with Idiopathic Insomnia

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Neuroscience & Medicine 2011年第3期2卷 178-184页

作者： Debora Yoaly Arana Lechuga Oscar Sánchez Escandón Miguel Collado Corona Carlos castillo Montoya González Robles R. Anabel Jiménez Anguiano Oscar Prospero García Javier Velázquez Moctezuma 不详

Objective: The main goal of the present research is to describe the electroencephalographic activity during sleep and the cyclic alternating pattern (CAP) on idiopathic insomniac patients. Methods: 22 idiopathic insomnia patients were included. Sleep recording included: fully conventional EEG recording (32 electrodes, with 16 channels getting ipsilateral bipolar recordings), EOG, EMG, EKG, thoracic and abdominal respiratory movements, nasal flow and oximetry. Results: Out of the 22 registered patients, 10 (45%) showed no electroencephalographic alteration, while 12 (55%) exhibited an electroencephalographic alteration (irritative activity). Concerning PSG variables, significant differences between groups (no EEG alteration and EEG alterations) were detected in: sleep latency, total sleep time, total wake time, sleep efficiency, light sleep percentage, slow waves sleep percentage and on the sub type A1 index of the cyclic alternant pattern CAP. Conclusions: The present data strongly suggest that within the population diagnosed with idiopathic insomnia, there is a subgroup in which the electroencephalographic alterations may play a critical role as the source of the sleep abnormality.

关键词： Irritative Activity Idiopathic Insomnia Cyclic Alternating Pattern

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Fatty Acid Deposition on Broiler Meat in Chickens Supplemented with Tuna Oil

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Food and Nutrition Sciences 2013年第9期4卷 16-20页

作者： Jesus Eduardo Morales-Barrera Mariano Jesus Gonzalez-Alcorta Rosa Maria castillo-Dominguez Omar Francisco Prado-Rebolledo Xochitl Hernandez-Velasco Anita Menconi Guillermo Tellez Billy Marshal Hargis Silvia Carrillo-Dominguez Departamento de Producción Agrícola y Animal Universidad Autónoma Metropolitana México City México Department of Poultry Science University of Arkansas Fayetteville USA. Depto. Nutrición Animal Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán México City México Facultad de Medicina Veterinaria y Zootecnia Universidad de Colima Colima México Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México México City México Universidad Autónoma Chapingo Estado de México México

The aim of the present study was to evaluate the effect of feeding four levels of tuna oil on performance and fatty acid (FA) profiles of broiler chicken meat. 240 Ross broiler chickens were randomly assigned to 20 pens and divided into four treatments: 0%, 0.75%, 1%, and 1.25% of tuna oil. At 49 days, breast and legs-thighs muscles were processed for FA analysis. Concentrations of FA in legs and thighs meat were significantly higher when compared with breast meat. In both types of meats (breast and legs-thighs), the inclusion of 1.0% or 1.25% of tuna oil in the diet significantly increased (P < 0.05) the concentration of n-3 FA (especially docosahexaenoic and eicosapentaenoic acids). Fat in broiler breast contained a proportion of 29% saturated FA (SFA): 36% monosaturated FA (MFA): 35% polyunsaturated FA (PUFA);while legs and thighs meat had a proportion of 28% SFA: 38% MFA: 33% PUFA. The addition of tuna oil in the broiler diet significantly reduced the deposition of SFA, MFA, and PUFA in breast meat, while in legs and thighs these reductions were less noticeable. The significant reduction in the concentration of n-6 PUFA and the increment of n-3 PUFA were more evident in breast than in legs and thighs, and with the addition of 1% and 1.25% of tuna oil. The results of the present study suggest a difference in FA deposition attributable to supplementation with tuna oil. The addition of tuna oil could be recommendable to increase n-3 PUFA in both broiler chicken breast and legs-thighs meats, providing a healthier and functional chicken meat to consumer.

关键词： n-3 Fatty Acids Broilers Tuna Oil Breast Meat Legs and Thighs Meat

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Immersion Tools as a Strategy for Adolescents Mental Health: A Qualitative Study

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Health 2020年第7期12卷 866-875页

作者： Diana Cecilia tapia-Pancardo Juan Carlos Gutiérrez-Martínez Rodolfo Martínez-Mondragón Claudia Gabriela Rivera-Ramírez Cristina Piñón-Atilano Wendy de Jesús Hernández-Bravo Andrea Navarrete-Mejorada Viviana Sánchez-Gómez Rafael Villalobos-Molina División de Investigación y Posgrado Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Enfermería. Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Background: Information and communication technologies have revolutionized education, due to development of didactic strategies to take advantage of them for maximizing learning. The aim was to analyze the influence of immersion tools as a strategy to improve adolescents’ mental health. Methods: Qualitative research was employed, and participants’ experiences, opinions, values, behaviors, emotions, feelings were recorded. Twenty six students of both sexes, aged 13 to 15 years, from the three grades of secondary school were selected by convenience, and supported by the school’s psychologist. A workshop on emotional intelligence (EI) based on educational technology was implemented using a video;students practiced a reflexive process to understand themselves and their surroundings, creating a video + audio as a product of the workshop. In it, students analyzed several problems they face and their relationship with their contextual situation. Data collection was through semi-structured interviews before and after the workshop on EI. Data analysis was according to Souza Minayo, and the theoretical framework according to Goleman, tapia et al., Gorostieta et al., and Vigotsky. Results: Two categories emerged: Category I, EI as a risk factors transformer from living with addictions to protection factors in adolescents. Category II, EI development through immersion tools to improve mental health in adolescents. Conclusions: Immersion tools favor user to be closer, with a humanist focus where real necessities are studied after the vivid experience of the problem to solve or get a better situation. The goal is that students experience real situations inside controlled surroundings, in such a way that they learn from their experiences and acquire knowledge through self-learning. EI program through immersion tools favored to modulate feelings, and to get a bett

关键词： Mental Health Adolescence Immersion Tools

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Optical Evaluation of Vibrations in a Roof by the LPD Method

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Journal of Civil Engineering and Architecture 2024年第11期18卷 540-544页

作者： Aníbal Valera Guido castillo Kevin Mejía Facultad de Ciencias Universidad Nacional de IngenieríaAv.Tupac AmaruLima 15333Perú

In this work,we present the results of the optical evaluation of resonance vibrations in a conventional *** this occasion,we took advantage of having an ordinary booth near the laboratory,making it easier for us to conduct this *** roof in question has a square geometry and is apparently made of *** our usual LPD(laser photo deflection)procedure,of exciting the vibrations of the structure through sound and detecting the response optically,we obtain by resonance the first 6 roof’s Eigen oscillations,the same ones that are identified as Modes(1,1),(1,2),(2,2),(1,3),(2,3)and(3,3).The occurrence of these modes in this work is justified in a first approximation through the classical acoustic resonator theory.

关键词： Structural vibrations resonance sound excitation LPD

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视网膜中央静脉阻塞行放射状视神经切开术后的脉络膜视网膜吻合

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美国医学会眼科杂志（中文版） 2004年第3期16卷 184-185页

作者： JoseGarcEa-Arumt AnnaBoixadeera VicenteMartinez-castillo Reinaldocastillo AntonioDou BorjaCorcostegui 陆遥

目的：评价视网膜中央静脉阻塞患者行放射状视神经切开术后脉络膜视网膜吻合的几率，并证实其对视力和中心凹厚度的影响。

关键词：视网膜中央静脉阻塞切开术吻合脉络膜视神经术后放射中心凹患者视力

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Acetylsalicylic Acid Administered in Patients with Type 2 Diabetes Mellitus and Its Effect on the Antioxidant Enzyme System

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Journal of Diabetes Mellitus 2022年第4期12卷 252-262页

作者： Sara Pascoe-González Karina Celia Morgado-castillo Maria Guadalupe Ramos-Zavala Ernesto Germán Cardona-Muñoz Fernando Grover-Paez María Claudia Espinel-Bermúdez Sandra Ofelia Hernández-González Instituto de Terapéutica Experimental y Clínica (INTEC) Departamento de Fisiología Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara México Unidad de Investigación Biomédica 02 Unidad Médica de Alta Especialidad Hospital de Especialidades Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social Guadalajara México

Type 2 diabetes mellitus and its complications are associated with oxidative stress and the depletion of antioxidant defenses. The influence of acetylsalicylic acid on reversing the decrease in antioxidants, insulin resistance, glucose homeostasis, and inflammatory cascade can help prevent diabetes complications. Purpose: The aim of the study was to evaluate the effect of acetylsalicylic acid on the antioxidant enzymatic system in patients with diabetes. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 21 patients of both sexes with Type 2 diabetes for less than five years at the time of diagnosis, without pharmacological treatment, and randomly selected. Acetylsalicylic acid (300 mg) was administered orally for three months to the study group (n = 11) compared to the placebo control group (n = 10). Before and after the intervention, anthropometric and metabolic measurements were taken, fasting plasma glucose, glycated hemoglobin A1c, lipid profile panel, glutathione peroxidase, superoxide dismutase, catalase, and antioxidant capacity/activity were determined;values are presented as mean ± standard deviation. Intra- and intergroup differences were tested by Wilcoxon signed rank and Mann-Whitney U test, respectively;p-value ≤ 0.05 was considered statistically significant. Results: The acetylsalicylic acid group showed a decrease in weight (85.6 ± 19.3 vs. 84.1 ± 19.0 kg p = 0.01), cholesterol (205.9 ± 16.6 vs. 186.0 ± 23.2 mg/dL p = 0.02), and glycated hemoglobin A1c (7.8% ± 0.9% vs. 7.0% ± 0.7% p = 0.02). The placebo group exhibited reduction in weight (76.1 ± 14.9 vs. 74.9 ± 15.0 kg p = 0.04), glycated hemoglobin A1c (6.9% ± 0.6% vs. 6.2% ± 0.4% p = 0.004), and total antioxidant capacity (4.1 ± 0.5 vs. 4.8 ± 0.3 mmol/L p = 0.002). Conclusion: The administration of acetylsalicylic acid did not modify the antioxidant enzyme system.

关键词： Type 2 Diabetes Mellitus Acetylsalicylic Acid Oxidative Stress Glucose Glycated Hemoglobin A1c

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墨西哥城埃琳娜·加罗文化中心

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现代装饰 2014年第3期 62-71页

作者： Fernanda Canales Jose castillo Ola Saidee Springall del Villar Sandra Pereznieto Jaime Navarro 姜敏华 Fernanda Canales+arquitectura 911sc

本案位于墨西哥城南部的科约阿坎区。设计团队根据这栋建造于20世纪初老房子的房屋特点，将其改造成为独立两层格局的图书馆文化中心，也为城市文化活动的举办提供了新的场所。

关键词：文化中心墨西哥城文化活动图书馆房屋房子场所

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