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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 818-828页

作者： Arturo Román-Messina Alejandro castillo-tapia David A.Román-García Marcos A.Hernández-Ortega Carlos A.Morales-Rergis Claudia M.Castro-Arvizu Center for Research and Advanced Studies(CINVESTAV)of the National Polytechnic Institute of Mexico GuadalajaraJal.45017Mexico Instituto Tecnológico y de Estudios Superiores de Monterrey GuadalajaraJal.45070Mexico Autonomous University of Guadalajara GuadalajaraJal.45129Mexico Centro de Enseñanza Técnica Industrial and he is also with UAGGuadalajaraJal.44638Mexico

The primary goal in the analysis of hierarchical distributed monitoring and control architectures is to study the spatiotemporal patterns of the interactions between areas or *** this paper,a novel conceptual framework for distributed monitoring of power system oscillations using multiblock principal component analysis(MB-PCA)and higher-order singular value decomposition(HOSVD)is proposed to understand,characterize,and visualize the global behavior of the power *** proposed framework can be used to evaluate the influence of a given area or utility on the oscillatory behavior,uncover low-dimensional structures from high-dimensional data,and analyze the effects of heterogeneous data on the modal characteristics and interpretation of power *** metrics are then investigated to examine the relationships between the dynamic patterns and participation of individual data blocks in the global behavior of the *** application of these techniques is demonstrated by case studies of two systems:a 14-machine test system and a 5449-bus 635-generator equivalent model of a large power system.

关键词： Distributed monitoring multiblock principal component analysis(MB-PCA) higher-order singular value decomposition(HOSVD) Tucker decomposition

Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia castillo-González Elena González-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

血清皮质醇和皮质素是部分11β-羟基类固醇脱氢酶2缺陷症的潜在生物标志

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中华高血压杂志 2019年第4期27卷 398-398页

作者： Carvajal CA tapia-castillo a Valdivia CP Allende F Solari S Lagos CF Campino C Martinez-Aguayo A Vecchiola A Pinochet C Godoy C Iturrieta V Baudrand R Fardella CE 不详

11β-羟基类固醇脱氢酶 2(11-beta hydroxysteroid dehydrogenase type 2 ,HSD11B2)基因的致病性变异可引起明显的盐皮质激素过量综合征(apparent mineralocorticoid excess, AME ) o然而关于携带HSD11B2基因致病性变异杂合子的受试者的表型信息很少。本研究调查血清皮质醇(cortisol,F)和皮质素(cortisone,E)的比值(F/E)和皮质素是否能有效地在这些杂合子受试者中鉴定出部分11β-HSD2缺陷症。方法:对确诊为AME的两对夫妻及其携带D223N或R213C突变的家人进行研究。同时健康对照受试者32人(13名儿童和19名成人)进行检测.以获得所有测量变量的正常参考值范围。

关键词： 11β-羟基类固醇脱氢酶2 血清皮质醇皮质素缺陷症生物标志正常参考值范围盐皮质激素受试者

醛固酮与肾素比值可预测非典型原发性醛固酮增多症患者的心脏代谢紊乱情况

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中华高血压杂志 2020年第4期28卷 398-398页

作者：陈云(编译) 叶鹏(审校) Vecchiola A Fuentes CA Barros ER Martínez-Aguayo A García H Allende F Solari S Olmos R Carvajal C tapia-castillo a Campino C Kalergis AM Baudrand R Fardella CE 不详

醛固酮与肥胖、代谢综合征(metabolic syndrome,MS)、炎症和血栓前状态有关;然而,大多数研究将这些指标与原发性醛固酮增多症(primary aldosteronism,PA)联系起来,排除了非PA的患者。本研究旨在确定在非PA人群中醛固酮、肾素或血浆醛固... 详细信息

醛固酮与肥胖、代谢综合征(metabolic syndrome,MS)、炎症和血栓前状态有关;然而,大多数研究将这些指标与原发性醛固酮增多症(primary aldosteronism,PA)联系起来,排除了非PA的患者。本研究旨在确定在非PA人群中醛固酮、肾素或血浆醛固酮与肾素比值(plasma aldosterone to renin ratio,ARR)与代谢紊乱和炎症/血管生物标志物是否相关。方法:对275例患者(包括2种性别和青少年)进行血浆和尿醛固酮检测,并测定血浆肾素活性。在所有受试者中,MS的诊断根据美国国家胆固醇教育计划成人治疗组(adult treatment panel,ATP)第三次报告Ⅲ(ATPⅢ)来确定,并对代表肾脏、血管、炎症和盐皮质激素活性的生物标记物进行评估。

关键词：血浆肾素活性原发性醛固酮增多症血浆醛固酮盐皮质激素血栓前状态尿醛固酮生物标记物代谢综合征

Seamount chains and hotspot tracks:Superficially similar,deeply different

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Geoscience Frontiers 2023年第6期14卷 307-326页

作者： Edgardo Cañón-tapia División de Ciencias de la Tierra CICESE.Carretera Ensenada-Tijuana#3985Ensenada Baja CaliforniaCP 22860Mexico

Nearly 80%of the seafloor extension has not been covered by high-resolution bathymetry,impeding direct observation of ***,lists of seamount location and height at a global scale have been produced using different *** this work four of such databases(publicly available)are compared with each other to assess their *** identify large differences among databases that could have exerted strong influences on models of seamount production and associated geodynamic *** those differences,it is shown that all databases allow the identification of seamount lines both along the present-day Mid Ocean Ridge(MOR)system and on intraplate ***,those seamount lines do not coincide with the so-called hotspot tracks that commonly were defined by selectively focusing attention on the larger *** of all the databases also shows that distinction based only on seamount size between seamounts produced at Mid-Ocean Ridge(MOR)environments from those associated with mantle-plum fed-hotspot activity has been ***,combined with the fact that most seamount lines defined by the available databases can be traced back to past locations of MOR indicates that most of the present-day intraplate linear arrays of seamounts,which include some large seamounts,were not produced by the action of underlying mantle anomalies envisaged in the form of mantle *** evidence presented here calls for a reassessment of the form in which volcanic and tectonic activities are conceptually related to each other.

关键词： Seamount origin Chains of seamounts Spatial distribution of volcanism Intraplate volcanism Mid Ocean Ridge volcanism

Response of bioaerosol cells to photocatalytic inactivation with ZnO and TiO_(2)impregnated onto Perlite and Poraver carriers

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 137-149页

作者： Mariana Valdez-castillo Sonia Arriaga Environmental Science Department Institute for Scientific and Technological Research of San Luis PotosiIPICYT.Camino Presa San Jose 2055Lomas 4a SeccionCP 78216San Luis PotosiMexico

Bioaerosols are airborne microorganisms that cause infectious sickness,respiratory and chronic health *** have become a latent threat,particularly in indoor *** is a promising process to inactivate completely bioaerosols from ***,in systems treating a continuous air flow,catalysts can be partially lost in the gaseous *** avoid such phenomenon,supporting materials can be used to fix *** the present work,four photocatalytic systems using Perlite or Poraver glass beads impregnated with ZnO or TiO_(2)were *** inactivation mechanism of bioaerosols and the cytotoxic effect of the catalysts to^bioaeros^ls were *** plug flow photocatalytic reactor treated a bioaerosol flow of 460×10^(6)cells/m^(3)_(air)with a residence time of 5.7 *** Cytometry(FC)was used to quantify and characterize bioaerosols in terms of dead,injured and live *** most efficient system was ZnO/Perlite with 72%inactivation of bioaerosols,maintaining such inactivation during 7.5 h due to the higher water retention capacity of Perlite(2.8 mL/gpcriite)in comparison with Poraver(1.5 mL/gperiite).However,a global balance showed that Ti0_(2)/Poraver system triggered the highest level of cytotoxicity to bioaerosols retained on the support after 96 h with 95%of dead *** and FC analyses showed that the mechanism of inactivation with ZnO was based on membrane damage,morphological cell changes and cell lysis;whereas only membrane damage and cell lysis were involved with Ti0_(2).Overall,results highlighted that photocatalytic technologies can completely inactivate bioaerosols in indoor environments.

关键词： Immobilized catalysts Continuous flow Photocatalysis Bioaerosols Cytotoxicity Inactivation mechanism

Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational Neurodegeneration 2017年第1期6卷 310-323页

作者： Rafael Lazo-Gomez Ricardo tapia División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(SIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)into the rat spinal cord *** and resveratrol were co-infused with AMPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AMPA[1 mM]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AMPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective SIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism,and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： Motor neuron disorder Quercetin Resveratrol Sirtuin Excitotoxicity

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2018年第10期13卷 1705-1710页

作者： Cheril tapia-Rojas Nibaldo C.Inestrosa Centro de Envejecimiento y Regeneración (CARE UC) Departamento de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de Chile Centre for Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South Wales Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de Magallanes

Alzheimer＇s disease（AD） is the most common form of dementia in the older population, however, the precise cause of the disease is unknown. The neuropathology is characterized by the presence of aggregates formed by amyloid-β（Aβ） peptide and phosphorylated tau; which is accompanied by progressive impairment of memory. Diverse signaling pathways are linked to AD, and among these the Wnt signaling pathway is becoming increasingly relevant, since it plays essential roles in the adult brain. Initially, Wnt signaling activation was proposed as a neuroprotective mechanism against Aβ toxicity. Later, it was reported that it participates in tau phosphorylation and processes of learning and memory. Interestingly, in the last years we demonstrated that Wnt signaling is fundamental in amyloid precursor protein（APP） processing and that Wnt dysfunction results in Aβ production and aggregation in vitro. Recent in vivo studies reported that loss of canonical Wnt signaling exacerbates amyloid deposition in a transgenic（Tg） mouse model of AD. Finally, we showed that inhibition of Wnt signaling in a Tg mouse previously at the appearance of AD signs, resulted in memory loss, tau phosphorylation and Aβ formation and aggregation; indicating that Wnt dysfunction accelerated the onset of AD. More importantly, Wnt signaling loss promoted cognitive impairment, tau phosphorylation and Aβ1–42 production in the hippocampus of wild-type（WT） mice, contributing to the development of an Alzheimer＇s-like neurophatology. Therefore, in this review we highlight the importance of Wnt/β-catenin signaling dysfunction in the onset of AD and propose that the loss of canonical Wnt signaling is a triggering factor of AD.

关键词： Wnt signaling Wnt target genes Wnt/β-catenin Alzheimer disease amyloid-β tau phosphorylation memory loss synaptic dysfunction

Proteomics and the genetics of sperm chromatin condensation

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Asian Journal of Andrology 2011年第1期13卷 24-30页

作者： Rafael Oliva Judit castillo Human Genetics Research Group IDI BAPS Department of Ciencias Fisiologicas I Faculty of Medicine University of Barcelona Barcelona 08036 Spain Biochemistry and Molecular Genetics Service Hospital Clinic i Provincial Barcelona 08036 Spain

Spermatogenesis involves extremely marked cellular, genetic and chromatin changes resulting in the generation of the highly specialized sperm cell. Proteomics allows the identification of the proteins that compose the spermatogenic cells and the study of their function. The recent developments in mass spectrometry （MS） have markedly increased the throughput to identify and to study the sperm proteins. Catalogs of thousands of testis and spermatozoan proteins in human and different model species are becoming available, setting up the basis for subsequent research, diagnostic applications and possibly the future development of specific treatments. The present review intends to summarize the key genetic and chromatin changes at the different stages of spermatogenesis and in the mature sperm cell and to comment on the presently available proteomic studies.

关键词： epigenetic imprinting protamine proteome spermatozoa

An alternative explanation for the Hf-Nd mantle array

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Science Bulletin 2017年第14期62卷 974-975页

作者： Paterno R.castillo Scripps Institution of Oceanography UCSD

The ^(176)Hf/^(177)Hf and143Nd/144Nd of mid-ocean ridge basalts(MORB)and ocean island basalts(OIB)are significantly correlated and form the so-called Hf-Nd mantle array[1,2](Fig.1a).Model calculations show that the association of OIB with the array is inconsistent with the distinctive Hf and Nd isotopic compositions of their purported ancient sediment sources in the mantle[1].A current consensus for the origin of the array is that the Lu/Hf

关键词：阵列地幔 HF 洋中脊玄武岩洋岛玄武岩