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IL-15 temporally reorients IL-10 biased B-la cells toward I L- 12 expression

Cellular & Molecular Immunology 2016年第2期13卷 229-239页

作者： Amlan Kanti Ghosh Debolina Sinha Subhadeep Mukherjee Ratna biswas tapas biswas Division of Immunology National Institute of Cholera and Enteric Diseases Kolkata India

Interleukin （IL）-15 is known to strongly modulate T-cell function; however, its role in controlling mucosal immunity, including its ability to modulate B-la cell activity, remains to be elucidated. Here, we show that IL-15 upregulates activation molecules and the costimulatory molecule CD80 on viable B-la cells. Cell activation was accompanied by the depletion of sialic acid-binding immunoglobulin-like lectin （Siglec）-G, an inhibitor of cell activation that is present on B-la cells. The IL-15 receptor CD122 was stimulated on B-la cells by the cytokine showing its direct involvement in IL-15-mediated responses. IL-IO is responsible for the long term survival of B-la cells in culture, which is initially promoted by IL-15. The upregulation of IL-IO was followed by the appearance of suppressor of cytokine signaling （SOCS）I in the presence of IL-15 and the loss of IL-IO. This resulted in the cells switching to IL-12 expression. This anti-inflammatory to pro-inflammatory shift in the B-la cell character was independent of the cell-specific marker CD5, which remained highly expressed throughout the in vitro life of the cells. The presence of the immunosuppressive receptor programmed cell death （PD）-I and its ligand PD-L2 were features of a predominantly IL-IO response. PD-1 and PD-L2 can mediate juxtacrine signaling. However, the abrogation of PD-1 and its ligand was observed when the cells expressed IL-12. This demonstrates an inverse relationship between the receptor and ligand and the pro-inflammatory cytokine. The induction of IgM and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-la cells to mount a mucosal immune response.

关键词： B-la cells IgM innate immunity interleukin-12 generation interleukin-15

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Oligomerization of Vibrio cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell

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Cellular & Molecular Immunology 2008年第3期5卷 231-234页

作者： Gayatri Mukherjee Kalyan K Banerjee tapas biswas Divisions of Immunology National Institute of Cholera and Enteric Diseases P-33 C.I.T. Road Scheme XM Kolkata-700 010 West Bengal India Biochemistry National Institute of Cholera and Enteric Diseases P-33 C.I.T. Road Scheme XM Kolkata-700 010 West Bengal India

The hemolysin oligomer promotes the proliferation of B-1a cells and the expression of CD25, which is indicative of cell activation, on B-1a cells. The upregulation of CD86 induced by the oligomer showed its selective bias for the B7-2 member of B7 family while the monomer failed to induce these effects. The oligomer induced the expression of CXCR3, associated with B cell activation, while the monomer induced the expression of CXCL4, a powerful angiostatic chemokine. In conclusion, we found that B-1a cells responded to the apoptogenic monomer by expressing CXCL4, whereas oligomerization of the immunogen induced CXCR3 to shift the response towards activation.

关键词： B-1a cell CD86 CXCL4 CXCR3 Vibrio cholerae hemolysin

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Experimental assessment of arsenic toxicity in garole sheep in India

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Emerging Contaminants 2016年第3期2卷 128-134页

作者： Chinmoy Maji Samar Sarkar Suman biswas Pabitra Hriday Patra Bakul Kumar Datta Samiran Bandyopadhyay tapas Kumar biswas Chandrakanta Jana Tapan Kumar Mandal Department of Veterinary Medicine Ethics&JurisprudenceFaculty of Veterinary and Animal SciencesWest Bengal University of Animal and Fishery SciencesKolkataWest BengalIndia Department of Veterinary Pharmacology and Toxicology Faculty of Veterinary and Animal SciencesWest Bengal University of Animal and Fishery SciencesKolkataWest BengalIndia Indian Veterinary Research Institute Eastern Regional StationKolkataWest BengalIndia Indian Veterinary Research Institute Regional Station MukteswarMukteshwarUttarakhandIndia

Arsenic,a dangerous bio-accumulative poison,is a grave threat affecting a large number of people as well as animals throughout theWorld,particularly in Bangladesh and West Bengal,*** is also a matter of concern as continuously entering into food chain through biotic and abiotic *** present study was conducted to evaluate the experimental effect of arsenic toxicosis on Garole sheep of West *** group was subjected to oral arsenic exposure@6.6 mg Kg1 over 133 days when rests considered as negative *** arsenic estimation in wool,urine and feces along with hemato-biochemical alteration were checked *** was evident from the study that long term arsenic exposure exerted a significant(p<0.01)alteration compared to normal animal which were further supported by clinical *** animals showed histological changes throughout major internal organs like coagulative necrosis of liver,tubular nephritis of kidney and acanthosis of skin *** bioaccumulative and excretion pattern of arsenic inside body were also well understood by the arsenic estimation study of wool,urine and feces which may be helpful for discussion regarding arsenic entry into food chain via animals.

关键词： Arsenic Garole sheep Excretion Bioaccumulation Liver Kidney

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人胎盘提取液的抗炎和抗血小板聚集作用

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Acta Pharmacologica Sinica 2003年第2期24卷 187-192页

作者： SUR tapas Kumar biswas Tuhin Kanti ALI Liaquat MUKHERJEE Biswapati SN Pradhan Centre for Neurosciences Dr BC Roy Postgraduate Institute of Basic Medical Sciences 244B Acharya J C Bose Road Calcutta 700020 India Research Division BIRDEM 122 Kazi Nazrul Islam Avenue Dhaka 1000 Bangladesh

AIM: To find the anti-inflammatory and anti-platelet aggregatory activity of human placental extract （HPE, Placentrex）.METHODS: The HPE was studied for anti-inflammatory effect in Wistar rats on carrageenin, serotonin （5-HT）,and prostaglandin E1（PGE1） induced edema in acute model and cotton pellet induced granuloma on sub-acute model. Anti-platelet aggregation was studied against protection of adinosine diphosphate （ADP）-induced aggregation of human platelet through in vitro study. RESULTS: HPE showed positive results both in acute and sub-acute models of inflammation. Highly significant （P<0.01） results were obtained against 5-HT induced acute inflammation and cotton pellet induced sub-acute inflammation in comparison with standard （diclofenac sodium） and control（normal saline） drugs. The anti-inflammatory property of HPE in animal model was well supported with clinical study of platelet aggregation. There was highly significant （P<0.01） inhibition of platelet aggregation with HPE at different doses against ADP. CONCLUSION: Our data suggest that human placental extract may be useful in suppressing inflammation and platelet aggregation.

关键词：胎盘提取物炎症角叉菜胶血小板聚集腺苷二磷酸

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Noise reduction methods in the analysis of near infrared lunar occultation light curves for high angular resolution measurements

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Research in Astronomy and Astrophysics 2013年第11期13卷 1363-1380页

作者： tapas Baug Thyagarajan Chandrasekhar Physical Research Laboratory

A lunar occultation （LO） technique in the near-infrared （NIR） provides angular resolution down to milliarcseconds for an occulted source, even with ground- based 1 m class telescopes. LO observations are limited to brighter objects because they require a high signal-to-noise ratio （S/N ~40） for proper extraction of angular diameter values. Hence, methods to improve the S/N ratio by reducing noise using Fourier and wavelet transforms have been explored in this study. A sample of 54 NIR LO light curves observed with the IR camera at Mt Abu Observatory has been used. It is seen that both Fourier and wavelet methods have shown an improvement in S/N compared to the original data. However, the application of wavelet transforms causes a slight smoothing of the fringes and results in a higher value for angular diameter. Fourier transforms which reduce discrete noise frequencies do not distort the fringe. The Fourier transform method seems to be effective in improving the S/N, as well as improving the model fit, particularly in the fainter regime of our sample. These methods also provide a better model fit for brighter sources in some cases, though there may not be a significant imorovement in S/N.

关键词： methods: analytical -- techniques: high angular resolution -- methods:lunar occultation -- infrared: stars -- stars: late type

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Effect of Rare Earth and Transition Metal Elements on the Glass Forming Ability of Mechanical Alloyed Al–TM–RE Based Amorphous Alloys

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Journal of Materials Science & Technology 2015年第11期31卷 1118-1124页

作者： Ram S.Maurya tapas Laha Department of Metallurgical & Materials Engineering Indian Institute of Technology Kharagpur

The present work aims to compare the amorphous phase forming ability of ternary and quaternary Al based alloys （Al86Ni8Y6, Al86GNi6Y6Co2, Al86NigLa6 and Al86Ni8Y45La15） synthesized via mechanical alloying by varying the composition, i.e. fully or partially replacing rare earth （RE） and transition metal （TM） elements based on similar atomic radii and coordination number. X-ray diffraction and high resolution transmission electron microscopy study revealed that the amorphization process occurred through formation of various intermetallic phases and nanocrystalline FCC Al. Fully amorphous phase was obtained for the alloys not containing lanthanum, whereas the other alloys containing La showed partial amorphization with reappearance of intermetallic phases attributed to mechanical crystallization. Differential scanning calorimetry study confirmed better thermal stability with wider transformation temperature for the alloys without La.

关键词： Al-TM-RE amorphous alloy Mechanical alloying Glass forming ability Microstructural transformation Intermetallics Glass transition temperature

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An efficient and comparative adsorption of Congo red and Trypan blue dyes on MgO nanoparticles: Kinetics, thermodynamics and isotherm studies

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Journal of Magnesium and Alloys 2021年第2期9卷 478-488页

作者： Barsharani Priyadarshini Tanaswini Patra tapas Ranjan Sahoo Department of Chemistry School of Applied SciencesKIIT deemed to be UniversityBhubaneswar 24OdishaIndia

Cubic phase of Mg O nanoparticles were prepared by microwave-assisted combustion synthesis and investigated for the removal of toxic dyes like Congo Red(CR)and Trypan blue(TB).The crystallite size of the Mg O nanoparticle was calculated to be 18 nm from XRD *** sample was further characterized by FTIR,TGA and FESEM *** dyes were subjected to prototypical batch adsorption process,including investigation of different parameters like Mg O dosage,dye concentration,solution pH,agitation speed and *** was found that,0.2 g of Mg O NPs showed maximum removal efficiency for both the dyes(more than 98%),having 25 ppm of dye concentration at an acidic p H(3–4).The maximum loading capacity of Mg O NPs was obtained to be 136 mg/g and 132 mg/g for CR and TB,*** thermodynamic parameters like△G^(0),△H^(0)and△S^(0)were *** negative△H^(0)and the positive△S^(0)values for both the dyes correspond to an exothermic process and an increase in randomness of the adsorbent and *** isotherm analysis exhibited that the Freundlich model fits better to the experimental equilibrium data,suggesting heterogeneous surface of the ***,the kinetic data revealed a pseudo 2 nd order rate for adsorption process.

关键词： Adsorption Congo red Trypan blue MgO NPs Kinetics Isotherm

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An account of the strategies to enhance the water splitting efficiency of noble-metal-free electrocatalysts

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Journal of Energy Chemistry 2021年第8期30卷 160-190,I0005页

作者： Subhasis Shit Saikat Bolar Naresh Chandra Murmu tapas Kuila Surface Engineering&Tribology Division Council of Scientific and Industrial Research-Central Mechanical Engineering Research InstituteMahatma Gandhi AvenueDurgapur 713209India Academy of Scientific and Innovative Research(AcSIR) CSIR-Human Resource Development Centre(CSIR-HRDC)CampusPostal Staff College AreaSector 19Kamla Nehru NagarGhaziabad 201002India

The electrolysis of water for hydrogen generation has shown immense promise as an energy conversion technology for the green energy *** concurrently occurring electrochemical reactions in water electrolysis(hydrogen and oxygen evolution reactions)are sluggish in nature and therefore the employment of electrocatalysts is highly ***-metal-based electrocatalysts(Pt,Ru O_(2),Ir O_(2),etc.)have shown superior activity towards these ***,their lower natural abundance and inferior stability make the cost to performance ratio of water electrolysis too ***,huge amount of research efforts are being carried out to develop electrocatalysts consisting of earth abundant elements(transition metals,carbon etc.)as the replacement of these noble-metal-based *** metal compounds,carbonaceous and hybrid materials have shown promise as efficient electrocatalysts but there is still huge gap between the activities of these materials and the noble-metal-based *** strategies like morphology modulation,elemental doping,defect engineering *** being deployed to enhance the activity of these noble-metal-free *** review summarizes these strategies and thoroughly discusses the reason behind the changes in activity of the electrocatalysts owing to these ***,the remaining research gaps and future prospects in this field are also discussed in detail.

关键词： Water splitting Electrocatalyst Morphology Doping Defect engineering Phase engineering

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Effect of sintering temperature on phase evolution of Al86Ni6Y4.5Co2La1.5 bulk amorphous composites synthesized via mechanical alloying and spark plasma sintering

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Progress in Natural Science:Materials International 2019年第1期29卷 32-40页

作者： Ashutosh Sahu Ram Sajeevan Maurya tapas Laha Department of Metallurgical and Materials Engineering Indian Institute of Technology Department of Metallurgical and Materials Engineering National Institute of Technology

Al86Ni6Y4.5Co2La1.5amorphous powders were synthesized by mechanical alloying for 200 h. Subsequent consolidation was performed via spark plasma sintering in the temperature range of 250 ℃ to 500 ℃ at the pressure of 500 MPa. The role of viscous flow on densification was investigated by studying the viscosity change of the amorphous phase at different consolidation temperatures. The decrease in viscosity at higher sintering temperatures resulted in better particle bonding and densification of consolidated samples. The formation of only FCC Al was observed in the consolidated samples at sintering temperatures ≤ 300 ℃ and the intermetallic phases formed at temperatures ≥ 400 ℃. The mechanical properties of the bulk samples were measured by Vickers microhardness and nanoindentation tests. The testing results showed that the average values of microhardness, nanohardness and elastic modulus of the sample consolidated at 500 ℃ were 3.06 ± 0.14 GPa,4.85 ± 1.14 GPa and 89.53 ± 9.25 GPa, respectively. The increase in hardness and elastic modulus of the higher temperature consolidated samples is attributed to the improvement in particle bonding, densification and distribution of various hard intermetallic phases in the amorphous matrix.

关键词： Al based glassy alloy Mechanical alloying Spark plasma sintering Intermetallic phase Viscosity

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Effect of Sintering Temperature and Heating Rate on Crystallite Size,Densification Behaviour and Mechanical Properties of Al-MWCNT Nanocomposite Consolidated via Spark Plasma Sintering

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Acta Metallurgica Sinica(English Letters) 2018年第10期31卷 1019-1030页

作者： Lavish Kumar Singh Alok Bhadauria Subhodeep Jana tapas Laha Department of Metallurgical and Materials Engineering Indian Institute of Technology Kharagpur Kharagpur India Centre for Healthcare Science and Technology Indian Institute of Engineering Science and Technology Shibpur India

Powder mixture of ball-milled aluminium and functionalized multi-walled carbon nanotubes was compacted via spark plasma sintering （SPS） to study effects of sintering temperature and heating rate. An increase in sintering temperature led to an increase in crystallite size and density, whereas an increase in heating rate exerted the opposite effect. The crystallite size and relative density increased by 85.0% and 14.3%, respectively, upon increasing the sintering temperature from 400 to 600℃, whereas increasing the heating rate from 25 to 100 ℃/min led to respective reduction by 30.0% of crystallite size and 1.8% of relative density. The total punch displacement during SPS for the nanocomposite sintered at 600 ℃ （1.96 mm） was much higher than that of the sample sintered at 400 ℃ （1.02 mm） confirming positive impact of high sintering temperature on densification behaviour. The maximum improvement in mechanical properties was exhibited by the nanocomposite sintered at 600 ℃ at a heating rate of 50℃/min displaying microhardness of 81 4- 3.6 VHN and elastic modulus of 89 4- 5.3 GPa. The nanocomposites consolidated at 400 ℃ and 100 ℃/min, in spite of having relatively smaller crystallite size, exhibited poor mechanical properties indicating the detrimental effect of porosity on the mechanical properties.

关键词： Al nanocomposite Multi-walled carbon nanotubes Ball milling Spark plasma sintering Densification behaviour Mechanical properties

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