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Young footballers, assessed by deep breathing test, have a higher vagal response

Open Journal of Molecular and Integrative Physiology 2012年第3期2卷 61-64页

作者： Souad Aboudrar Hanane Rkain Leila Errguig Youssouf Radjab Latéfa Oukerraj Abdellatif Azzaoui Azeddine Ibrahimi Leslie Coghlan Mohammed Cherti Halima Benjelloun taoufiq dakka Al Akhawayn University School of Science and Engineering Ifrane Morocco Centre de Recherche Epidémiologique et Essais Cliniques (CRECET) Laboratoire de Pharmacologie et de Toxicologie Faculté de Institut National des Sports Moulay Rachid Salé Marocco Laboratoire de Physiologie Faculté de Médecine et de Pharmacie de Rabat Université MohammedⅤSouissi Marocco Service de Cardiologie B Faculté de Médecine et de Pharmacie de Rabat Université Mohammed Ⅴ Souissi Marocco Unité d’exploration du Système Nerveux Autonome Service Cardiologie A CHU Ibn Sina Rabat Maroc

Parasympathetic function can be assessed by the deep breathing test (DB) as a simple and reproducible cardiovascular reflex. The aim of this study is to use this test to compare the vagal response of a young footballers group to of age-matched untrained normal subjects. Deep breathing test was performed in 2 groups: one of 20 adult young footballers (average age of 19.3 ± 0.6 years), and a second age-matched group of 20 untrained subjects (average age of 19.6 ± 0.6 years). Subjects underwent the DB test after 30 min resting in supine position, and responses were expressed as a percentage of variation of heart rate during the stimulation. Student’s t-test was used to evaluate statistical differences among the two groups for all parameters (vagal response, heart rate, VO2max….) and considering p < 0.05 as a significant difference. The results showed that vagal response to deep breathing test was significantly higher in the young footballers when compared to the untrained controls (72.6% ± 16.2% vs 55.0% ± 12.8%, respectively, p = 0.03). The basal heart rate was significantly lower in footballers than in the controls group (52.1 ± 7.4 bat/min vs 69.8 ± 14.3 bat/min, p < 0.01). The use of the simple test of deep breathing allowed us to demonstrate that adult young footballers have a significantly lower basal HR and higher parasympathetic response in comparison to untrained subjects.

关键词： Deep Breathing Test Parasympathetic Response Autonomic Nervous System Sudden Death Trained Footballers

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Essential oils of Origanum compactum increase membrane permeability,disturb cell membrane integrity,and suppress quorum-sensing phenotype in bacteria

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Journal of Pharmaceutical Analysis 2019年第5期9卷 301-311页

作者： Abdelhakim Bouyahya Jamal Abrini Nadia dakka Youssef Bakri Laboratory of Human Pathologies Biology Department of Biology Faculty of Sciences and Genomic Center of Human Pathologies Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco Biology and Health Laboratory Department of Biology Faculty of Science Abdelmalek Essaadi University Tetouan Morocco

The aim of this study was to investigate antibacterial activity of Origanum compactum essential oils collected at three phenological stages on Escherichia coli and Bacillus subtilis. The antibacterial activity was evaluated using the agar-well diffusion assay. The MIC and MBC values were determined using the micro-dilution assay. The investigation of the antibacterial action was carried out by the evaluation of the effect of O. compactum essential oils on the antibacterial kinetic growth, the integrity of cell membrane and permeability of the cell membrane. The anti-quorum sensing activity was tested by the inhibition of the biofilm formation. The findings of this study showed that O. compactum essential oil has potent antibacterial activities against E. coli and B. subtilis. The lowest inhibition value against B. subtilis was obtained with O. compactum essential oil at the post-flowering stage (MIC=MBC=0.0312%(v/v)). The antibacterial mechanisms of O. compactum essential oils are related to the disturbing of the cell membrane integrity and the increasing of the membrane permeability, which leads to the leakage of genetic materials (DNA and RNA). Moreover, O. compactum essential oils inhibited the formation of the biofilms, a phenotype that has been known to be quorum sensing regulated.

关键词： Origanum compactum Essential oil Antibacterial action Cell membrane Quorum sensing inhibition

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Medicinal plant products targeting quorum sensing for combating bacterial infections

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 795-809页

作者： Abdelhakim Bouyahya Nadia dakka Abdeslam Et-Touys Jamal Abrini Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesMohammed V UniversityRabatMorocco Biology and health Laboratory Department of BiologyFaculty of ScienceAbdelmalek Essaadi UniversityTetouanMorocco

Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances.

关键词：察觉到的治安法官 Biofilms 细菌的抵抗自然混合物

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Characterisation and Valorisation of the Moroccan Diatomite

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Journal of Geoscience and Environment Protection 2022年第2期10卷 109-134页

作者： Bahaj Hanane Rahmouna Jihad Berry Naima Targhi Soukaina Barhoun Nadia Bachiri taoufiq Naima Geosciences and Applications Laboratory (“LGA”) Faculty of Science Ben M’sik Hassan II University of CasablancaSidi Othmane Casablanca Morocco

Morocco is known for the diversity of its natural resources. In particular, the mineral substances, diatomites, material relatively abundant but poorly exploited in Morocco. The aim of this work is to determine the geochemical and textural characteristics of the different diatomite deposits of north-eastern Morocco in order to compile a database with the different properties of these sediments. These data are valuable to guide the use and exploitation of this natural georesource. Samples from 3 deposits were characterised by different techniques of analysis: sedimentological (granulometry, calcimetry), chemical (pH, X-ray diffraction, infrared spectrometry and transmission electron microscopy coupled with EDX). We also performed thermogravimetric analysis of some samples. Results revealed that diatomite is a fine, moderately refractory material with a basic pH. While, the CaCo3 content varies between different deposits. It is composed mainly of silica and has a well-developed porosity. In addition, thermogravimetric analysis revealed a loss of mass with temperature increase. A moderate variation in the chemical composition of the diatomite was observed from one deposit to another. Generally, we can stipulate that the diatomite from the Rif deposit is relatively a good quality. It has relatively the same physico-chemical properties as the neighbouring regions.

关键词： Diatomite Morocco Physico-Chemical Characteristics Thermogravimetric Analysis

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Chemical composition of Mentha suaveolens and Pinus halepensis essential oils and their antibacterial and antioxidant activities

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Asian Pacific Journal of Tropical Medicine 2019年第3期12卷 117-122页

作者： Abdelhakim Bouyahya Omar Belmehdi Jamal Abrini Nadia dakka Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesFaculty of Medicine and PharmacyMohammed V University in Rabat Biology and Health Laboratory Department of BiologyFaculty of SciencesAbdelmalek Essaadi University

Objective: To determin the chemical compounds of Mentha suaveolens(M. suaveolens) and Pinus halepensis(P. halepensis) essential oils(Eos) and evaluate their antioxidant and antibacterial activities. Methods: The chemical composition of P. halepensis and M. suaveolens EOs was determined by GC-MS analysis. The antioxidant activity was evaluated using DPPH,ABTS and FRAP assays. The antibacterial effect was tested against 6 bacterial strains using the well diffusion method and micro-dilution assay. Results: The major components of P. halepensis EOs were β-caryophyllene(28.04%),myrcene(23.81%) and α-pinene(12.02%). However,piperitenone oxid(56.28%),piperitenone(11.64%) and pulegone(6.16%) were the major components of M. suaveolens EOs. M. suaveolens EOs showed remarkable antioxidant activities compared with P. halepensis EOs,showing antioxidant capacity values of IC50=(64.76±2.24) μg/mL,IC50=(82.73±3.34) μg/mL,and IC50=(93.35±4.45) μg/mL,revealed by DPPH,ABTS and FRAP assays,respectively. However,P. halepensis EOs showed interesting antibacterial effects against all bacterial strains. The most sensible strains to P. halepensis EOs were Staphylococcus aureus [(34.00±0.50) mm],Listeria monocytogenes [(31.00±1.50)] mm and Proteus mirabilis [(29.00±2.25)mm]. Furthermore,the lowest minimal inhibitory concentration(MIC) and minimal bactericidal concentration(MBC) values were revealed by P. halepensis EOs against Staphylococcus aureus [MIC=MBC=0.125%(v/v)] and Listeria monocytogenes [MIC=MBC=0.25%(v/v)]. Conclusions: P. halepensis and M. suaveolens EOs contain bioactive compounds that could have potential applications against bacterial infections and oxidative stress related diseases as well as for food conservation. However,further investigations are necessary to isolate and investigate the action mechanisms of these bioactive compounds.

关键词： Mentha suaveolens Pinus halepensis Essential oil Antioxidant effect Antibacterial activity

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Aerodynamic Flow Characteristics of Utilizing Delta Wing Configurations in Supersonic and Subsonic Flight Regimes

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通讯和计算机（中英文版） 2016年第6期13卷 299-318页

作者： William Ruffles Sam M. dakka Department of Engineering and Math Sheffield Hallam University Howard Street Sheffield S1 1 WB United Kingdom

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Study of Ionospheric Variability Using GNSS Observations

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Positioning 2018年第4期9卷 79-96页

作者： Jouan taoufiq Bouziani Mourad Azzouzi Rachid Christine Amory-Mazaudier Institute of Agronomy and Veterinary Medicine Rabat Morocco Université Pierre et Marie Curie (UPMC) Paris France T/ICT4D Abdus Salam ICTP Trieste Italy

With the increasing number of applications of Global navigation satellite system, the modeling of the ionosphere is a crucial element for precise positioning. Indeed, the ionosphere delays the electromagnetic waves which pass through it and induces a delay of propagation related to the electronic density (TEC) Total Electronic Content and to the frequency of the wave. The impact of this ionospheric error often results in a poor determination of the station’s position, particularly in strong solar activity. The first part of this paper focuses on a bibliographic study oriented first of all on the study of the ionosphere in relation to solar activity and secondly on the determination of the total electron content using GNSS measurements from the IGS network reference stations. Measurements were made on two permanent stations “RABT”, “TETN”. We selected years of GNSS measurements to evaluate the geomagnetic impact on the ionosphere, 2001, 2009 and 2013. A description of the ionospheric disturbances and geomagnetic storms was analyzed by determination of TEC, especially in high solar activity. The results show a strong dependence of the ionospheric activity with the geomagnetic activity.

关键词： GNSS TEC IGS

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Post Traumatic Diaphragmatic Hernia Revealing a Colonic Tumor

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Open Journal of Thoracic Surgery 2016年第3期6卷 13-17页

作者： Mohammed Elkehal Sani Rabiou Boubacar Efared Saad Slaiki Hicham Elbouhadouti Yassine Ouadnouni Nawal Hammas taoufiq Harmouch Mohamed Smahi Department of Visceral Surgery Hassan II University Hospital Fez Morocco Department of Thoracic Surgery Hassan II University Hospital Fez Morocco Department of Cyto-Pathology Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy Sidi Mohamed Benabdellah University Fez Morocco

Post traumatic diaphragmatic injuries have long been known. However their varied clinical, expressions lead to difficulties which cause its delay. The occurrence of herniation of hollow viscera in the thoracic cavity followed by its necrosis or perforation, is a delayed complication, a rare entity with a poor prognosis. The discovery of a colonic tumor in a diaphragmatic hernia is an exceptional clinical circumstance. Here we report the case of a patient with a complicated diaphragmatic hernia, whose symptoms are precipitated by the presence of a colon stenosing tumor. The management consisted of an exclusive laparotomy had allowed dealing in one surgical intervention with both the abdominal and thoracic injuries.

关键词： Diaphragmatic Hernia Gastrointestinal Tumor Surgery

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Scrotal Skin Metastases of Renal Cell Carcinoma: A Case Report

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Case Reports in Clinical Medicine 2015年第3期4卷 93-96页

作者： Khadija Benhayoune Hinde El Fatemi Jamal El Fassi Soufiane Mellas Hassan Farih Laila Chbani Nawal Hammas taoufiq Harmouch Laboratory of Surgical Pathology CHU Hassan II Fez Morocco Department of Urology CHU Hassan II Fez Morocco

Cutaneous metastasis from renal cell carcinoma is believed to be rare. We present a 66-year-old man operated for kidney cancer 20 years ago and has consulted for a scrotal lesion that had started 20 days. The physical examination revealed an erythematous lesion. A biopsy of the scrotal skin was made. We found a scrotal metastasis of renal cell carcinoma.

关键词： Scrotal Skin Renal Cell Carcinoma Metastasis 20 Years

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