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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan Zheng Jing Zhu Yu Wang Zhan-zhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

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On the longitudinal shifts of the Agulhas retroflection point

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Acta Oceanologica Sinica 2024年第5期43卷 16-29页

作者： Weiwei Zhang Xiaoyi Yang Wei zhuang Xiaohai Yan State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361002China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Center for Remote Sensing College of EarthOcean and EnvironmentUniversity of DelawareNewarkDE 19716USA Joint Center for Remote Sensing University of Delaware-Xiamen UniversityNewarkDE 19716USA and Xiamen 361002China

The Agulhas system is the strongest western boundary current system in the Southern Hemisphere and plays an important role in modulating the Indian-to-Atlantic Ocean water exchange by the Agulhas *** is difficult to measure in situ transport of the Agulhas leakage as well as the Agulhas retroflection position due to their intermittent *** this study,an innovative kinematic algorithm was designed and applied to the gridded altimeter observational data,to ascertain the longitudinal position of Agulhas retroflection,the stability of Agulhas jet stream,as well as its *** results show that the east-west shift of retroflection is related neither to the strength of Agulhas current nor to its *** analysis uncovers the connection between the westward extension of Agulhas jet stream and an anomalous cyclonic circulation at its northern side,which is likely attributed to the local wind stress curl *** confirm the effect of local wind forcing on the east-west shift of retroflection,numerical sensitivity experiments were *** results show that the local wind stress can induce a similar longitudinal shift of the retroflection as altimetry *** statistical and case study indicates that whether an Agulhas ring can continuously migrate westward to the Atlantic Ocean or re-merge into the main flow depends on the retroflection ***,the westward retroflection may contribute to a stronger Agulhas leakage than the eastward retroflection.

关键词： Agulhas system Agulhas leakage retroflection position local wind stress curl

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Flow Boiling Heat Transfer Characteristics and Delayed Dry-Out Ability of Non-Azeotropic Mixtures R245fa/R134a in Microchannels

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Journal of Thermal Science 2024年第3期33卷 1174-1188页

作者： LU Yongjie LING Yongjun zhuang Yuan LI Chenyang OUYANG Hongsheng HAN Xiaohong Key Laboratory of Refrigeration and Cryogenic Technology of Zhejiang Province Institute of Refrigeration and CryogenicsZhejiang UniversityHangzhou310007China Zhejiang Zhongguang Electrical Co. Ltd.Lishui323000China State Key Lab for Fluorine Greenhouse Gases Replacement and Control Treatment Zhejiang Research Institute of Chemical IndustryHangzhou310014China

Microchannel flow boiling heat transfer has the advantages of strong heat dissipation capacity,good temperature uniformity,and compact *** is an excellent way to thermally manage electronic devices,but when the heat flux exceeds CHF(Critical Heat Flux),the heat transfer performance deteriorates as the working fluid dries ***-azeotropic mixtures have the potential to effectively delay or avoid dry-out during the boiling process due to their temperature slide characteristics which causes the mass transfer *** understand the influence of non-azeotropic mixtures on microchannel flow boiling,using the phase-change microchannel heat sink as the research object,the experiments on the flow boiling heat transfer performance of R245fa/R134a mixtures under different working conditions were carried out,and the characteristics of flow boiling heat transfer were obtained under the different working conditions,and comparison was developed with those of pure substance *** results demonstrated that a small amount of low-boiling-point components in the high-boiling-point working fluid inhibited boiling heat transfer to some extent,and lowered the average heat transfer coefficient under the non-dryout condition slightly lower than that of the pure substance;however,it also effectively delayed the onset of local dry-out and prevented significant deterioration in thermal transfer performance under the lower mass flow rate and higher heat flux,which could enhance the heat sink's stability.

关键词： microchannel flow boiling non-azeotropic mixture heat transfer characteristics dry-out

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Investigation on mechanical properties regulation of rock-like specimens based on 3D printing and similarity quantification

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International Journal of Mining Science and Technology 2024年第5期34卷 573-585页

作者： Duanyang zhuang Zexu Ning Yunmin Chen Jinlong Li Qingdong Li Wenjie Xu Center for Hypergravity Experiment and Interdisciplinary Research Zhejiang UniversityHangzhou 310058China MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China

3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical *** is necessary to regulate the mechanical properties of 3D-printed specimens to make them proportionally similar to natural *** study investigates mechanical properties of 3D-printed rock analogues prepared by furan resin-bonded silica sand *** mechanical property regulation of 3D-printed specimens is realized through quantifying its similarity to sandstone,so that analogous deformation characteristics and failure mode are *** similarity conversion,uniaxial compressive strength,cohesion and stress–strain relationship curve of 3D-printed specimen are similar to those of *** the study ranges,the strength of 3D-printed specimen is positively correlated with the additive content,negatively correlated with the sand particle size,and first increases then decreases with the increase of curing *** regulation scheme with optimal similarity quantification index,that is the sand type of 70/140,additive content of 2.5‰and curing temperature of 81.6℃,is determined for preparing 3D-printed sandstone analogues and *** effectiveness of mechanical property regulation is proved through uniaxial compression contrast *** study provides a reference for preparing rock-like specimens and engineering models using 3D printing technology.

关键词： 3D printing Mechanical property regulation Similarity quantification Rock analogue Sandstone

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Enhancement of liquid-liquid micromixing performance in curved capillary microreactor by generation of Dean vortices

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Chinese Journal of Chemical Engineering 2024年第4期68卷 76-82页

作者： Shaoyun Wu zhuang Ma Zichi Yang Suying Zhao Caijin Zhou Huidong Zheng Fujian Engineering Research Center of Advanced Manufacturing Technology for Fine Chemicals College of Chemical EngineeringFuzhou UniversityFuzhou 350108China Qingyuan Innovation Laboratory Quanzhou362114China

Micromixing efficiency is an important parameter for evaluating the multiphase mass transfer performance and reaction efficiency of *** this work,the novel curved capillary reactor with different shapes was designed to generate Dean flow,which was used to enhance the liquid-liquid micromixing *** Villermaux-Dushman probe reaction was employed to characterize the micromixing performance in different curved capillary *** effects of experiment parameters such as liquid flow rate,inner diameter,tube length,and curve diameter on micromixing performance were systematically *** the optimal conditions,the minimum value of the segmentation factor XS was *** was worth noting that at the low Reynolds number(Re<30),the change of curved shape on the capillary microreactor can significantly improve the micromixing performance with XS reduced by 37.5%.Further,the correlations of segment index XS with dimensionless factor such as Reynolds number or Dean number were developed,which can be used to predict the liquid-liquid micromixing performance in capillary microreactors.

关键词： Microreactor Process intensification Micromixing performance Dean flow

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Self-Powered Piezo-Supercapacitors Based on ZnO@Mo-Fe-MnO2 Nanoarrays

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Energy & Environmental Materials 2024年第4期7卷 304-314页

作者： Luo Sun Zhiguo Ye Xinyuan Peng Shaojie zhuang Duosheng Li Zhong Jin School of Materials Science and Engineering Nanchang Hangkong University State Key Laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic Chemistry MOE Key Laboratory of High Performance Polymer Materials and Technology Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University

The development of self-charging supercapacitor power cells （SCSPCs） has profound implications for smart electronic devices used in different ***,we epitaxially electrodeposited Mo-and Fe-codoped MnO2films on piezoe... 详细信息

关键词： MnO2 piezoelectric self-charging supercapacitors ZnO nanoarray

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Optimization of Generator Based on Gaussian Process Regression Model with Conditional Likelihood Lower Bound Search

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 32-42页

作者： Xiao Liu Pingting Lin Fan Bu Shaoling zhuang Shoudao Huang CES&IEEE the College of Electrical and Information Engineering Hunan UniversityChangsha 410082China CES

The noise that comes from finite element simulation often causes the model to fall into the local optimal solution and over fitting during optimization of ***,this paper proposes a Gaussian Process Regression(GPR)model based on Conditional Likelihood Lower Bound Search(CLLBS)to optimize the design of the generator,which can filter the noise in the data and search for global optimization by combining the Conditional Likelihood Lower Bound Search *** the efficiency optimization of 15 kW Permanent Magnet Synchronous Motor as an ***,this method uses the elementary effect analysis to choose the sensitive variables,combining the evolutionary algorithm to design the super Latin cube sampling plan;Then the generator-converter system is simulated by establishing a co-simulation platform to obtain data.A Gaussian process regression model combing the method of the conditional likelihood lower bound search is established,which combined the chi-square test to optimize the accuracy of the model ***,after the model reaches the accuracy,the Pareto frontier is obtained through the NSGA-II algorithm by considering the maximum output torque as a ***,the constrained optimization is transformed into an unconstrained optimizing problem by introducing maximum constrained improvement expectation(CEI)optimization method based on the re-interpolation model,which cross-validated the optimization results of the Gaussian process regression *** above method increase the efficiency of generator by 0.76%and 0.5%respectively;And this method can be used for rapid modeling and multi-objective optimization of generator systems.

关键词： Generator optimization Gaussian Process Regression(GPR) Conditional Likelihood Lower Bound Search(CLLBS) Constraint improvement expectation(CEI) Finite element calculation

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“Radicalism”and“Conservatism”:The Philosophical Argument of Human Enhancement Technologies(HET)and Its Resolution

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Fudan Journal of the Humanities and Social Sciences 2024年第3期17卷 437-454页

作者： Yi Xianfei Liu zhuang Center for Moral and Cultural Studies School of MarxismHunan Normal UniversityChangshaHunan 410081China School of Marxism Hunan International Economics UniversityChangshaHunan 410205China

The philosophical debate between“radicalism”and“conservatism”in emerging human enhancement technologies(HET)has never *** their theoreti-cal claims seem to be distinct from each other,they actually share certain common-alities,which are mainly manifested in three aspects:first,they both hold certain illusions about emerging HET;second,they both reflect the loss of human subjec-tivity in the debate;and third,they both leave the premise of their propositions in *** on the reflection and grasp of these commonalities,we can grasp the possible boundaries of the dissolution of the two oppositions:let HET be“where it is in,”reconfigure anthropocentrism,suspend metaphysical myths,and turn to the“reality of human beings.”

关键词： HET-Radicalism Conservatism Philosophical controversy

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Modification of the CuO electronic structure for enhanced selective electrochemical CO_(2) reduction to ethylene

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Nano Research 2024年第8期17卷 7194-7202页

作者： Xin Wu zhuang Tong Yunliang Liu Yaxi Li Yuanyuan Cheng Jingwen Yu Peng Cao Chunqiang zhuang Qiuzhong Shi Naiyun Liu Xiang Liu Hongyu Liang Haitao Li Institute for Energy Research School of Energy and Power EngineeringJiangsu UniversityZhenjiang 212013China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Institute of Medicine&Chemical Engineering Zhenjiang CollegeZhenjiang 212013China Institute of Advanced Manufacturing and Modern Equipment Technology School of Mechanical EngineeringJiangsu UniversityZhenjiang 212013China

Electrochemical carbon dioxide reduction reaction(CO_(2)RR)can produce value-added hydrocarbons from renewable electricity,providing a sustainable and promising approach to meet dual-carbon targets and alleviate the energy ***,it is still challenging to improve the selectivity and stability of the products,especially the C^(2+) *** we propose to modulate the electronic structure of copper oxide(CuO)through lattice strain construction by zinc(Zn)doping to improve the selectivity of the catalyst to *** performance and in situ characterization analyses show that the compressive strain generated within the CuO lattice and the electronic structure modulation by Zn doping enhances the adsorption of the key intermediate*CO,thereby increasing the intrinsic activity of CO_(2)RR and inhibiting the hydrogen precipitation *** the best catalysts had significantly improved ethylene selectivity of 60.5%and partial current density of 500 mA·cm^(–2),and the highest C^(2+) Faraday efficiency of 71.47%.This paper provides a simple idea to study the modulation of CO_(2)RR properties by heteroatom doped and lattice strain.

关键词： CO_(2) reduction heteroatom-doped lattice strain ethylene selectivity

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Photoelectrochemical seawater oxidation with metal oxide materials:Challenges and opportunities

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Journal of Energy Chemistry 2024年第10期97卷 767-782页

作者： Miao Kan Hangyu Hu Weijie zhuang Meng Tao Shiqun Wu Jinlong Zhang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai Engineering Research Center for Multimedia Environmental Catalysis and Resource Utilization East China University of Science and Technology

Photocatalytic water oxidation is a crucial counter-electrode reaction in the process of photoelectrochemical energy *** its importance,challenges remain in effectively and sustainably converting water to oxygen,particularly with readily available and inexpensive electrolyte solutions such as *** metal oxide materials have demonstrated their advantages in promoting efficiency by reducing overpotential and improving light utilization,stability remains limited by corrosion in multicomponent *** this paper,we reviewed the relationship between four basic concepts including photoelectrochemistry,metal oxide,water oxidation and seawater to better understand the challenges and opportunities in photoelectrochemical(PEC) seawater *** overcome these challenges,the advances in material design,interfacial modification,local environment control and reactor design have been further reviewed to benefit the industrial PEC seawater ***,we demonstrate engineered layered metal oxide electrodes and cell structures that enable powerful and stable seawater *** also outline and advise on the future direction in this area.

关键词： Anode Metal oxide Photoelectrochemistry Seawater Stability Water oxidation

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