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Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora ***1

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Marine Life Science & Technology 2024年第1期6卷 102-114页

作者： Ge Zou Wencong Yang Tao Chen Zhaoming Liu Yan Chen taobo Li Gulab Said Bing Sun Bo Wang Zhigang She School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Pharmacy Anhui Medical UniversityHefei 230032China Department of Chemistry Women University SwabiSwabi 23430Pakistan

Marine microorganisms have long been recognized as potential sources for drug *** was one of the first antifungal natural products and has been used as an antifungal agent for *** this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora ***1 treated with 0.3%NaCl or 2%NaBr in rice solid *** 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HRESIMS),ECD spectra,computational calculation,DP4+analysis,and X-ray single-crystal *** 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2S,6'S;2R,6'R;2S,6'R;2R,6'S),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture *** the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(SAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity.

关键词： Mangrove endophytic fungus Nigrospora sp. Griseofulvin Antifungal activity

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分布式光伏电源接入后配电线路的保护措施研究分析

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现代工业经济和信息化 2024年第4期14卷 80-81,107页

作者：刘涛波国电电力大同发电有限责任公司山西大同037043

对分布式光伏电源接入后配电线路的故障特征进行分析,提出无通道保护措施,并进行RTDS仿真试验验证,判定保护措施的可行性和可靠性。后将保护措施应用于某段配电线路当中,对应用的经济性进行分析研究。

关键词：分布式光伏电源配电线路故障特征无通道保护

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新能源风力发电项目66 kV系统应用前景研究

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今日自动化 2024年第6期 66-68页

作者：李陶波山东电力工程咨询院有限公司山东济南250000

随着“3060”碳达峰、碳中和目标的实施,大容量风电基地将不断出现,未来风电机组单机容量越来越大,集电线路采用66 kV电压等级,由于其在投资和电能损耗方面的优势,将是风电场发展的必然趋势。文章对35 kV与66 kV集电线路的经济性进行分... 详细信息

随着“3060”碳达峰、碳中和目标的实施,大容量风电基地将不断出现,未来风电机组单机容量越来越大,集电线路采用66 kV电压等级,由于其在投资和电能损耗方面的优势,将是风电场发展的必然趋势。文章对35 kV与66 kV集电线路的经济性进行分析,以期为相关人员提供参考。

关键词：碳达峰碳中和大型风电基地集电线路 66 kV

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Optimized Separation of Pharmacologically Active Xanthones from Securidaca inappendiculata by Capillary Electrophoresis

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Chinese Chemical Letters 2002年第3期13卷 269-272页

作者： taobo XueDongYANG 等 ChemistryDepartment PekingUniversityBeijing100871 InstituteofMedicinalPlantDevelopment PekingUnionMedicalCollegeandChineseAcademyofMedicalSciencesBeijing100094

A capillary electrophoresis (CE) method has been firstly used for the separation of the therapeutically important xanthones from Securidaca inappendiculata. The separation of the nine xanthones was systematically optimized with respect to pH, concentration of running buffers, addition of sulfated b-CD, applied voltage and column temperature. Baseline separation was achieved for the nine xanthones in less than 15 minutes using a background electrolyte consisting of 200 mmol/L borate (pH 9.5) and 10 mmol/L sulfated b-CD.

关键词： Separation xanthones Securidaca inappendiculata capillary electrophoresis sulfated b-CD. Introduction

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Separation of Biphenyl Nitrile Compounds by Microemulsion Electrokinetic Chromatography with Mixed Surfactants

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Chinese Chemical Letters 2004年第9期15卷 1063-1066页

作者： SuXuanGONG taobo LanHUANG KeAnLI HuWeiLIU KeyLaboratoryofBioorganicChemistryandMolecularEngineeringofMinistryofEducation CollegeofChemistryandMolecularEngineeringPekingUniversityBeijing100871

A mixture of nine biphenyl nitrile compounds with high hydrophobicity and similar structures was successfully separated by microemulsion electrokinetic chromatography (MEEKC) within 30 min. The buffer system contained 100 mmol/L sodium dodecyl sulfate (SDS), 80 mmol/L sodium cholate (SC), 0.81% heptane, 7.5% n-butanol, 10% acetonitrile and 10 mmol/L borate. The addition of SC, organic modifiers, sample preparation and temperature all showed remarkable effect on the separation. Meanwhile, the MEEKC method was briefly compared with micellar electrokinetic chromatography (MEKC) method.

关键词： Microemulsion electrokinetic chromatography separation mixed surfactant biphenyl nitrile compounds micellar electrokinetic chromatography .

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Genetic Stability of Resistance of Bean(Phasedus vulgaris L.)to Glyphosate

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Journal of Northeast Agricultural University(English Edition) 1996年第1期3卷 15-19页

作者： taobo LuanFengxia 等 NortheastAgriculturalUniversity Harbin150030PRChina. HeilongjiangCommodityInspectionBureau Harbin150030PR

Thirty lines of bean were tested for resistance to glyphosate in the *** difference in resistance response to glyphosate was detected when glyphosate was applied at the rate of 1kg ai/ha on the 15th day after emergence of *** ling 89-05 showed high resistance with a survival of 77%.Even after glyphosate was reapplied,the survival rats was still 20%.Obvious segregation was found in Progency of 89-05 for resistance to glyphosate;the survival rate of lined 89-05-1 89-05-2 and 89-05-3 were,respectively.42.3%,51.4% and 85.7% at 1kg ai/ha of the *** 89-05-3 continued to show resistance and lines 89-05-3-5 and 89-05-3-7 both had a survival rate of 100%.When glyphosate was applied with a rate over 1kg ai/ha, the survival rate of the 89-05 -3- 5 was still between 50%-98%.

关键词： glyphosate,stability,bean risistance

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反应堆中子注量率对数测量技术研究

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核电子学与探测技术 2024年第3期44卷 536-541页

作者：孙琦高志宇包超罗庭芳龚涛波张芸单伟核反应堆系统设计技术重点实验室成都610213

反应堆核仪表系统通过一系列布置在堆外的中子探测器进行反应堆中子注量率测量,为反应堆启动、运行和安全提供初始测量信号。中间量程中子注量率测量范围超过6个量级,同时探测器输出的电流十分微弱,最小达到10 pA,对测量技术要求较高。... 详细信息

反应堆核仪表系统通过一系列布置在堆外的中子探测器进行反应堆中子注量率测量,为反应堆启动、运行和安全提供初始测量信号。中间量程中子注量率测量范围超过6个量级,同时探测器输出的电流十分微弱,最小达到10 pA,对测量技术要求较高。线性电流测量方法会产生由量程切换带来的测量跳变,影响反应堆周期测量稳定性,从而影响反应堆安全。本文详细分析了对数测量原理,利用对数放大电路具有宽动态范围的特点,实现了很宽的动态范围的中子注量率快速测量,避免了量程切换带来的测量数值跳变,提高了中子注量率测量和周期计算的精度。模拟探测器信号输入10 pA~100μA的微电流进行测量,结果表明,对于范围达7个数量级的输入电流,测量的相对误差低于0.5%,该方案适用于反应堆中子注量率的中间量程测量。

关键词：中子注量率对数放大微电流中间量程动态范围

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Influences of top clearance and liquid throughput on the performances of an external loop airlift slurry reactor integrated mixing and separation

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1514-1521页

作者： Hongyan Liu Zhuo Li Shujun Geng Fei Gao taobo He Qingshan Huang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess Technology(QIBEBT)Chinese Academy of Sciences(CAS)Qingdao 266101China Dalian National Laboratory for Clean Energy(DNL) Dalian 116023China Petrochemical Research Institute China National Petroleum Corporation(CNPC)Beijing 100083China

A new developed external loop airlift slurry reactor, which was integrated with gas–liquid–solid three-phase mixing, mass transfer, and liquid–solid separation simultaneously, was deemed to be a promising slurry reactor due to its prominent advantages such as achieving continuous separation of clear liquid from slurry and cyclic utilization of solid particles without any extra energy, energy-saving, and intrinsic safety design. The principal operating parameters, including gas separator volume, handling capacity, and superficial gas velocity, are systematically investigated here to promote the capabilities of mixing, mass transfer, and yield in the pilot external loop airlift slurry reactor. The influences of top clearance and throughput of the clear liquid on flow regime and gas holdup in the riser, liquid circulating velocity, and volumetric mass transfer coefficient with a typical high solid holdup and free of particles are examined experimentally. It was found that increasing the gas separator volume could promote the liquid circulating velocity by about 14.0% at most. Increasing the handling capacity of the clear liquid from 0.9 m3·h-1 to 3.0 m3·h-1 not only could increase the output without any adverse consequences, but also could enhance the liquid circulating velocity as much as 97.3%. Typical operating conditions investigated here can provide some necessary data and guidelines for this new external loop airlift slurry reactor to upgrade its performances.

关键词： External loop airlift reactor Mixing Separation Hydrocyclone Hydrodynamics Mass transfer

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Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy

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Genes & Diseases 2022年第3期9卷 659-667页

作者： taobo Hu Wei Hou Enhua Xiao Mengping Long Department of Breast Surgery Peking University People’s HospitalBeijing 100044PR China Department of Pathology Peking University Cancer HospitalBeijing 100142PR China Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011PR China

Stress granules are non-membranous cytoplasmic foci induced by various stress *** is a protective strategy used by cells to suppress overall translation during *** cancer cells,it was thought that the formation of stress granules could protect them from apoptosis and induces resistance towards anti-cancer drugs or radiation treatment which makes the stress granules a potential target for cancer ***,most of our understanding of stress granules are still in the stage of molecular and cell biology,and a transitional gap for its actual effect on clinical settings *** this review,we summarize the mechanism and effect of stress granules formation in cancer and try to illuminate its potential applications in cancer therapy,using breast cancer as an example.

关键词： Apoptosis Breast cancer Drug resistance Stress granules Translation initiation

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AluScanCNV2:An R package for copy number variation calling and cancer risk prediction with next-generation sequencing data

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Genes & Diseases 2019年第1期6卷 43-46页

作者： taobo Hu Si Chen Ata Ullah Hong Xue Division of Life Science Applied Genomics Centre and Centre for Statistical ScienceHong Kong University of Science and TechnologyClear Water BayHong Kong School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingChina

The usage of next-generation sequencing(NGS)to detect copy number variation(CNV)is widely accepted in cancer *** on an AluScanCNV software developed by us previously,an AluScanCNV2 software has been developed in the present study as an R package that performs CNV detection from NGS data obtained through AluScan,wholegenome sequencing or other targeted NGS *** applications would include the expedited usage of somatic CNVs for cancer subtyping,and usage of recurrent germline CNVs to perform machine learning-assisted prediction of a test subject’s susceptibility to cancer.

关键词： AluScan Bioinformatics Cancer subtyping Cancer predisposition Machine learning

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