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Toward in vivo translation of superresolution localization photoacoustic computed tomography using liquid-state dyed droplets

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Light(Science & Applications) 2019年第1期8卷 676-677页

作者： Wonseok Choi Chulhong kim Departments of Creative IT Engineering Electrical EngineeringMechanical EngineeringInterdisciplinary Bioscience and BioengineeringPohang University of Science and TechnologyPohangGyeongbuk 37673Republic of Korea

Super-resolution localization photoacoustic computed tomography has been successfully performed in live animals using an injection of unprecedentedly absorptive liquid-state dyed droplets,which promises a disruptive m... 详细信息

关键词： has translation dis

Quantum dots-labeled polymeric scaffolds for in vivo tracking of degradation and tissue formation

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Bioactive Materials 2022年第10期7卷 285-292页

作者： Kun Hee Sim Seyed Mohammand Mir Sophia Jelke Solaiman Tarafder Jinho kim Chang H.Lee Regenerative Engineering Laboratory Center for Dental and Craniofacial ResearchColumbia University Irving Medical Center630 West 168th StreetVC12-211New YorkNY10032USA Department of Biomedical Engineering Stevens Institute of TechnologyHobokenNJ07030USA

The inevitable gap between in vitro and in vivo degradation rate of biomaterials has been a challenging factor in the optimal designing of scaffold’s degradation to be balanced with new tissue *** enable non-/minimum-invasive tracking of in vivo scaffold degradation,chemical modifications have been applied to label polymers with fluorescent ***,the previous approaches may have limited expandability due to complicated synthesis ***,we introduce a simple and efficient method to fluorescence labeling of polymeric scaffolds via blending with near-infrared(NIR)quantum dots(QDs),semiconductor nanocrystals with superior optical ***-labeled,3D-printed PCL scaffolds showed promising efficiency and reliability in quantitative measurement of degradation using a custom-built fiber-optic imaging ***,QDs-PCL scaffolds showed neither cytotoxicity nor secondary labeling of adjacent ***-PCL scaffolds also supported the engineering of fibrous,cartilaginous,and osteogenic tissues from mesenchymal stem/progenitor cells(MSCs).In addition,QDs-PCL enabled a distinction between newly forming tissue and the remaining mass of scaffolds through multi-channel ***,our findings suggest a simple and efficient QDs-labeling of PCL scaffolds and minimally invasive imaging modality that shows significant potential to enable in vivo tracking of scaffold degradation as well as new tissue formation.

关键词： Key terms:quantum dots Polycaprolactone Tissue engineering In vivo tracking Degradation

Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization

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World Journal of Gastroenterology 2016年第47期22卷 10406-10414页

作者： Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad Department of Radiation Oncology H Lee Moffitt Cancer Center and Research Institute Department of Interventional Radiology H Lee Moffitt Cancer Center and Research Institute Department of Gastrointestinal Oncology H Lee Moffitt Cancer Center and Research Institute

AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver *** We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization.

关键词： F-18 fluorodeoxyglucose PET Hepatocellular carcinoma Radioembolization Prognosis Biomarker

Updates in the management of cranial dural arteriovenous fistula

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Stroke & Vascular Neurology 2020年第1期5卷 50-58页

作者： Humain Baharvahdat Yinn Cher Ooi Wi Jin kim Ashkan Mowla Alexander L Coon Geoffrey P Colby Neurosurgery Ronald Reagan UCLA Medical CenterLos AngelesCaliforniaUSA Neurointerventional Radiology UCLALos AngelesCaliforniaUSA Western Neuro Carondelet Health NetworkTucsonArizonaUSA

Dural arteriovenous fistula(dAVF)accounts for approximately 10%of all intracranial vascular *** they can be benign lesions,the presence of retrograde venous drainage and cortical venous reflux makes the natural course of these lesions aggressive high risk of haemorrhage,neurological injury and *** treatment is often the first line of treatment for *** transarterial and transvenous approaches are used to cure *** selection of treatment approach depends on the angioarchitecture of the dAVF,the location,the direction of venous *** and,to a lesser extent,stereotactic radiosurgery are used when endovascular approaches are impossible or unsuccessful.

关键词： Surgery arterial treatment

Emamectin benzoate 9.7%SL as a new formulation for a trunkinjections against pine wood nematode,Bursaphelenchus xylophilus

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Journal of Forestry Research 2020年第4期31卷 1399-1403页

作者： Sung-Chan Lee Hyo-Rim Lee Dong-Soo kim Jun-Hyeong Kwon Min-Jung Huh Il-Kwon Park Department of Forest Sciences College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Science College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Forest Biomaterials Research Center National Institute of Forest ScienceJinjuGyeongnam 52817Republic of Korea

In this study,we investigated the preventive effects of emamectin benzoate 9.7%SL,which was newly developed to reduce the injection volume and number of injection holes required to protect against pine wood *** of the Pinus thunbergii trees injected with emamectin benzoate 9.7%SL at 0.3 mL/cm diameter at breast height(DBH)died within 2 years of inoculation with pine wood *** benzoate 9.7%SL injected at 0.6 mL/cm DBH resulted in no tree mortality for 3 *** residue of emamectin benzoate 9.7%SL in pine twigs injected with 0.3 mL/cm DBH was 0.490μg/g at 1 year after injection and 0.303μg/g after 2 *** residues values are greater than 0.031μg/g,previously determined IC95 value for emamectin benzoate against the pine wood *** field experiment and residue analysis showed that emamectin benzoate 9.7%SL could be a substitute agent for emamectin benzoate 2.15%EC,which is widely used to prevent pine wood nematode in the field and that injection volume and number of injection holes can be greatly educed using this new formulation,which will reduce injury to the cambium,interruption of water movement,and infection of inoculation wounds by wood-decay or blue stain fungi.

关键词： Emamectin benzoate 9.7%SL Emamectin benzoate 2.15%EC Trunk injection Pine wood nematode Residue

Seoul Food Culture Viewed from High-Class Korean-Styled Restaurants and Korean Female Entertainers in the 1930s

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Journal of Food Science and Engineering 2014年第6期4卷 301-310页

作者： kim Bok-Rae Department of European Culture and Tourism Andong National University Andong 760-749 South Korea

Since Korea-Japan annexation in 1910, Japan has promoted the migration and/or tourism into colonial Chosun （old Korea） as an efficient cultural strategy for extending imperialism into Korean peninsula. In many tour guide books, the gisaeng （Korean female entertainers） was not only a symbol of Chosun tradition, but a main icon of Chosun tourism. The high class Korean-styled restaurants （yorijoem） were established as tourist attraction for Japanese inlanders, with singing and dancing gisaengs, ondol （Korean heating floor） house and Korean authentic cuisine, etc. The aim of this paper is firstly to explore the existential change of gisaengs in the yorijoem through its spatial significance in the 1930s, and secondly to explore the identity of Seoul local food culture and its metamorphosis under the colonial modernity.

关键词： Gisaeng yorijoem gisaeng tourism Seoul food culture colonial modernity.

AKT regulates IL-1β-induced proliferation and activation of hepatic stellate cells

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BIOCELL 2023年第3期47卷 669-676页

作者： YONGDAE YOON SOONJAE HwanG FATEMA TUJ SAIMA MOON YOUNG kim SOON KOO BAIK YOUNG WOO EOM Regeneration Medicine Research Center Yonsei University Wonju College of MedicineWonju26426Korea Department of Biochemistry Lee Gil Ya Cancer and Diabetes InstituteGAISTGachon University College of MedicineIncheon21999Korea Cell Therapy and Tissue Engineering Center Yonsei University Wonju College of MedicineWonju26426Korea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju26426Korea

Background:Activated hepatic stellate cells(HSCs)are closely involved in the initiation,perpetuation,and resolution of liver ***-inflammatory cytokine levels are positively correlated with the transition from liver injury to fibrogenesis and contribute to HSC pathophysiology in liver ***:In this study,we investigated the effect of the pro-inflammatory cytokine interleukin(IL)-1βon the proliferation and signaling pathways involved in fibrogenesis in LX-2 cells,an HSC cell line,using western blotting and cell proliferation ***:IL-1βincreased the proliferation rate andα-smooth muscle actin(SMA)expression of LX-2 cells in a dose-dependent *** 1 h after IL-1βtreatment,c-Jun N-terminal kinase(JNK),p38,and nuclear factor-κB(NF-κB)signaling was activated in LX-2 ***,protein kinase B(AKT)phosphorylation and an increase inα-SMA expression were observed in LX-2 *** inhibitor of JNK,p38,or NF-κB decreased cell proliferation,AKT phosphorylation,andα-SMA expression in IL-1β-treated LX-2 ***:These results indicate that JNK,p38,and NF-κB signals converge at AKT phosphorylation,leading to LX-2 activation by IL-1β.Therefore,the AKT signaling pathway can be used as a target for alleviating liver fibrosis by the inflammatory cytokine IL-1β.

关键词： Hepatic stellate cell Interleukin-1β AKT Cell proliferation Fibrosis

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF KR-008 IN BIOLOGICAL FLUIDS

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Chinese Chemical Letters 1993年第12期4卷 1071-1074页

作者： Yun Seon SONG Jae Chun RYU Myungsoo kim Doping Control Center Korea Institute of Science and Technology Seoul Korea

A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment,the compounds were separated and analysed on a reversed- phase column under isocratic conditions,including ion *** in urine and bile were determined by an external standard *** detection limit was 0.8μg/ml in *** data showed that,following ***(120mg/kg)of KR-008 to rats,approximately 2.8% of the dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;in bile it was 0.73% excreted as unchanged form and above 0.29% as the *** peak biliary concentration of KR-008 was 0.39mg/ml at 20min after dosing.

关键词： KR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF KR-008 IN BIOLOGICAL FLUIDS

Predictions of Galapagos Volcanic Eruption, El Niño, Ecuadorian Earthquake, Global Volcanic Eruption and Forest Fire by Sunspot Number

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Natural Science 2020年第1期12卷 12-27页

作者： Tai-Jin kim Department of Chemical Engineering University of Suwon Hwasung-City South Korea

The earthquake number was correlated (R2 = 0.8781) with the volcano number in the East Pacific and Central American countries. The year of volcanic eruptions in the Galapagos Hot Spot (GHS) was proportional to the year of El Niño events (R2 = 0.9939) as well as to the year of earthquake events (R2 = 0.9943) in Ecuador, Colombia, and Peru from 1977 to 2016. Therefore, there can be El Niño and earthquake events in Ecuador, Colombia and Peru if there are strong volcanic eruptions either from aboveground volcanoes or undersea seamounts in the GHS during the maximal sunspot number’s period. Global volcanic eruptions were occurred during the maximal temperature departure, the latter being reversely proportional (R2 = 0.4512) to the sunspot number from 1980 to 2019. Forest fires occurred in middle latitude countries (South Korea, California, western Russia, Australia) around 35 degree from Pacific Equator during La Niña events at the time of the minimal sunspot number. Since there were intense forest fires in South Korea, Australia and California in 2019, more are expected in 2030 due to the 11 year cyclical variation in the sunspot number. The sequence of forest fires can be schematically summarized as below. 1) La Niña event in Equator causes the low vapor pressure of water due to the low sea surface temperature (SST);2) There is the pumping of freshwater from the warm Pacific Ocean to cold Equator with simultaneous transfer of heat (warm Pacific Ocean to cold Equator) and mass (water enriched Pacific Ocean to water lean Equator);3) Strong winds from dry zone pass Mountains to cause the forest fires in the residential land with bushes and trees. 4) According to the Bernoulli’s principle, the pressure gradient between the high Mountains and the low Ocean, induces the decrease of static velocity gradient for vigorously upwards flares in the Mountains and the residential land during the forest fires, which may be why it is difficult to extinguish the forest

关键词： Prediction Volcanic Eruption Ecuadorian Earthquake Forest Fire Sunspot Number