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Dialectical study of disulfidptosis and clinical outcome in patients with colorectal cancer

Traditional Medicine Research 2024年第10期9卷 52-63页

作者： Hua-Mei Zhu yu-tao chen Yang Ye yue-Feng Hu Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000China The Second School of Medicine Wenzhou Medical UniversityWenzhou 325000China

Background:Colorectal cancer(CRC)is a leading cause of cancer mortality *** study aims to develop a prognostic model based on disulfidptosis-related genes to assess survival outcomes in CRC,highlighting the tumor microenvironment’s ***:The thought of traditional Chinese medicine syndrome differentiation and treatment runs through the whole *** analyzed CRC tissue data from The Cancer Genome Atlas and the Gene Expression Omnibus using single-sample gene set enrichment and weighted gene correlation network analyses to identify prognostic markers and evaluate immune *** also investigated predictive drug ***:We identified seven disulfidptosis-related markers–complement C1q A chain(C1QA),solute carrier family 11 member 1(SLC11A1),cluster of differentiation 36(CD36),cluster of differentiation 6(CD6),interleukin 1 receptor associated kinase 3(IRAK3),S100 calcium binding protein A8(S100A8),and CD8 subunit alpha(CD8A)–that significantly influence *** classified in the low-risk group demonstrated improved overall survival compared to those in the high-risk group across training(P=0.0026)and validation cohorts(P=0.032).Differential gene expression was significant in the high-risk group(P<0.001),and prevalent mutations included APC regulator of WNT signaling pathway(APC),tumor protein P53(TP53),Titin(TTN),and Kirsten rat sarcoma viral oncogene(KRAS).The risk score correlated linearly with tumor microenvironment *** results of drug analysis showed that some traditional drugs may have anticancer effects through the vertical action of ***:Our prognostic model,integrating seven disulfidptosis-related genes,categorizes CRC patients by survival probability and underscores these genes as potential biomarkers linked to the tumor *** findings support their use in refining therapeutic strategies for CRC.

关键词： colorectal cancer tumor microenvironment disulfidptosis WGCNA LASSO regression

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Discovery of two rotational modulation periods from a young hierarchical triple system

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Science China(Physics,Mechanics & Astronomy) 2023年第9期66卷 179-189页

作者： yu-tao chen Hai-Jun Tian Min Fang Xiao-Xiong Zuo Sarah ABird Di Liu Xin-yu Zhu Peng Zhang Gao-Chao Liu Sheng Cui Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443002China School of Science HangZhou Dianzi UniversityHangZhou 310018China Space Information Research Institute Hangzhou Dianzi UniversityHangZhou 310018China School of Physics and Astronomy China West Normal UniversityNanChong 637002China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

GW Ori is a young hierarchical triple system located in λ Orionis, consisting of a binary(GW Ori A and B), a tertiary star(GW Ori C) and a rare circumtriple disk. Due to the limited data with poor accuracy, several short-period signals were detected in this system, but the values from diferent studies are not fully consistent. As one of the most successful transiting surveys, the transiting exoplanet survey satellite(TESS) provides an unprecedented opportunity to make a comprehensive periodic analysis of GW Ori. In this work we discover two significant modulation signals by analyzing the light curves of GW Ori's four observations from TESS, i.e.,(3.02 ± 0.15) and(1.92 ± 0.06) d, which are very likely to be the rotational periods caused by starspot modulation on the primary and secondary components, respectively. We calculate the inclinations of GW Ori A and B according to the two rotational periods. The results suggest that the rotational plane of GW Ori A and B and the orbital plane of the binary are almost coplanar. We also discuss the aperiodic features in the light curves;these may be related to unstable accretion. The light curves of GW Ori also include a third(possible) modulation signal with a period of(2.51±0.09) d, but the third is neither quite stable nor statistically significant.

关键词： GW Ori pre-main sequence fundamental parameters triple stars

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Percutaneous vertebroplasty versus percutaneous kyphoplasty for the treatment of delayed post-traumatic vertebral body collapse(Kümmell’s disease) in Chinese patients: a systematic review and meta-analysis

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Frontiers of Nursing 2019年第4期6卷 273-283页

作者： Peng-Fei Han cheng-Long chen tao-yu chen Zhi-Liang Zhang Xiao-Dong Li Peng-Cui Li Xiao-Chun Wei Department of Orthopaedic Surgery The Second People’s Hospital of ChangzhiChangzhiShanxi 046000China China Department of Orthopaedic Surgery The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030009China

Objective: To compare the clinical efficacy between percutaneous vertebroplasty(PVP) and percutaneous kyphoplasty(PKP) in the treatment of Kümmell's disease in Chinese ***: The studies using randomized controlled trials to compare clinical efficacy between PVP and PKP in the treatment of Kümmell's disease in Chinese patients were retrieved from Embase, Pubmed, Central, Cinahl, PQDT, CNKI, CQVIP, Wanfang Data, and CBM(from September 2008 to September 2018). Keywords for both Chinese and English search were: percutaneous vertebroplasty, PVP, percutaneous kyphoplasty, PKP, and Kümmell's disease. A total of 132 articles were retrieved based on the search strategy through online database searching and manual searching. Finally, one foreign report and seven Chinese reports were included. After extracting the data, statistical software Review Manager 5.3 was used for data ***: Through comparison, Cobb angle(95% CI [0.54, 4.42), P = 0.01] and Oswestry Dysfunction Index(ODI)(95% CI [0.21, 2.15], P= 0.02) of PKP group was smaller than that of PVP group. Postoperative anterior vertebral body height of the PKP group was better than PVP group(95% CI [-1.27,-0.66], P < 0.001]. However, the PVP group had shorter operation time than PKP group(95% CI [-13.48,-7.43), P = 0.001]. In the other outcome measures, including Visual Analogue Scale(VAS) score(95% CI [-0.04, 0.27), P = 0.15), cement volume(95% CI [-0.82, 0.32], P = 0.39) and cement leakage(95% CI [0.90, 2.76], P = 0.11), there was no significant differences between the two ***: At this stage, there is sufficient evidence to support that PKP is better than PVP in the treatment of Kümmell's disease in Chinese patients. Although PVP surgery requires much less operation time, PKP has better postoperative radiological results and lower ODI. Moreover, both of them had similar clinical results(e.g., analgesic effects, cement dosage, and leakage rate). Further evidence is dependent on the

关键词： Kümmell’s disease percutaneous vertebroplasty percutaneous kyphoplasty post-trauma vertebral body collapse meta-analysis systematic review

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing chen Chao Wu Xiaoling Liu Biao Meng tao chen yu Han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

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National Science Review 2021年第8期8卷 147-157页

作者： Li Zhang Lei Cao Xing-Su Gao Bin-Yang Zheng Yong-Qiang Deng Jing-Xin Li Rui Feng Qian Bian Xi-Ling Guo Nan Wang Hong-Ying Qiu Lei Wang Zhen Cui Qing Ye Geng chen Kui-Kui Lu Yin chen yu-tao chen Hong-Xing Pan Jiaping yu Wenrong Yao Bao-Li Zhu Jianping chen Yong Liu cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu National Health Commission of the People’s Republic of China Key Laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention) Center for Global Health School of Public HealthNanjing Medical University CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences Guangzhou Regenerative Medicine and Health Guangdong Laboratory Jiangsu Rec-biotechnology Co.Ltd State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology

Mutations and transient conformational movements of the receptor binding domain(RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). To mitigate viral escape, we developed a cocktail of neutralizing antibodies(NAbs) targeting epitopes located on different domains of spike(S) protein. Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs, targeting the N-terminal domain(NTD) and RBD domain of S, effective at n M concentrations. Remarkably, a combination of RBD-targeting NAbs and NTD-binding NAbs, FC05, enhanced the neutralization potency in cell-based assays and an animal model. Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM) structures of antigen-binding fragments bound to S unveil determinants of immunogenicity. Combinations of immunogens, identified in the NTD and RBD of S, when immunized in rabbits and macaques, elicited potent protective immune responses against SARS-CoV-2. More importantly, two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge, without observable antibody-dependent enhancement of infection. These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD.

关键词： SARS-CoV-2 neutralizing antibodies vaccine development structure-based immunogen design

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柔性框架结构动力非线性分析的刚体准则法

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工程力学 2021年第11期38卷 57-65页

作者：陈朝晖陶宇宸何敏重庆大学土木工程学院重庆400045 山地城镇建设与新技术教育部重点实验室(重庆大学) 重庆400045 浙江大学建筑工程学院浙江杭州310058

大跨、高层等柔性结构,其动力响应往往表现出大位移、大转动等非线性特征。动力非线性问题的分析关键在于运动方程的高效稳定求解,以及单元大转动产生的结点力增量的有效计算。动力时程分析通常采用直接积分法,但对于强非线性动力问题,... 详细信息

大跨、高层等柔性结构,其动力响应往往表现出大位移、大转动等非线性特征。动力非线性问题的分析关键在于运动方程的高效稳定求解,以及单元大转动产生的结点力增量的有效计算。动力时程分析通常采用直接积分法,但对于强非线性动力问题,直接积分法难以兼顾计算精度与稳定性。该文基于几何非线性分析的刚体准则,针对杆件结构大转动小应变的非线性问题,提出了一种新型空间杆系结构动力非线性分析的刚体准则法。该方法采用满足刚体准则的空间非线性梁单元,结合HHT-α法求解结构运动方程,并将刚体准则植入动力增量方程的迭代求解过程以计算结点力增量。通过典型柔性框架算例结果表明,该文方法可以有效分析柔性框架结构的强动力非线性行为。与高精度单元相比,该文采用的单元刚度矩阵构造简明,计算过程简洁;与商业软件所用方法相比,单元数和迭代步少,精度高,适于工程应用。

关键词：动力非线性分析柔性框架结构直接积分法几何非线性刚体准则 HHT-α法

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Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

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Frontiers of Nursing 2018年第2期5卷 91-96页

作者： Peng-Fei Han Zhi-Liang Zhang tao-yu chen Rui-Peng Zhao Rong Zhang Xiao-Dong Li Peng-Cui Li Lei Wei Zhi Lv Xiao-Chun Wei Second People's Hospital of Changzhi City ChangzhiShanxi 046010China Second Affiliated Hospital of Shanxi Medical University TaiyuanShanxi 030001China Affiliated Peace Hospital of Changzhi Medical College ChangzhiShanxi 046010China

The main pathological change in post-traumatic osteoarthritis （PTOA） is cartilage degeneration, which is closely related to inflammation and oxidative stress. Inflammation can cause degeneration of articular cartilage. Cartilage degeneration can also stimulate the progression of inflammation. It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways, mainly mitogen-activated protein kinase, nuclear transcription factor kappa B, and Wnt-p-catenin signal transduction pathways. This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.

关键词： post-traumatic osteoarthritis cartilage degeneration pminflammatory cytokine signaling pathway

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我国低碳城市发展影响机制研究——基于35个副省级以上城市样本的实证分析

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经济问题 2017年第8期 111-116页

作者：赵涛于晨霞潘辉天津大学管理与经济学部天津300072 天津城建大学经济与管理学院天津300384

基于3E1S系统模型,从能源、经济、环境和社会四个方面建立指标体系,选取我国35个副省级以上城市作为研究样本,采用2010-2014年的面板数据,运用结构方程模型,对我国低碳城市发展的影响因素进行了实证分析,确定了关键影响路径,以期为低碳... 详细信息

基于3E1S系统模型,从能源、经济、环境和社会四个方面建立指标体系,选取我国35个副省级以上城市作为研究样本,采用2010-2014年的面板数据,运用结构方程模型,对我国低碳城市发展的影响因素进行了实证分析,确定了关键影响路径,以期为低碳城市建设提供借鉴参考。结果表明:能源结构及消耗水平、经济发展能力、社会发展能力以及城市环境承载能力对低碳城市发展产生直接或间接的影响,其影响程度逐渐减小。低碳城市的发展水平最终取决于各影响因素之间的相互协同作用。

关键词：低碳城市系统结构方程模型

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen Xin Zhang Lingcong Chao Liang chen Ding Zhang tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang chen Yongyue Zhuang Yanxin Qiao yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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