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Upregulation of circ0000381 atienuates microglial/macrophage pyroptosis after spinal cord injury

Neural Regeneration Research 2024年第6期19卷 1360-1366页

作者： Yan zhang Wenkai zhang tao Liu Ziqian Ma Wenxiu zhang Yun Guan Xueming Chen Central Laboratory Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedics Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Emergency Medicine Aerospace Center HospitalBeijingChina Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neurological Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Neuroinflammation exacerbates secondary damage after spinal cord injury,while microglia/macrophage pyroptosis is important to *** RNAs(circRNAs)play a role in the central nervous ***,the functional role and mechanism of circRNAs in regulating microglia/macrophage pyroptosis after spinal cord injury are still poorly *** the present study,we detected microglia/macrophage pyroptosis in a female rat model of spinal cord injury,along with upregulated levels of circ0000381 in the spinal *** further experimental results suggest that circ0000381 may function as a sponge to sequester endogenous microRNA423-3p(miR-423-3p),which can increase the expression of NOD-like receptor 3(NLRP3),a pyroptosis ***,upregulation of circ0000381 may be a compensatory change after spinal cord injury to attenuate microglia/macrophage ***,knockdown of circ0000381 expression exacerbated microglia/macrophage ***,our findings provide novel evidence for the upregulation of circ0000381,which may serve as a neuroprotective mechanism to attenuate microglia/macrophage pyroptosis after spinal cord ***,circ0000381 may be a novel therapeutic target for the treatment of spinal cord injury.

关键词： circ0000381 inflammasome macrophage microglia miR-423-3p neuroinflammation neuroprotection NLRP3 pyroptosis RNA-Seq spinal cord injury

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A Blockchain and CP-ABE Based Access Control Scheme with Fine-Grained Revocation of Attributes in Cloud Health

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Computers, Materials & Continua 2024年第2期78卷 2787-2811页

作者： Ye Lu tao Feng Chunyan Liu Wenbo zhang School of Computer&Communication Lanzhou University of TechnologyLanzhou730000China School of Economics&Management Lanzhou University of TechnologyLanzhou730000China School of Computer Science Baoji University of Arts and ScienceBaoji721000China

The Access control scheme is an effective method to protect user data *** access control scheme based on blockchain and ciphertext policy attribute encryption(CP–ABE)can solve the problems of single—point of failure and lack of trust in the centralized ***,it also brings new problems to the health information in the cloud storage environment,such as attribute leakage,low consensus efficiency,complex permission updates,and so *** paper proposes an access control scheme with fine-grained attribute revocation,keyword search,and traceability of the attribute private key distribution *** technology tracks the authorization of attribute private *** credit scoring method improves the Raft protocol in consensus ***,the interplanetary file system(IPFS)addresses the capacity deficit of *** the premise of hiding policy,the research proposes a fine-grained access control method based on users,user attributes,and file *** optimizes the data-sharing *** the same time,Proxy Re-Encryption(PRE)technology is used to update the access *** proposed scheme proved to be *** analysis and experimental results show that the proposed scheme has higher efficiency and more *** can meet the needs of medical institutions.

关键词： Blockchain access-control CP-ABE cloud health

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Numerical simulation of flow field deposition and erosion characteristics around bridge-road transition section

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Journal of Mountain Science 2024年第5期21卷 1491-1508页

作者： zhang Kai WANG Zhenghui WANG tao TIAN Jianjin zhang Hailong LIU Yonghe College of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Wind-sand flow generates erosion and deposition around obstacles such as bridges and roadbeds, resulting in sand damage and endangering railway systems in sandy regions. Previous studies have mainly focused on the flow field around roadbeds, overlooking detailed examinations of sand particle erosion and deposition patterns near bridges and roadbeds. This study employs numerical simulations to analyze the influence of varying heights and wind speeds on sand deposition and erosion characteristics at different locations: the bridge-road transition section(side piers), middle piers, and roadbeds. The results show that the side piers, experience greater accumulation than the middle piers. Similarly, the leeward side of the roadbed witnesses more deposition compared to the windward side. Another finding reveals a reduced sand deposition length as the vertical profile, in alignment with the wind direction, moves further from the bridge abutments at the same clearance height. As wind speeds rise, there’s a decline in sand deposition and a marked increase in erosion around the side piers, middle piers and roadbeds. In conclusion, a bridge clearance that’s too low can cause intense sand damage near the side piers, while an extremely high roadbed may lead to extensive surface sand deposition. Hence, railway bridges in areas prone to sandy winds should strike a balance in clearance height. This research provides valuable guidelines for determining the most suitable bridge and roadbed heights in regions affected by wind and sand.

关键词： Sandstorm Flow field Bridge-road transition section Sedimentation erosion Numerical simulation

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OsDA1 positively regulates grain width in rice

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The Crop Journal 2024年第1期12卷 92-101页

作者： Cong Li Jun Liu Liya zhang tao Li Hongyu Li Bin Liu tao Zhao Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Nanfan&Seed Industry Guangdong Academy of SciencesGuangzhou 510316GuangdongChina

The size and shape of rice grains influence their yield and commercial *** investigated the role of OsDA1,a rice homolog of the Arabidopsis DA1 gene,in regulating grain size and ***1 was highly expressed in young spikelets and *** overexpression led to enlarged seeds with increased width and decreased length/width ratio(LWR)and knocking out OsDA1 reduced grain width and increased grain length and LWR.A R310K point mutation in the DA1-like domain is a potential target for breeding for increased grain width and ***1 interacted with TCP gene-family proteins to regulate grain size and *** findings deepen our understanding of the molecular mechanisms underlying grain size regulation and provide useful information for improving grain yield.

关键词： Rice Osda1 Grain size Grain shape Grain length/width ratio TCP

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A Finite-Time Convergent Analysis of Continuous Action Iterated Dilemma

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 563-565页

作者： Zhen Wang Xiaoyue Jin tao zhang Dengxiu Yu Northwestern Polytechnical University

Dear Editor,In this letter, a finite-time convergent analysis of continuous action iterated dilemma(CAID) is proposed. In traditional evolutionary game theory, the strategy of the player is binary(cooperation or defec... 详细信息

关键词： lemma letter convergent

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Selective nickel-electrocatalyzed benzylic C-H oxygenation of functionalized alkyl arenes

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Chinese Chemical Letters 2024年第2期35卷 396-401页

作者： Shunyao Tang Siyi Wang Dongmei zhang Xinxing zhang Guang Yang Yanwei Wang Youai qiu State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education)Renewable Energy Conversion and Storage Center (RECAST)Frontiers Science Center for New Organic MatterNankai UniversityTianjin 300071China

Herein, a site-selective paired electrochemical C–H oxidation of functionalized alkyl arenes promoted by nickel catalyst is disclosed. A Ni(Ⅱ)-dioxygen species formed in situ efficiently enable the oxidation process under mild conditions with a broad substrate scope with excellent functional group compatibilities,such as free carboxylic acid, aldehyde, halogen(including aryl iodide), amide and amino acid. The use of the nickel catalyst in combination with water provides a safe, green and economical method for oxidation of a range of molecules varying in complexity and drug derivatives, demonstrating its potential application in organic synthesis and the pharmaceutical industry. Reaction outcomes and mechanistic studies revealed the key role of the in situ Ni(Ⅱ)-dioxygen species for the subsequent oxidation of C(sp^(3))–H bonds,and short-lived reactive intermediates(aryl radical cation) was rapidly captured by the combination of a bipolar ultramicroelectrode(BUME) with nano-electrospray ionization mass spectrometry.

关键词： Electrochemical C-H oxidation Functionalized alkyl arenes Paired nickel-electrocatalysis H_(2)O oxidation Ketones

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Key role of interferon regulatory factor 1(IRF-1)in regulating liver disease:progress and outlook

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 451-470页

作者： tao CHEN Shipeng LI Dewen DENG Weiye zhang Jianjun zhang Zhongyang SHEN First Central Clinical School Tianjin Medical UniversityTianjin 300192China Department of Organ Transplant Tianjin First Central HospitalTianjin 300192China Research Institute of Transplant Medicine Nankai UniversityTianjin 300192China Department of Hepatobiliary Surgery Henan Provincial People’s HospitalZhengzhou 450000China Key Laboratory of Organ Transplant Tianjin First Central HospitalTianjin 300192China

Interferon regulatory factor 1(IRF-1)is a member of the IRF *** is the first transcription factor to be identified that could bind to the interferon-stimulated response element(ISRE)on the target gene and displays crucial roles in the interferoninduced signals and ***-1,as an important medium,has all of the advantages of full cell cycle regulation,cell death signaling transduction,and reinforcing immune surveillance,which are well *** studies indicate that IRF-1 is of vital importance to the occurrence and evolution of multifarious liver diseases,including but not limited to inhibiting the replication of the hepatitis virus(A/B/C/E),alleviating the progression of liver fibrosis,and aggravating hepatic ischemiareperfusion injury(HIRI).The tumor suppression of IRF-1 is related to the clinical characteristics of liver cancer patients,which makes it a potential indicator for predicting the prognosis and recurrence of liver cancer;additionally,the latest studies have revealed other effects of IRF-1 such as protection against alcoholic/non-alcoholic fatty liver disease(AFLD/NAFLD),cholangiocarcinoma suppression,and uncommon traits in other liver diseases that had previously received little ***,several compounds and drugs have featured a protective function in specific liver disease models in which there is significant involvement of the IRF-1 *** this paper,we hope to propose a prospective research basis upon which to help decipher translational medicine applications of IRF-1 in liver disease treatment.

关键词： Interferon regulatory factor(IRF-1) Hepatitis virus Liver fibrosis Hepatic ischemia-reperfusion injury(HIRI) Liver cancer

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A modified PVDF-HFP/PMMA crosslinked co-polymer for high-performance all-solid-state lithium metal batteries

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Particuology 2024年第10期93卷 203-210页

作者： Sijia Wang Liang He Mengting Wang Xingtong Guo Xiangyun qiu Shoudong Xu Petr Senin Ting Bian tao Wei School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang212003China Power&Energy Storage System Research Center College of Mechanical and Electrical EngineeringQingdao UniversityQingdao266071China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan030024China Institute of Mechanics and Power Engineering Ogarev Mordovia State UniversitySaransk430005Russia

For all-solid-state lithium batteries(ASSLBs),polymer-blended solid composite electrolytes(SCEs)have drawn wide interest owing to their significance in improving the interfacial solid-solid contacts and inhibiting the growth of lithium *** this work,SCEs based on PVDF-HFP/PMMA matrix containing MOFs(NH2-MIL-53(Al))and LiTFSI were designed and synthesized employing an easy solution casting *** synthesized samples were examined by XRD,SEM,EDS,and electrochemical *** was found that MPP-2 SCE not only has excellent ionic conductivity at 60℃ of 5.54×10^(−4) S cm^(−1),but also exhibits superior interfacial compatibility in Li||Li symmetric batteries,which can constantly cycle for about 800 h at 0.1 mA cm^(−2) with no *** assembled Li|MPP-2|LiFePO4 cell exhibited a first discharge specific capacity of up to 157.1 mAh g^(−1) at 60℃ and 0.2 *** work may help to further advance the progress of ASSLBs in the future.

关键词： NH_(2)-MIL-53(AI) All solid-state lithium batteries(ASSLBs) PMMA PVDF-HFP Solid composite electrolytes(SCEs)

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In-situ construction of MnCO3@CNTs nanosheets for high-capacity aqueous zinc ion batteries

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Science China Technological Sciences 2024年第11期67卷 3394-3404页

作者： LI tao DAI GeLiang LIU SiYu zhang JingYu SUN AoKui School of Packaging and Materials Engineering Hunan University of Technology

Owing to severe agglomeration of manganese carbonate（MnCO3） during its synthesis,it exhibits rapid decay cycle performance when used as a cathode material in aqueous zinc ion *** overcome this drawback,we synthesized a MnCO3material with carbon nanotubes（CNTs）(i.e.,MnCO3@CNTs) via a one-step solvothermal method using a hybrid modification ***3nanospheres were grown in-situ on a two-dimensional（2D） plane that was orderly interwoven by tubular single fibers of carbon to form a leaf-like nanosheet *** surface area of the MnCO3@CNTs material was enlarged enormously through the special nanosheet structure,and its stability was improved by the supporting structure of the *** a result,the MnCO3@CNTs exhibited a discharge capacity of 247.6 mAh g-1at a current density of 0.1 A *** energy storage mechanism of MnCO3@CNTs was further explored using a series of electrochemical kinetic analyses and ex-situ characterization *** modification method not only broadens the application field of MnCO3,but also provides the possibility of modifying more cathode materials.

关键词： manganese carbonate cathode materials aqueous zinc ion batteries energy storage mechanism

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Reactive air wetting and brazing of Al_(2)O_(3) ceramics using Ag-Nb_(2)O_(5) filler: Performance and interfacial behavior

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Journal of Advanced Ceramics 2024年第2期13卷 135-142页

作者： Yudi qiu Shunjian Xu Xiangzhao zhang Mingfen zhang Qinhan Guo Beiji Wang Guanjun Qiao Guiwu Liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Intelligent Manufacturing Huzhou CollegeHuzhou 313000China

We firstly performed the reactive air wetting and brazing of Al_(2)O_(3) ceramics using Ag-(0.5-12)Nb_(2)O_(5) fillers,where Nb_(2)O_(5) can react with liquid Ag and O2 from air to generate AgNbO_(3).The contact angle of the Ag-Nb_(2)O_(5)/Al_(2)O_(3) system almost linearly decreases from~71.6°to 32.5°with the Nb_(2)O_(5) content increasing,and the joint shear strength reaches the maximum of~65.1 MPa while employing the Ag-4Nb_(2)O_(5) filler,which are mainly related to the formation and distribution of the AgNbO_(3) phase at the ***,the interfacial bonding and electronic properties of related interfaces were investigated by first-principles *** calculated works of adhesion(Wa)of Ag(111)/Ag-O-AgNbO_(3)(001)and AgNbO_(3)(001)/Al_(2)O_(3)(100)interfaces are higher than that of the Ag(111)/Al_(2)O_(3)(110)interface,indicating good reliability of the Ag/AgNbO_(3)/Al_(2)O_(3) *** relatively large interfacial charge transfer indicates the formation of Ag-Ag,Al-O,and Ag-O bonds in the Ag/AgNbO_(3)/Al_(2)O_(3) structure,which can contribute to the interfacial bonding.

关键词： reactive air brazing(RAB) wettability microstructure shear strength first-principles calculations

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