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Effects of physical exercise on the quality-of-life of patients with haematological malignancies and thrombocytopenia:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第10期10卷 3143-3155页

作者： Yu-Pei Yang Shuang-Jun Pan Shu-Lin Qiu tao-hsin tung Department of Hematology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Department of Neurosurgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Institute for Hospital Management Tsing Hua UniversityShenzhen 518055Guangdong ProvinceChina Evidence-Based Medicine Center Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

BACKGROUND Annually,there are an estimated 1187000 new patients worldwide diagnosed with haematological malignancies.Effective strategies are needed to alleviate side effects and prevent the physical and psychosocial degeneration of patients in active treatment for haematological malignancies.AIM To explore the effects of physical exercise on quality of life(Qo L)of patients with haematological malignancies and thrombocytopenia.METHODS Cochrane Library,Pub Med and Embase were searched for all relevant articles reporting randomized controlled trials(RCTs)that were published up to 31 July 2021.Two authors independently selected articles in accordance with the inclusion criteria,evaluated their quality,and collected information.Any controversy was resolved through discussion with a third senior author.The PRISMA 2009 checklist was followed.RESULTS Seven RCTs were selected in the systematic review and three were included in the final meta-analysis.There were significant differences in Qo L between physical exercise groups[mean score difference=8.81;95%confidence interval(CI):1.81-15.81,P=0.01],especially in emotional functioning(mean score difference=12.34;95%CI:4.64-20.04,P=0.002)and pain(mean score difference=–12.77;95%CI:-3.91 to-21.63,P=0.005).CONCLUSION Physical exercise has clinical effects on Qo L and improves emotional function and pain indices of patients with haematological malignancies and thrombocytopenia.

关键词： Haematological malignancies Thrombocytopenia Exercise Quality-of-life Systematic review Meta-analysis

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Clinical practice of rapid antigen tests for SARS-CoV-2 Omicron variant:A single-center study in China

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Virologica Sinica 2022年第6期37卷 842-849页

作者： Mengyuan Chen Jiaqin Xu Lingjun Ying Miaoguo Cai tao-hsin tung Kai Zhou Yufen Zheng Xiaojie Bi Jing Wang Xi Tu Bo Shen Dongqing Lv Department of Laboratory Medicine Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Hepatology and Infectious Diseases Center Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Department of Radiation Oncology Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Evidence-based Medicine Center Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China Department of Respiratory and Critical Diseases Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou317000China

Responding to the fast-spreading SARS-CoV-2 Omicron variant, to improve screening efficiency, rapid antigen tests(RATs) were first added as a supplementary detection method in China in mid-March, 2022. What and how big a role RATs should play need to be supported by clinical data. Here, RAT performance and relevant factors in comparison with nucleic acid amplification tests(NAATs) were assessed in Omicron-infected inpatients. From the NAAT results, nasopharyngeal swabs(NPs) performed better than oropharyngeal swabs(OPs). RATs tested on NAAT positive NPs performed better than those with OP-positive samples. The RAT positivity rate was strongly associated with high levels of N and OFR1ab genes, especially in NPs where patients also had significantly longer hospital stays and shorter days from symptom onset to RAT testing. Self-performed RATs had a detection accuracy that was comparable to professionally performed RATs when the subjects were well guided. The antigen negative rate of the studied patients was 100% at discharge. These findings suggest that, in addition to a supplementary detection role, RATs can be an important strategy for evaluating the disease progression of Omicron-infected inpatients. This study provides important clinical data to support better rules regarding RATs under China’s COVID-19 prevention and control policy.

关键词： SARS-CoV-2 Omicron variant Rapid antigen tests(RATs) Dynamic zero-COVID policy COVID-19 progression evaluation

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Healthcare practice strategies for integrating personalized medicine:Management of COVID-19

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World Journal of Clinical Cases 2021年第29期9卷 8647-8657页

作者： Wen-Yi Liu Ching-Wen Chien tao-hsin tung Department of Health Policy and Management Bloomberg School of Public HealthJohns Hopkins UniversityMD 21205United StatesShanghai Bluecross Medical Science InstituteShanghai 201100Shanghai ProvinceChina Institute for Hospital Management Tsing Hua UniversityShenzhen CampusShenzhen 518055Guangdong ProvinceChina Evidence-based Medicine Center Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

Personalized medicine is the tailor-made clinical treatment to the individual characteristics of each patient.It may be considered an extension of traditional approaches to knowing and treating diseases.Personalized medicine has the potential to change the way of identification and management of health problems.Coronavirus disease 2019(COVID-19)is an infectious disease that primarily affects the patients’lungs.The first case of pneumonia of unknown cause was reported in Wuhan,China on December 31,2019.As thus,we are quickly approaching the era of personalized medicine.This review discusses the practices currently used in the management of COVID-19 and how they relate to person-alized medicine.

关键词： Healthcare Personalized medicine COVID-19 SARS-CoV-2

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Epidemiology,management,and economic evaluation of screening of gallstone disease among type 2 diabetics:A systematic review

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World Journal of Clinical Cases 2015年第7期3卷 599-606页

作者： Lujie Chen Yu-Ting Peng Fu-Li Chen tao-hsin tung Faculty of Public Health College of MedicineFu-Jen Catholic University Department of Medical Research and Education Cheng-Hsin General Hospital

The knowledge of gallstone disease(GSD) is crucial to manage this condition when organizing screening and preventive strategies and identifying the appropriated clinical therapies. Although cholecystectomy still be the gold standard treatment for patients with symptomatic GSD, expectant management could be viewed as a valid therapeutic method for this disorder. If early treatment of GSD decreases the morbidity or avoids further cholecystectomy, it may save clinical care costs in later disease periods sufficiently to offset the screening and early treatment costs. In addition, whether routine screening for GSD is worthwhile depends on whether patients are willing to pay the ultrasonography screening cost that would reduce the risk of cholecystectomy. In this review we discuss the epidemiology, management, and economic evaluation of screening of GSD among type 2 diabetics.

关键词： Gallstone disease Epidemiology Management Economic evaluation Type 2 diabetes

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Economic and medical benefits of ultrasound screenings for gallstone disease

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World Journal of Gastroenterology 2015年第11期21卷 3337-3343页

作者： Hung-Ju Shen Chung-Te Hsu tao-hsin tung Cheng hsin General Hospital Faculty of Public Health School of MedicineFu-Jen Catholic University Department of Nursing Kang-Ning Junior College of Medical Care and Management

AIM:To investigate whether screening for gallstone disease was economically feasible and clinically effective.METHODS:This clinical study was initially conducted in2002 in Taipei,Taiwan.The study cohort total included2386 healthy adults who were voluntarily admitted to a regional teaching hospital for a physical check-up.Annual follow-up screening with ultrasound sonography for gallstone disease continued until December 31,2007.A decision analysis using the Markov Decision Model was constructed to compare different screening regimes for gallstone disease.The economic evaluation included estimates of both the cost-effectiveness and cost-utility of screening for gallstone disease.RESULTS:Direct costs included the cost of screening,regular clinical fees,laparoscopic cholecystectomy,and hospitalization.Indirect costs represent the loss of productivity attributable to the patient’s disease state,and were estimated using the gross domestic product for 2011 in Taiwan.Longer time intervals in screening for gallstone disease were associated with the reduced efficacy and utility of screening and with increased cost.The cost per life-year gained(average cost-effectiveness ratio)for annual screening,biennial screening,3-year screening,4-year screening,5-year screening,and no-screening was new Taiwan dollars(NTD)39076,NTD 58059,NTD 72168,NTD 104488,NTD 126941,and NTD 197473,respectively(P<0.05).The cost per quality-adjusted life-year gained by annual screening was NTD 40725;biennial screening,NTD64868;3-year screening,NTD 84532;4-year screening,NTD 110962;5-year screening,NTD 142053;and for the control group,NTD 202979(P<0.05).The threshold values indicated that the ultrasound sonography screening programs were highly sensitive to screening costs in a plausible range.CONCLUSION:Routine screening regime for gallstone disease is both medically and economically valuable.Annual screening for gallstone disease should be recommended.

关键词： Decision analysis Gallstone disease Economic evalu

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A population-based follow-up study on gallstone disease among type 2 diabetics in Kinmen,Taiwan

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World Journal of Gastroenterology 2006年第28期12卷 4536-4540页

作者： tao-hsin tung Hsiao-Man Ho Hui-Chuan Shih Pesus Chou Jorn-Hon Liu Victor TK Chen De-Chuan Chan Chi-Ming Liu Cheng hsin Rehabilitation Medical Center TaipeiTaiwan National Taipei College of Nursing TaipeiTaiwanChina Department of Mathematics and Science Education National Taipei Teachers CollegeTaipeiTaiwanChina Department of Nursing Kaohsiung Military General HospitalKaohsiungTaiwan I-Shou University KaohsiungTaiwanChina Community Medicine Research Center & Institute of Public Health National Yang-Ming UniversityTaipeiTaiwanChina Cheng hsin Rehabilitation Medical Center Faculty of Medicine School of MedicineNational Yang-Ming UniversityTaipeiTaiwanChina Cardinal Tien Hospital College of Medicine Fu-Jen Catholic University National Defence Medicine Center TaipeiTaiwanChina Division of General Surgery Tri-Service General HospitalNational Defense Medical CenterTaipeiTaiwanChina Community Medicine Research Center and Institute of Public Health National Yang-Ming UniversityTaipeiTaiwanChina

瞄准：估计发生并且在 Kinmen 在类型 2 糖尿病患者之中为胆石疾病(GSD ) 冒因素的风险，台湾。方法：为 GSD 的一个屏蔽节目被采用了即时腹的超声在病人们有 fasted 至少八个小时以后，检验腹的区域的二位专家执行。屏蔽，它在 2001 ... 详细信息

瞄准：估计发生并且在 Kinmen 在类型 2 糖尿病患者之中为胆石疾病(GSD ) 冒因素的风险，台湾。方法：为 GSD 的一个屏蔽节目被采用了即时腹的超声在病人们有 fasted 至少八个小时以后，检验腹的区域的二位专家执行。屏蔽，它在 2001 被进行，包含了与类型 2 糖尿病诊断的 848 个病人。在有流行 GSD 的 63 个题目的排除以后，没有 GSD 的 377 个参加者为秒轮屏蔽在 2002 被邀请。281 的一个总数(74.5%) 使遭到是 re-examined。结果：在 281 类型之中没在首先屏蔽有 GSD 的 2 名糖尿病患者， 10 在 2002 开发了 GSD。发生每年是 3.56%(95% CI：1.78% 每 year-6.24% 每年) 。用一个考克斯回归模型，变老(RR = 1.07， 95% CI：1.00-1.14 ) ，腰圆周(RR = 1.12， 95% CI：1.01-1.29 ) ，并且中高音(RR = 1.13， 95%CI：1.01-1.26 ) 看起来显著地与 GSD 的开发被相关。结论：老年是为 GSD 的发展的一个已知的风险因素。我们那更大的腰圆周和提高的中高音铺平的学习表演也在 Kinmen 在类型 2 糖尿病患者之中与 GSD 的发展被联系。

关键词：胆结石糖尿病并发症治疗

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Evidence-Based Medicine of Screening of Diabetic Retinopathy among Type 2 Diabetes: A Clinical Overview

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Health 2015年第7期7卷 873-883页

作者： Yeu-Tyng Lin Yen-Chen Chen Yu-Ting Peng Lujie Chen Jorn-Hon Liu Fu-Li Chen tao-hsin tung Department of Family and Community Medicine Cheng-Hsin General Hospital Taipei Taiwan Department of Ophthalmology Cheng-Hsin General Hospital Taipei Taiwan Faculty of Public Health College of Medicine Fu-Jen Catholic University Taipei Taiwan Department of M edical Research and Education Cheng-Hsin General Hospital Taipei Taiwan

Diabetic retinopathy (DR) is a well-characterized chronic ocular disorder that developed in nearly all diabetic patients in the long run. The knowledge of DR is crucial to manage this disorder when planning screening and preventive programs and identifying the appropriated therapeutic strategies among. Expectant management may represent a valid therapeutic approach depending upon the clinical manifestations of the disease and, in particular, on the changes over time. If early treatment of DR reduces the probability of severe stage or slows the progression of blindness, it might sufficiently reduce treatment costs in later years to offset the costs of screening and early treatment. In addition, whether screening for DR is worthwhile is contingent on whether subjects are willing to pay the eye screening program that would decrease the risk of photocoagulation. In this review we discuss epidemiology, management, and economic evaluation of screening of DR among type 2 diabetes.

关键词： Diabetic Retinopathy Epidemiology Economic Evaluation Screening Type 2 Diabetes

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Clinical correlation of gallstone disease in a Chinese population in Taiwan:Experience at Cheng hsin General Hospital

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World Journal of Gastroenterology 2006年第8期12卷 1281-1286页

作者： Chi-Ming Liu tao-hsin tung Pesus Chou Victor Tze-Kai Chen Chung-Te Hsu Wu-Shyong Chien Yeu-Tyng Lin Hsu-Feng Lu Hui-Chuan Shih Jorn-Hon Liu Community Medicine Research Center & Institute of Public Health National Yang-Ming University Cheng hsin General Hospital Taipei Taiwan China Community Medicine Research Center & Institute of Public Health National Yang-Ming University Taipei TaiwanChina Cardinal Tien Hospital College of Medicine Fu-Jen Catholic University National Defence Medicine Center Taipei Taiwan China Department of Nursing Kaohsiung Military General Hospital Kaohsiung Taiwan China Faculty of Medicine School of Medicine National Yang-Ming University Cheng hsin General Hospital TaipeiTaiwan China

瞄准：在与它有关的台湾和联系条件的因素探索胆石疾病(GSD ) 的流行。方法：我们自愿地学习了 2386 个健康成年人(1235 男性和 1151 女性) 的一个总数为在 2002 年 1 月和 2002 年 12 月之间的付的物理检查承认了到 Cheng hsin 医院将... 详细信息

瞄准：在与它有关的台湾和联系条件的因素探索胆石疾病(GSD ) 的流行。方法：我们自愿地学习了 2386 个健康成年人(1235 男性和 1151 女性) 的一个总数为在 2002 年 1 月和 2002 年 12 月之间的付的物理检查承认了到 Cheng hsin 医院将军。血样品和超声 sonography 结果是镇定的。结果：在这张学习人口之中的 GSD 的全面流行是 5.3% ，包括 1.7%(n=40 ) 有一块单个石头， 2.3%(n=55 ) 有多重石头，并且 1.3%(n=31 ) 有胆囊炎。流行与增加年龄(P 或 = 70 年对或 = 27 kg/m2 对或 = 126 mg/dL 对或 = 50 年) ，肥胖(BMI > 或 = 27 kg/m2 ) ，并且类型 2 糖尿病(FPG > 或 = 126 mg/dL ) 与 GSD 的流行被联系。

关键词：胆石疾病中国台湾省医院

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Reduced bile duct contractile function in rats with chronic hyperglycemia

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Health 2010年第9期2卷 1072-1077页

作者： Chi-Ming Liu Hui-Chen Su Yen-Ting Wang tao-hsin tung Pesus Chou Yiing-Jeng Chou Jorn-Hon Liu Jan-Kan Chen 不详

The incidence of gallstone is higher in patients with diabetes mellitus than in general popula- tion. It is generally attributed to hypomotility and lowered emptying function of the gallblad- der. In this study, we investigate if chronic hy- perglycemia is correlated with reduced contrac- tile function of the bile ducts in rat. Hypergly- cemic rats were induced by streptozotocin-nic-otinamide treatment. Hyperglycemic rats were sacrificed eight months after induction and bile ducts were removed for the subsequent studies. The bile duct contractility of the normal rats is consistently higher than that of the hypergly- cemic rats. The contractities were measured to be 5.5 ± 0.2 mg vs. 4.2 ± 0.1 mg without CCK stimulation, and 5.5 ± 0.3 mg vs. 7.9 ± 0.4 mg with CCK stimulation, respectively for hypergly-cemic and normal rats. There was no significant difference in plasma CCK concentration in hy- perglycemic rats and normal rats. The expres- sion of CCK-A receptor protein in the bile duct tissue was decreased in hyperglycemic rats compared with that of the normal rats, and it may, at least in part, responsible for a reduced contractility. A reduced bile duct motility may cause bile retention, and may be one of the factors predispose to gallstone formation in type 2 diabetes patients, which is characterized with chronic hyperglycemia.

关键词： Hyperglycemia Bile Duct Contractile

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Serum insulin, insulin resistance, p-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: A community-based study in Kinmen, Taiwan

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World Journal of Gastroenterology 2005年第45期11卷 7159-7164页

作者： Chi-Ming Liu tao-hsin tung Shih-Tzer Tsai Jorn-Hon Liu Yeh-Kuang Tsai Victor Tze-Kai Chen Tseng-Nip Tam Hsu-Feng Lu Kuang-Kuo Wang Chung-Te Hsu Hui-Chuan Shih De-Chuan Chan Pesus Chou Community Medicine Research Center and Institute of Public Health National Yang-MingUniversity Cheng Hsin General Hospital Taipei Taiwan China Department of medicine Veterans GeneralHospital Taipei Taiwan China Cheng hsin General Hospital Faculty ofMedicine School of Medicine National Yang-Ming UniversityTaipei Taiwan China University of California San Francisco SanFrancisco CA United States Cardinal Tien Hospital College ofMedicine Fu-Jen Catholic University National Defence MedicineCenter Taipei Taiwan China Cheng hsin General Hospital Taipei Taiwan China Department of Nursing Kaohsiung MilitaryGeneral Hospital Kaohsing Taipei Taiwan China Division of General Surgery Tri-ServiceGeneral Hospital National Defence Medical Center TaipeiTaiwan China Community Medicine Research Center and Instituteof Public Health National Yang-Ming University Taipei TaiwanChina

AIM: To explore the association of serum insulin, insulin resistance, and β-cell dysfunction with gallstone disease (GSD) in type 2 diabetics. METHODS: We used a community-based study conducted between 1991 and 1993 in Kinmen, Taiwan to identify type 2 diabetics. A screening program for GSD was performed in 2001 by a panel of specialists who employed real-time ultrasound sonography to examine the abdominal region after the patient had fasted for at least 8 h. Screening was conducted in 2001 on 848 patients diagnosed with type 2 diabetes. The HOMA method was used to compare the profile differences for insulin resistance (HOMA IR) and β-cell dysfunction (HOMA β-cell). RESULTS: We studied 440 type 2 diabetics who attended sonography check-ups. After excluding eight insulin-treated diabetics, the prevalence of GSD among the remaining 432 was 13.9% (26/187) among males and 14.7% (36/245) among females. After adjustment for other GSD-associated risk factors in addition to age and obesity, GSD risk increased among females with levels of serum insulin [4th vs 1st quartile odds ratios (OR) = 4.46 (95%CI: 1.71-11.66)] and HOMA IR [4th vs 1st quartile OR = 4.46 (95%CI: 1.71-11.66)]. Better HOMA β-cell function was significantly related to decreased risk of GSD [4th vs 1st quartile OR = 0.16 (95%CI: 0.03-1.70)]. Among males, age and central obesity were the most significant risk factors for GSD. No association of GSD with serum insulin, HOMA IR, and HOMA β-cell was observed among males. CONCLUSION: Serum insulin, insulin resistance, and β-cell dysfunction are risk factors for GSD in females, but not males with type 2 diabetes.

关键词：血清胰岛素胰岛素抵抗胆结石糖尿病

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