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Mirizzi syndrome:Problems and strategies

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 234-240页

作者： Jun Wu Shuang-Yong Cai Xu-Liang Chen zhi-tao Chen Shao-Hua Shi Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of Jiulongpo DistrictChongqing 400050China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310003China

Mirizzi syndrome is a serious complication of gallstone disease.It is caused by the impacted stones in the gallbladder neck or cystic duct.One of the features of Mirizzi syndrome is severe inflammation or dense fibrosis at the Calot’s triangle.In our clinical practice,bile duct,branches of right hepatic artery and right portal vein clinging to gallbladder infundibulum are often observed due to gallbladder infundibulum adhered to right hepatic hilum.The intraoperative damage of branches of right hepatic artery occurs more easily than that of bile duct,all of which are hidden pitfalls for surgeons.Magnetic resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)are the preferable tools for the diagnosis of Mirizzi syndrome.Anterograde cholecystectomy in Mirizzi syndrome is easy to damage branches of right hepatic artery and bile duct due to gallbladder infundibulum adhered to right hepatic hilum.Subtotal cholecystectomy is an easy,safe and definitive approach to Mirizzi syndrome.When combined with the application of ERCP,a laparoscopic management of Mirizzi syndrome by well-trained surgeons is feasible and safe.The objective of this review was to highlight its existing problems:(1)low preoperative diagnostic rate,(2)easy to damage bile duct and branches of right hepatic artery,and(3)high concomitant gallbladder carcinoma.Meanwhile,the review aimed to discuss the possible therapeutic strategies:(1)to enhance its preoperative recognition by imaging findings,and(2)to avoid potential pitfalls during surgery.

关键词： Mirizzi syndrome Bile duct injury Artery injury Surgical treatment Subtotal cholecystectomy

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Biofilm formation and invasive ability contribute to CC17 serotype III group B Streptococcus virulence

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中华医学杂志(英文版) 2022年第7期135卷 869-871页

作者： Wang Lijun tao zhi Lu Binghuai China-Japan Friendship Hospital Beijing 100029 Department of Clinical Laboratory Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing 102218 China Department of Obstetrics and Gynecology Department of Pulmonary and Critical Care Medicine Laboratory of Clinical Microbiology and Infectious Diseases

Group B Streptococcus (GBS) colonizes the vagina and rectum of 7-30% of pregnant women and contributes to materno-neonatal invasive infections. To date, the pathogenesis of clinical GBS strains has remained elusive.

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Causal roles of gut microbiota in cholangiocarcinoma etiology suggested by genetic study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1319-1333页

作者： zhi-tao Chen Chen-Chen Ding Kai-Lei Chen Yang-Jun Gu Chi-Cheng Lu Qi-Yong Li Division of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000Zhejiang ProvinceChina Pediatric Psychology The Affiliated Mental Health Centre&Hangzhou Seventh People’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang Shuren UniversityHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang Chinese Medical University Zhejiang Shuren CollegeHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with poor prognosis.Previous studies have implicated the gut microbiota in CCA,but evidence for causal mechanisms is lacking.AIM To investigate the causal relationship between gut microbiota and CCA risk.METHODS We performed a two-sample mendelian randomization study to evaluate potential causal associations between gut microbiota and CCA risk using genome-wide association study summary statistics for 196 gut microbial taxa and CCA.Genetic variants were used as instrumental variables.Multiple sensitivity analyses assessed result robustness.RESULTS Fifteen gut microbial taxa showed significant causal associations with CCA risk.Higher genetically predicted abundance of genus Eubacteriumnodatum group,genus Ruminococcustorques group,genus Coprococcus,genus Dorea,and phylum Actinobacteria were associated with reduced risk of gallbladder cancer and extrahepatic CCA.Increased intrahepatic CCA risk was associated with higher abundance of family Veillonellaceae,genus Alistipes,order Enterobacteriales,and phylum Firmicutes.Protective effects against CCA were suggested for genus Collinsella,genus Eisenbergiella,genus Anaerostipes,genus Paraprevotella,genus Parasutterella,and phylum Verrucomicrobia.Sensitivity analyses indicated these findings were reliable without pleiotropy.CONCLUSION This pioneering study provides novel evidence that specific gut microbiota may play causal roles in CCA risk.Further experimental validation of these candidate microbes is warranted to consolidate causality and mechanisms.

关键词： Cholangiocarcinoma Mendelian randomization Gut microbiota Instrumental variables Sensitivity analyses

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Normalized solutions of Kirchhoff equation with Hartree type nonlinearity

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Acta Mathematica Sinica,English Series 2024年

作者： Xiao Jing FENG Hai Dong LIU zhi tao ZHANG School of Mathematical Sciences University of Chinese Academy of Sciences School of Mathematical Sciences Shanxi University HLM Academy of Mathematics and Systems Science Chinese Academy of Sciences Institute of Mathematics Jiaxing University School of Mathematical Sciences Jiangsu University Zhenjiang 212013 P.R.China

Consider the Kirchhoff equation with Hartree type nonlinearity ■ where a, b> 0,λ,μ∈R, 2 0, also known as normalized solutions, are of particular interest in the current paper. Under various assumptions onμ, c and q, we establish the existence, nonexistence and asymptotic behavior of normalized solutions for the above elliptic equation.

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Distribution of Na+and Mechanical Properties of Hardened Body of Alkali-activated Cementitious Materials

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Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 849-856页

作者：卞立波 tao zhi 王秀芳 WANG Shaohui YE Kangjun HU Xingbo School of Civil and Traffic Engineering Beijing University of Civil Engineering and ArchitectureBeijing102616China Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation School of ScienceBeijing University of Civil Engineering and ArchitectureBeijing102616China Beijing Shoufa Tianren Ecological Landscape Co. LtdBeijing102699China

To explore the distribution of and the mechanical properties(compressive strength)of the hardened body of alkali slag-fly ash cementitious materials,this study was conducted by using the XRD,FTIR,SEM/EDS,and other test methods in three conditions:airtight drying(AD),airtight immersion(AI),and airtight soaking(AS).The 1D distribution law of free of hardened body under standard curing conditions was explored.The experimental results show that under standard curing conditions,the 1D distribution of within 0d-3 d shows a∨-shaped distribution,within 3-7 d show a∧-shaped distribution,and within 7-28 d tends to be balanced.The test results of leaching rate show that the free was the most stable under AD conditions and the hardened body bound the most by XRD,FTIR and SEM/EDS.And the compressive strength of the hardened body was the highest.The compressive strength of 28th reached 95.9 MPa.The definite distribution of provides an important reference for the strength development and durability evaluation of the hardened body of alkaliexcited cementitious materials.

关键词： alkali-activated cementitious materials ion migration leaching rate curing condition compressive strength

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Experimental Study on the Film Cooling Characteristics of Three Complex Tip Structures

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Journal of Thermal Science 2023年第4期32卷 1378-1392页

作者： LIN Juqiang LI Haiwang YOU Ruquan LIU Runzhou tao zhi LIU Song School of Energy and Power Engineering Beihang UniversityBeijing100191China Research Institute for Aero-Engines Beihang UniversityBeijing100191China National Key Laboratory of Science and Technology on Aero Engines Aero-thermodynamics Beijing100191China AECC Sichuan Gas Turbine Establishment Sichuan610500China

The turbine blades of aircrafts must be properly cooled to prevent engine failure.Thus,to investigate the influence of the tip structure on the film cooling effect,pressure-sensitive paint test technology was used to determine the adiabatic film cooling effectiveness in this study.The experiment was completed in a cascade comprising three straight blades.The effects of the blowing ratio,density ratio,tip clearance,and tip structure on film cooling efficiency were analyzed.The experimental results demonstrated that,as the blowing ratio increased,the film coverage area and film cooling efficiency increased under most experimental conditions.However,the film cooling efficiency was found to initially increase,and subsequently decrease,as the blowing ratio increased.The respective influences of the density ratio and tip clearance on the film cooling efficiency were found to be significant.The density ratio experiments revealed that a high-density ratio can result in better film coverage than the low-density-ratio air.The tip clearance experimental results indicated that a small tip clearance promotes an increase in film cooling efficiency;this is because the small tip clearance negatively affects the main stream leakage flow,which can reduce the film coverage area.Under the conditions of the Base case 2 configuration,a blowing ratio of 2.1,and a tip clearance of 0.6%h,the average film cooling efficiency of the blade tip was 0.22.Among the three blade tip structures applied in this study,Base case 2 demonstrated higher film cooling efficiency than the other two blade tip structures under the conditions of the same blowing ratio,tip clearance,and density ratio.

关键词： film cooling tip structure pressure-sensitive paint leakage flow

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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou Huang Wen-Qing Ai Na Wei Ling-Shuang Zhu zhi-Qiang Liu Chao-Wen Zhou Man-Fei Deng Wen-tao Zhang Jia-Chen Zhang Chun-Qing Yang Ya-Zhuo Hu zhi-tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China Department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family history.Although genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of dementia.However,the underlying mechanisms of social isolation in AD progression remain elusive.In the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD mice.We also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related proteins.Interestingly,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious cycle.Finally,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its partners.Moreover,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD mice.Taken together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

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Experimental Investigation of the Secondary Flow in a Rotating Smooth Channel Subjected to Thermal Boundary Conditions

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Journal of Thermal Science 2020年第6期29卷 1463-1474页

作者： LI Haiwang YOU Haoliang YOU Ruquan tao zhi National Key Laboratory of Science and Technology on Aero-Engines Aero-thermodynamics Beihang UniversityBeijing 100191China

In the current study,thermal boundary conditions are considered in a rotating smooth channel with a square cross-section to investigate the secondary flow and compare it to that of the same channel without heating.The measurement is conducted at three streamwise planes(X=445 mm,525 mm,605 mm).The flow parameters are the Reynolds number(Re=4750,which was based on the average longitudinal or primary velocity U and the hydraulic diameter D of the channel cross-section),the rotation number(Ro=?D/U,where?is the rotational velocity,ranging from 0 to 0.26),and the aspect ratio of the channel cross-section(AR=1,which is calculated by dividing the channel height by the channel width).The leading and trailing walls are heated under a constant heat flux qw=380 W/m^2,and the top and bottom walls are isothermal at room temperature.This work is in a series with our previous work without thermal boundary conditions.Based on the experimental data,we obtained a four-vortex regime.There is a counter-rotating vortex pair near the leading side and the trailing side.Because the leading and trailing walls are heated,the buoyancy force increases the relative vertical position of the vortex pair near the trailing side from 5%to 12.5%of the hydraulic diameter.When moving upstream along the streamwise direction,the upper vortex near the trailing wall becomes weaker,whereas the lower vortex becomes stronger.As the rotational speed increases,the vortex pair near the trailing side is inhibited by the Coriolis force.Under heated thermal boundary conditions,the vortex pair near the trailing side reappears due to the effect of buoyancy force.These results indicate that the buoyancy force has a substantial effect on the secondary flow regime under thermal boundary conditions.

关键词： flow dynamic rotating smooth channel secondary flow buoyancy force

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Experimental investigation of surface roughness effects on flow behavior and heat transfer characteristics for circular microchannels

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Chinese Journal of Aeronautics 2016年第6期29卷 1575-1581页

作者： Yuan Xing tao zhi Li Haiwang Tian Yitu National Key Laboratory of Science and Technology on Aero-Engine Beihang University Collaborative Innovation Center for Advanced Aero-Engine of China of Aerodynamics Beihang University

This paper experimentally investigates the effect of surface roughness on flow and heat transfer characteristics in circular microchannels. All test pieces include 44 identical, parallel circular microchannels with diameters of 0.4 mm and 10 mm in length. The surface roughness of the microchannels is R_a= 0.86, 0.92, 1.02 lm, and the Reynolds number ranges from 150 to 2800.Results show that the surface roughness of the circular microchannels has remarkable effects on the performance of flow behavior and heat transfer. It is found that the Poiseuille and Nusselt numbers are higher when the relative surface roughness is larger. For flow behavior, the friction factor increases consistently with the increasing Reynolds number, and it is larger than the constant theoretical value for macrochannels. The Reynolds number for the transition from laminar to turbulent flow is about 1500, which is lower than the value for macrochannels. For the heat transfer property, Nusselt number also increases with increasing Reynolds number, and larger roughness contributes to higher Nusselt number.

关键词： Circular Flow behavior Heat transfer Microchannels Roughness

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Effect of turbulence models on predicting convective heat transfer to hydrocarbon fuel at supercritical pressure

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Chinese Journal of Aeronautics 2016年第5期29卷 1247-1261页

作者： tao zhi Cheng Zeyuan Zhu Jianqin Li Haiwang National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics School of Energy and Power Engineering Beihang University

A variety of turbulence models were used to perform numerical simulations of heat transfer for hydrocarbon fuel flowing upward and downward through uniformly heated vertical pipes at supercritical pressure. Inlet temperatures varied from 373 K to 663 K, with heat flux rang- ing from 300 kW/m2 to 550 kW/m2. Comparative analyses between predicted and experimental results were used to evaluate the ability of turbulence models to respond to variable thermophysical properties of hydrocarbon fuel at supercritical pressure. It was found that the prediction performance of turbulence models is mainly determined by the damping function, which enables them to respond differently to local flow conditions. Although prediction accuracy for experimental results varied from condition to condition, the shear stress transport （SST） and launder and sharma models performed better than all other models used in the study. For very small buoyancy-influenced runs, the thermal-induced acceleration due to variations in density lead to the impairment of heat transfer occurring in the vicinity of pseudo-critical points, and heat transfer was enhanced at higher temperatures through the combined action of four thermophysical properties： density, viscosity, thermal conductivity and specific heat. For very large buoyancy- influenced runs, the thermal-induced acceleration effect was over predicted by the LS and AB models.

关键词： Buoyancy effect Hydrocarbon fuel Supercritical pressure Turbulence models Variable properties

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