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Global research trends and hotspots in overweight/obese comorbid with depression among children and adolescents: A bibliometric analysis

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World Journal of Psychiatry 2024年第8期14卷 1267-1284页

作者： Ya-Qi Wang tao-tao Wu Yan Li Shi-En Cui Ying-Shuai Li College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310051Zhejiang ProvinceChina National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Overweight/obesity combined with depression among children and adolescents(ODCA)is a global *** bidirectional relationship between depression and overweight/obesity often leads to their *** and adolescence represent critical periods for physical and psychological development,during which the comorbidity of overweight/obesity and depression may increase the risk of adverse health *** To evaluate the relationship between ODCA,we conduct a bibliometric analysis to aid in formulating prevention and treatment *** From 2004 to 2023,articles related to ODCA were selected using the Science Citation Index Expanded from the Web of Science Core *** analysis of relevant publications,including countries/regions,institutions,authors,journals,references,and keywords,was conducted using the online bibliometric analysis platforms,CiteSpace,VOSviewer,and *** Between 2004 and 2023,a total of 1573 articles were published on *** United States has made leading contributions in this field,with Harvard University emerging as the leading contributor in terms of research output,and Tanofsky being the most prolific *** J Adolescent Health has shown significant activity in this *** on the results of the keyword and reference analyses,inequality,adverse childhood experiences,and comorbidities have become hot topics in ***,the impact of balancedrelated behavior and exploration of the biological mechanisms,including the potential role of key adipocytokines and lipokines,as well as inflammation in ODCA,have emerged as frontier *** The trend of a significant increase in ODCA publications is expected to *** research findings will contribute to elucidating the pathogenic mechanisms of ODCA and its prevention and treatment.

关键词： Children Adolescents Overweight Obesity Depression Bibliometric analysis Research trends

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Gender differences in the impact on subjective well-being in China

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Economic and Political Studies 2018年第4期6卷 349-367页

作者： tao tao Byron Y.Lee Lynda Jiwen Song Xiangdong Liu School of Sociology and Population Studies Center for Population and Development StudiesRenmin University of ChinaBeijingChina China Europe International Business School(CEIBS) ShanghaiChina School of Business Renmin University of ChinaBeijingChina

This article examines the relationship among subjective well-being(SWB),income and education in China through self-perceived social *** and women appear to use different socioeconomic markers to determine their self-perceived social status,which ultimately affects their subjective reports of *** using the data from the 2010 China General Social Survey(CGSS),this study finds a positive association between income and SWB for *** result also shows a positive association between education and SWB for ***,for women self-perceived social status is a strong mediator of income and happiness;while for men,selfperceived social status mediates the relationship between education and *** study highlights the importance of the cultural influence in understanding the differences in self-perceived social status outcomes by gender and how these differences ultimately influence the subjective measures of well-being in China.

关键词： China gender selfperceived status subjective well-being(SWB)

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Dynamic event-triggered data-driven iterative learning bipartite tracking control for nonlinear MASs with prescribed performance

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Science China(Information Sciences) 2025年第1期68卷 292-305页

作者： tao SHI Wei-Wei CHE School of Mechatronic Engineering and Automation Shanghai University State Key Laboratory of Synthetical Automation for Process Industries Northeastern University College of Information Science and Engineering Northeastern University

This article proposes a distributed dynamic event-triggered data-driven iterative learning control(DET-DDILC)scheme under a predefined performance to tackle the bipartite tracking control problem for multiagent systems(MASs). An improved dynamic linearization technique is utilized to convert the nonlinear MASs into an iterative linear data model. First,a peer-to-peer mapping function is introduced to map the constrained distributed system output homeomorphism to an unconstrained one. In addition, a DET mechanism based on a time-iteration-varying function is devised to conserve network communication resources. Based on the unconstrained transformation and the designed DET mechanism, the DET-DDILC algorithm is devised to ensure that the bipartite tracking performance of MASs can be within the preset range. Finally, the effectiveness and feasibility of the designed control scheme are demonstrated via a simulation case by a comparison.

关键词： bipartite tracking control prescribed performance event-triggered iterative learning control multiagent systems

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Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer

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World Journal of Gastroenterology 2018年第9期24卷 1004-1012页

作者： Mu-Lin Liu Qiao Zhang Xiao Yuan Long Jin Li-Li Wang tao-tao Fang Wen-Bin Wang Department of Gastrointestinal Surgery the First Affiliated Hospital of Bengbu Medical College Department of General Surgery the First Affiliated Hospital of Xinxiang Medical University Department of General Surgery the Fourth Affiliated Hospital of Anhui Medical University

AIM To investigate the role of long noncoding RNA(lnc RNA) RP4 in colorectal *** Lentivirus-mediated lnc RNA RP4 overexpression and knockdown were performed in the colorectal cancer cell line SW480. Cell proliferation, tumor growth, and early apoptosis were evaluated by a cell counting kit-8 assay, an in vivo xenograft tumor model, and annexin V/propidium iodide staining, respectively. Analysis of the lnc RNA RP4 mechanism involved assessment of the association of its expression with mi R-7-5 p and the SH3 GLB1 gene. Western blot analysis was also performed to assess the effect of lnc RNA RP4 on the autophagy-mediated cell death pathway and phosphatidylinositol-3-kinase(PI3 K)/Akt *** Cell proliferation, tumor growth, and early apoptosis in SW480 cells were negatively regulated by lnc RNA RP4. Functional experiments indicated that lnc RNA RP4 directly upregulated SH3 GLB1 expression by acting as a competing endogenous RNA(ce RNA) for mi R-7-5 p. This interaction led to activation of the autophagy-mediated cell death pathway and de-repression of PI3 K and Akt phosphorylation in colorectal cancer cells in *** Our results demonstrated that lnc RNA RP4 is a ce RNA that plays an important role in the pathogenesis of colorectal cancer, and could be a potential therapeutic target for colorectal cancer treatment.

关键词： Colorectal cancer long noncoding RNA RP4 SH3GLB1 miR-7-5p competing endogenous RNA

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Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 507-514页

作者： Xiao-Dong Chen Ming-Yang Su tao-tao Chen Hai-Yan Hong Ai-Dong Han Wen-Sheng Li Xiamen Eye Center of Xiamen University Xiamen University Department of Ophthalmology Xi’an No.1 HospitalShaanxi Institute of OphthalmologyShaanxi Provincial Key Laboratory of Ophthalmology State Key Laboratory for Cellular Stress Biology School of Life SciencesXiang’an CampusXiamen UniversityXiang’an District

AIM：To investigate the cross-talk between oxidative stress and the epidermal growth factor receptor（EGFR）/AKT signaling pathway in retinal pigment epithelial（ RPE） ***：Human RPE cell lines（ARPE-19 cell） were treated with different doses of epidermal growth factor（EGF） and hydrogen peroxide（H2O2）.Cell viability was determined by a methyl thiazolyl tetrazolium *** proliferation was examined by a bromodeoxyuridine（Brd U） incorporation ***/AKT signaling was detected by Western *** localization was also detected by *** addition,EGFR/AKT signaling was intervened upon by EGFR inhibitor（erlotinib）,PI3 K inhibitor（A66） and AKT inhibitor（MK-2206）,respectively.H2O2-induced oxidative stress was blocked by antioxidant N-acetylcysteine（NAC）.RESULTS：EGF treatment increased ARPE-19 cell viabili ty and proliferation through inducing phosphorylation of EGFR and AKT.H2O2 inhibited ARPE-19 cell viability and proliferation and also suppressed EGF-stimulated increase of RPE cell viability and proliferation by affecting the EGFR/AKT signaling *** inhibitor erlotinib blocked EGF-induced phosphorylation of EGFR and AKT,while A66 and MK-2206 only blocked EGF-induced phosphorylation of ***-induced phosphorylation andendocytosis of EGFR were also affected by H2O2 *** addition,antioxidant NAC attenuated H2O2-induced inhibition of ARPE-19 cell viability through all eviating reduction of EGFR,and phosphorylated and total AKT ***：Oxidative stress affects RPE cell viability and proliferation through interfering with the EGFR/AKT signaling *** EGFR/AKT signaling pathway may be an important target in oxidative stress-induced RPE cell dysfunction.

关键词： oxidative stress epidermal growth factor receptor AKT retinal pigment epithelial cell

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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

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Zoological Research 2024年第3期45卷 648-662页

作者： Dan Yang Bin-Bin Nie Jin-Gang He Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen tao tao Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong 524045China Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei 430071China Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghai 200082China Department of Nutrition and Food Hygiene Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Institute of Neuroscience and Brain Diseases/Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei 441021China Songjiang Hospital and Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghai 201600China Department of Anesthesiology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability *** PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely *** potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced *** this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term *** indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury *** kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of ***,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying ***,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for *** studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

关键词： Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics fMRI Cerebellum

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Classification of microseismic events in high stress zone

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Mining Science and Technology 2009年第6期19卷 718-723页

作者： CAO An-ye DOU Lin-ming YAN Ru-ling JIANG Heng LU Cai-ping DU tao-tao LU Zhen-yu State Key Laboratory for Coal Resource and Mine Safety China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China School of Mines China University of Mining ＆ Technology Xuzhou Jiangsu 221006 China

For the purpose of having a better understanding of failure mechanisms of rock fracturing in mines, the equivalent point source models of tensile, shear and explosive seismic events were established, and the relationship between far-field seismic displacements of the waves and the corresponding equivalent forces were analyzed as well. Based on the results of a microseismic monitoring carried out in the mining progress of 9202 working face under the upper remnant coal pillar in Sanhejian Mine, the waveform features of the seismic events associated with different failure modes were further analyzed. The results show that the signals corresponding to different failure mechanisms have different radiation patterns of the seismic displacements, and different characteristics in waveform features, such as dominant frequency, energy released, the ratio of S- to P-wave energy, and so on. In addition, the rock burst happened in the high stress zone is mainly the result of the strong shear fracturing in the mining process. The results of this study have significantly improved the understanding of the characteristics of the failures associated with underground mining, and will greatly benefit the prevention and control of rock burst hazards in burst-prone mines.

关键词： rock burst microseismic monitoring failure mechanism waveform characteristics

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Field-driven merging of polarizations and enhanced electrocaloric effect in BaTiO_(3)-based lead-free ceramics

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Journal of Advanced Ceramics 2022年第11期11卷 1777-1788页

作者： Xiang NIU Xiaodong JIAN Weiping GONG Wei LIANG Xuetian GONG Guangzu ZHANG Shenglin JIANG Kun YU Xiaobo ZHAO Yingbang YAO tao tao Bo LIANG Sheng-Guo LU Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter School of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices Huizhou UniversityHuizhou 516007China Science and Technology on Reliability Physics and Application of Electronic Component Laboratory The 5th Electronics Research Institute of the Ministry of Industry and Information TechnologyGuangzhou 510610China Dongguan South China Design Innovation Institute Dongguan 523808China School of Optical and Electronic Information Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

Solid-state cooling technology based on electrocaloric effect(ECE)has been advanced as an alternative to replace the vapour-compression approach to overcome the releasing of the global warming ***,the development in high ECE materials is still a *** this work,polarization merging strategy was proposed to achieve a large ECE in xBa(Sn_(0.07)Ti_(0.93))O_(3)–(1−x)Ba(Hf_(0.1)Ti_(0.9))O_(3) ferroelectric ceramics,where x=0,0.2,0.4,0.6,0.8,and ***(Sn_(0.07)Ti_(0.93))O_(3) with an orthorhombic phase and Ba(Hf_(0.1)Ti_(0.9))O_(3) with a rhombohedral phase at room temperature were prepared beforehand as precursors,and phase-coexisted xBSnT–(1−x)BHfT ceramics were formed via a solid-state reaction *** coexisting structures were confirmed using the X-ray *** merged polarization was confirmed by the dielectric and ferroelectric *** ECEs were obtained for 0.2BSnT–0.8BHfT ceramics,i.e.,adiabatic temperature change DT=2.16±0.08 K at 80℃and 5 MV/m,and DT=3.35±0.09 K at 80℃and 7 MV/m.

关键词： lead-free ferroelectric microstructure permittivity polarization electrocaloric effect(ECE)

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CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway

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Current Medical Science 2022年第5期42卷 1022-1032页

作者： Xue-qi CHEN Jia-yu MAO Chun-saier WANG Wen-bin LI tao-tao HAN Ke LV Jing-nan LI Department of Medical Ultrasound Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing100730China Department of Critical Care Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing100730China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Department of Gastroenterology Beijing HospitalNational Center of GerontologyInstitute of Geriatrics MedicineChinese Academy of Medical SciencesBeijing100730China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical Science Key Laboratory of Gut Microbiota Translational Medicine Research Chinese Academy of Medical ScienceBeijing100730China

Objective While the upregulation of cytochrome P450 family 24 subfamily A member 1(CYP24A1)gene expression has been reported in colon cancer,its role in tumorigenesis remains largely *** this study,we aimed to investigate the involvement of CYP24A1 in Wnt pathway regulation via the nuclear factor kappa B(NF-κB)*** The human colon cancer cell lines HCT-116 and Caco-2 were subjected to stimulation with interleukin-6(IL-6)as well as tumor necrosis factor alpha(TNF-α),with subsequent treatment using the NF-κB pathway-specific inhibitor ammonium pyrrolidinedithiocarbamate(PDTC).Furthermore,CYP24A1 expression was subjected to knockdown via the use of small interfering RNA(siRNA).Subsequently,NF-κB pathway activation was determined by an electrophoretic mobility shift assay,and the transcriptional activity ofβ-catenin was determined by a dual-luciferase reporter assay.A mouse ulcerative colitis(UC)-associated carcinogenesis model was established,wherein TNF-αand the NF-κB pathway were blocked by anti-TNF-αmonoclonal antibody and NF-κB antisense oligonucleotides,*** the tumor size and protein level of CYP24A1 were *** IL-6 and TNF-αupregulated CYP24A1 expression and activated the NF-κB pathway in colon cancer *** significantly inhibited this increase in CYP24A1 ***,knockdown of CYP24A1 expression by siRNA could partially antagonize Wnt pathway *** CYP24A1 expression was observed in the colonic epithelial cells of UC-associated carcinoma mouse ***-TNF-αmonoclonal antibody and NF-κB antisense oligonucleotides decreased the tumor size and suppressed CYP24A1 *** Taken together,this study suggests that inflammatory factors may increase CYP24A1 expression via NF-κB pathway activation,which in turn stimulates Wnt signaling.

关键词： CYP24A1 Wnt/β-catenin signaling pathway colorectal neoplasms

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Effect of Nephritis Rehabilitation Tablets combined with tacrolimus in treatment of idiopathic membranous nephropathy

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World Journal of Clinical Cases 2021年第34期9卷 10464-10471页

作者： Wei Lv Mei-Rong Wang Cheng-Zhen Zhang Xue-Xu Sun Zhen-Zhen Yan Xiao-Min Hu tao-tao Wang Department of Nephology China People’s Liberation Army 32298Weifang 261000Shandong ProvinceChina Department of Pharmacy China People’s Liberation Army 32298Weifang 261000Shandong ProvinceChina Department of Blood Purification China People’s Liberation Army 32298Weifang 261000Shandong ProvinceChina

BACKGROUND Idiopathic membranous nephropathy(IMN)has a high incidence in the middleaged and elderly population,and poses a great threat to the physical and mental health and quality of life of *** Rehabilitation Tablets have many potential effects,such as clearing residual toxins,tumefying the kidney and spleen,replenishing qi,and nourishing yin,and have played an important role in the treatment of a variety of kidney *** To investigate the efficacy and safety of Nephritis Rehabilitation Tablets combined with tacrolimus in the treatment of *** Eighty-four patients with IMN recruited from January 2017 to September 2020 were randomly divided into a study group(n=42)and a control group(n=42).On the basis of routine symptomatic treatment,both groups were treated with tacrolimus,and the study group was additionally treated with Nephritis Rehabilitation *** groups were treated for 12 *** therapeutic effect,the levels of renal function indexes[serum creatinine(Scr),serum albumin,and 24-h urinary protein],urinary immunoglobulin(IgG4),membrane attack complex(C5b-9),and the incidence of adverse reactions were measured before and after 12 wk of *** The total effective rate in the study group was significantly higher than that of the control *** treatment,there was no significant difference in Scr,serum albumin,or 24 h urinary protein between the two *** 12 wk of treatment,the levels of Scr and 24-h urinary protein in both groups were significantly lower and serum albumin was significantly higher than those before treatment(P<0.05),and the levels of Scr and 24-h urinary protein were significantly lower(P=0.003 and 0.000,respectively),and the level of serum albumin was significantly higher(P=0.00)in the study group than in the control *** treatment,there was no significant difference in urinary IgG4 and C5b-9 levels between the study group and the control group(P=0.336 and 0.438,respectively).Af

关键词： Nephritis Rehabilitation Tablets Tacrolimus Idiopathic membranous nephropathy Renal function IgG4 C5b-9

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