检索结果-南通市图书馆

Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2017年第10期44卷 483-492页

作者： Daqing Jin Diqi Zhu Yabo Fang Yiwei Chen Gaihong Yu Weijun pan Dong Liu Fen Li tao p.zhong State Key Laboratory of Genetic Engineering School of Life Sciences Zhong Shan Hospital Fudan University Shanghai 200438 China Department of pediatric Cardiology Shanghai Children's Medical Center Affiliated to Shanghai fiaotong University School of MedicineShanghai 200127 China Shanghai Key Laboratory of Regulatory Biology Institute of Molecular Medicine School of Life Sciences East China Normal UniversityShanghai 200241 China Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sdences Shanghai 200025 China Co-innovation Center of Neuroregeneration Jiangsu Key Laboratory of Neuroregeneration Nantong University Nontong 226001 China

Vascular endothelial growth factor A（Vegfa） signaling regulates vascular development during embryogenesis and organ ***,the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely *** this study,we utilized transcription activator-like effector nuclease（TALEN） to generate zebrafish vegfaa ***^-/- embryos are embryonic lethal,and display a complete loss of the dorsal aorta（DA） and expansion of the cardinal *** of Vegfa signaling expands the arterial cell population at the expense of venous cells during vasculogenesis of the axial vessels in the *** signaling regulates endothelial cell（EC） proliferation after arterial-venous *** deficiency and overexpression inhibit the formation of tip cell filopodia and interfere with the pathfinding of intersegmental vessels（ISVs）.In the head vasculature,vegfaa^-/- causes loss of a pair of mesencephalic veins（MsVs） and central arteries（CtAs）,both of which usually dvelop via sprouting *** results indicate that Vegfa signaling induces the formation of the DA at the expense of the cardinal vein during the trunk vasculogenesis,and that Vegfa is required for the angiogenic formation of MsVs and CtAs in the *** findings suggest that Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures.

关键词： Vegfa TALEN Arterial-venous specification Zebrafish

Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第1期13卷 41-58页

作者： Xiangwen peng Kaa Seng Lai peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.poss tao p.zhong State Key Laboratory of Genetic Engineering School of Life SciencesZhong Shan HospitalFudan UniversityShanghai 200438China Shanghai Key Laboratory of Regulatory Biology Institute of Molecular MedicineEast China Normal University School of Life SciencesShanghai 200241China Department of Cell Biology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of pathology and Laboratory Medicine McAllister Heart InstituteUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Developmental and Cell Biology Vanderbilt University School of MedicineNashvilleTN 37232USA T These authors share first authorship.

Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely ***,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury *** blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and *** Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound *** analyses indicated that p21-activated kinase 2(pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled ***-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to ***,inactivation of pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation.

关键词： heart regeneration Wnt signaling pAK2 kinase cardiomyocyte proliferation cardiomyocyte dedifferentiation zebrafish

Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2020年第1期12卷 42-54页

作者： Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen peng Yating Zhou Xuejiao Zhu ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang tao p.zhong State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Department of Cardiology Daping HospitalThird Military Medical UniversityChongqing 400042China Shanghai Key Laboratory of Regulatory Biology Institute of Molecular MedicineEast China Normal University School of Life SciencesShanghai 200241China Vanderbilt Institute of Chemical Biology Vanderbilt UniversityNashvilleTN 37232USA Department of Cell and Developmental Biology Vanderbilt UniversityNashvilleTN 37232USA MOE Key Laboratory of Model Animal for Disease Study Model Animal Research CenterNanjing UniversityNanjingChina

There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart *** have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse *** related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell *** find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured *** treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle ***,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial *** hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin *** findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads.

关键词： small molecule screen Wnt inhibitor regeneration

pGE2 activates Ep4 in subchondral bone osteoclasts to regulate osteoarthritis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2022年第2期10卷 378-393页

作者： Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian tao pzhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo Yangzhi Rehabilitation Hospital(Sunshine Rehabilitation Centre) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Departments of Orthopaedic Surgery and Biomedical Engineering and Institute of Cell Engineering The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology and Metabolism The University of SheffieldSheffieldUK

prostaglandin E2(pGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of pGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which pGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that pGE2 acts via Ep4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while pGE2 mediates migration and osteoclastogenesis via its Ep2 and Ep4 receptors, tissue-specific knockout of only the Ep4 receptor in osteoclasts(Ep4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the Ep4 Lys M mice, with reduced Netrin-1 secretion and CGRp-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(pDGF-BB) was also lower in the Ep4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent Ep4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the Ep4 Lys Mmice. Finally, we showed that the Gαs/pI3 K/AKT/MApK signaling pathway is downstream of Ep4 activation via pGE2 in osteoclasts. Together, our data demonstrate that pGE2/Ep4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of Ep4 with HL-43 has therapeutic potential in OA.

关键词： osteoclast homeostasis pGE2

High‑Entropy Electrode Materials:Synthesis,properties and Outlook

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li Chang Liu Shusheng tao Jieming Cai Biao zhong Jie Li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

Localization of q-form fields on a de Sitter brane in chameleon gravity

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第3期19卷 11-18页

作者： Yi zhong tao-tao Sui School of physics and Electronics Science Hunan UniversityChangsha 410082China Lanzhou Center for Theoretical physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory of Quantum Theory and Applications of MoELanzhou UniversityLanzhou 730000China College of physics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Recently,it was found that the vector field can be naturally localized on the thick brane in chameleon *** this work,we extend this study to encompass de Sitter brane *** focus on the localization of q-form *** scalar and vector fields can be localized on the de Sitter brane,while the KR field cannot be *** condition for localization of the scalar and vector fields is ***,we investigate the localization characteristics in two examples with given conformal factor b(ϕ).In the first case,the effective potentials and KK modes of the matter fields are obtained asymmetric even though the de Sitter brane has Z2 *** the second case,volcano-like effective potentials are generated in the de Sitter brane model.

关键词： brane q-form field chameleon gravity

Reinforcement Learning for Linear Continuous-time Systems: an Incremental Learning Approach

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 433-440页

作者： tao Bian zhong-ping Jiang Bank of America Merrill Lynch IEEE the Control and Networks Lab Department of Electrical and Computer Engineering Tandon School of Engineering New York University

In this paper, we introduce a novel reinforcement learning(RL) scheme for linear continuous-time dynamical systems. Different from traditional batch learning algorithms,an incremental learning approach is developed, which provides a more efficient way to tackle the on-line learning problem in realworld applications. We provide concrete convergence and robust analysis on this incremental-learning algorithm. An extension to solving robust optimal control problems is also given. Two simulation examples are also given to illustrate the effectiveness of our theoretical result.

关键词： Adaptive optimal control robust dynamic programming value iteration(Ⅵ)

Spoof surface plasmon polaritons excited leaky-wave antenna with continuous scanning range from endfire to forward

在线全文

学校读者我要写书评

暂无评论

Chinese physics B 2020年第9期29卷 320-325页

作者： tao zhong Hou Zhang Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China

A novel leaky-wave antenna(LWA)utilizing spoof surface plasmon polaritons(SSpps)excitation is proposed with continuous scanning range from endfire to *** designed transmission line unit supports two SSppS modes,of which the 2nd order mode is applied in the design.A novel strategy has been devised to excite the spatial radiation of the-1st order harmonics by arranging periodic counter changed sinusoidal structures on both sides of the SSpps transmission *** full-wave simulation and measurement results show that the proposed LWA presents wide scanning angle from endfire to *** the frequency range from 4 GHz to 10 GHz,LWAs achieve scanning from 90°to+20°,covering the entire backward quadrant continuously.

关键词： leaky-wave antenna spoof surface plasmon polaritons wide scanning-angle

Bending analysis of a functionally graded piezoelectric cantilever beam

在线全文

学校读者我要写书评

暂无评论

Science China(physics,Mechanics & Astronomy) 2007年第1期50卷 97-108页

作者： YU tao zhong Zheng School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

A new analysis based on Airy stress function method is presented for a functionally graded piezoelectric material cantilever beam. Assuming that the mechanical and electric properties of the material have the same variations along the thickness direction, a two-dimensional plane elasticity solution is obtained for the coupling electroelastic fields of the beam under different loadings. This solution will be useful in analyzing FGpM beam with arbitrary variations of material properties. The influences of the functionally graded material properties on the structural response of the beam subjected to different loads are also studied through numerical examples.

关键词： functionally graded piezoelectric material cantilever beam bending electroelastic fields