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Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m^(6)A-YTHDF1–dependent manner

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Journal of Animal Science and Biotechnology 2023年第3期14卷 950-965页

作者： Huanfa gong Tao Gong Youhua Liu Yizhen Wang Xinxia Wang Key Laboratory of Molecular Animal Nutrition Ministry of EducationCollege of Animal SciencesZhejiang UniversityHangzhou 310058People’s Republic of China Key Laboratory of Animal Nutrition and Feed Science in Eastern China Ministry of AgricultureCollege of Animal SciencesZhejiang UniversityHangzhou 310058People’s Republic of China

Background Intramuscular fat(IMF)content is a critical indicator of pork quality,and abnormal IMF is also relevant to human disease as well as aging.Although N6-methyladenosine(m^(6)A)RNA modification was recently found to regulate adipogenesis in porcine intramuscular fat,however,the underlying molecular mechanisms was still unclear.Results In this work,we collected 20 longissimus dorsi muscle samples with high(average 3.95%)or low IMF content(average 1.22%)from a unique heterogenous swine population for m^(6)A sequencing(m^(6)A-seq).We discovered 70genes show both differential RNA expression and m^(6)A modification from high and low IMF group,including ADIPOQ and SFRP1,two hub genes inferred through gene co-expression analysis.Particularly,we observed ADIPOQ,which contains three m^(6)A modification sites within 3’untranslated and protein coding region,could promote porcine intramuscular preadipocyte differentiation in an m^(6)A-dependent manner.Furthermore,we found the YT521-B homology domain family protein 1(YTHDF1)could target and promote ADIPOQ mRNA translation.Conclusions Our study provided a comprehensive profiling of m^(6)A methylation in porcine longissimus dorsi muscle and characterized the involvement of m^(6)A epigenetic modification in the regulation of ADIPOQ mRNA on IMF deposition through an m^(6)A-YTHDF1-dependent manner.

关键词： ADIPOQ Intramuscular fat N6-methyladenosine Pig YTHDF1

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Climbing robots for manufacturing

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National Science Review 2023年第5期10卷 59-81页

作者： Bo tao Zeyu gong Han Ding State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and Technology

Robotized intelligent manufacturing is a growing trend in the manufacturing of large and complex components in aviation,aerospace,marine engineering and other industries.With their expansive workspaces and flexible deployment,climbing manufacturing robots can create a revolutionary manufacturing paradigm for large and complex components.This paper defines the climbing manufacturing robot based on the application status of climbing robots and then analyzes four key technical re quirements:adhesion,locomotion,localization and control.Subsequently,the current research status of climbing robots in these four areas is classified and reviewed,along with a clarification of the research frontiers and trends in each area,and the applicability of the relevant research to manufacturing-oriented climbing robotic systems is analyzed.Finally,by concluding the development trends of robotized intelligent manufacturing equipment in terms of manufacturing dimension and scale,environmental adaptability and cluster collaboration capability,we clarify the major challenges for climbing manufacturing robots in terms of adhesion principles,motion mechanisms,positioning technology and control methods,and propose future research directions in these fields.

关键词： climbing manufacturing robot climbing robot robotized intelligent manufacturing

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Whole-brain Optical Imaging:A Powerful Tool for Precise Brain Mapping at the Mesoscopic Level

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Neuroscience Bulletin 2023年第12期39卷 1840-1858页

作者： tao Jiang Hui gong Jing Yuan Huazhong University of Science and Technology-Suzhou Institute for Brainsmatics Jiangsu Industrial Technology Research InstituteSuzhou215123China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China

The mammalian brain is a highly complex network that consists of millions to billions of densely-interconnected neurons.Precise dissection of neural circuits at the mesoscopic level can provide important structural information for understanding the brain.Optical approaches can achieve submicron lateral resolution and achieve“optical sectioning”by a variety of means,which has the natural advantage of allowing the observation of neural circuits at the mesoscopic level.Automated whole-brain optical imaging methods based on tissue clearing or histological sectioning surpass the limitation of optical imaging depth in biological tissues and can provide delicate structural information in a large volume of tissues.Combined with various fluorescent labeling techniques,whole-brain optical imaging methods have shown great potential in the brain-wide quantitative profiling of cells,circuits,and blood vessels.In this review,we summarize the principles and implementations of various whole-brain optical imaging methods and provide some concepts regarding their future development.

关键词： Whole-brain optical imaging Optical sectioning Micrometer resolution Brain connectome Neural circuits Neuron

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Risk transmission evaluation for parallel construction of warships based on IFCM and the cloud model

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Journal of Systems Engineering and Electronics 2022年第6期33卷 1224-1237页

作者： gong Jun HU tao YAO Lu Department of Management Engineering and Equipment Economics Naval University of EngineeringWuhan 430033China

To cope with multi-directional transmission coupling,spreading, amplification, and chain reaction of risks during multiproject parallel construction of warships, a risk transmission evaluation method is proposed, which integrates an intuitionistic cloud model with a fuzzy cognitive map. By virtue of expectancy Ex, entropy En, and hyper entropy He, the risk fuzziness and randomness of the knowledge of experts are organically combined to develop a method for converting bi-linguistic variable decision-making information into the quantitative information of the intuitionistic normal cloud(INC) model. Subsequently, the threshold function and weighted summation operation in the traditional fuzzy cognitive map is converted into the INC ordered weighted averaging operator to create the risk transmission model based on the intuitionistic fuzzy cognitive map(IFCM) and the algorithm for solving it. Subsequently, the risk influence sequencing method based on INC and the risk rating method based on nearness are proposed on the basis of Monte Carlo simulation in order to realize the mutual conversion of the qualitative and quantitative information in the risk evaluation results.Example analysis is presented to verify the effectiveness and practicality of the methods.

关键词： risk evaluation multi-project parallel intuitionistic fuzzy cognitive map(IFCM) intuitionistic normal cloud(INC)model warship construction.

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Robotic cluster machining:Manufacturing revolution for large and complex components

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Science China(Technological Sciences) 2022年第9期65卷 2215-2217页

作者： tao Bo gong ZeYu &DING Han State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

Large complex components, such as aircraft skins, aerospace hulls, ship and high-speed train shells, are key components for aviation, aerospace, marine and transportation industries.The high-efficiency and high-quality manufacturing of these products is not only a major need for industry, but also a frontier hotspot in the field of intelligent manufacturing.

关键词： frontier cluster aviation

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Common Injuries and Repair Mechanisms in the Endothelial Lining

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Chinese Medical Journal 2018年第19期131卷 2338-2345页

作者： Ling-Bing Meng Kun Chen Yuan-Meng Zhang Tao Gong Department of Neurology Beijing Hospital National Center of Gerontology Beijing 100730 China National Center for Clinical Laboratories Beijing Hospital National Center of Gerontology Beijing 100730 China Department of Internal Medicine Jinzhou Medical University Jinzhou Liaoning 121001 China

Objective：Endothelial cells （ECs） are important metabolic and endocrinal organs which play a significant role in regulating vascular function.Vascular ECs,located between the blood and vascular tissues,can not only complete the metabolism of blood and interstitial fluid but also synthesize and secrete a variety of biologically active substances to maintain vascular tension and keep a normal flow of blood and long-term patency.Therefore,this article presents a systematic review of common injuries and healing mechanisms for the vascular endothelium.Data Sources：An extensive search in the PubMed database was undertaken,focusing on research published after 2003 with keywords including endothelium,vascular,wounds and injuries,and wound healing.Study Selection：Several types of articles,including original studies and literature reviews,were identified and reviewed to summarize common injury and repair processes of the endothelial lining.Results：Endothelial injury is closely related to the development of multiple cardiovascular and cerebrovascular diseases.However,the mechanism of vascular endothelial injury is not fully understood.Numerous studies have shown that the mechanisms of EC injury mainly involve inflammatory reactions,physical stimulation,chemical poisons,concurrency of related diseases,and molecular changes.Endothelial progenitor cells play an important role during the process of endothelial repair after such injuries.What＇s more,a variety of restorative cells,changes in cytokines and molecules,chemical drugs,certain RNAs,regulation of blood pressure,and physical fitness training protect the endothelial lining by reducing the inducing factors,inhibiting inflammation and oxidative stress reactions,and delaying endothelial caducity.Conclusions：ECs are always in the process of being damaged.Several therapeutic targets and drugs were seeked to protect the endothelium and promote repair.

关键词： Endothelium Vascular Wound Healing Wounds and lnjuries

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Artificial intelligence and evidence-based research will promote the development of traditional medicine

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Acupuncture and Herbal Medicine 2024年第1期4卷 134-135页

作者： Xinran Liu Tao Gong College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK College of Acupuncture and Chinese Medicine Northwestern Health Sciences UniversityBloomingtonUSA

Traditional medicine(TM)has progressively achieved international recognition.The recent first-ever World Health Organization(WHO)Traditional Medicine Global Summit 2023 has undoubtedly highlighted the significance of TM^([1]).This conference was held in India during August 17–18,2023^([2]),aiming to mobilize political commitment and evidence-based action supporting TM and integrating it to advance the health and well-being of the people and planet.

关键词： integrating doubt planet

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Nanomaterials and bone regeneration

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Bone Research 2015年第3期3卷 123-129页

作者： Tao Gong Jing Xie Jinfeng Liao tao Zhang Shiyu Lin Yunfeng Lin State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic （mainly collagen） and inorganic （mainly nano-hydroxyapatite） components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article, we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part.

关键词： bone ECM

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Low-dimensional perovskite materials and their optoelectronics

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InfoMat 2021年第10期3卷 1039-1069页

作者： tao Zhu Xiong gong School of Polymer Science and Polymer Engineering College of Engineering and Polymer ScienceThe University of AkronAkronOhioUSA

Three-dimensional(3D)organic-inorganic metal halide perovskite materials possess great potential applications for approaching efficient optoelectronics due to the unique optoelectronic properties of perovskite materials and costeffective manufacturing possibilities of optoelectronics.However,the scientific and technical challenges of 3D perovskite materials were their inferior long-term stability,which hampered their practical applications.The lowdimensional perovskite materials composed of alternating organic and inorganic layers are one of the most credible paths toward stable perovskite photovoltaics and optoelectronics.In this short review,we first present a discussion of the crystal structure and nontrivial optoelectronic properties of the low-dimensional halide perovskites.The synthetic methods for the preparation of the low-dimensional halide perovskites are reviewed.After that,we focus on the recent development of perovskite photovoltaics,light-emitting diodes,and lasers by the low-dimensional halide perovskites.Finally,we outline the challenges of the low-dimensional halide perovskites and their applications.

关键词： lasers light emitting diodes low-dimensional perovskite photodetectors solar cells

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Effect of fluid shear stress on the internalization of kidney-targeted delivery systems in renal tubular epithelial cells

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Acta Pharmaceutica Sinica B 2020年第4期10卷 680-692页

作者： Yingying Xu Shuo Qin Yining Niu Tao Gong Zhirong Zhang Yao Fu Key Laboratory of Drug-Targeting and Drug Delivery Systems of Ministry of Education and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Renal tubular epithelial cells(RTECs)are important target cells for the development of kidney-targeted drug delivery systems.Under physiological conditions,RTECs are under constant fluid shear stress(FSS)from original urine in the renal tubule and respond to changes of FSS by altering their morphology and receptor expression patterns,which may affect reabsorption and cellular uptake.Using a microfluidic system,controlled shear stress was applied to proximal tubule epithelial cell line HK-2.Next,2-glucosamine,bovine serum albumin,and albumin nanoparticles were selected as representative carriers to perform cell uptake studies in HK-2 cells using the microfluidic platform system with controlled FSS.FSS is proven to impact the morphology of HK-2 cells and upregulate the levels of megalin and clathrin,which then led to enhanced cellular uptake efficiencies of energy-driven carrier systems such as macromolecular and albumin nanoparticles in HK-2 cells.To further investigate the effects of FSS on endocytic behavior mediated by related receptors,a mice model of acute kidney injury with reduced fluid shear stress was established.Consistent with in vitro findings,in vivo studies have also shown reduced fluid shear stress down-regulated the levels of megalin receptors,thereby reducing the renal distribution of albumin nanoparticles.

关键词： Fluid shear stress Kidney-targeted drug delivery HK-2 cells Acute kidney injury

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