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Functional analysis of a miRNA‐like small RNA derived from Bombyx mori cytoplasmic polyhedrosis virus

Insect Science 2020年第3期27卷 449-462页

作者： Jian-Yong Guo Yong-Sheng Wang Tian Chen Xiao-Xu Jiang Ping Wu tao geng Zhong-Hua Pan Meng-Ke Shang Cheng-Xiang Hou Kun Gao Xi-Jie Guo School of Biotechnology Jiangsu University of Science and TechnologyZhenjiangChina Sericultural Research Institute Chinese Academy of Agricultural SciencesZhenjiangChina Environment and Plant Protection Institute Chinese Academy of Tropical Agricultural SciencesHaikoouChina School of Biology&Basic Medical Science Soochow UniversitySuzhouChina

Bombyx mori cytoplasmic polyhedrosis virus(BmCPV)is a major pathogen of the economic insect silkworm,Bombyx ***‐encoded microRNAs(miRNAs)have been proven to play important roles in host–pathogen *** this study we identified a BmCPV‐derived miRNA‐like 21 nt small RNA,BmCPV‐miR‐1,from the small RNA deep sequencing of BmCPV‐infected silkworm larvae by stem‐loop quantitative real‐time PCR(qPCR)and investigated its functions with qPCR and lentiviral expression *** mori inhibitor of apoptosis protein(BmIAP)gene was predicted by both target prediction software miRanda and Targetscan to be one of its target genes with a binding site for BmCPV‐miR‐1 at the 5′untranslated *** was found that the expression of BmCPV‐miR‐1 and its target gene BmIAP were both up‐regulated in BmCPV‐infected *** the same time,it was confirmed that BmCPV‐miR‐1 could up‐regulate the expression of BmIAP gene in HEK293T cells with lentiviral expression systems and in BmN cells by transfecting ***,BmCPV‐miR‐1 mimics could up‐regulate the expression level of BmIAP gene in midgut and fat body in the *** the midgut of BmCPV‐infected larvae,BmCPV‐miR‐1 mimics could be further up‐regulated and inhibitors could lower the virus‐mediated expression of BmIAP *** the viral genomic RNA segments S1 and S10 as indicators,BmCPV‐miR‐1 mimics could up‐regulate and inhibitors down‐regulate their replication in the infected *** results implied that BmCPV‐miR‐1 could inhibit cell apoptosis in the infected silkworm through up‐regulating BmIAP expression,providing the virus with a better cell circumstance for its replication.

关键词： Bombyx mori cytoplasmic polyhedrosis virus inhibitor of apoptosis protein miRNA-like small RNA

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德国汉堡的社会音乐文化生活印象

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人民音乐（评论） 2005年第11期 49-51页

作者：耿涛浙江省绍兴文理学院音乐学院

一、电台媒体的音乐传播汉堡的社会音乐文化生活给了我十分强烈的印象.首先是流行音乐一统天下.汉堡市的调频电台每天向公众播放的音乐有两大类:一类是流行音乐(Popular music),其中,绝大多数是摇滚歌曲,大约有7、8个音乐频道24小时不... 详细信息

一、电台媒体的音乐传播汉堡的社会音乐文化生活给了我十分强烈的印象.首先是流行音乐一统天下.汉堡市的调频电台每天向公众播放的音乐有两大类:一类是流行音乐(Popular music),其中,绝大多数是摇滚歌曲,大约有7、8个音乐频道24小时不间断地滚动播放,所唱歌曲的歌词大多是德语,极少数歌曲是英语,各种摇滚歌曲的旋律与节奏极富有动荡感,激情澎湃.

关键词：德国汉堡市社会音乐文化生活流行音乐音乐厅音乐会

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Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 513-528页

作者： Miao CHU Guangdong CHEN Kai CHEN Pengfei ZHU Zhen WANG Zhonglai QIAN Huaqiang tao Yaozeng XU Dechun geng Department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics Yixing People’s HospitalYixing 214200China Department of Orthopedics Hai’an People’s HospitalHai’an 226600China Department of Orthopedics Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215028China

Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the *** activation plays a crucial role in the occurrence of subchondral bone loss in early ***,the specific mechanism of osteoclast differentiation in OA remains *** our study,gene expression profiles related to OA disease progression and osteoclast activation were screened from the Gene Expression Omnibus(GEO)***2R and Funrich analysis tools were employed to find differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses demonstrated that chemical carcinogenesis,reactive oxygen species(ROS),and response to oxidative stress were mainly involved in osteoclast differentiation in OA subchondral ***,fourteen DEGs that are associated with oxidative stress were *** first ranked differential gene,heme oxygenase 1(HMOX1),was selected for further *** results showed that osteoclast activation in the pathogenesis of OA subchondral bone is accompanied by the downregulation of *** was revealed to inhibit osteoclastogenesis by targeting HMOX1 and upregulating the expression of antioxidant protein in ***,carnosol was found to alleviate the severity of OA by inhibiting the activation of subchondral osteoclasts in *** research indicated that the activation of osteoclasts due to subchondral bone redox dysplasia may serve as a significant pathway for the advancement of *** HMOX1 in subchondral osteoclasts may offer novel insights for the treatment of early OA.

关键词： Osteoclast Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) Carnosol

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Clinical value of regional lymph node sorting in gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第12期14卷 2393-2403页

作者： Chuan Li Xiao-Jie Tian geng-tao Qu Yu-Xin Teng Zhu-Feng Li Xin-Yang Nie Dong-Jie Liu Tong Liu Wei-Dong Li Department of General Surgery Tianjin General Surgery InstituteTianjin Medical University General HospitalTianjin 300000China

BACKGROUND Increasing evidence have shown that regional lymph node metastasis is a critical prognostic factor in gastric cancer(GC).In addition,lymph node dissection is a key factor in determining the appropriate treatment for ***,the association between the number of positive lymph nodes and area of lymph node metastasis in GC remains *** To investigate the clinical value of regional lymph node sorting after radical gastrectomy for *** This study included 661 patients with GC who underwent radical gastrectomy at Tianjin Medical University General Hospital between January 2012 and June *** patients were divided into regional sorting and non-sorting *** data were collected and retrospectively reviewed to determine the differences in the total number of lymph nodes and number of positive lymph nodes between the *** sample t-tests were used for intergroup *** variables that did not conform to a normal distribution were expressed as median(interquartile range),and the Mann-Whitney U test was used for inter-group *** There were no significant differences between the groups in terms of the surgical method,tumor site,immersion depth,and degree of *** total number of lymph nodes was significantly higher in the regional sorting group(n=324)than in the non-sorting group(n=337)(32.5 vs 21.2,P<0.001).There was no significant difference in the number of positive lymph nodes between the two groups.A total of 212 patients with GC had lymph node metastasis in the lymph node regional sorting group,including 89(41.98%)cases in the first dissection station and 123(58.02%)cases in the second dissection *** and multivariate logistic regression results showed that the number of positive lymph nodes(P<0.001)was an independent risk factor for lymph node metastases at the second dissection *** Regional sorting of lymph nodes after radical gastrectomy

关键词： Radical gastrectomy Regional lymph node sorting Lymph node dissection Lymph node staging Metastasis Gastric cancer

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谐振腔内的高质量圆对称艾里光束的产生方法

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物理学报 2020年第1期69卷 256-264页

作者：朱一帆耿滔上海理工大学光电信息与计算机工程学院上海市现代光学系统重点实验室教育部光学仪器与系统工程研究中心

本文提出一种在谐振腔内产生高质量圆对称艾里光束的方法,通过使用针对特定参数光束设计的衍射光学元件替代反射腔镜,可在腔内获得所需的特定参数光束.研究结果表明,该方法产生的圆对称艾里光束的参数可控;模式能量损耗低,接近高斯基模... 详细信息

本文提出一种在谐振腔内产生高质量圆对称艾里光束的方法,通过使用针对特定参数光束设计的衍射光学元件替代反射腔镜,可在腔内获得所需的特定参数光束.研究结果表明,该方法产生的圆对称艾里光束的参数可控;模式能量损耗低,接近高斯基模光束;光束质量高,明显优于目前常用的傅里叶空间纯相位全息编码法.接着,讨论了组装系统时产生的腔长误差和同轴度误差,以及加工衍射元件时产生的刻蚀误差对产生光束的影响.结果表明,现有的机械调节技术和微纳加工技术,完全能满足系统误差的精度要求,显示该方法对误差有较好的容差性.

关键词：圆对称艾里光谐振腔特征向量法衍射光学元件

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“媚俗”正义

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东南学术 2005年第2期 150-155页

作者：耿涛中国人民大学中文系

昆德拉用小说艺术的形式重新为我们摊开了虚无与独断这一时代文化难题的生动图景。昆德拉藉媚俗所谈论的实际上是摆脱虚无-独断之争是否可能及如何可能的问题。在这文化难题辐射之下,昆德拉为我们隐逸地开启了一条出路。对这条出路的理... 详细信息

昆德拉用小说艺术的形式重新为我们摊开了虚无与独断这一时代文化难题的生动图景。昆德拉藉媚俗所谈论的实际上是摆脱虚无-独断之争是否可能及如何可能的问题。在这文化难题辐射之下,昆德拉为我们隐逸地开启了一条出路。对这条出路的理解必须回到对“真诚”、“真实”、“趋真”三个向度的贞别,即:昆德拉的“媚俗”实际上是将真诚的性情、感动等同于作为“最高的好”的“真实”,消去了“趋真”这一践履意义上的动态的心灵的内在祈向这一度,从而造成独断;而反抗媚俗的“轻”实际上将这等同于“真实”从而坐实化、定势化的“真诚”连同“真实”这最高的价值本身一同否定掉,从而造成了虚无。走出“虚无—独断之辨”的真正出路在于守住“趋真”这一向着“最高的好”(真实)的永无终止的践履着的内在祈向。这是反抗“执着于定势”的媚俗所开示给我们的超越虚无-独断文化难题的真义。

关键词：定势真诚真实趋真

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从经典影像到多元视角——当代建筑摄影中的控制与表达

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建筑学报 2014年第6期 86-91页

作者：耿涛南京林业大学家具与工业设计学院南京210037 东南大学建筑学院南京210096

通过对建筑学中经典建筑案例拍摄过程的回顾,探讨了建筑师与建筑摄影师的合作方式,结合对当代建筑摄影多元视角及其特征的归纳,揭示出建筑影像背后所隐含的各种意图和具体控制,以此阐述建筑摄影对当代建筑学演进的特殊意义。

关键词：建筑摄影经典影像视角控制表达

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Scalp acupuncture combined with body acupuncture for 32 cancer cases with intractable hiccups after radiochemotherapy

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Journal of Acupuncture and Tuina Science 2015年第5期13卷 312-314页

作者：耿涛邓樱 Jiangsu Province Hospital of Traditional Chinese Medicine

Objective： To observe the therapeutic effect of scalp acupuncture combined with body acupuncture in treating cancer patients with intractable hiccups after radiochemotherapy. Methods; Thirty-two cancer patients with intractable hiccups after radiochemotherapy who met the inclusion criteria were selected. The Line 2 Lateral to Forehead （MS 3） of scalp stimulation areas as well as body acupoints including Danzhong （CV 17）, Zhongwan （CV 12）, bilateral Cuanzhu （BL 2）, Neiguan （PC 6）, Zusanli （ST 36） and Taichong （LR 3） were punctured. The treatment was given once a day, 5 treatments constituted a course, and the efficacy was evaluated after 2 treatment courses. Results： After 10 treatments, 26 cases were cured, 4 cases were improved, and 2 cases were invalid, and the total effective rate was 93.8%. Conclusion： Scalp acupuncture combined with body acupuncture in treating intractable hiccups in cancer patients after radiochemotherapy has reliable therapeutic effect, and it is easy-to-operate and can effectively alleviate the suffering of patients with less adverse reaction.

关键词： Acupuncture Therapy Scalp Acupuncture Scalp Stimulation Areas Neoplasms Chemoradiotherapy Drug-related Side Effects and Adverse Reactions Hiccup

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Automatic Camera Viewfinder Based on TI DaVinci

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Semiconductor Photonics and Technology 2009年第1期15卷 21-24,40页

作者： WANG Hai-gang XIAO Zhi-tao geng Lei School of Information and Communication Engineering Tianjin Polytechnic University Tianjin 300160 CHN

Presented is an automatic camera viewfinder based on T1 DaVinci digital platform and discussed mainly is the scheme of software system based on linux. This system can give an alarm and save the picture when the set features appear in the view, and the saved pictures can be downloaded and zoomed out. All functions are operated in OSD menu. It *** established for its flexible operations, powerful functions, multitasking and stable performance.

关键词： DSP Embedded linux OSD Boot

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电子强关联效应对掺杂型锰钙钛矿中Jahn-Teller效应的影响

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人工晶体学报 2011年第5期40卷 1286-1289,1298页

作者：韩增智耿滔上海理工大学理学院上海200093 上海理工大学上海市现代光学系统重点实验室上海200093

本文利用密度泛函理论对典型庞磁电阻材料La0.75Ca0.25MnO3的电子结构进行了计算。通过分析研究Jahn-Teller畸变和电子强关联对材料电子结构和物理特性的影响,发现与未掺杂的原型材料LaMnO3不同,在掺杂后,电子强关联效应对材料中的Jahn-... 详细信息

本文利用密度泛函理论对典型庞磁电阻材料La0.75Ca0.25MnO3的电子结构进行了计算。通过分析研究Jahn-Teller畸变和电子强关联对材料电子结构和物理特性的影响,发现与未掺杂的原型材料LaMnO3不同,在掺杂后,电子强关联效应对材料中的Jahn-Teller畸变起到了抑制作用,从而使得基态更加稳定。

关键词： La0.75Ca0.25MnO3 电子强关联 Jahn-Teller效应

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