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A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

Signal Transduction and Targeted Therapy 2024年第7期9卷 3112-3129页

作者： Yuzheng Zhou Zongpeng Chen Sijie Liu Sixu Liu Yujie Liao Ashuai Du Zijun Dong Yongxing Zhang Xuan Chen Siyi tao Xin Wu Aroona Razzaq Gang Xu De-an Tan Shanni Li Youwen deng Jian Peng Shuyan Dai Xu deng Xianwen Zhang Taijiao Jiang Zheng Zhang Gong Cheng Jincun Zhao Zanxian Xia Department of Cell Biology School of Life SciencesCentral South University410013 ChangshaChina Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and Technology518112 ShenzhenChina Department of Basic medicine School of MedicineHunan Normal University410081 ChangshaChina Department of spine surgery The Third Xiangya HospitalCentral South University410013 ChangshaChina School of Basic medical Sciences Anhui Medical University230032 HefeiChina Hunan Key Laboratory of Neurorestoratology 921 Hospital of Joint Logistics Support Force People’s Liberation Army of China(The Second Affiliated Hospital of Hunan Normal University)410003 ChangshaHunanChina Department of Geriatric Surgery Xiangya HospitalCentral South University410008 ChangshaChina Xiangya School of Pharmaceutical Sciences Central South University410013 ChangshaChina Institute of Infectious Diseases Shenzhen Bay Laboratory518132 ShenzhenChina Guangzhou Laboratory 510005 GuangzhouChina Tsinghua University-Peking University Joint Center for Life Sciences School of MedicineTsinghua University100084 BeijingChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouChina Hunan Key Laboratory of Animal models for Human Diseases Hunan Key Laboratory of Medical Genetics&Center for Medical GeneticsSchool of Life SciencesCentral South University410008 ChangshaChina

The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune *** its significance,the precise regulatory mechanisms underlying its function remain *** the present study,we unveil that the ORF9b protein of SARS-CoV-2,including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these ***,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOm70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a *** this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize ***,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2 ***-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2 may exploit HSP90αto evade the host *** study identifies the CUL5-TOm70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2 in clinical settings.

关键词： stability modulator offering

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Synergistic injection of the thermosensitive hydrogel and Bi-based alloy bone cement for orthopaedic repair

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Science China(Technological Sciences) 2024年第7期67卷 2153-2163页

作者： LIU SiCong LI Lei JIANG ChanYuan WANG QianYu deng ZhongShan Key Laboratory of Cryogenic Science and Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Cleft Lip and Palate Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Low-melting-point alloys have the advantages of good biocompatibility, plasticity, and near-bone mechanical strength, making them suitable as bone defect-filling materials for direct injection into defective bone sites. However, using low-melting-point alloys for orthopedic implants poses the challenge of causing thermal damage to the surrounding bone tissue during injection. In this study, a thermosensitive hydrogel is prepared and synergistically injected into the bone defect site with BiInSn. BiInSn solidifies and releases heat during injection, while the thermosensitive hydrogel absorbs heat and transforms into a gel state,encapsulating BiInSn. Therefore, the surrounding bone tissue is effectively protected from thermal damage. When BiInSn and the thermosensitive hydrogel were injected synergistically, in vitro thermal experiments revealed that the maximum temperature of the surrounding bone tissue reached 42℃. This temperature is below the 47℃ threshold, which causes permanent damage to bone tissues. In vivo experiments demonstrated that rats in the BiInSn-thermosensitive hydrogel group exhibited better recovery at the bone defect sites. These results suggest that the synergistic injection of Bi-based alloy and thermosensitive hydrogel is beneficial in reducing thermal damage to bone tissue, guiding bone tissue growth, and effectively facilitating the repair of bone defects.

关键词： bone defects thermosensitive hydrogel thermal damage to tissue bismuth-based alloy bone cement

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Special issue on electrochemical energy storage and conversion

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Frontiers in Energy 2024年第2期18卷 125-127页

作者： Yun ZHENG Gaixia ZHANG Sixu deng Jiujun ZHANG Institute of New Energy materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Department of Electrical Engineering École de Technologie Supérieure(ÉTS)Universitédu QuébecMontréalH3C 1K3Canada Department of Chemical and materials Engineering Concordia UniversityMontrealQC H3G 1M8Canada

The escalating global consumption of fossil fuels has significantly elevated the levels of CO_(2)in the atmosphere,leading to an undesirable global energy crisis and environmental *** deployment of renewable energy resources is crucial to mitigate these *** recent years,there has been noteworthy progress in electrochemical energy storage and conversion techniques and devices,including hydrogen energy and fuel cells,advanced energy storage and power batteries,and CO_(2)electrochemical conversion and utilization.

关键词： electrochemical energy elevated

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A statistical sensing method by utilizing Wi-Fi CSI subcarriers:Empirical study and performance enhancement

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Journal of Information and Intelligence 2024年第4期2卷 365-374页

作者： tao deng Bowen Zheng Rui Du Fan Liu Tony Xiao Han Wireless Technology Laboratory Huawei Techologies Co.Ltd.Shenzhen 518000China School of System Design and Intelligent manufacturing(SDIm) Southern University of Science and TechnologyShenzhen 518000China

In modern Wi-Fi systems,channel state information(CSI)serves as a foundational support for various sensing ***,existing CSI-based techniques exhibit limitations in terms of environmental *** such,optimizing the utilization of subcarrier CSI stands as a critical avenue for enhancing sensing *** the OFDm communication framework,this work derives sensing outcomes for both detection and estimation by harnessing the CSI from every individual measured subcarrier,subsequently consolidating these *** contrasted against results derived from CSI based on specific extraction protocols or those obtained through weighted summation,the methodology introduced in this study offers substantial improvements in CSI-based detection and estimation *** approach not only underscores the significance but also serves as a robust exemplar for the comprehensive application of CSI.

关键词： CSI Subcarrier Wi-Fi sensing

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A methodology for laser tool setters calibration and its precise mathematical model

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Chinese Journal of Aeronautics 2024年第7期37卷 564-581页

作者： tao FANG Zixi FANG Ze Zhong CHEN Zhiyong CHANG School of mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Gina Cody School of Engineering and Computer Science Concordia UniversityMontrealQuebec H3G 1M8Canada Changsha Optimum CNC Corporation Changsha 410221China Institute for Aero-engine Smart Assembly of Shaanxi Province Xi’an 710072China

On-machine tool setting is a pivotal approach in achieving intelligent manufacturing,and laser tool setters have become a crucial component of smart machine *** tool setters play a crucial role in precisely measuring the dimensions of cutting tools during the part machining process,focusing on tool length and *** a measuring instrument,the positions of the laser axis of the laser tool setter need to be accurately calibrated before ***,in actual calibration scenarios,traditional calibration methods face challenges due to installation errors in the tool setter and geometric errors in the measuring *** address this issue,this study proposes a novel calibration ***,the calibration mechanism of the laser beam axis is *** on the accurate mathematical model of the laser beam and the measuring rod,and using the polygon clipping algorithm,the mathematical mechanism of the laser tool setter’s work is ***,a novel method is introduced to calculate the compensation distance between the laser beam reference point and the rod bottom center point at each moment during ***,by utilizing the kinematic chain of the tool setter calibration system,a new calibration method is developed to accurately calibrate the position of the laser beam axis in the machine tool coordinate ***,the accuracy of the calibration method is verified through simulation experiments and calibration *** method improves the calibration accuracy of the tool setter,and the mathematical model of the laser tool setter can be extended to the measurement of tools,thereby improving the precision of tool *** research significantly improves the efficient production performance of smart machine tools.

关键词： On-machine tool setting Smart machine tools mathematical model Calibration method Laser tool sette

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教师教育教学改革:通用人工智能时代的应为、难为与可为

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电化教育研究 2024年第8期45卷 97-104页

作者：黄悦邓涛东北师范大学教师教育研究院吉林长春130024 东北师范大学教育学部吉林长春130024

教师教育是教育事业的“工作母机”,通用人工智能时代的教学改革是教育高质量发展与数字化转型的应有之义。通用人工智能为教师教育赋予“增量”,能够实现其价值取向从“一个学生”到“每个学生”、培养范式由“相对割裂”向“相称统一... 详细信息

教师教育是教育事业的“工作母机”,通用人工智能时代的教学改革是教育高质量发展与数字化转型的应有之义。通用人工智能为教师教育赋予“增量”,能够实现其价值取向从“一个学生”到“每个学生”、培养范式由“相对割裂”向“相称统一”、教学目标自“知识技能”至“全息素养”、教育手段由“各自游离”变“多向合作”。但技术的高效性与其风险相伴而生,技术获取开源性与师生信任、技术使用广泛性与情感维系、技术发展智能性与基础资源三对矛盾成为教学改革的实然困境。基于此,教师教育应该以自建智能教学资源为物质性支撑、平等互动交流对话为行为性支持、顶层设计总体部署为制度性推动、教学改革自发自觉为精神性引领,积极构建通用人工智能时代教师教育教学的质量文化,在发展新质生产力、建设现代化中国中彰显教育服务能力。

关键词：教师教育通用人工智能教学改革高质量发展质量文化

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Health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National Science Review 2024年第2期11卷 103-113页

作者： tao Xue Ruohan Wang meng Wang Yanying Wang Dan Tong Xia meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao mingkun Tong Xueqiu Ni Hengyi Liu Jianyu deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu Institute of Reproductive and Child Health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced Institute of Information Technology Peking University Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University Department of Earth System Science Tsinghua University School of Public Health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation Clean Air Asia

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[Pm2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to Pm2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to Pm2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of Pm2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of Pm2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

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The Roadmap of 2D materials and Devices Toward Chips

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Nano-micro Letters 2024年第6期16卷 343-438页

作者： Anhan Liu Xiaowei Zhang Ziyu Liu Yuning Li Xueyang Peng Xin Li Yue Qin Chen Hu Yanqing Qiu Han Jiang Yang Wang Yifan Li Jun Tang Jun Liu Hao Guo tao deng Songang Peng He Tian Tian‑Ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100049People’s Republic of China School of microelectronics Fudan UniversityShanghai 200433People’s Republic of China State Key Laboratory of Dynamic measurement Technology Shanxi Province Key Laboratory of Quantum Sensing and Precision MeasurementNorth University of ChinaTaiyuan 030051People’s Republic of China High‑Frequency High‑Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029People’s Republic of China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049People’s Republic of China ImECAS-HKUST-Joint Laboratory of microelectronics Beijing 100029People’s Republic of China

Due to the constraints imposed by physical effects and performance degra certain limitations in sustaining the advancement of moore’s ***-dimensional(2D)materials have emerged as highly promising candidates for the post-moore era,offering significant potential in domains such as integrated circuits and next-generation ***,in this review,the progress of 2D semiconductors in process engineering and various electronic applications are summarized.A careful introduction of material synthesis,transistor engineering focused on device configuration,dielectric engineering,contact engineering,and material integration are given *** 2D transistors for certain electronic applications including digital and analog circuits,heterogeneous integration chips,and sensing circuits are ***,several promising applications(artificial intelligence chips and quantum chips)based on specific mechanism devices are ***,the challenges for 2D materials encountered in achieving circuit-level or system-level applications are analyzed,and potential development pathways or roadmaps are further speculated and outlooked.

关键词： Two-dimensional materials Roadmap Integrated circuits Post-moore era

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Complementary monogamy and polygamy properties among multipartite systems

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Chinese Physics B 2024年第3期33卷 207-213页

作者：李陶周静怡孙琪靳志祥梁登峰罗婷 School of mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048China School of Computer Science and Techonology Dongguan University of TechnologyDongguan 523808China People's Public Security University of China Academy of Information Network SecurityBeijing 100038China

monogamy and polygamy relations are essential properties of quantum entanglement,which characterize the distributions of entanglement in multipartite *** this paper,we establish the general monogamy relations forγ-th(0≤γ≤α,α≥1)power of quantum entanglement based on unified-(q,s)entanglement and polygamy relations forδ-th(δ≥β,0≤β≤1)power of entanglement of assistance based on unified-(q,s)entanglement of assistance,which provides a complement to the previous research in terms of different parameter regions ofγandδ.These results are then applied to specific quantum correlations,e.g.,entanglement of formation,Renyi-q entanglement of assistance and Tsallis-q entanglement of assistance to get the corresponding monogamy and polygamy ***,typical examples are presented for illustration.

关键词： monogamy relation polygramy relation

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Synthesis of betanin by expression of the core betalain biosynthetic pathway in carrot

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Horticultural Plant Journal 2024年第3期10卷 732-742页

作者： Bo Wang Yahui Wang Yuanjie deng Quanhong Yao Aisheng Xiong State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research Institute of Shanghai Academy of Agricultural ScienceShanghai 201106China

Betalain has received increased attention because of its high nutritional value and crucial physiological *** on the elucidation of its core biosynthetic pathway,betalain can be produced in additional plants by metabolic *** of betalain in carrot(Daucus carota L.)can improve its nutritional quality and economic value by extracting betalain from the fleshy root,non-edible part,and processing residue of *** this study,two different constructs,namely,pYB:mCD(AomelOS,BvCYP76AD1S,and BvDODA1S)and p YB:CDD(BvCYP76AD1S,BvDODA1S,and mjcDOPA5GTS),were introduced into carrot for betanin synthesis by Agrobacterium-mediated *** can be synthetized in both transgenic calli,and p YB:m CD-transgenic callus can be used to produce betacyanin by suspension ***,pYB:mCD-transgenic seedlings can synthetize betanin only by tyrosine *** p YB:CDD-transgenic lines can synthetize betanin in whole *** betanin content in fleshy root of pYB:CDD-transgenic carrot was(63.4±9)μg·g^(-1)fresh weight according to quantitative *** betanin-producing carrot plant materials can be used to synthesize betanin for industrial application or consumption as dietary sources.

关键词： Daucus carota L. Betanin Biosynthesis metabolic engineering Biofortification

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