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Efﬁciency and safety of sofosbuvir in Bangladeshi children with chronic hepatitis C virus

iLIVER 2023年第3期2卷 146-150页

作者： Salahuddin Mahmud Jahida Gulshan MdBelayet Hossain Madhabi Baidya Rafia Rashid farhana Tasneem Ahmed Rashidul Hasan tanzila farhana Mohammed Reaz Mobarak MdJahangir Alam Syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology&NutritionBangladesh Shishu Hospital&InstituteDhakaBangladesh Institute of Statistical Research and Training(ISRT) University of DhakaDhakaBangladesh Department of Pediatric Hematology&Oncology Bangladesh Shishu Hospital&InstituteDhakaBangladesh Department of Pediatric Gastroenterology Dr.M R Khan Shishu Hospital&Institute of Child HealthDhakaBangladesh Department of Pediatrics BIHS General HospitalDiabetic Association of BangladeshDhakaBangladesh Department of Epidemiology&Research Bangladesh Shishu Hospital&InstituteDhakaBangladesh Bangladesh Shishu Hospital&Institute DhakaBangladesh

Background and aims:Currently,treatment with oral direct-acting antivirals is recommended for all hepatitis C virus(HCV)-infected pediatric *** aim of this study was to evaluate the efficacy and safety of sofosbuvir and ribavirin combination ther apy for children and adolescents in Bangladesh who are living with chronic HCV in ***:An experimental study was performed from January 2021 to December *** polymerase chain reaction(PCR)-positive thalassemic children,who were 6–18 years of age,were enrolled by consecutive non-probability *** features were recorded,and investigations were *** patients were initially treated with sofosbuvir(200 mg for 6-to 11-year-olds and 400 mg for 12-to 18-year-olds)and ribavirin(10–15 mg/kg/day)and were assessed clinically on a four-weekly basis,along with liver-function *** total duration of therapy was 24 *** PCR was done at the end of treatment and 12 weeks after the completion of treatment to see the sustained virological ***:There were 26 cases in total,with a mean age of 9.26?2.82 years;14 were males(53.8%),and 12 females(46.2%).Twenty-five(96.15%)patients achieved a sustained virological response,and the end-of-treatment PCR was *** patient(3.85%)was a nonresponder even after 24 weeks of *** medication was well received,with only four patients(15.3%)reporting headaches that were reported ***:The combination of sofosbuvir and ribavirin is effective in treating chronic HCV infection and is not accompanied by any major negative side effects.

关键词： Hepatitis C virus Direct-acting antivirals Sofosbuvir Ribavirin

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