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Retrospective Analysis of the Correlation between TMD, Headache and Bruxism

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Open Journal of Stomatology 2023年第4期13卷 125-133页

作者： Audrey Morris Patricia Grabowski tanya Al Talib Neamat Hassan Abubakr School of Dental Medicine University of Nevada Las Vegas Nevada USA

Aims: To evaluate the association between bruxism, headaches, and temporomandibular disorder (TMD). Methods: A keyword search of the clinical notes of patients’ charts in AxiUmTM was performed using the search terms “TMD”, “headache”, and “sleep bruxism” to identify these patients. The inclusion criteria were patients with partial of full dentition, aged 18 to 65 years old who attended the UNLV School of Dental Medicine clinics between January 2014 and September 2018. Patients with incomplete records and those who were completely edentulous formed the exclusion criteria. Data were analyzed using the Pearson Correlation Coefficient. Results: The final sample was made up of 529 patients. The highest percentage of study subjects were in the age range of 29 - 34 (17.9%), with a statistically significant correlation to pain on opening (P = 0.0403). Females showed a statistically significant correlation to TMJ clicking (P = 0.0033). Caucasians also had a statistically significant correlation to TMJ clicking (P = 0.0001). In addition, a statistically significant correlation between pain on opening or chewing and headaches was also observed (P = 0.0081). Conclusion: Within the limitations of the present study, Caucasians, and females presented with more TMJ clicking than the other study subjects. Young adults, in particular, experienced more pain on opening or chewing.

关键词： TMD Bruxism Headaches TMJ Clicking Pain

Characterization of two α4/7-conotoxins,Mrl.1 and Lpl.4,as novel antagonists of nicotinic acetylcholine receptors

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Characterization of two α4/7-conotoxins,Mrl.1 and Lpl.4,as ...

Characterization of a novel alpha4/4-conotoxin,Qc1.2,from vermivorous Conus quercinus

第九届中国生物毒素学术研讨会

作者： tanya Sanders Geoffrey Chew Edward Hawrot Department of Molecular Pharmacology.Physiology and Biotechnology Brown Medical SchoolProvidenceRhode Island 02912USA

＜正＞α-Conotoxins from cone snails are small disulfide-constrained peptides that act as potent and selective antagonists on specific subtypes of nicotinic acetylcholine receptors（nAChRs）.We recently identified two conopeptides in venom duct mRNA and muscle tissue genomic DNA from the South China Sea species,Mr1.1 from the molluscivorous Conus marmoreus and Lp1.4 from the vermivorous Conus *** have the typical 4/7-type framework characteristic of the subfamily ofα-conotoxins that act on neuronal-type *** two toxins were chemically synthesized and folded into the globular disulfide isomer through different oxidative approaches. Functional studies were carried out in oocytes expressing various nAChRs and with a rat model of inflammatory *** synthetic Mr1.1 primarily inhibited ACh-evoked currents reversibly in the ratα7 receptor,whereas Lp1.4 s unexpectedly a specific blocker of the mouse fetal muscleα1β1γδ*** the two toxins share low-affinity inhibition of nAChRs at high toxin concentrations,their unique receptor recognition profiles make them valuable tools for studying the toxin-receptor *** 1.1 was also shown to potently suppress the inflammatory response to pain in vivo,suggesting that it should be further investigated with respect to the molecular role of Mr1.1 in analgesia and its mechanism or therapeutic target for the treatment of pain.

关键词： Conus α4/7-conotoxins nicotinic acetylcholine receptors analgesia

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Characterization of a novel alpha4/4-conotoxin,Qc1.2,from ve...

Long Term Outcome of Bisphosphonate Therapy in Patients with Primary Hyperparathyroidism

第九届中国生物毒素学术研讨会

作者： tanya Sanders Geoffrey Chew Edward Hawrot Department of Molecular Pharmacology Physiology and BiotechnologyBrown Medical SchoolProvidenceRhode Island 02912USA

＜正＞Theα4/4-conotoxin first identified in a vermivorous Conus speices, designated Qc1.2,was originally obtained by cDNA and genomic DNA cloning from Conus quercinus collected in the South China *** predicted mature toxin of Qc1.2 contains 14 amino acid residues with two disulfide bonds（Ⅰ-Ⅲ,Ⅱ-Ⅳconnectivity） in a native globular *** mature peptide of Qc1.2 is supposed to contain an N-terminal posttranslationally processed pyroglutamate residue and a free carboxyl *** peptide was chemically synthesized and refolded for further characterizing its function *** synthetic Qc1.2 has two interconvertible conformations in aqueous solution,which may due to the cis-trans isomerization of the two successive Pro residues in its first cysteine *** the Xenopus oocyte heterologous expression system,Qc1.2 was shown to selectively inhibit both rat neuronalα3β2 andα3β4 subtypes of nicotinic acetylcholine receptors with low potency.A block of approximately 63%and 37%of the ACh-evoked currents was observed,respectively,and the toxin dissociated rapidly from the *** to other characterizedα-conotoxin members,the unusual structural features in Qc1.2 that confer to its receptor recognition profile are addressed.

关键词： nicotinic acetylcholine receptor subtypes α4/4-conotoxins posttranslational modification Xenopus oocytes

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International Journal of Clinical Medicine 2014年第14期5卷 829-835页

作者： Dalitso Segula tanya Nikolova Eileen Marks Lakshminarayan Ranganath Vinita Mishra Department of Clinical Biochemistry & Metabolic Medicine Royal Liverpool & Broadgreen University Hospital NHS Trust Liverpool UK

Context: Primary hyperparathyroidism (PHPT) is commonly associated with reduced bone mineral density (BMD) presenting with osteoporosis, increasing the risk of bone fragility fractures in these patients. Bisphosphonates, due to their anti-resorptive action, are known to improve the BMD and reduce the risk of bone fragility fractures. Therefore, bisphosphonates are considered as an alternative to surgical treatment in managing osteoporosis in PHPT patients. Aim: The aim of this observational study was to assess the effect of long term bisphosphonate therapy on BMD, bone fragility fracture and biochemical markers of bone metabolism in patients with PHPT. Methodology: Fifty patients (mean age 74 years) with PHPT who were treated with long term bisphosphonate therapy were studied retrospectively. The mean baseline (before commencing bisphosphonate therapy) BMD T-scores for lumbar spine (L2-L4) and left femoral neck were -2.5 and -2.1, respectively. Fourteen patients had bone fragility fractures before initiation of bisphosphonate therapy. Results: After an average of 5 years of bisphosphonate treatment, there was a significant increase in lumbar BMD T-score (-2.5 to -2.1, p = 0.013) and a non-significant change in left femoral neck BMD T-score (-2.1 to -2.2, p = 0.497). There was no increase in bone fragility fracture rate (p = 0.167). Serum corrected calcium reduced from 2.74 mmol/L to 2.60 mmol/L (p 0.001) and urine calcium to creatinine ratio from 0.70 to 0.55 (p 0.0001), both within the reference range. Conclusions: Our study suggests that long term bisphosphonate therapy improves lumbar BMD and prevents increase in bone fragility fracture rate. Additionally it improves hypercalcaemia in PHPT.

关键词： Primary Hyperparathyroidism Bisphosphonates Hypercalcaemia Bone Mineral Density

Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family

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World Journal of Gastroenterology 2006年第48期12卷 7848-7851页

作者： tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky Laboratory of Molecular Pathology University Hospital of Obstetrics and Gynecology Bulgaria Clinic of Abdominal Surgery Queen Giovanna Hospital Bulgaria Department of Pathology Queen Giovanna Hospital Bulgaria Department of Medical Genetics Medical University Bulgaria Department of Chemistry and Biochemistry Medical University Bulgaria Institute of Human Genetics University of Munster Germany

AIM： To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer （HNPCC） family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers.METHODS： The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the proband. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced.RESULTS： The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining.CONCLUSION： The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor, The primary tumor Iocalizatlons were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria.

关键词： Colon cancer Hereditary non-polyposiscolorectal cancer MLH1 Microsatellite instability

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管理中的“海盗智慧”

现代企业文化(上旬) 2013年第Z1期 61-63页

作者： tanya

海盗是个不合法的行业,但海盗的首领—海盗王却往往在内部制定了一系列富有智慧的制度法则,这些管理制度以及各种法则对我们当今的企业管理者来说,也是非常值得学习的。每一个成功的海盗王都是一名优秀的管理者,他们面对一群极度自由化... 详细信息

海盗是个不合法的行业,但海盗的首领—海盗王却往往在内部制定了一系列富有智慧的制度法则,这些管理制度以及各种法则对我们当今的企业管理者来说,也是非常值得学习的。每一个成功的海盗王都是一名优秀的管理者,他们面对一群极度自由化、素质低劣、好勇斗狠的海盗船成员,却能够打造出训练有素的海上势力,在动荡不安的环境中,为整个海盗团队谋取最大的利益。

关键词：海盗船卡律布狄斯索马里海盗战略与管理赎金

Role of TNFSF15 in the intestinal inflammatory response

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World Journal of Gastrointestinal Pathophysiology 2018年第4期9卷 73-78页

作者： tanya Kadiyska Ivan Tourtourikov Ana-Maria Popmihaylova Hilda Kadian Ani Chavoushian Department of Medical Chemistry and Biochemistry Sofia Medical UniversitySofia 1431Bulgaria Genetic Medico-Diagnostic Laboratory Genica Sofia 1612Bulgaria Bulgarian Association for Inflammatory Bowel Diseases Sofia 1527Bulgaria University of Montpellier Montpellier 34090France Department of Gastroenterology Acibadem City Clinic Oncology CenterSofia 1784Bulgaria

Gastrointestinal diseases, specifically Crohn's disease, ulcerative colitis, diverticular disease, and primary biliary cirrhosis are all characterized by complicated inflammation of the digestive tract. Their pathology is multifactorial, and risk factors encompass both genetic and environmental factors. Recent advances in the genetic component of inflammatory bowel diseases(IBDs) have revealed that the tumor necrosis factor superfamily member 15(TNFSF15) contains a number of risk alleles associated not only with IBD but also with other diseases such as diverticular disease and primary biliary cirrhosis. These risk alleles in TNFSF15 and the altered expression of its gene product can serve as the common ground between these disorders by explaining at least some of the underlying processes that lead to a dysregulated immune response and subsequent chronic inflammation. Here, we aim to outline how the TNFSF15 gene is involved in the proliferation and cell fate of different populations of T cells and subsequently in the control of both pro-and anti-inflammatory cytokines. Furthermore, we summarize what is currently known of TNFSF15 control region variants, how they are associated with each mentioned disease, and how these variants can explain the autoimmune pathology of said diseases through altered TNFSF15 expression.

关键词： Tumor necrosis factor superfamily member 15 Diverticular disease Death receptor 3 Ulcerative colitis Crohn’s disease Primary biliary cirrhosis

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伦敦:你是春天的痒痒挠

优品 2012年第6期 282-285页

作者： tanya 伦敦旅游局

总觉得春天是一个暖昧的季节,它让万物有了蠢蠢欲动的天理,那是一种不可抗拒的自然性,尤其是当你心中本来就生长着一棵小毛草的时候,那种"野火烧不尽,春风吹又生"的欲罢不能的滋味,真的是让你坐立不安,辗转反侧。好吧,谁让我遇到了你,... 详细信息

总觉得春天是一个暖昧的季节,它让万物有了蠢蠢欲动的天理,那是一种不可抗拒的自然性,尤其是当你心中本来就生长着一棵小毛草的时候,那种"野火烧不尽,春风吹又生"的欲罢不能的滋味,真的是让你坐立不安,辗转反侧。好吧,谁让我遇到了你,在某一个春天的伦敦,我只能说那是一个在对的地方遇到对的人的很正点的故事,很可惜,时间错误。

关键词：野火烧不尽你我自然性你喜欢我生费德勒小哥纳达尔英国绅士三件套

Performance of Different Orthodontic Brackets after Exposure to Dietary Components: An <i>in Vitro</i>Pilot Study

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Open Journal of Stomatology 2021年第9期11卷 341-348页

作者： Anthony Fusco Syed Ahmed Jared Link tanya Al-Talib Neamat Hassan Abubakr DMD School of Dental Medicine University of Nevada Las Vegas NV USA Department of Clinical Sciences School of Dental Medicine University of Nevada Las Vegas NV USA Department of Biomedical Sciences School of Dental Medicine University of Nevada Las Vegas NV USA

Introduction: The aim of this study was to determine whether there was a significant difference in shear bond strength between metal and ceramic brackets when exposed to acidic dietary components (beverages) and to observe the chromogenic potential of each in vitro. Methods: Metal and clear orthodontic brackets were placed on extracted maxillary second premolars and exposed to select beverages three times daily for four weeks. Shade was taken using a colorimeter device at seven intervals and the shear bond strength of each bracket was recorded. Results: There was a variable change in tooth shade with respect to the various beverages in which they were submerged. Coffee and Dr. Pepper had the most pronounced change, whereas Red Bull and water produced little to none, respectively. Compared to controls, brackets submerged in coffee had the greatest reduction in shear bond strength, followed by Dr. Pepper, then Red Bull. Overall, clear brackets showed higher shear bond strength than metal brackets. Conclusion: Acidic dietary components have a negative effect on the shear bond strength of orthodontic brackets, and more pigmented beverages have a higher chromogenic staining potential.

关键词： Bracket Shear Bond Strength Orthodontics Tooth Shade