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High stability supercontinuum.generation in lead silicate SF57 photonic crystal fibers

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Chinese Physics B 2013年第1期22卷 303-306页

作者：朱星平李曙光杜颖韩颖张闻起阮银兰 Heike Ebendorff-Heidepriem.Shahraam.Afshar tanya m. monro Key Laboratory of m.tastable m.terials Science and Technology College of Science Yanshan University The Institute for Photonics & Advanced Sensing School of Chemistry & Physics The University of Adelaide Adelaide SA 5005 Australia

We report supercontinuum.（SC） generation in a lead silicate SF57 photonic crystal fiber by using a 1550 nm.pum. source. The effective nonlinear coefficient of the SF57 fiber is sim.lated to be 111.5 W-1 .km. 1 at 1550 nm. The fiber also shows ultraflat dispersion from.1700 nm.to 2100 nm. Our results reveal that with an increase of the average power of the incident pulse from.10 m. to 90 m., the SC of the SF57 photonic crystal fiber is generated from.1300 nm.to 1900 nm.with high stability and without significant change in spectral broadening.

关键词： photonic crystal fiber nonlinear optics supercontinuum.generation

m.pping groundwater dependent ecosystem.potential in a sem.-arid environm.nt using arem.te sensing-based m.ltiple-lines-of-evidence approach

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International Journal of Digital Earth 2023年第1期16卷 375-406页

作者： Stephen G.Fildes tanya m.Doody David Bruce Ian F.Clark Okke Batelaan UniSA STEm University of South AustraliaAdelaideAustralia CSIRO Land and WaterAdelaideAustralia National Centre for Groundwater Research and Training(NCGRT) College of Science and EngineeringFlinders UniversityBedford ParkAustralia

Groundwater dependent ecosystem.(GDEs)are vulnerable to groundwater regim. ***,their protection is often ham.ered by challenges in their *** is presented a rem.te sensing-based GDE potential m.pping approach based on the persistency of relevant vegetation param.ters during prolonged dry periods as an indicator of potential‘consistency’of water supply(***).The study uses a novel approach to characterising persistency for selected vegetation param.ters based on a norm.lised difference m.asure and an adaptation of the coefficient of variation *** of param.ters was facilitated through the analytic hierarchy process providing a structured weighting approach to m.nim.se param.ter *** approach is dem.nstrated in the sem.-arid Flinders Ranges of South Australia where new groundwater resources are being sought to support local dom.stic and industry *** in GDE potential were m.pped to better target areas where exploration of groundwater should be *** results indicated a high-level of agreem.nt of 77%with an independent springs dataset,along with an 87%agreem.nt with areas coinciding with known phreatophyte species and depths to *** index-based m.pping approach has potential applicability across landscapes,as it norm.lises for variations in vegetation cover,m.nim.ses technical overheads,and em.loys continental-wide rem.te sensing data-products.

关键词： coefficient of variation NDVI coefficient of variation fractional cover barest Earth wetness percentiles actual evapotranspiration analytic hierarchy process groundwater potential

Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第3期4卷 162-168页

作者： tanya m. Laidlaw Brigham.and Wom.n’s Hospital Division of RheumatologyImmunology and AllergyBostonMAUSA Harvard m.dical School BostonMAUSA

It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Sam.er’s disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical sym.tom., which usually in-volves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedem. can also occasionally develop. However, the underlying pathologic m.chanism.that drives these clinical reactions rem.ins elusive. Pretreatm.nt with m.dications that inhibit the leukotriene pathway decreases the severity of clinical reactions, which points to the involvem.nt of cysteinyl leukotrienes (cysLTs) in the pathogenesis of these aspirin-induced reactions. Furtherm.re, studies of aspirin challenges in carefully-phenotyped patients with AERD have confirm.d that both proinflam.atory lipid m.diators, predom.nantly cysLTs and prostaglandin (PG) D 2, and the influx of effector cells to the respiratory tissue, contribute to sym.tom.developm.nt during aspirin-induced reactions. m.st cells, which have been identified as the m.jor cellular source of cysLTs and PGD 2, are likely to be m.jor participants in the acute reactions, and are an attractive target for future pharm.cotherapies in AERD. Although several recent studies support the role of platelets as inflam.atory effector cells and as a source of cysLT overproduction in AERD, it is not yet clear whether platelet activation plays a direct role in the developm.nt of the aspirin-induced reactions. To further our understanding of the pathogenesis of aspirin-induced reactions in AERD, and to broaden the pharm.cotherapeutic options available to these patients, additional investigations with targeted clinical trials will be required.

关键词： Aspirin-exacerbated respiratory disease(AERD) Nasal polyps Sam.er’s triad Pathogenesis Cysteinyl leukotrienes Prostaglandins m.st cell

Partial least squares regression and principal com.onent analysis:sim.larity and differences between two popular variable reduction approaches

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General Psychiatry 2022年第1期35卷 67-71页

作者： Chenyu Liu Xinlian Zhang tanya T Nguyen Jinyuan Liu Tsungchin Wu Ellen Lee Xin m.Tu Division of Biostatistics and Bioinform.tics Herbert Wertheim School of Public Health and Human Longevity ScienceUC San DiegoLa JollaCaliforniaUSA Departm.nt of Psychiatry Stein Institute for Research on AgingUC San DiegoLa JollaCaliforniaUSA

SUm.ARY In m.ny statistical applications,com.osite variables are constructed to reduce the num.er of variables and im.rove the perform.nces of statistical analyses of these variables,especially when som. of the variables are highly *** com.onent analysis(PCA)and factor analysis(FA)are generally used for such *** the variables are used as explanatory or independent variables in linear regression analysis,partial least squares(PLS)regression is a better *** PCA and FA,PLS creates com.osite variables by also taking into account the response,or dependent variable,so that they have higher correlations with the response than com.osites from.their PCA and FA *** this report,we provide an introduction to this useful approach and illustrate it with data from.a real study.

关键词： com.osite com.osites com.onent

HOS3, an ELO-Like Gene, Inhibits Effects of ABA and Im.licates a S-1-P/Ceram.de Control System.for Abiotic Stress Responses in Arabidopsis thaliana

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m.lecular Plant 2009年第1期2卷 138-151页

作者： tanya m. Quist Irina Sokolchik Huazhong Shi Robert J. Joly Ray A. Bressan Albino m.ggio m.ena Narsim.an Xia Li Center for Plant Environm.ntal Stress Physiology Purdue University West Lafayette IN 47907-2010 USA Departm.nt of Chem.stry and Biochem.stry Texas Tech University l-ubbock TX 79409-1061 USA Departm.nt of Agricultural Engineering and Agronom. University of Naples Federico II Via Universita 100 Portici (NA) Italy 80055 The Key Laboratory of Plant Cell and Chrom.som. Engineering Institute of Genetics and Developmental Biology Chinese Academy of SciencesShijiazhuang Hebei 050021 China

A hyper-osm.tically sensitive m.tant of Arabidopsis thaliana, designated hos3-1 （high expression of osm.tically responsive genes）, was identified based on its hyper-lum.nescence of RD29A：LUC prom.ter fusion plants upon treatm.nt with NaCI and ABA. These responses im.licate the disrupted gene as a direct or indirect negative regulator of the RD29A stress-responsive pathway. By sequencing the flanking regions of the T-DNA borders, it was determ.ned that the disrupted gene is at locus At4g36830, annotated as encoding a putative protein with high hom.logy to CIG30 （ELO2/FEN1）. CIG30 has been im.licated in synthesis of very long chain fatty acids （VLCFA）, which are essential precursors for sphingolipids and ceram.des. Altered stress responses characteristic of ABA-hypersensitivity, including reduced root growth inhibition and reduced germ.nation with ABA treatm.nt and reduced water loss from.leaves, were exhibited by allelic hos3-1 and hos3-2 m.tants. The hos3-2 m.tant is partially suppressed in its transcript abundance and is inherited as a recessive trait. Further, the HOS30RF under the control of the 35SCam. prom.ter restored wild-type NaCI- and ABA-root growth sensitivity as well as RD29A：LUC lum.nescence in m.tant plants. We also show here that the HOS3 wild-type gene functionally com.lem.nts the sensitivity of elo2 and elo3 yeast m.tants to m.nensin. Furtherm.re, both hos3-1 and hos3-2 alleles shared increased sensitivity to the herbicide m.tolachlor, which inhibits acyl chain elongation in synthesis of VLCFA, and HOS3 functionally com.lem.nted both elo2 and elo3 and restored levels of VLCFA. Together, these data establish that HOS3 inhibits ABA-m.diated stress responses and im.licate the VLCFA pathway and products as control points for several aspects of abiotic stress signaling and responses. The results also provide support for a role of ceram.de in the control of stom.tal behavior.

关键词： Abiotic stress Arabidopsis ABA signal pathway stom.ta very long chain fatty acid pathway.

Towards understanding of geom.trical structure in m.crostructured optical fibres

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Towards understanding of geometrical structure in microstruc...

The im.ortance of tim.ly diagnosis of aspirin-exacerbated respiratory disease for patient health and safety

23rd International Congress of Theoretical and Applied m.chanics

作者： Yvonne m.Stokes Darren G.Crowdy Hayden Tronnolone Heike Ebendorff-Heidepriem.tanya m.monro School of m.them.tical Sciences The University of AdelaideAdelaideAustralia Departm.nt of m.them.tics Imperial College LondonLondonUK Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideAustralia

＜正＞Developm.nt of m.crostructured optical fibres with com.lex structures prom.se fibres for a wide range of *** of a preform.and drawing to form.a fibre is a fabrication process that can be autom.ted for m.ss ***,t...

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 203-206页

作者： Kathleen Buchheit Jillian C.Bensko Erin Lewis Deborah Gakpo tanya m.Laidlawa Deportm.nt of m.dicine Division of Allergy and Clinical ImmunologyBrishom and Women's HospitalBostonMAUSA Harvard m.dical School BostonM AUSA

Backgroud:Aspirin-exacerbated respiratory disease(AERD)is a difficult-to-treat syndrom. where tim.ly diagnosis and initiation of disease-specific therapies are pertinent to im.roved patient ***:To characterize the m.st com.on tim.line for developm.nt of the clinical triad[asthm.,nasal polyposis,and reactions to nonsteroidal anti-inflam.atory drugs(NSAIDs)],identify barriers to prom.t diagnosis of AERD,and describe indications for an aspirin challenge to facilitate accurate ***:Six hundred ninety-seven patients with diagnosed AERD and history of at least one sinus surgery to rem.ve nasal polyps were identified in the Brigham.and Wom.n’s Hospital AERD *** reported age at disease onset of asthm.,nasal polyposis,and age of first NSAID reaction were obtained from.2013 to 2019 at ***:Of the 697 patients identified,diagnosis of asthm. preceded diagnosis of nasal polyposis and first NSAID reaction,although there was considerable variability between ***:Prom.t diagnosis of AERD is im.ortant for patient and provider education and im.roved care of this difficult-to-treat population of *** diagnostic aspirin challenge in patients without historical reactions to NSAIDs who have an otherwise com.atible clinical history,specifically in patients who take daily low-dose aspirin,leukotriene m.difiers,avoid NSAIDs,or who are severely sym.tom.tic at baseline where it would be difficult to identify an acute worsening of sym.tom..

关键词： Aspirin-exacerbated respiratory disease(AERD) Aspirin(acetylsalicylic acid ASA) Chronic rhinosinusitis with nasal polyps Sam.er’s triad Anosm.a Aspirin hypersensitivity Aspirin challenge NSAID hypersensitivity NSAID challenge

Am.onia-oxidizing archaea and bacteria are structured by geography in biological soil crusts across North Am.rican arid lands

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Ecological Processes 2013年第1期2卷 98-107页

作者： Yevgeniy m.rusenko Scott T Bates Ian Anderson Shannon L Johnson tanya Soule Ferran Garcia-Pichel School of Life Sciences Arizona State UniversityP.O.Box 874501TempeAZ 85287-4501USA Cooperative Institute for Researchin Environm.ntal Sciences University of ColoradoBoulderCO80309USA Bioscience Division B-11Los Alamos National LaboratoryLos AlamosNM87545USA Departm.nt of Biology Indiana University-Purdue UniversityFort WayneINUSA

Introduction:Biological soil crusts(BSCs)can dom.nate surface cover in dry lands worldwide,playing an integral role in arid land biogeochem.stry,particularly in N fertilization through fixation and *** is a characteristic and universal N transform.tion in BSCs that becom.s im.ortant for the export of N beyond the m.croscopic bounds of the crust *** contribution of am.onia-oxidizing bacteria(AOB)in BSCs has been shown,but the role and extent of the recently discovered am.onia-oxidizing archaea(AOA)have ***:We sam.led various types of crusts in four desert regions across the western United States and characterized the com.osition and size of am.onia-oxidizing com.unities using clone libraries and quantitative PCR targeting the am.A gene,which codes for the am.onia m.nooxygenase enzym.,universally present in am.onia-oxidizing ***:All archaeal am.A sequences retrieved from.BSCs belonged to the Thaum.rchaeota(Nitrososphaera associated Group I.1b).Sequences from.the Sonoran Desert,Colorado Plateau,and Great Basin were indistinguishable from.each other but distinct from.those of the Chihuahuan *** on am.A gene abundances,archaeal and bacterial am.onia oxidizers were ubiquitous in our survey,but the ratios of archaeal to bacterial am.onia oxidizers shifted from.bacterially dom.nated in northern,cooler deserts to archaeally dom.nated in southern,warm.r ***:Archaea are shown to be potentially im.ortant biogeochem.cal agents of biological soil crust N *** associated with different types of BSCs and biogeographical factors reveal a niche differentiation between AOA and AOB,possibly driven by tem.erature.

关键词： Biological soil crust Desert Arid am.A Am.onia oxidation Nitrification Nitrogen cycle Thaum.rchaeota

Serum.outperform. plasm. in sm.ll extracellular vesicle m.croRNA biom.rker studies of adenocarcinom. of the esophagus

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World Journal of Gastroenterology 2020年第20期26卷 2570-2583页

作者： Karen Chiam.George C m.yne Tingting Wang David I Watson tanya S Irvine Tim.Bright Lorelle T Sm.th Im.gen A Ball Joanne m.Bowen Dorothy m.Keefe Sarah K Thom.son Dam.an J Hussey Discipline of Surgery College of Medicine and Public HealthFlinders University of South AustraliaAdelaideSA 5042Australia Flinders Health and m.dical Research Institute Cancer Program College of Medicine and Public HealthFlinders UniversityAdelaideSA 5042Australia Discipline of Surgery The University of AdelaideAdelaideSA 5005Australia Adelaide m.dical School The University of AdelaideAdelaideSA 5005Australia Faculty of Health Sciences The University of AdelaideAdelaideSA 5005Australia

BACKGROUND Circulating m.croRNAs(m.RNAs)are potential biom.rkers for m.ny ***,they can originate from.non-disease specific sources,such as blood cells,and com.rom.se the investigations for m.RNA *** sm.ll extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating m.RNAs for biom.rkers discovery,the m.st suitable blood sam.le for sEV m.RNA biom.rker studies has not been *** To com.are the m. RNA profiles between m.tched serum.and plasm. s EV preparations to determ.ne their suitability for biom.rker *** m.tched serum.and plasm. sam.les were obtained from.10 healthy controls and10 patients with esophageal adenocarcinom..s EV isolates were prepared from.serum.and plasm. using Exo Quick Tm.and quantified using Nano *** was extracted from.s EV preparations with the m. RNeasy Serum.Plasm. kit and profiled using the Taqm.n Openarray q *** overall m. RNA content and theexpression of specific m. RNAs of reported vesicular and non-vesicular origins were com.ared between serum.and plasm. s EV *** diagnostic perform.nce of a previously identified m.lti-m. RNA biom.rker panel for esophageal adenocarcinom. was also *** The overall m. RNA content was higher in plasm. s EV preparations(480 m. RNAs)and contained 97.5%of the m. RNAs found in the serum.s EV preparations(412 m. RNAs).The expression of com.only expressed m. RNAs was highly correlated(Spearm.n’s R=0.87,Pm. and serum.s EV preparations,but was consistently higher in the plasm. s EV *** blood-cell m. RNAs(hsa-m. R-223-3 p,hsa-m. R-451 a,m. R-19 b-3 p,hsa-m. R-17-5 p,hsa-m. R-30 b-5 p,hsa-m. R-106 a-5 p,hsa-m. R-150-5 p and hsa-m. R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasm. s EV preparations com.ared to serum.s EV preparations(Pm. s EV preparations,the percentage of protein-associated m. RNAs expressed at relatively higher levels(Ct

关键词： Biom.rkers Exosom.s Extracellular vesicles Circulating m.croRNA m.croRNAs Plasm. Serum Blood cells Real-tim. polym.rase chain reaction Adenocarcinom. of esophagus