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Experimental Evaluation of Trilateration-Based Outdoor Localizationwith LoRaWAN

计算机、材料和连续体（英文） 2023年第4期75卷 845-862页

作者： Saeed ahmed Magsi Mohd Haris Bin Md Khir Illani Bt Mohd Nawi Muath Al Hasan Zaka Ullah Fasih Ullah Khan Abdul Saboor Muhammad Aadil siddiqui Department of Electrical and Electronic Engineering Universiti Teknologi PETRONASSeri Iskandar32610Malaysia Balochistan University of Information Technology Engineeringand Management SciencesQuetta37500Pakistan College of Engineering Al Ain UniversityAl Ain64141United Arab Emirates Department of Technology The University of LahoreLahore54000Pakistan High Performance Cloud Computing Centre(HPC3) Universiti Teknologi PETRONASSeri Iskandar32610Malaysia

Long Range Wide Area Network (LoRaWAN) in the Internet ofThings (IoT) domain has been the subject of interest for researchers. Thereis an increasing demand to localize these IoT devices using LoRaWAN dueto the quickly growing number of IoT devices. LoRaWAN is well suited tosupport localization applications in IoTs due to its low power consumptionand long range. Multiple approaches have been proposed to solve the localizationproblem using LoRaWAN. The Expected Signal Power (ESP) basedtrilateration algorithm has the significant potential for localization becauseESP can identify the signal’s energy below the noise floor with no additionalhardware requirements and ease of implementation. This research articleoffers the technical evaluation of the trilateration technique, its efficiency,and its limitations for the localization using LoRa ESP in a large outdoorpopulated campus environment. Additionally, experimental evaluations areconducted to determine the effects of frequency hopping, outlier removal, andincreasing the number of gateways on localization accuracy. Results obtainedfrom the experiment show the importance of calculating the path loss exponentfor every frequency to circumvent the high localization error because ofthe frequency hopping, thus improving the localization performance withoutthe need of using only a single frequency.

关键词： LoRaWAN localization expected signal power(ESP) path loss exponent(PLE) trilateration

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A Novel Device for Real-Time Monitoring of High Frequency Phenomena in CENELEC PLC Band

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Smart Grid and Renewable Energy 2012年第2期3卷 152-157页

作者： Bashir ahmed siddiqui Pertti Pakonen Pekka Verho Department of Electrical Energy Engineering Tampere University of Technology Tampere Finland.

This paper proposes the design and development of a novel, portable and low-cost intelligent electronic device (IED) for real-time monitoring of high frequency phenomena in CENELEC PLC band. A high speed floating-point digital signal processor (DSP) along with 4 MSPS analog-to-digital converter (ADC) is used to develop the intelligent electronic device. An optimized algorithm to process the analog signal in real-time and to extract the meaningful result using signal processing techniques has been implemented on the device. A laboratory environment has setup with all the necessary equipment including the development of the load model to evaluate the performance of the IED. Smart meter and concentrator is also connected to the low voltage (LV) network to monitor the PLC communication using the IED. The device has been tested in the laboratory and it has produced very promising results for time domain as well as frequency domain analysis. Those results imply that the IED is fully capable of monitoring high frequency disturbances in CENELEC PLC band.

关键词： Power Line Communication (PLC) Digital Signal Processor (DSP) Analog-to-Digital Converter (ADC) Fast Fourier Transform (FFT) High Frequency (HF) Interference

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Liver transplantation during global COVID-19 pandemic

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World Journal of Clinical Cases 2021年第23期9卷 6608-6623页

作者： Mostafa Alfishawy Nso Nso Mahmoud Nassar Jonathan Ariyaratnam Sakil Bhuiyan Raheel S siddiqui Matthew Li Howard Chung Amira Al Balakosy ahmed Alqassieh Tibor Fülöp Vincent Rizzo ahmed Daoud Karim M Soliman Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt IDCARECairo 0000Egypt Department of Medicine Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Clinical pharmacy department Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Tropical Medicine Department Ain Shams UniversityCairo 11517Egypt Department of Surgery Medical University of South CarolinaCharlestonSC 29425United States Department of Medicine Medical University of South CarolinaCharlestonSC 29425United States Department of Medicine Kasr Alainy Medical SchoolCairo UniversityCairo 11562Egypt

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory disease respiratory syndrome coronavirus-2 has significantly impacted the health care systems *** transplantation(LT)has faced an unequivocal challenge during this unprecedented *** targeted review aims to cover most of the clinical issues,challenges and concerns about LT during the COVID-19 pandemic and discuss the most updated literature on this rapidly emerging subject.

关键词： COVID-19 Calcineurin inhibitors Cytokine Distributive justice End-stage liver disease Immunosuppression Liver transplantation Mortality

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Rational drug design,synthesis,and biological evaluation of novel N-(2-arylaminophenyl)-2,3-diphenylquinoxaline-6-sulfonamides as potential antimalarial,antifungal,and antibacterial agents

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Digital Chinese Medicine 2021年第4期4卷 290-304页

作者： ahmed Hassen Shntaif Sharuk Khan Ganesh Tapadiya Anand Chettupalli Shweta Saboo Mohd Sayeed Shaikh Falak siddiqui Ramkoteswra Rao Amara College of Science for Women Babylon UniversityHillaBabil 00964Iraq MUPs College of Pharmacy(B Pharm) WashimMaharashtra 444506India Shreeyash Institute of Pharmaceutical Education and Research AurangabadMaharashtra 431010India Department of Pharmaceutical Sciences Center for NanomedicineAnurag UniversityHyderabad 501301India Government College of Pharmacy KaradMaharashtra 415124India Department of Pharmacy Shri Jagdishprasad Jhabarmal Tibrewala UniversityVidya NagariRajasthan 333001India

Objective Sulfanilamide,sulfadiazine,and dapsone were the first sulfonamides to be used to treat malaria by disrupting the folate biosynthesis process,which is essential for parasite ***,we aimed to synthesize novel N-(2-arylaminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide derivatives through a rational drug design *** All compounds were synthesized by the conventional method,and the products were characterized by spectral analysis(1 H NMR and mass spectrometry).The progression of the reaction was monitored using thin-layer chromatography(TLC).All the derivatives were analyzed for their effective binding mode in the allosteric site of the plasmodium cysteine protease *** and antifungal activities were determined using the broth dilution *** S6(N-(2-thiazol-4 yl)-acetyl-aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide and S9(N-(1 H-benzo[d]imidazol-2-yl)aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide formed five hydrogen bonds;S8(N-(2-1 H-imidazol-2 yl)aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide and S10(N-(1 H-benzo[d]imidazol-5-yl)aminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide formed four hydrogen bonds with the allosteric site of the *** the docking scores and formation of hydrogen bonds with the target enzyme,the novel derivatives were processed for wet lab *** the newly synthesized derivatives were subjected to in vitro antimalarial,antifungal,and antibacterial *** the derivatives exhibited sufficient sensitivity to the Plasmodium falciparum strain compared to the ***,compounds S9 and S10 showed the most potent dual antimicrobial and antimalarial *** also exhibited powerful molecular interactions in molecular docking *** Based on the above results,it was concluded that N-(2-arylaminophenyl)-2,3-diphenylquinoxaline-6-sulfonamide derivatives have excellent biological potential to act as antimalarial,antifungal,

关键词： Sulfonamides Antimalarials Antifungal Antibacterial Plasmodium cysteine protease falcipain-2 2,3-Diphenylquinoxaline-6-sulfonamide Plasmodium falciparum

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The effect of treatment package time in head and neck cancer patients treated with adjuvant radiotherapy and concurrent systemic therapy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第3期5卷 160-167页

作者： ahmed I.Ghanem Matthew Schymick Souheyla Bachiri Aniruddh Mannari Jawad Sheqwara Charlotte Burmeister Steven Chang Tamer Ghanem Farzan siddiqui Department of Radiation Oncology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Medical Oncology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Public Health Science Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Otolaryngology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Alexandria Clinical Oncology Department Alexandria UniversityQasm Bab SharqiAlexandria Governate00302Egypt

Objectives:In patients with head and neck carcinoma,“treatment package time”(TPT)was proven to impact outcomes in cases receiving adjuvant radiotherapy *** impact in patients receiving radiotherapy with concurrent systemic therapy has not been studied *** TPT influence on survival endpoints for patients treated with surgery followed by radiation and concurrent systemic therapy was ***:Institutional database to identify head and neck carcinoma cases treated with definitive surgery followed by concomitant chemo(bio)radiotherapy(CRT)was *** was the number of days elapsed between surgery and the last day of radiation.%FINDCUT SAS macro tool was used to search for the cutoff TPT that was associated with significant survival ***-Meier curves,log-rank tests as well as univariate and multivariate analyses were used to assess overall survival(OS)and recurrence free survival(RFS).Results:One hundred and three cases with a median follow up of 37 months were included in the *** tumors were 43%,oral cavity 40%and laryngeal 17%of *** systemic therapy included platinum and cetuximab in 72%and 28%,*** TPT was found to be<100 days with significantly better OS(P=0.002)and RFS(P=0.043)compared to TPT≥100 *** multivariate analysis;TPT<100 days,extracapsular nodal extension,high-risk score,iymphovascular space and perineural invasion were independent predictors for worse OS(P<0.05).T4,extracapsular nodal extension and high-risk score were all significantly detrimental to RFS(P<0.05).Conclusions:Addition of concomitant systemic therapy to adjuvant radiotherapy did not compensate for longer TPT in head and neck squamous cell *** coordinated care must be provided to ensure the early start of CRT with minimal treatment breaks.

关键词： Head and neck cancer Treatment package time Adjuvant radiation therapy Concomitant systemic therapy Survival

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Analgesic Activities of Methanol Extract of <i>Terminalia chebula</i>Fruit

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Pharmacology & Pharmacy 2015年第12期6卷 547-553页

作者： Shadab ahmed Auroj Naved Rafeeq Alam Khan Shahida siddiqui 1Department of Pharmacology Faculty of Pharmacy University of Karachi Karachi Pakistan Department of Pharmacognosy Faculty of Pharmacy University of Karachi Karachi Pakistan

Pain is a sensation which in many cases represents the only symptom for the diagnosis of several disorders. Throughout ages man has used many different remedies for pain relief, among which medicinal herbs are most common due to their efficacy and relative safety due to their natural origin. In present study methanol extract of Terminalia chebula fruit was evaluated for its analgesic effects in albino mice. The extract was prepared using whole dried powdered fruit with seeds in absolute methanol. It was then subjected to rotary evaporator under reduced pressure to get concentrated extract;different doses (300, 500 and 1000 mg/kg) were assessed for analgesic activity by tail immersion technique and acetic acid induced writhing test. Similar doses of Aspirin were used as standard drug (positive control) for comparison. Results of both tail flick method and acetic acid induced writhing test revealed that T. chebula fruit extract possessed varying degree of analgesic activity significant at 300 mg/kg and highly significant at 500 and 1000 mg/kg in comparison to control. The results were almost similar to standard drug. In acetic acid induced writhing test, maximum inhibition of writhing was observed at 1000 mg/kg where the number of writhes decreased from 14.1 to 5.2 indicating 63.1% inhibition. Above findings suggest that T. chebula fruit extract possesses significant analgesic activity in albino mice with reference to positive and negative control groups;however further studies on a large number of animals with clinical trials are required to confirm safe and effective use of this fruit extract in humans for analgesic purpose.

关键词： Terminalia chebula Methanol Extract Pain Tail Flick Test Writhing Test

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A Photonic Crystal Fiber Based Asymmetric Slotted Structured Highly Sensitive Refractive Index Plasmonic Biosensor

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Journal of Sensor Technology 2022年第1期12卷 1-17页

作者： Md. Arafat Rahman tanvir ahmed Md. Ismail Haque Md. Shamim Anower Department of Electrical and Electronic Engineering Rajshahi University of Engineering and Technology Rajshahi Bangladesh Department of Electrical and Electronic Engineering International Islamic University Chittagong Chittagong Bangladesh

Surface plasmon resonance (SPR) sensors have grown in popularity owing to their sensitivity, precision, and capacity for a variety of applications, including detection, monitoring, and sensing, among others. Sensitivity and resolution are two areas where this technology has room for development. A plasmonic biosensor based on an asymmetric slotted PCF structure with extremely high sensitivity has been described and theoretically investigated. This high performance sensor is constructed and completely characterized using finite element method in COMSOL Multiphysics software environment. Sensitivity and resolution are analyzed as performance parameters for the proposed sensor. Numerical simulation exhibits the maximum wavelength-sensitivity of 1100 nm/RIU with 9.09 × 10-6 RIU resolution in the broad measurement range of refractive index from 1.30 to 1.44. A polarization controller can be used to fine-tune this extremely sensitive and wide-ranging refractive index sensor to fulfil a variety of practical needs. This is performed with the consideration of the variation in the refractive index (RI) of the analyte channels. In comparison with earlier PCF-based sensors, the fiber design structure is basic, symmetrical, simple to produce, and cost-effective. Because of the asymmetric air holes and higher sensitivities of the refractive index detector, it is possible to identify biomolecules, biochemicals and other analytes.

关键词： Surface Plasmon Resonance (SPR) Sensor High Sensitivity Photonic Crystal Fiber (PCF) Optical Fiber Sensor

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Frequency of Musculoskeletal Pain and Associated Factors among Undergraduate Students

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Case Reports in Clinical Medicine 2018年第2期7卷 131-145页

作者： Muniba Mehmood Hasan Uzair Yaqoob Sara Shaukat Ali Adeel ahmed siddiqui Sindh Medical College Dow University of Health Sciences Karachi Pakistan Dow University of Health Sciences Karachi Pakistan

Objective: To study and compare the prevalence of musculoskeletal pain in Medical and non-medical students and find out the specific factors associated with the occurrence of this pain. Methodology: This is a cross-sectional study from March-May 2017 where a total of 400 medical and 350 non-medical students were registered using a structured questionnaire made by modification of Nordic questionnaire. Characteristics of musculoskeletal pain were determined Pain was also graded by using a grading scale. Results: Mean age for medical and non-medical students was 21.36 and 20.97 respectively. The prevalence of musculoskeletal pain was higher among females. More data were collected from 2nd and 5th year of medical and 1st and 2nd year of non-medical students. High incidence was found in medical students with occurrence mostly in Neck. This frequency of musculoskeletal pain was quiet high during the last 7 days. The long study hours and use of computer/laptop were found to be greater among medical undergraduates but no significant association was found in medical unlike non-medical students. Majority of undergraduate students reported a normal BMI. Our study has found no co-relation of BMI with prevalence of pain. It was also observed that medical students with musculoskeletal pain spent more time on travelling when compared to non-medical. Association was found with the use of back packs. The study observed the level of many daily activities like exercise and outdoor sports etc. but no significant relation was found. Conclusion: Prevalence of musculoskeletal pain among undergraduate students is truly high, more so in medical students. Medical students have shown no association of studying for long hours and use of computer/laptop with musculoskeletal pain when compared to non-medical students. More studies should be done to know contributing factors of musculoskeletal pain among undergraduate students.

关键词： Musculoskeletal Pain Undergraduates Medical Students Non Medical Students Neck Pain

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Quantitative Estimation of Gallic Acid as Biomarker in Lipitame Tablets by HPTLC Densitometry for Diabetic Dyslipidemia

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Chinese Medicine 2014年第4期5卷 170-178页

作者： Sheeraz siddiqui Khan Usmanghani Aqib Zahoor Zeeshan ahmed Sheikh Saleha Suleman Khan Faculty of Eastern Medicine Hamdard University Karachi Pakistan Research and Development Department Herbion Pakistan (Pvt.) Limited Karachi Pakistan

Lipitame is a poly herbal formulation comprised of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica. The formulation is investigated for its analysis evaluation. Biomarkers of three herbs such as Terminalia arjuna, Terminalia belerica, and Phyllanthus emblica have been already cited to contain gallic acid, which was qualitatively and quantitatively estimated. In the present study rapid and inexpensive qualification methods for the quality control of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica on thin layer chromatography (TLC) were developed and validated. The solvent system used was toluene:ethyl acetate:formic acid:methanol (12:9:4:0.5). The scanning of plate was performed linearly at 273 nm (absorption) by use of a TLC Scanner III CAMAG with a deuterium source, and the area of spots corresponding to Gallic acid standard was integrated. It was found that gallic acid has been found in the Lipitame tablets on HPTLC densitometry assessment compared with authentic gallic acid reference standard.

关键词： Lipitame Tablets Quantitative Estimation Densitometry Diabetic Dyslipidemia

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Primary Isolated Extra Nodal Esophageal Hodgkin Lymphoma in Diabetic Patient

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Journal of Cancer Therapy 2021年第9期12卷 497-504页

作者： Mayson A. Alameen ahmed Ibrahim Touqeer ahmed siddiqui Mervat Mohrous Fadhel Alotaibi Abdel Aziz Al Hamad Hussein Farghaly Department of Oncology Prince Sultan Medical City Riyadh Saudi Arabia Researches & Biostatistics Department Prince Sultan Cardiac Center Al Hassa Saudi Arabia Histopathology Prince Sultan Medical City Riyadh Saudi Arabia

Primary isolated esophageal Hodgkin’s lymphoma is seldom in localization and when seen, it is usually the non-Hodgkin’s type. We reported a 68-year-old, diabetic and ex-smoker, presented to our hospital complaining of progressive difficulty of swallowing for nine months for both solid and liquid. He was on proton pump inhibitors. Recently, he had fever and drenching night sweat and significant loss of weight. He was diagnosed as a case of isolated esophageal Hodgkin’s lymphoma that was diagnosed based on endoscopic and radiological findings. Clinical manifestations, radiological imagines and histopathological features were described. Clinical management, fellow-up and outcome were precisely discussed.

关键词： Esophagus Chemotherapy Radiotherapy Non-Hodgkin’s Lymphoma

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