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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi tanvir ahmed siddiqui Md.Muzahid ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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Aldosterone synthase inhibitor“Baxdrostat”for resistant hypertension:A clinical approach or futuristic idea?

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Chronic Diseases and Translational Medicine 2024年第2期10卷 146-148页

作者： Muhammad Osama siddiqui Ayaan ahmed Qureshi Arooba siddiqui Noor ul ain Liaquat National Hospital and Medical College KarachiSindhPakistan Karachi Medical and Dental College KarachiSindhPakistan

The American College of Cardiology/American Heart Association defines resistant hypertension(RH)as a clinical blood pressure(BP)reading of>130/80 mmHg in patients taking three antihypertensive drugs,including a renin–angiotensin system inhibitor,a calcium channel blocker(CCB),and a diuretic at well-tolerated doses.1,2 It is reported from multiple population-based surveys that in the United States,there is an approximately 12%–15%prevalence of RH among adults diagnosed with hypertension.2 A prospective study demonstrates that 20%of people diagnosed with RH had primary hyperaldosteronism.3,4 In addition to the classic three antihypertensive drugs,spironolactone and mineralocorticoid are also administered for ***,with respect to the safety profile of spironolactone,it has been reported to have several side effects such as low testosterone production,menstrual irregularities,and excessively raised serum potassium levels,leaving the drug unfit for the longitudinal therapeutic purpose of treating RH.

关键词： hypertension drugs hypertensive

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Is the Sundarbans of Bangladesh in a State of Pollution?

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Open Journal of Forestry 2024年第1期14卷 19-41页

作者： Mahmood Hossain Chameli Saha Sanjoy Saha Hawlader Mohammed Nurul Islam Mushfiq ahmed tanvir ahmed Abdul Halim Farhad Sikder Md. Mutasim Billah Forestry and Wood Technology Discipline Khulna University Khulna Bangladesh Institute for Integrated Studies on the Sundarbans and Coastal Ecosystems (IISSCE) Khulna University Khulna Bangla-desh Ecology Forestry and Biodiversity Division Center for Environmental and Geographic Information Services (CEGIS) Dhaka Bangladesh

The Sundarbans is the world’s most extensive natural mangrove forest and home to various natural resources. The population in the vicinity has increased, causing more dependency on the resources of the Sundarbans. The increasing industrialization, urbanization, aquaculture, intensive agricultural practices, seaports, tourism facilities, and so on in the peripheral areas of the Sundarbans have made significant changes in the surrounding and upstream land uses of the Sundarbans. This situation may have detrimental influences on the ecosystem components of the Sundarbans. Therefore, it is highly demanded to prepare a piece of baseline information or database of different sources of pollution and their present status in the various components of the Sundarbans. This effort helps to identify issues and concerns, determine the key elements of the ecosystem to monitor the level or overall quality of the Sundarbans ecosystem. The present study systematically collects the potential sources of pollution, types, and current levels in the ecosystem components of the Sundarbans using academic databases, libraries, and online resources. Discharge of industrial waste into water, soil and air, heavy metal pollution, use of agrochemicals, oil (refined and crude) pollution, plastic materials from urban areas, and tourism are the major issues and concerns related to the sustainability of the Sundarbans ecosystem. The air quality of the Sundarbans is in good condition with 0 - 50 AQI of Bangladesh. While BOD, COD, TDS, TSS varied from 2.0 to 3.8 mg/L, 21.6 to 416 mg/L, 146.9 to 24,100 mg/L and 54 to 155 mg/L, respectively. Soil EC, organic carbon, total nitrogen, and total phosphorus ranged from 3.01 - 5.82 mS/cm, 1.41% - 2.69%, 0.51 - 1.05 mg/g, and 0.32 - 0.51 mg/g respectively. The air, water and soil quality parameters varied with the sites and seasons and not much at the state of contamination. Indeed, we must pay much attention to the Sundarbans’ air, water and soil quality with

关键词： Ecosystem Mangroves Monitoring Pollution Soil Sundarbans

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Biomaterial-based in vitro 3D modeling of glioblastoma multiforme

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Cancer Pathogenesis and Therapy 2023年第3期1卷 177-194页

作者： tanvir ahmed Department of Pharmaceutical Sciences North South UniversityBashundharaDhaka1229Bangladesh

Adult-onset brain cancers,such as glioblastomas,are particularly *** with glioblastoma multiforme(GBM)do not anticipate living for more than 15 months if there is no *** results of conventional treatments over the past 20 years have been *** aggressiveness,location,and lack of systemic therapies that can penetrate the blood–brain barrier are all contributing *** GBM treatments that appear promising in preclinical studies,there is a considerable rate of failure in phaseⅠandⅡclinical ***,access becomes impossible due to the intricate architecture of *** vitro,bioengineered cancer models are currently being used by researchers to study disease development,test novel therapies,and advance specialized *** different techniques for creating in vitro systems have arisen over the past few decades due to developments in cellular and tissue ***-stage research may yield better results if in vitro models that resemble brain tissue and the blood–brain barrier are *** the use of 3D preclinical models made available by biomaterials,researchers have discovered that it is possible to overcome these *** in vitro models for the treatment of GBM are possible using biomaterials and novel drug *** review discusses the benefits and drawbacks of 3D in vitro glioblastoma modeling systems.

关键词： Glioblastoma multiforme Biomaterials In vitro 3D modeling Bioengineering

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Exploiting Structural Similarities to Classify Citations

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Computers, Materials & Continua 2021年第2期66卷 1195-1214页

作者： Muhammad Saboor ahmed Muhammad tanvir Afzal Capital University of Science and Technology IslamabadPakistan

Citations play an important role in the scientific community by assisting in measuring multifarious policies like the impact of journals,researchers,institutions,and *** cite papers for different reasons,such as extending previous work,comparing their study with the state-of-the-art,providing background of the field,*** recent years,researchers have tried to conceptualize all citations into two broad categories,important and *** a categorization is very important to enhance scientific output in multiple ways,for instance,(1)Helping a researcher in identifying meaningful citations from a list of 100 to 1000 citations(2)Enhancing the impact factor calculation mechanism by more strongly weighting important citations,and(3)Improving researcher,institutional,and university rankings by only considering important *** of these uses depend upon correctly identifying the important citations from the list of all citations in a *** date,researchers have utilized many features to classify citations into these broad categories:cue phrases,in-text citation counts,and metadata features,***,contemporary approaches are based on identification of in-text citation counts,mapping sections onto the Introduction,Methods,Results,and Discussion(IMRAD)structure,identifying cue phrases,*** such features accurately is a challenging task and is normally conducted manually,with the accuracy of citation classification demonstrated in terms of these manually extracted *** research proposes to examine the content of the cited and citing pair to identify important citing papers for each cited *** content similarity approach was adopted from research paper recommendation ***,a novel section-based content similarity approach is also *** results show that solely using the abstract of the cited and citing papers can achieve similar accuracy as the stateof-the-art *** makes the propose

关键词： Section-wise similarity citation classification content similarity important citation

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Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan siddiqui Misbah Shaikh Afia Salman Muhammad ahmed Ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I²=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I²=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I²=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I2=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I2=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatment.

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

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Achieving Energy Efficiency in Wireless Sensor Networks Using Dynamic Channel Polling and Packet Concatenation

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China Communications 2021年第8期18卷 249-270页

作者： Shama siddiqui Anwar ahmed Khan Sayeed Ghani Department of Computer Science DHA Suffa UniversityKarachiPakistan Department of Computer Science Institute of Business AdministrationKarachiPakistan Department of Computer Science Sindh Institute of Management&TechnologyKarachiPakistan

There has been a significant interest of researchers to combine different schemes focused on optimizing energy performance while developing aMAC protocol for Wireless Sensor Networks(WSNs).In this paper,we propose to integrate two cross-layer schemes:dynamic channel polling and packet concatenation using a recent asynchronous MAC protocol“Adaptive&Dynamic Polling MAC”(ADPMAC).ADP-MAC dynamically selects the polling interval distribution based on characterization of incoming traffic patterns using Coefficient of variation(CV).Packet Concatenation(PC)refers to combining the individually generated data packets into a single super packet and sending it at the polling ***,the Block Acknowledgement(BA)scheme has been developed for ADP-MAC to work in conjunction with the packet *** proposed schemes have been implemented in Tiny-OS for Mica2 platform and Avrora emulator has been used for conducting *** results have revealed that the performance both in terms of energy&packet loss improves when ADP-MAC is used in conjunction with the additional features of PC&***,the proposed scheme has been compared with a stateof-art packet concatenation primitive PiP(Packet-in-Packet).It has been observed that ADP-MAC supersedes the performance of PiP in terms of PDR(Packet Delivery Ratio)due to better management of synchronization between source and sink.

关键词： energy efficiency concatenation dynamic polling

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Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2′-bipyridyl)ruthenium(II)Chloride-diperiodatocuprate(III)Reaction

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Chemical Research in Chinese Universities 2021年第3期37卷 629-638页

作者： ahmed Khan MUHAMMAD Asghar MOHAMMED Yaqoob MASOOD ahmed siddiqui SAMAR Ali Department of Chemistry University of BalochistanSariab RoadQuetta87300Pakistan

A sensitive and selective method employing chemiluminescence(CL)coupled with flow injection(FI)is reported for nalbuphine hydrochloride(NAL)assay in pharmaceutical *** enhancement effect of NAL on the CL reaction between tris(2,2′-bipyridyl)ruthenium(II)chloride-diperiodatocuprate(III){Ru[(bpy)_(3)]^(2+)-Cu(III)complex}in acidic medium is used as analytical *** optimal conditions of the CL reaction were sulfuric acid 1.0×10^(−3) mol/L,Ru[(bpy)s]2+7.5×10^(−5) mol/L,Cu(III)/Ag(III)complexes 4.0×10^(−4)/5.0×10^(−4) mol/L,sample loop volume of 120µL and flow rate of 2.5 mL/*** sensitivities of the method in terms of detection(S/N=3)and quantification(S/N=10)limits are 5×10^(−4) and 0.001 ppm(1 ppm=1 mg/L),*** linear response of the instrument in the form of CL intensity with respect to NAL concentration is over the range 0.001-15.0 ppm(R^(2)=0.9999)with relative standard deviation from 0.8%to 3.2%and injection throughput of 120 injection/*** applications of the method include the quantitative analysis of NAL in pharmaceutical injection *** and the average results of the proposed method are not significantly different from the results of a reported method by applying F-and paired student *** most likely CL reaction mechanism is written in accordance with spectrophotometric and CL studies.

关键词： Ru[(bpy)_(3)]^(2+) Cu(III)/Ag(III)complex Chemiluminescence Flow injection analysis Nalbuphine hydrochloride Pharmaceutical

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Vegetation-environment relationships in the forests of Chitral district Hindukush range of Pakistan

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Journal of Forestry Research 2013年第2期24卷 205-216页

作者： Nasrullah Khan Syed Shahid Shaukat Moinuddin ahmed Muhammad Faheem siddiqui Department of Botany University of Malakand Dept. of Botany University of Karachi Laboratory of Dendrochronology and Plant Ecology Department of Botany Federal Urdu University of Arts Science and Technology

We investigated the composition of plant communities to quantify their relationships with environmental parameters in the Chitral Hindukush range of Pakistan. We sampled tree vegetation using the Point Centered Quarter （PCQ） method while understory vegetation was sampled in 1.5-m circular quadrats. Cedrus deodara is the national symbol of Pakistan and was dominant in the sampled communities. Because environmental variables determine vegetation types, we analyzed and evaluated edaphic and topographic factors. DCA-Ordination showed the major gradient as an amalgam of elevation （p〈0.05） and slope （p〈0.01） as the topographic factors correlated with species distribution. Soil variables were the factors of environmental significance along DCA axes. However, among these factors, Mg2＋ , K ＋ and N2＋ contributed not more than 0.054% 0.20% and 0.073%, respectively, to variation along the first ordination axis. We conclude that the principal reason for weak or no correlation with many edaphic variables was the anthropogenic disturbance of vegetation. The understory vegetation was composed of perennial herbs in most communities and was most dense under the tree canopy. The understory vegetation strongly regulates tree seedling growth and regeneration patterns. We recommend further study of the understory vegetation using permanent plots to aid development of forest regeneration strategies.

关键词： environmental relationship multivariate analysis cluster analysis ordination anthropogenic factors forest, Hindukush range

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Population structure,age and growth rates of conifer species and their relation to environmental variables at Malam Jabba,Swat District,Pakistan

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Journal of Forestry Research 2020年第2期31卷 429-441页

作者： Arsalan Muhammad Faheem siddiqui Moinuddin ahmed Syed Shahid Shaukat Alamdar Hussain Department of Botany University of KarachiKarachi 75270Pakistan Dr.Moinuddin ahmed Laboratory of Plant Ecology and Dendrochronology Department of BotanyFederal Urdu UniversityKarachiPakistan Institute of Environmental Studies University of KarachiKarachiPakistan Department of Botany Karakoram International UniversityGilgitGilgit-BaltistanPakistan

This study focuses on age,growth rate and diameter distribution of pine forests in the Malam Jabba area,Swat District,*** core samples were taken from twenty *** smithiana was the oldest at 234 years with a 112-cm *** pindrow was 125 years with an 80-cm diameter while the oldest Pinus wallichiana was 122 years with 75-cm *** fastest overall growth rate of 1.5±0.1 year/cm was for *** on a west-facing aspect,while the slowest 5.8±2.6 year/cm growth was *** on an eastfacing *** and *** exhibited marked differences in growth rates over a 5-year *** highest growth was by *** from 1966 to *** showed less growth over the same years,such pattern simultaneously reverse from 1911 to *** relationship between diameter and age,diameter and growth rate and age and growth rate were *** and *** ages were correlated with diameter and growth *** age was positive correlated with ***,topographic and edaphic factors did not show significant correlations with growth rates,although some appreciable correlations were *** growth of *** was correlated with elevation while *** was correlated with maximum water retaining *** and age produced uneven size classes and many size gaps,which could be the result of anthropogenic disturbances.

关键词： Dendrochronology Environmental variables Conifer species Forest structure Age classes

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